Why do some people refute the realities of climate change, reject evolution, or exhibit an unwillingness to get vaccinated? Public science skepticism - defined as the systematic rejection of empirical evidence of established scientific findings - represents one of the key societal challenges of the 21st century. Even though research into science skepticism has been rapidly developing in recent years, state-of-the art understanding of psychological factors contributing to science skepticism remains somewhat fragmented and limited. Antecedents of skepticism are often studied in isolation, which renders comparison across science domains difficult. Moreover, established antecedents of science skepticism are generally unmalleable individual difference factors such as ideological or religious beliefs. The current project aims to establish and test a construct that goes beyond the domain-specific, immutable, and mostly descriptive determinants of science skepticism. This construct is Psychological Distance to Science (PSYDISC). Psychological distance to science refers to perceptions of science in terms of its tangibility and relevance for the individual. In other words, PSYDISC pertains to how one evaluates science from the perspective of the self. The central proposition of the project is that perceived psychological distance to science in temporal, spatial, social and hypothetical terms contributes to science skepticism across various science domains. PSYDISC aims to offer a comprehensive approach to understanding and predicting science skepticism across domains, such as climate science, vaccination, genetic modification, evolution, and nano technology. The objective of the project is to provide a theoretically informed account of science skepticism and as such provide the scaffolding necessary for a long-term research agenda aimed at improving our understanding of the psychology of science skepticism.