Precision medicine for muscoloskeletal regeneration, prosthetics and active ageing

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Abstracts of 30 articles submitted to peer-reviewed international journals and conferences through SyGMa
Project website
Publication of proceedings from Dissemination/soft skills workshops and Final Conference

Report on in silico design of optimized biomaterials and on their risk assessment by advanced 3D in vitro models
Report on Network-wide Recruitment procedures
Network Events Training Package - second period
Network events training package - first period

Network events training package first period

Report on validation of in vitro and in silico models and validation of omic signature with clinical data
Reports on safety and efficacy assessment of biomaterials using both in 3D in vitro by risk models
Report on interaction between biomaterials, extracellular matrix and cells from different sources
Report on validation of 3D cocultures models to test biomaterials in comparison with in-vivo data regarding materials implantation, previously acquired
Potential inputs for policy makers
"Report on patient healing and regeneration profile by ""omic"" analysis"

Report on patient healing and regeneration profile by omic analysis

Reports on chemical, chemical-physical, topographical and mechanical characterization of reference materials and protocol for their preparation

Reports on chemical chemicalphysical topographical and mechanical characterization of reference materials and protocol for their preparation

Report on validation of in-silico models with in-vitro data obtained in 3D advanced models

Publications

Octacalcium Phosphate-Laden Hydrogels on 3D-Printed Titanium Biomaterials Improve Corrosion Resistance in Simulated Biological Media

Author(s): Aydin Bordbar-Khiabani, Ilijana Kovrlija, Janis Locs, Dagnija Loca, Michael Gasik
Published in: International Journal of Molecular Sciences, Issue Volume 24, Number 17, 13135, 2023, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms241713135

Smart Hydrogels for Advanced Drug Delivery Systems

Author(s): Aydin Bordbar-Khiabani, Michael Gasik
Published in: International Journal of Molecular Sciences, Issue Volume 23, number 7: 3665, 2022, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23073665

In vitro cytocompatibility of antibacterial silver and copper-doped bioactive glasses

Author(s): Lallukka Mari, Houaoui Amel, Miola Marta, Miettinen Susanna, Massera Jonathan, Verné Enrica
Published in: Ceramics International, Issue Volume 49, Issue 22, Part B, 2023, Page(s) 36044–36055, ISSN 1873-3956
Publisher: Elsevier BV
DOI: 10.1016/j.ceramint.2023.08.284

Fusion and classification algorithm of octacalcium phosphate production based on XRD and FTIR data

Author(s): Nascimben Mauro, Kovrlija Ilijana, Locs Janis, Loca Dagnija, Rimondini Lia
Published in: Scientific Reports, Issue Volume 14, number 1489, 2024, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-024-51795-0

Pore graded borosilicate bioactive glass scaffolds: in vitro dissolution and cytocompatibility

Author(s): Agata Szczodra, Amel Houaoui, Turkka Salminen, Markus Hannula, Virginia Alessandra Gobbo, Sonya Ghanavati, Susanna Miettinen, Jonathan Massera
Published in: Journal of Materials Science: Materials in Medicine, Issue Volume 35, article number 17 (2024), 2024, ISSN 1573-4838
Publisher: Springer Nature
DOI: 10.1007/s10856-024-06791-1

Gallium containing calcium phosphates: Potential antibacterial agents or fictitious truth

Author(s): Marika Mosina, Ilijana Kovrlija, Liga Stipniece, Janis Locs
Published in: Acta Biomaterialia, Issue Volume 150, 2022, Page(s) 48-57, ISSN 1878-7568
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2022.07.063

A Gut-Ex-Vivo System to Study Gut Inflammation Associated to Inflammatory Bowel Disease (IBD)

Author(s): Mara Gagliardi, Romina Monzani, Nausicaa Clemente, Luca Fusaro, Valentina Saverio, Giovanna Grieco, Elżbieta Pańczyszyn, Nissan Yissachar, Francesca Boccafoschi, Marco Corazzari
Published in: Biology, Issue 10/7, 2021, Page(s) 605, ISSN 2079-7737
Publisher: MDPI
DOI: 10.3390/biology10070605

Deep Flow Cytometry Unveils Distinct Immune Cell Subsets in Inducible T Cell Co-Stimulator Ligand (ICOSL)- and ICOS-Knockout Mice during Experimental Autoimmune Encephalomyelitis

Author(s): Raineri Davide, Abreu Hugo,Vilardo Beatrice, Kustrimovic Natasa, Venegoni Chiara, Cappellano Giuseppe, Chiocchetti Annalisa
Published in: International Journal of Molecular Sciences, Issue Volume 25, number 5, 2509, 2024, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms25052509

Cutting-Edge Technologies for Inflamed Joints on Chip: How Close Are We?

Author(s): Emine Kahraman, Ricardo Ribeiro, Meriem Lamghari, Estrela Neto
Published in: Frontiers in Immunology, Issue Volume 13, Article 802440, 2022, ISSN 1664-3224
Publisher: Frontiers Media S.A.
DOI: 10.3389/fimmu.2022.802440

Challenging applicability of ISO 10993-5 for calcium phosphate biomaterials evaluation: Towards more accurate in vitro cytotoxicity assessment

Author(s): Ilijana Kovrlija, Ksenia Menshikh, Hugo Abreu, Andrea Cochis, Lia Rimondini, Olivier Marsan, Christian Rey, Christèle Combes, Janis Locs, Dagnija Loca
Published in: Biomaterials Advances, Issue Volume 160, June 2024, 213866, 2024, ISSN 2772-9508
Publisher: Elsevier BV
DOI: 10.1016/j.bioadv.2024.213866

Functionalization of a chemically treated Ti6Al4V-ELI alloy with nisin for antibacterial purposes

Author(s): Gobbo, V.A., Lallukka, M., Gamna, F., Prato, M., Vitale, A., Ferraris, S., Najmi, Z., Cochis, A., Rimondini, L., Massera, J., Spriano, S.
Published in: Applied Surface Science, Issue Volume 620, 2023, Page(s) 156820, ISSN 0169-4332
Publisher: Elsevier BV
DOI: 10.1016/j.apsusc.2023.156820

Tuning biomechanical behavior and biocompatibility of Mg–Zn–Ca alloys by Mn3O4 incorporated plasma electrolytic oxidation coatings

Author(s): Sara Bahrampour, Aydin Bordbar-Khiabani, M. Hossein Siadati, Michael Gasik
Published in: Ceramics International, Issue Volume 50, Issue 17, Part A, 2024, Page(s) 29703-29710, ISSN 1873-3956
Publisher: Elsevier BV
DOI: 10.1016/j.ceramint.2024.05.267

Surface modification of silicate, borosilicate, and phosphate bioactive glasses to improve/control protein adsorption: PART II

Author(s): Virginia Alessandra Gobbo, Paula Turkki, Cristina Santos Dias Palma, Vijay Singh Parihar, Enrica Vernè, Silvia Spriano, Andre Sanches Ribeiro, Vesa P. Hytönen, Jonathan Massera
Published in: Ceramics International, Issue Volume 49, Issue 8, 15 April 2023, 2023, Page(s) 12856-12865, ISSN 0272-8842
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.ceramint.2022.12.157

Molecular Toxicity Virtual Screening Applying a Quantized Computational SNN-Based Framework

Author(s): Nascimben Mauro, Rimondini Lia
Published in: Molecules, Issue Volume 28, number 3, 1342, 2023, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules28031342

Octacalcium phosphate: Innovative vehicle for the local biologically active substance delivery in bone regeneration

Author(s): Ilijana Kovrlija, Janis Locs, Dagnija Loca
Published in: Acta Biomaterialia, 2021, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2021.08.021

Concomitant silanization and controlled fibronectin adsorption on S53P4 bioactive glass enhances human adipose stem cells spreading and differentiation

Author(s): Virginia Alessandra Gobbo, Amel Houaoui, Kimiya Tajik, Vesa P. Hytönen, Susanna Miettinen, Jonathan Massera
Published in: Applied Surface Science Advances, Issue Volume 23, September 2024, 100635, 2024, ISSN 2666-5239
Publisher: Elsevier BV
DOI: 10.1016/j.apsadv.2024.100635

Biomechanical Aspects in Bone Tumor Engineering

Author(s): Menshikh Ksenia, Banicevic Ivana, Obradovic Bojana, Rimondini Lia
Published in: Tissue Engineering, Part B: Reviews, Issue Volume 30, Number 2, 2023, Page(s) 217-229, ISSN 1937-3376
Publisher: Mary Ann Liebert
DOI: 10.1089/ten.teb.2023.0106

Improving the inflammatory-associated corrosion behavior of magnesium alloys by Mn3O4 incorporated plasma electrolytic oxidation coatings

Author(s): Bahrampour Sara, Bordbar-Khiabani Aydin, Siadati M. Hossein, Gasik Michael, Mozafari Masoud
Published in: Chemical Engineering Journal, Issue Volume 483, 1 March 2024, 149016, 2024, ISSN 1873-3212
Publisher: Elsevier BV
DOI: 10.1016/j.cej.2024.149016

Surface Functionalization of Ti6Al4V-ELI Alloy with Antimicrobial Peptide Nisin

Author(s): Lallukka Mari, Gamna Francesca, Gobbo Virginia Alessandra, Prato Mirko, Najmi Ziba, Cochis Andrea, Rimondini Lia, Ferraris Sara, Spriano Silvia
Published in: Nanomaterials, Issue Volume 12, Issue 23, 4332, 2022, ISSN 2079-4991
Publisher: MDPI
DOI: 10.3390/nano12234332

Double-stage discretization approaches for biomarker-based bladder cancer survival modeling

Author(s): Mauro Nascimben, Manolo Venturin, Lia Rimondini
Published in: Communications in Applied and Industrial Mathematics, Issue 12/1, 2021, Page(s) 29-47, ISSN 2038-0909
Publisher: Sciendo
DOI: 10.2478/caim-2021-0003

Incorporation of Barium Ions into Biomaterials: Dangerous Liaison or Potential Revolution?

Author(s): Ilijana Kovrlija; Janis Locs; Dagnija Loca
Published in: Materials, Issue Volume 14, Issue 19, 2021, ISSN 1996-1944
Publisher: MDPI Open Access Publishing
DOI: 10.3390/ma14195772

Cu-doped bioactive glass with enhanced in vitro bioactivity and antibacterial properties

Author(s): Lallukka Mari, Miola Marta, Najmi Ziba, Cochis Andrea, Spriano Silvia, Rimondini Lia, Verné Enrica
Published in: Ceramics International, Issue Volume 50, Issue 3, Part B, 2024, Page(s) 5091-5103, ISSN 1873-3956
Publisher: Elsevier BV
DOI: 10.1016/j.ceramint.2023.11.253

Extracellular Vesicle Protein Expression in Doped Bioactive Glasses: Further Insights Applying Anomaly Detection.

Author(s): Nascimben, M.; Abreu, H.; Manfredi, M.; Cappellano, G.; Chiocchetti, A.; Rimondini, L.
Published in: International Journal of Molecular Sciences, Issue Vol. 25, num. 6, 2024, Page(s) 3560, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms25063560

FSP1 is a predictive biomarker of osteosarcoma cells’ susceptibility to ferroptotic cell death and a potential therapeutic target

Author(s): Elzbieta Panczyszyn, Valentina Saverio, Romina Monzani, Mara Gagliardi, Jelena Petrovic, Jasmina Stojkovska, Licio Collavin & Marco Corazzari
Published in: Cell Death Discovery, Issue 10, Article number: 87 (2024), 2024, ISSN 2058-7716
Publisher: Springer Nature
DOI: 10.1038/s41420-024-01854-2

Algorithm-Based Risk Identification in Patients with Breast Cancer-Related Lymphedema: A Cross-Sectional Study

Author(s): Nascimben Mauro, Lippi Lorenzo, de Sire Alessandro, Invernizzi Marco, Rimondini Lia
Published in: Cancers, Issue Volume 15, Issue 2: 336, 2023, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers15020336

Human T-Cell Responses to Metallic Ion-Doped Bioactive Glasses

Author(s): Abreu, H., Lallukka, M., Miola, M., Spriano, S., Vernè, E., Raineri, D., Leigheb, M., Ronga, M., Cappellano, G., & Chiocchetti, A
Published in: International Journal of Molecular Sciences, Issue Volume 25, Issue 8, 4501, 2024, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms25084501

Probiotics Supplements Reduce ER Stress and Gut Inflammation Associated with Gliadin Intake in a Mouse Model of Gluten Sensitivity

Author(s): Eleonora Ferrari; Romina Monzani; Valentina Saverio; Mara Gagliardi; Elżbieta Pańczyszyn; Valeria Raia; Valeria Rachela Villella; Gianni Bona; Marco Pane; Angela Amoruso; Marco Corazzari
Published in: Nutrients, Issue Volume 13, Issue 4, 2021, ISSN 2072-6643
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu13041221

Surface modification of silicate, borosilicate and phosphate bioactive glasses to improve/control protein adsorption: PART I

Author(s): Virginia Alessandra Gobbo, Vijay Singh Parihar, Mirko Prato, Minna Kellomäki, Enrica Vernè, Silvia Spriano, Jonathan Massera
Published in: Ceramics International, Issue Volume 49, Issue 1, 1 January 2023, 2023, Page(s) 1261-1275, ISSN 0272-8842
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.ceramint.2022.09.105

Bifunctional Mesoporous Glasses for Bone Tissue Engineering: Biological Effects of Doping with Cerium and Polyphenols in 2D and 3D In Vitro Models

Author(s): Ksenia Menshikh, Ajay Kumar Reddy, Andrea Cochis, Francesca Fraulini, Alfonso Zambon, Gigliola Lusvardi, Lia Rimondini
Published in: Biomaterials and Biosystems, Issue Volume 14, June 2024, 100095, 2024, ISSN 2666-5344
Publisher: Elsevier BV
DOI: 10.1016/j.bbiosy.2024.100095

Sound-based assembly of a microcapillary network in a saturn-like tumor model for drug testing

Author(s): Nicola Di Marzio, Preeta Ananthanarayanan, Anne Géraldine Guex, Mauro Alini, Chiara Riganti, Tiziano Serra
Published in: Materials Today Bio, Issue Volume 16, December 2022, 100357, 2022, ISSN 2590-0064
Publisher: Elsevier BV
DOI: 10.1016/j.mtbio.2022.100357

Gut-Ex-Vivo system as a model to study gluten response in celiac disease

Author(s): Mara Gagliardi, Nausicaa Clemente, Romina Monzani, Luca Fusaro, Eleonora Ferrari, Valentina Saverio, Giovanna Grieco, Elżbieta Pańczyszyn, Flavia Carton, Claudio Santoro, Sara Del Mare-Roumani, Sivan Amidror, Nissan Yissachar, Francesca Boccafoschi, Silvia Zucchelli, Marco Corazzari
Published in: Cell Death Discovery, Issue 7/1, 2021, ISSN 2058-7716
Publisher: Springer Nature
DOI: 10.1038/s41420-021-00430-2

Surface functionalization of anodized tantalum with Mn3O4 nanoparticles for effective corrosion protection in simulated inflammatory condition

Author(s): Aydin Bordbar-Khiabani, Sara Bahrampour, Masoud Mozafari, Michael Gasik
Published in: Ceramics International, Issue Volume 48, Issue 3, 2022, Page(s) 3148-3156, ISSN 0272-8842
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.ceramint.2021.10.088

Understanding glycosylation: Regulation through the metabolic flux of precursor pathways

Author(s): Scheper Aert, Schofield Jack, Bohara Raghvendra, Ritter Thomas, Pandit Abhay
Published in: Biotechnology Advances, Issue Volume 67, October 2023, 108184, 2023, ISSN 0734-9750
Publisher: Elsevier BV
DOI: 10.1016/j.biotechadv.2023.108184

The Neuroimmune Interplay in Joint Pain: The Role of Macrophages

Author(s): Daniela P Vasconcelos, Clive Jabangwe, Meriem Lamghari, Cecília J Alves
Published in: Frontiers in Immunology, Issue Volume 13, Article 812962, 2022, ISSN 1664-3224
Publisher: Frontiers Media S.A.
DOI: 10.3389/fimmu.2022.812962

Differential proteomics profile of microcapillary networks in response to sound pattern-driven local cell density enhancement

Author(s): N. Di Marzio; R. Tognato; E. Della Bella; V. De Giorgis; M. Manfredi; A. Cochis; M. Alini; T. Serra
Published in: Biomaterials and Biosystems, Issue Vol. 14, June 2024, 100094, 2024, ISSN 2666-5344
Publisher: Elsevier BV
DOI: 10.1016/j.bbiosy.2024.100094

Extracellular Vesicles in Musculoskeletal Regeneration: Modulating the Therapy of the Future

Author(s): Abreu, Hugo; Canciani, Elena; Raineri, Davide; Cappellano, Giuseppe; Rimondini, Lia; Chiocchetti, Annalisa
Published in: Cells, Issue 11(1), 43, 2021, ISSN 2073-4409
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cells11010043

Electrochemical behavior of additively manufactured patterned titanium alloys under simulated normal, inflammatory, and severe inflammatory conditions

Author(s): Aydin Bordbar-Khiabani, Michael Gasik
Published in: Journal of Materials Research and Technology, Issue Vol. 26, 2023, Page(s) 356 – 370, ISSN 2214-0697
Publisher: Elsevier
DOI: 10.1016/j.jmrt.2023.07.113

The waves that make the pattern: a review on acoustic manipulation in biomedical research

Author(s): A.G. Guex, N. Di Marzio, D. Eglin, M. Alini, T. Serra
Published in: Materials Today Bio, Issue 10, 2021, Page(s) 100110, ISSN 2590-0064
Publisher: Elsevier - Materials Today Bio
DOI: 10.1016/j.mtbio.2021.100110

High levels of circulating osteopontin in inflammatory lung disease regardless of Sars‐CoV‐2 infection

Author(s): Cappellano, G., Abreu, H., Raineri, D., Scotti, L., Castello, L., Vaschetto, R., & Chiocchetti, A.
Published in: EMBO Molecular Medicine, Issue 13(5), 2021, Page(s) e14124, ISSN 1757-4684
Publisher: EMBO Press
DOI: 10.15252/emmm.202114124

Polygenic risk modeling of tumor stage and survival in bladder cancer

Author(s): Nascimben Mauro, Rimondini Lia, Corà Davide, Venturin Manolo
Published in: BioData Mining, Issue Volume 15, article number: 23, 2022, ISSN 1756-0381
Publisher: BioMed Central
DOI: 10.1186/s13040-022-00306-w

Silver-doped glass-ceramic scaffolds with antibacterial and bioactive properties for bone substitution

Author(s): Lallukka, M., Miola, M., Verné, E., Baino, F.
Published in: Ceramics International, Issue Volume 50, Issue 17, Part B, 2024, Page(s) 30997-31005, ISSN 0272-8842
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.ceramint.2024.05.404

Exploring the Formation Kinetics of Octacalcium Phosphate from Alpha-Tricalcium Phosphate: Synthesis Scale-Up, Determination of Transient Phases, Their Morphology and Biocompatibility

Author(s): Ilijana Kovrlija, Ksenia Menshikh, Olivier Marsan, Christian Rey, Christèle Combes, Janis Locs, Dagnija Loca
Published in: Biomolecules, Issue Volume 13, number 3, 462, 2023, ISSN 2218-273X
Publisher: MDPI
DOI: 10.3390/biom13030462

A software suite for limb volume analysis applicable in clinical settings: upper limb quantification

Author(s): Nascimben Mauro, Lippi Lorenzo, Invernizzi Marco, Fusco Nicola, Rimondini Lia
Published in: Frontiers in Bioengineering and Biotechnology, Issue Volume 10, May 2022, Article 863689, 2022, ISSN 2296-4185
Publisher: Frontiers Media S.A
DOI: 10.3389/fbioe.2022.863689

Doxorubicin loaded octacalcium phosphate particles as controlled release drug delivery systems: Physico-chemical characterization, in vitro drug release and evaluation of cell death pathway

Author(s): Kovrlija Ilijana, Panczyszyn Elzbieta, Demir Oznur, Laizane Marta, Corazzari Marco, Locs Janis, Loca Dagnija
Published in: International Journal of Pharmaceutics, Issue Volume 653, 25 March 2024, 123932, 2024, ISSN 1873-3476
Publisher: Elsevier BV
DOI: 10.1016/j.ijpharm.2024.123932

Bio-Fabrication: Convergence of 3D Bioprinting and Nano-Biomaterials in Tissue Engineering and Regenerative Medicine

Author(s): Nicola Di Marzio, David Eglin, Tiziano Serra, Lorenzo Moroni
Published in: Frontiers in Bioengineering and Biotechnology, Issue 8, 2020, ISSN 2296-4185
Publisher: Frontiers
DOI: 10.3389/fbioe.2020.00326

Electrochemical and biological characterization of Ti–Nb–Zr–Si alloy for orthopedic applications

Author(s): Aidin Bordbar-Khiabani, Michael Gasik
Published in: Scientific Reports, Issue Volume 13, Article number: 2312, 2023, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-023-29553-5

Physiologically relevant assessment of biomaterials in biomimetic bioreactors aimed for regeneration of skeletal tissues

Author(s): Bojana Obradovic, Jasmina Stojkovska, Jovana Zvicer, Ivana Banicevic, Medic Ana, Sasa Novak, Djordje Veljovic, Vesna Miskovic Stankovic
Published in: TERMIS - 6th World Congress, Book of Abstracts, Issue Volume 28, Issue S1, 2021, Page(s) 429, ISSN 1937-3341
Publisher: Mary Ann Liebert
DOI: 10.5281/zenodo.5898509

Visually Enhanced Python Functions for Clinical Equality of Measurement Assessment

Author(s): Nascimben Mauro, Rimondini Lia
Published in: Annals of Computer Science and Information, Issue Volume 32, 2022, Page(s) 241–249, ISSN 2300-5963
Publisher: Polish Information Processing Society (PTI)
DOI: 10.15439/2022f32

Development of a physiologically relevant 3D in vitro model for osteosarcoma cell cultivation comprising alginate composite scaffolds and a perfusion bioreactor system

Author(s): Banicevic Ivana, Radonjic Mia, Pavlovic Marija, Milivojevic Milena, Stevanovic Milena, Stojkovska Jasmina, Obradovic Bojana
Published in: Nineteenth Young Researchers' Conference - Material Science and Engineering: Programme and Book of Abstracts, 2021, Page(s) 6, ISBN 978-86-80321-36-3
Publisher: Institute of Technical Sciences of SASA
DOI: 10.5281/zenodo.5898252

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