INnovation in Safety Pharmacology for Integrated cardiovascular safety assessment to REduce adverse events and late stage drug attrition.

Livrables

Publications and conference attendance by ESRs (1st report)

A detailed report on all publications and conference attendance by ESRsDuring all communications presentations publciations the EUlogo and the Grant Number will be acknowledgedFirst report M24

Final report on engagement of ESRs in outreach to the public

Final report on engagement of ESRs in outreach to the public.(final report on M48, interim report on M24)

Implementation of outreach strategy to the general public

Implementation of outreach strategy to the general publicContinuous effort1st report on M242nd report on M48

First report on (new) MoA of structural/functional cardiotoxicity

First report on new MoA of structuralfunctional cardiotoxicity

Interim Report on engagement of ESRs in outreach to the public

Report on engagement of ESRs in outreach to the publicinterim report on M24 final report on M48

Potential inputs for policy feedback

Consortium should include any relevant information, results, activities who could contribute to any policy development in their domain. This information could then be used for policy feedback purposes.

Publications and conference attendance by ESRs (2nd report)

A detailed report on all publications and conference attendance by ESRs.During all communications (presentations, publciations) the EU-logo and the Grant Number will be acknowledged.First report: M24

Final report on new MoA in cardio-oncology and possible risk mitigation by biomarkers or preventive strategies

Final report on new MoA in cardio-oncology and possible risk mitigation by biomarkers or preventive strategies.

Report on added value of arterial flow/stiffness measures for SP

Report on added value of arterial flow/stiffness measures for SP.

All ESRs recruited, enrolled in PhD training and declarations of conformity signed

All ESRs recruited enrolled in PhD training and declarations of conformity signed

Organisation of the Outreach Conference

Two outrach events will be organised in collaboration with the SPS, respectively at M21 and M45

Start recruitment procedure

Start recruitment (advertisements, selection criteria). Positioned advertised and application platform in place

Awarding PhD degrees to ESRs

Awarding PhD degrees to ESRs.

Promotional materials such as a project website, flyer, semi-annual newsletters, social media posts, etc.

Promotional materials such as a project website, flyer, semi-annual newsletters, social media posts etc. Importantly, reaching this deliverable is just the start of the outreach campaign, afterwards outreach to the general public and the scientific community will be a continuous process; all communication activities will also be listed on the website.

Publications

Optimization of bioanalysis of dried blood samples

Auteurs: Elham Ataei Alizadeh, Georg Rast, Chris Cantow, Jessica Schiwon, Florian Krause, Guido R.Y. De Meyer, Pieter-Jan Guns, Brian D. Guth, Michael Markert
Publié dans: Journal of Pharmacological and Toxicological Methods, Numéro 107296, 2023, ISSN 1056-8719
Éditeur: Elsevier BV
DOI: 10.1016/j.vascn.2023.107296

Empagliflozin decreases ageing-associated arterial stiffening and vascular fibrosis under normoglycemic conditions

Auteurs: Cédric H.G. Neutel, Callan D. Wesley, Melissa Van Praet, Celine Civati, Lynn Roth, Guido R.Y. De Meyer, Wim Martinet, Pieter-Jan Guns
Publié dans: Vascular Pharmacology, Numéro Vol. 152, 107212, 2023, ISSN 1537-1891
Éditeur: Elsevier BV
DOI: 10.1016/j.vph.2023.107212

Improved on-tissue detection of the anti-cancer agent doxorubicin by quantitative matrix-assisted laser desorption/ionization mass spectrometry imaging

Auteurs: Charles Van Assche, Dustin Krüger, Bryn Flinders, Michiel Vandenbosch, Constantijn Franssen, Pieter-Jan Guns, Ron M A Heeren, Berta Cillero-Pastor
Publié dans: Talanta, Numéro Vol. 271, 2024, Page(s) PMID: 38245959, ISSN 0039-9140
Éditeur: Elsevier BV
DOI: 10.1016/j.talanta.2024.125667

Measuring Locomotor Activity and Behavioral Aspects of Rodents Living in the Home-Cage

Auteurs: Klein Christian J. M. I., Budiman Thomas, Homberg Judith R., Verma Dilip, Keijer Jaap, van Schothorst Evert M.
Publié dans: Frontiers in Behavioral Neuroscience, Numéro 16, 2022, ISSN 1662-5153
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fnbeh.2022.877323

The effect of cyclic stretch on aortic viscoelasticity and the putative role of smooth muscle focal adhesion

Auteurs: Cédric H. G. Neutel, Callan D. Wesley, Guido R. Y. De Meyer, Wim Martinet, and Pieter-Jan Guns
Publié dans: Frontiers in Physiology, Numéro Volume 14 - 2023, 2023, ISSN 1664-042X
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fphys.2023.1218924

Monitoring haemodynamic changes in rodent models to better inform safety pharmacology: Novel insights from in vivo studies and waveform analysis

Auteurs: Marieke Van Daele, Samantha L Cooper, Patrizia Pannucci, Edward S Wragg, Julie March, Iwan de Jong and Jeanette Woolard
Publié dans: JRSM Cardiovascular Disease, Numéro Vol. 11, 2022, Page(s) 1–9, ISSN 2048-0040
Éditeur: SAGE Publications Ltd
DOI: 10.1177/20480040221092893

Artificial Neural Network Comparison on hERG Channel Blockade Detection

Auteurs: Haibo Liu,Tessa De Korte,Sylvain Bernasconi,Christophe Bleunven,Damiano Lombardi,Muriel Boulakia
Publié dans: International Journal of Computer Applications, Numéro Volume 184 - No.14, 2022, Page(s) 0975 - 8887, ISSN 0975-8887
Éditeur: Foundation of Computer Science
DOI: 10.5120/ijca2022922119

Role of endothelin ETA receptors in the hypertension induced by the VEGFR-2 kinase inhibitors axitinib and lenvatinib in conscious freely-moving rats

Auteurs: Patrizia Pannucci, Marieke Van Daele, Samantha L. Cooper, Edward S. Wragg, Julie March, Marleen Groenen, Stephen J. Hill
Publié dans: Biochemical Pharmacology, Numéro 116007, 2023, ISSN 0006-2952
Éditeur: Elsevier BV
DOI: 10.1016/j.bcp.2023.116007

Characterization of systolic and diastolic function, alongside proteomic profiling, in doxorubicin-induced cardiovascular toxicity in mice

Auteurs: Dustin N. Krüger, Matthias Bosman, Charles X.L. Van Assche, Callan D. Wesley, Berta Cillero-Pastor, Leen Delrue, Ward Heggermont, Jozef Bartunek, Guido R. Y. De Meyer, Emeline M. Van Craenenbroeck, Pieter-Jan Guns & Constantijn Franssen
Publié dans: Cardio-Oncology, Numéro 10, 40 (2024), 2024, ISSN 2057-3804
Éditeur: BioMed Central Ltd unless otherwise stated. Part of Springer Nature.
DOI: 10.1186/s40959-024-00241-1

Involvement of β- adrenoceptors in the cardiovascular responses induced by selective adenosine A2A and A2B receptor agonists

Auteurs: Edward S. Wragg, Patrizia Pannucci, Stephen J. Hill, Jeanette Woolard, Samantha L. Cooper.
Publié dans: Pharmacology Research & Perspectives, Numéro Vol. 10, Numéro3, 2022, ISSN 2052-1707
Éditeur: Wiley
DOI: 10.1002/prp2.975

Doxorubicin impairs smooth muscle cell contraction : novel insights in vascular toxicity

Auteurs: Bosman Matthias, Kruger Dustin N., Favere Kasper, Wesley Callan D., Neutel Cédric, Van Asbroeck Birgit, Diebels Owen R., Faes Bart, Schenk Timen J., Martinet Wim, De Meyer Guido, van Craenenbroeck Emeline, Guns Pieter-Jan
Publié dans: International journal of molecular sciences, Numéro 22:23(2021), 12812, 2021, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms222312812

Circulating MicroRNA as Biomarkers of Anthracycline-Induced Cardiotoxicity: JACC: CardioOncology State-of-the-Art Review

Auteurs: Hanne M. Boen, Martina Cherubin, Constantijn Franssen, Andreas B. Gevaert, Isabel Witvrouwen, Matthias Bosman, Pieter-Jan Guns, Hein Heidbuchel, Bart Loeys, Maaike Alaerts, and Emeline M. Van Craenenbroeck
Publié dans: Journal of American College of Cardiology Foundation, Numéro Vol. 6 No. 2, 2024, Page(s) 183–199, ISSN 2666-0873
Éditeur: Published by Elsevier on Behalf of The American College of Cardiology Foundation
DOI: 10.1016/j.jaccao.2023.12.009

Characterisation of tyrosine kinase inhibitor-receptor interactions at VEGFR2 using sunitinib-red and nanoBRET

Auteurs: Marieke Van Daele, Laura E. Kilpatrick, Jeanette Woolard, Stephen J. Hill
Publié dans: Biochemical Pharmacology, Numéro Vol. 214, 2023, ISSN 0006-2952
Éditeur: Elsevier BV
DOI: 10.1016/j.bcp.2023.115672

The impact of environmental and biological factors on the resting heart rate of dogs as assessed using 20 years of data from safety pharmacology studies

Auteurs: Elham Ataei Alizadeh, Thomas Trautmann, Florian Krause, Benjamin Knoeferl, Pieter-Jan Guns, Guido De Meyer, Brian D. Guth, Michael Markert
Publié dans: Journal of Pharmacological and Toxicological Methods, Numéro Volume 121, May–June 2023, 107263, 2023, ISSN 1056-8719
Éditeur: Elsevier BV
DOI: 10.1016/j.vascn.2023.107263

Doxorubicin-induced cardiovascular toxicity: a longitudinal evaluation of functional and molecular markers

Auteurs: Matthias Bosman, Dustin Krüger, Charles Van Assche, Hanne Boen, Cédric Neutel, Kasper Favere, Constantijn Franssen, Wim Martinet, Lynn Roth, Guido R Y De Meyer, Berta Cillero-Pastor, Leen Delrue, Ward Heggermont, Emeline M Van Craenenbroeck, Pieter-Jan Guns
Publié dans: Cardiovascular Research, Numéro cvad 136, 2023, Page(s) 1-12, ISSN 0008-6363
Éditeur: Elsevier BV
DOI: 10.1093/cvr/cvad136

COVID-19-Induced Myocarditis: Pathophysiological Roles of ACE2 and Toll-like Receptors

Auteurs: Patrizia Pannucci , Sophie R. Jefferson, Jonathan Hampshire, Samantha L. Cooper, Stephen J. Hill, and Jeanette Woolard
Publié dans: International Journal Molecular Science 2023, Numéro 24(6), 5374, 2023, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24065374

Regionally selective cardiovascular responses to adenosine A2A and A2B receptor activation

Auteurs: Samantha L. Cooper,Edward S. Wragg,Patrizia Pannucci,Mark Soave,Stephen J. Hill,Jeanette Woolard
Publié dans: FASEB Journal, Numéro Monthly, with an annual supplement, 2022, Page(s) NA, ISSN 0892-6638
Éditeur: Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.202101945r

Dexrazoxane does not mitigate early vascular toxicity induced by doxorubicin in mice

Auteurs: Bosman Matthias, Krüger Dustin, Favere Kasper, De Meyer Guido, Franssen Constantijn, van Craenenbroeck Emeline, Guns Pieter-Jan
Publié dans: PLoS ONE, Numéro 18:11(2023), e0294848, 2023, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0294848

Thirty years of telemetry-based data acquisition for cardiovascular drug safety evaluation: Applications and optimization

Auteurs: Elham Ataei Alizadeh, Karin Graf, Jessica Schiwon, Thomas Trautmann, Florian Krause, Werner Mayer, Katrin Christ, Eric Martel, Brian D. Guth, Michael Markert
Publié dans: Journal of Pharmacological and Toxicological Methods, Numéro Vol. 122, July–August 2023, 107279, 2023, ISSN 1056-8719
Éditeur: Elsevier BV
DOI: 10.1016/j.vascn.2023.107279

Parameter identification through gradient flow on latent variables

Auteurs: Muriel Boulakia, Haibo Liu, Damiano Lombardi
Publié dans: Hal Open Science, 2023
Éditeur: Hal Open Science

Comparison of statistical, machine learning, and mathematical modelling methods to investigate the effect of ageing on dog’s cardiovascular system

Auteurs: Elham Ataei Alizadeh, Sara Costa Faya, Haibo Liu, Damiano Lombardi, Sylvain Bernasconi, Pieter-Jan Guns and Michael Markert
Publié dans: ESAIM: Proceedings and Surveys, Numéro Vol. 73, 2023, Page(s) 2-27, ISSN 2267-3059
Éditeur: EDP Sciences
DOI: 10.1051/proc/202373002

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