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Unification of treatments and Interventions for Tinnitus patients

Descripción del proyecto

Análisis de los tratamientos para el tinnitus

El tinnitus es la percepción de un ruido fantasma, un trastorno discapacitante que afecta a más del 10 % de la población general. Estudios recientes indican que la prevalencia del tinnitus aumenta con el tiempo y la edad, pero no se conocen bien ciertas características de quienes lo padecen, como el genotipo y la etiología. Actualmente no existe consenso sobre el tratamiento del tinnitus. El proyecto financiado con fondos europeos UNITI se propone desarrollar un modelo informático predictivo basado en datos longitudinales y abordar el enfoque de tratamiento óptimo para cada paciente. Se analizarán datos clínicos, epidemiológicos, genéticos y audiológicos gracias a las bases de datos existentes. Además, se definirán factores predictivos para diferentes grupos de pacientes y se valorará su valor de pronóstico en un ensayo clínico con diferentes grupos de pacientes sometidos a diversos tratamientos centrados en el sistema nervioso central y el sistema auditivo.

Objetivo

Tinnitus is the perception of a phantom sound and the patient’s reaction to it. Tinnitus remains a scientific and clinical enigma of iTinnitus is the perception of a phantom sound and the patient’s reaction to it. Although much progress has been made, tinnitus remains a scientific and clinical enigma of high prevalence and high economic burden. It affects more than 10% of the general population, whereas 1% of the population considers tinnitus their major health issue. Recent cohort studies show that tinnitus prevalence tends to increase over time and with older age. Assuming that there is no cure to be found, the prevalence estimates in Europe would double by 2050. A large variety of patient characteristics - including genotyping, aetiology, and phenotyping - are poorly understood, because integrated systems approaches are still missing to correlate patient`s characteristics to predict responses to combinatorial therapies. Although genetic causes of tinnitus have been neglected for decades, recent findings of genetic analysis in specific subgroups (gender and phenotype) have highlighted that bilateral tinnitus in men reached a heritability of 0.68. This heritability is close to autism, schizophrenia and Attention Deficit Hyperactive Disorder (ADHD). There is no current consensus on tinnitus treatment. UNITI’s overall aim is to deliver a predictive computational model based on existing and longitudinal data attempting to address the question which treatment approach is optimal for a specific patient based on specific parameters. Clinical, epidemiological, medical, genetic and audiological data, including signals reflecting ear-brain communication, will be analysed from existing databases. Predictive factors for different patient groups will be extracted and their prognostic relevance will be tested in a randomized controlled trial (RCT) in which different groups of patients will undergo a combination of therapies targeting the auditory and central nervous systems.

Convocatoria de propuestas

H2020-SC1-BHC-2018-2020

Consulte otros proyectos de esta convocatoria

Convocatoria de subcontratación

H2020-SC1-2019-Two-Stage-RTD

Régimen de financiación

RIA - Research and Innovation action

Coordinador

KLINIKUM DER UNIVERSITAET REGENSBURG
Aportación neta de la UEn
€ 884 948,75
Dirección
FRANS JOSEF STRAUSS ALLEE 11
93053 Regensburg
Alemania

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Región
Bayern Oberpfalz Regensburg, Kreisfreie Stadt
Tipo de actividad
Higher or Secondary Education Establishments
Enlaces
Coste total
€ 884 948,75

Participantes (13)