Networking for excellence in functional pharmacology to study the role of fatty acid metabolism in neurological disorders

Livrables

1st dissemination and communication report
Minutes from the 3rd year Executive Board meeting

Minutes from the FAT4BRAIN 3rd year Executive Board meeting

Report on organized events and trainings M1-12
Report on visits and participation in capacity-building events

Report on UU and EKUT researcher visits and participation in capacitybuilding events

Minutes from the 2nd year Executive Board meeting

Minutes from the FAT4BRAIN 2nd year Executive Board meeting

Strategy and plan for ESR involvement

Strategy and plan for ESR involvement in FAT4BRAIN activities and establishment of mentoring platform

Report on organized events and trainings M25-40

Report on organized events and trainings M2540

Report on LIOS researcher visits and participation in capacity-building events

Report on LIOS researcher visits and participation in capacitybuilding events

Minutes from the kick-off meeting
Communication channels and visual identity

Created FAT4BRAIN communication channels and visual identity

Communication Strategy and Plan of Exploitation and Dissemination of Results
Report on organized events and trainings M13-24

Report on organized events and trainings M1324

Report on researcher visits and participation in capacity-building events

Report on OROBOROS researcher visits and participation in capacitybuilding events

Minutes from the 1st year Executive Board meeting

Minutes from the FAT4BRAIN 1st year Executive Board meeting

2nd dissemination and communication report

Data management plan

Development of data management plan

Publications

Effects of Transient Administration of the NMDA Receptor Antagonist MK-801 in Drosophila melanogaster Activity, Sleep, and Negative Geotaxis

Auteurs: Moulin TC, Stojanovic T, Rajesh RP, Pareek T, Donzelli L, Williams MJ, Schiöth HB
Publié dans: Biomedicines, 2023, ISSN 2227-9059
Éditeur: MDPI
DOI: 10.3390/biomedicines11010192

Low cardiac content of long-chain acylcarnitines in TMLHE knockout mice prevents ischaemia-reperfusion-induced mitochondrial and cardiac damage

Auteurs: Liepinsh E, Kuka J, Vilks K, Svalbe B, Stelfa G, Vilskersts R, Sevostjanovs E, Goldins NR, Groma V, Grinberga S, Plaas M, Makrecka-Kuka M, Dambrova M
Publié dans: Free Radical Biology and Medicine, 2021, ISSN 1873-4596
Éditeur: Elsevier
DOI: 10.1016/j.freeradbiomed.2021.10.035

Empagliflozin Protects Cardiac Mitochondrial Fatty Acid Metabolism in a Mouse Model of Diet-Induced Lipid Overload

Auteurs: Marina Makrecka-Kuka, Stanislava Korzh, Melita Videja, Karlis Vilks, Helena Cirule, Janis Kuka, Maija Dambrova, Edgars Liepinsh
Publié dans: Cardiovascular Drugs and Therapy, Numéro 34/6, 2020, Page(s) 791-797, ISSN 0920-3206
Éditeur: Kluwer Academic Publishers
DOI: 10.1007/s10557-020-06989-9

Linking atypical depression and insulin resistance-related disorders via low-grade chronic inflammation: Integrating the phenotypic, molecular and neuroanatomical dimensions

Auteurs: Zümrüt Duygu Sen, Lena Vera Danyeli, Marie Woelfer, Femke Lamers, Gerd Wagner, Thomas Sobanski, Martin Walter
Publié dans: Brain, Behavior, and Immunity, Numéro 93, 2021, Page(s) 335-352, ISSN 0889-1591
Éditeur: Academic Press
DOI: 10.1016/j.bbi.2020.12.020

Inhibition of Fatty Acid Metabolism Increases EPA and DHA Levels and Protects against Myocardial Ischaemia-Reperfusion Injury in Zucker Rats

Auteurs: Kuka J, Makrecka-Kuka M, Vilks K, Korzh S, Cirule H, Sevostjanovs E, Grinberga S, Dambrova M, Liepinsh E
Publié dans: Oxidative Medicine and Cellular Longevity, 2021, ISSN 1942-0994
Éditeur: Hindawi
DOI: 10.1155/2021/7493190

Heart-Type Fatty Acid Binding Protein Binds Long-Chain Acylcarnitines and Protects against Lipotoxicity

Auteurs: Zelencova-Gopejenko D, Videja M, Grandane A, Pudnika-Okinčica L, Sipola A, Vilks K, Dambrova M, Jaudzems K, Liepinsh E
Publié dans: International Journal of Molecular Sciences, 2022, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24065528

Acylcarnitines: Nomenclature, biomarkers, therapeutic potential, drug targets and clinical trials

Auteurs: Dambrova M, Makrecka-Kuka M, Kuka J, Vilskersts R, Nordberg D, Attwood M, Smesny S, Duygu Sen Z, Chi Guo A, Oler E, Tian S, Wishart D, Liepinsh E, Schiöth H
Publié dans: Pharmacological Reviews, 2022, ISSN 1521-0081
Éditeur: ASPET
DOI: 10.1124/pharmrev.121.000408

Reduced GFAP Expression in Bergmann Glial Cells in the Cerebellum of Sigma-1 Receptor Knockout Mice Determines the Neurobehavioral Outcomes after Traumatic Brain Injury

Auteurs: Stelfa G, Vavers E, Svalbe B, Serzants R, Miteniece A, Lauberte L, Grinberga S, Gukalova B, Dambrova M, Zvejniece L
Publié dans: International Journal of Molecular Sciences, 2021, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms222111611

Multidrug Resistance Like Protein 1 Activity in Malpighian Tubules Regulates Lipid Homeostasis in Drosophila

Auteurs: Liu W, Cao H, Kimari M, Maronitis G, Williams MJ, Schiöth HB
Publié dans: Membranes (Basel), 2021, ISSN 2077-0375
Éditeur: Molecular Diversity Preservation International
DOI: 10.3390/membranes11060432

Transient Administration of Dopaminergic Precursor Causes Inheritable Overfeeding Behavior in Young Drosophila melanogaster Adults

Auteurs: Moulin TC, Ferro F, Berkins S, Hoyer A, Williams MJ, Schiöth HB
Publié dans: Brain Sciences, 2020, ISSN 2076-3425
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/brainsci10080487

Rodent Heart and Brain Tissue Preparation for Digital Macro Photography after Ischemia-reperfusion

Auteurs: Liepinsh E, Kuka J, Zvejniece L, Vilskersts R, Dambrova M
Publié dans: Journal of visualized experiments, 2022, ISSN 1940-087X
Éditeur: MYJoVE Corporation
DOI: 10.3791/62942

Excitability, synaptic balance, and addiction: The homeostatic dynamics of ionotropic glutamatergic receptors in VTA after cocaine exposure

Auteurs: Thiago C. Moulin, Helgi B. Schiöth
Publié dans: Behavioral and Brain Functions, Numéro 16/1, 2020, ISSN 1744-9081
Éditeur: BioMed Central
DOI: 10.1186/s12993-020-00168-4

Evidence for Prepulse Inhibition of Visually Evoked Motor Response in Drosophila melanogaster

Auteurs: Schiöth HB, Donzelli L, Williams MJ, Moulin TC
Publié dans: Biology, 2023, ISSN 2079-7737
Éditeur: MDPI
DOI: 10.3390/biology12040635

Sigma-1 receptor and seizures.

Auteurs: Vavers E, Zvejniece L, Dambrova M
Publié dans: Pharmacological Research, 2023, ISSN 2667-1425
Éditeur: Elsevier
DOI: 10.1016/j.phrs.2023.106771

Trimethylamine N-oxide impairs pyruvate and fatty acid oxidation in cardiac mitochondria

Auteurs: Marina Makrecka-Kuka, Kristine Volska, Unigunde Antone, Reinis Vilskersts, Solveiga Grinberga, Dace Bandere, Edgars Liepinsh, Maija Dambrova
Publié dans: Toxicology Letters, Numéro 267, 2017, Page(s) 32-38, ISSN 0378-4274
Éditeur: Elsevier BV
DOI: 10.1016/j.toxlet.2016.12.017

Plasma acylcarnitine concentrations reflect the acylcarnitine profile in cardiac tissues

Auteurs: Marina Makrecka-Kuka, Eduards Sevostjanovs, Karlis Vilks, Kristine Volska, Unigunde Antone, Janis Kuka, Elina Makarova, Osvalds Pugovics, Maija Dambrova, Edgars Liepinsh
Publié dans: Scientific Reports, Numéro 7/1, 2017, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-017-17797-x

The activity of selective sigma-1 receptor ligands in seizure models in vivo

Auteurs: Edijs Vavers, Baiba Svalbe, Lasma Lauberte, Ilmars Stonans, Ilga Misane, Maija Dambrova, Liga Zvejniece
Publié dans: Behavioural Brain Research, Numéro 328, 2017, Page(s) 13-18, ISSN 0166-4328
Éditeur: Elsevier BV
DOI: 10.1016/j.bbr.2017.04.008

Effects of the N-methyl-d-aspartate receptor antagonist, MK-801, on spatial memory and influence of the route of administration

Auteurs: Baiba Svalbe, Gundega Stelfa, Edijs Vavers, Baiba Zvejniece, Solveiga Grinberga, Eduards Sevostjanovs, Osvalds Pugovics, Maija Dambrova, Liga Zvejniece
Publié dans: Behavioural Brain Research, Numéro 372, 2019, Page(s) 112067, ISSN 0166-4328
Éditeur: Elsevier BV
DOI: 10.1016/j.bbr.2019.112067

Decrease in Long-Chain Acylcarnitine Tissue Content Determines the Duration of and Correlates with the Cardioprotective Effect of Methyl-GBB

Auteurs: Janis Kuka, Marina Makrecka-Kuka, Helena Cirule, Solveiga Grinberga, Eduards Sevostjanovs, Maija Dambrova, Edgars Liepinsh
Publié dans: Basic & Clinical Pharmacology & Toxicology, Numéro 121/2, 2017, Page(s) 106-112, ISSN 1742-7835
Éditeur: Nordic Pharmacological Society
DOI: 10.1111/bcpt.12775

Mitochondrial metabolites acylcarnitines: therapeutic potential and drug targets

Auteurs: Dambrova M, Cecatto C, Vilskersts R, Liepinsh E
Publié dans: Bioenergetics Communications, 2022, ISSN 2791-4690
Éditeur: BEC
DOI: 10.26124/bec:2022-0015

Rodent and fly models in behavioral neuroscience: An evaluation of methodological advances, comparative research, and future perspectives

Auteurs: Moulin TC, Covill LE, Itskov PM, Williams MJ, Schiöth HB
Publié dans: Neuroscience & Biobehavioral Reviews, 2021, ISSN 0149-7634
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.neubiorev.2020.11.014

Neurological manifestations of COVID-19: A comprehensive literature review and discussion of mechanisms

Auteurs: Johansson A, Mohamed MS, Moulin TC, Schiöth HB
Publié dans: Journal of Neuroimmunology, 2021, ISSN 1872-8421
Éditeur: Elsevier
DOI: 10.1016/j.jneuroim.2021.577658

The Drosophila melanogaster Levodopa-Induced Depression Model Exhibits Negative Geotaxis Deficits and Differential Gene Expression in Males and Females

Auteurs: Moulin TC, Ferro F, Hoyer A, Cheung P, Williams MJ, Schiöth HB
Publié dans: Frontiers in Neuroscience, 2021, ISSN 1662-453X
Éditeur: Frontiers
DOI: 10.3389/fnins.2021.653470

Acylcarnitines in health and disease: biomarkers and drug targets

Auteurs: Dambrova M, Liepinsh E
Publié dans: Macedonian Pharmaceutical Bulletin, 2022, ISSN 1857-8969
Éditeur: Skopje Makedonsko farmacevtsko društvo
DOI: 10.33320/maced.pharm.bull.2022.68.03.006

Sex differences in COVID-19: the role of androgens in disease severity and progression

Auteurs: Mohamed S. Mohamed, Thiago C. Moulin, Helgi B. Schiöth
Publié dans: Endocrine, Numéro 71/1, 2021, Page(s) 3-8, ISSN 1355-008X
Éditeur: Springer Link
DOI: 10.1007/s12020-020-02536-6

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