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Superconducting Mass Spectrometry and Molecule Analysis

Risultati finali

Iterated SNWD design, specification, fabrication, delivery

Iterated SNWD design specification fabrication delivery

Optimized ion steering and Chip cleaning in cryochamber

Optimized ion steering and Chip cleaning in cryochamber

SNWD sensitivity to internal molecular energy

Report on SNWD sensitivity to internal molecular energy

Validation 5: Peptides with green PCTs synthesized and validated
Validation 3: peptides/proteins detected by 8-pixel SNWA prototype

Validation 3 peptidesproteins detected by 8pixel SNWA prototype

Validation 9: Preparation of a mass selected neutral protein beam

Validation 9 Preparation of a mass selected neutral protein beam

128-pixel array prototype, shipped Vienna

128pixel packaged array prototype shipped to Vienna

Report on reliability in UHV, thermal cycling, molecular irradiation

Report on reliability in UHV thermal cycling molecular irradiation

Strategies for increasing density and collimation of neutral protein beams
Validation 2: Optimized SNWD tested with proteins

Validation 2 Optimized SNWD tested with proteins

Validation 11: SNWD assisted detection of absorption in neutral macromolecules

Validation 11 SNWD assisted detection of absorption in neutral macromolecules

Validation 6: Peptides with blue PCTs synthesized and validated

Validation 6 Peptides with blue PCTs synthesized and validated

Complete mass spectrometer design: selectors, optics zones, cryogenic chamber
8-pixel packaged array prototype, shipped to Vienna

8pixel packaged array prototype shipped to Vienna

Validation 8: SNWD detection of singly-charged mass selected 100 kDa proteins

Validation 8 SNWD detection of singlycharged mass selected 100 kDa proteins

Validation 10: SNWD assisted detection of absorption in biopolymer ions

Validation 10 SNWD assisted detection of absorption in biopolymer ions

Pubblicazioni

A 0.32 × 0.12 mm^2 Cryogenic BiCMOS 0.1–8.8 GHz Low Noise Amplifier Achieving 4 K Noise Temperature for SNWD Readout

Autori: Y. Peng, J. Benserhir, M. Castaneda, A. Fognini, C. Bruschini and E. Charbon
Pubblicato in: IEEE Transactions on Microwave Theory and Techniques, 2024, ISSN 1557-9670
Editore: IEEE
DOI: 10.1109/tmtt.2024.3354828

Highly sensitive single-molecule detection in slow protein ion beams

Autori: M. Strauß, A. Shayeghi, M.F.X. Mauser, P. Geyer, T. Kostersitz, J. Salapa, O. Dobrovolskiy, S. Daly, J. Commandeur, Y. Hua, V. Köhler, M. Mayor, J. Benserhir, C. Bruschini, E. Charbon, M. Castaneda, M. Gevers, R. Gourgues, N. Kalhor, A. Fognini, and M. Arndt
Pubblicato in: Science Advances, Numero 9, 2023, Pagina/e 48, ISSN 2375-2548
Editore: American Society Association for the Advancement of Science
DOI: 10.1126/sciadv.adj2801

Giving the Green Light to Photochemical Uncaging of Large Biomolecules in High Vacuum

Autori: Yong Hua, Marcel Strauss, Sergey Fisher, Martin F. X. Mauser, Pierre Manchet, Martina Smacchia, Philipp Geyer, Armin Shayeghi, Michael Pfeffer, Tim Henri Eggenweiler, Steven Daly, Jan Commandeur, Marcel Mayor, Markus Arndt, Tomáš Šolomek, and Valentin Köhler
Pubblicato in: JACS, 2023, ISSN 2691-3704
Editore: ACS Publications
DOI: 10.1021/jacsau.3c00351

Giving the green light to photochemical uncaging of large biomolecules in high vacuum

Autori: Yong Hua, Marcel Strauss, Sergey Fisher, Martin F. X. Mauser , Pierre Manchet, Martina Smacchia, Philipp Geyer, Armin Shayeghi, Michael Pfeffer, Tim Henri Eggenweiler, Steven Daly, Jan Commandeur, Marcel Mayor, Markus Arndt, Tomáš Šolomek, Valentin Köhler
Pubblicato in: 2023
Editore: -
DOI: 10.26434/chemrxiv-2023-mgqg3

Click, Lock & Dye: a chromogenic handle for selective cysteine modification

Autori: Yong Hua, Zhi Zou, Alessandro Prescimone,Thomas R. Ward, Marcel Mayor, Valentin Köhler
Pubblicato in: 2023
Editore: ChemRxiv

Superconducting quantum detectors and single photon charge control for mass spectrometry

Autori: Marcel Strauß, Armin Shayeghi, Martin Mauser, Pierre Manchet, Martina Smacchia, Julia Salapa, Tim Kostersitz, Philipp Geyer, Steven Daly, Jan Commandeur, Yong Hua, Alfredo Di Silvestro, Marcel Mayor, Valentin Köhler, Jad Benserhir, Claudio Bruschini, Edoardo Charbon, Mario Castaneda, Monique Gevers, Ronan Gourgues, Nima Kalhor, Andreas Fognini, Markus Arndt
Pubblicato in: Proceedings of SPIE - Proceedings Volume 12447, Quantum Sensing, Imaging, and Precision Metrology; 124470I (2023), 2023, Pagina/e 124470I-1 to 124470I-7
Editore: Proceedings of SPIE
DOI: 10.1117/12.2657258

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