Metabolic crosstalk in the regulation of inflammation

Project Information

Metabinnate

Grant agreement ID: 834370

DOI 10.3030/834370

EC signature date 10 May 2019

Start date 1 June 2019

End date 31 May 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 484 858,00

EU contribution € 2 484 858,00

Coordinated by

THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
Ireland

Publications

Peer reviewed articles (32)

Caspase-4: A Therapeutic Target for Peptic Ulcer Disease

Author(s): Zbigniew Zaslona, Ewelina Flis, Ciara Nulty, Jay Kearney, Rebecca Fitzgerald, Atiyekeogbebe R. Douglas, Deirdre McNamara, Sinead Smith, Luke A. J. O’Neill, Emma M. Creagh
Published in: ImmunoHorizons, Issue 4/10, 2020, Page(s) 627-633, ISSN 2573-7732
Publisher: AAI
DOI: 10.4049/immunohorizons.2000080

Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages.

Author(s): Runtsch MC, Angiari S, Hooftman A, Wadhwa R, Zhang Y, Zheng Y, Spina JS, Ruzek MC, Argiriadi MA, McGettrick AF, Mendez RS, Zotta A, Peace CG, Walsh A, Chirillo R, Hams E, Fallon PG, Jayamaran R, Dua K, Brown AC, Kim RY, Horvat JC, Hansbro PM, Wang C, O'Neill LAJ.
Published in: Cell Metabolism, 2022, Page(s) 487-501, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2022.02.002

Pseudomonas Persists by Feeding off Itaconate

Author(s): Marah C. Runtsch, Luke A.J. O’Neill
Published in: Cell Metabolism, Issue 31/6, 2020, Page(s) 1045-1047, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2020.05.005

Modification of Proteins by Metabolites in Immunity

Author(s): Ciana Diskin , Tristram Ryan , L A J O'Neill
Published in: Immunity, 2021, Page(s) 19-31, ISSN 1074-7613
Publisher: Cell Press
DOI: 10.1016/j.immuni.2020.09.014

The Immunomodulatory Potential of the Metabolite Itaconate

Author(s): Alexander Hooftman, Luke A.J. O’Neill
Published in: Trends in Immunology, Issue 40/8, 2019, Page(s) 687-698, ISSN 1471-4906
Publisher: Elsevier BV
DOI: 10.1016/j.it.2019.05.007

Fumarate hydratase as a metabolic regulator of immunity

Author(s): Christian G Peace, Shane M O'Carroll and Luke A J O'Neill
Published in: Trends in Cell Biology, Issue S0962-8924(23)00209-X., 2023, Page(s) S0962-8924(23)00209-X., ISSN 1879-3088
Publisher: Elsevier
DOI: 10.1016/j.tcb.2023.10.005

Daily variation in macrophage phagocytosis is clock‐independent and dispensable for cytokine production

Author(s): Sarah S. Geiger, Annie M. Curtis, Luke A. J. O'Neill, Richard M. Siegel
Published in: Immunology, Issue 157/2, 2019, Page(s) 122-136, ISSN 0019-2805
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/imm.13053

Caspase-11 promotes allergic airway inflammation

Author(s): Zbigniew Zasłona, Ewelina Flis, Mieszko M. Wilk, Richard G. Carroll, Eva M. Palsson-McDermott, Mark M. Hughes, Ciana Diskin, Kathy Banahan, Dylan G. Ryan, Alexander Hooftman, Alicja Misiak, Jay Kearney, Gunter Lochnit, Wilhelm Bertrams, Timm Greulich, Bernd Schmeck, Oliver J. McElvaney, Kingston H. G. Mills, Ed C. Lavelle, Małgorzata Wygrecka, Emma M. Creagh, Luke A. J. O’Neill
Published in: Nature Communications, Issue 11/1, 2020, Page(s) monthly, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-14945-2

Protein targeting by the itaconate family in immunity and inflammation

Author(s): Emily A Day and Luke A J O'Neill
Published in: Biochemical Journal, Issue 479(24), 2022, Page(s) 2499-2510, ISSN 1470-8728
Publisher: Portland Press
DOI: 10.1042/bcj20220364

The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation

Author(s): Alexander Hooftman, Stefano Angiari, Svenja Hester, Sarah E. Corcoran, Marah C. Runtsch, Chris Ling, Melanie C. Ruzek, Peter F. Slivka, Anne F. McGettrick, Kathy Banahan, Mark M. Hughes, Alan D. Irvine, Roman Fischer, Luke A.J. O’Neill
Published in: Cell Metabolism, Issue 32/3, 2020, Page(s) 468-478.e7, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2020.07.016

Targetting mitochondria to beat HIV

Author(s): Emily Day, Luke O'Neill
Published in: Nature Immunology, 2021, Page(s) 398-399, ISSN 1529-2908
Publisher: Nature Publishing Group
DOI: 10.1038/s41590-021-00881-w

The itaconate family of immunomodulators grows

Author(s): Anne F McGettrick and Luke A J O'Neill
Published in: Nature Metabolism, Issue 4(5), 2022, Page(s) 499-500, ISSN 2522-5812
Publisher: Nature Portfolic
DOI: 10.1038/s42255-022-00578-w

Macrophage fumarate hydratase restrains mtRNA-mediated interferon production

Author(s): Hooftman A et al and including Emily Day, Juliana E Toller Kawahisa, Tristram Ryan and Luke O'Neill
Published in: Nature, Issue 615(7952), 2023, Page(s) 490-498, ISSN 1476-4687
Publisher: Nature Portfolio
DOI: 10.1038/s41586-023-05720-6

Targeting immunometabolism as an anti-inflammatory strategy

Author(s): Eva M. Pålsson-McDermott, Luke A. J. O’Neill
Published in: Cell Research, Issue 30/4, 2020, Page(s) 300-314, ISSN 1001-0602
Publisher: Kexue Chubaneshe/Science Press
DOI: 10.1038/s41422-020-0291-z

How should we talk about metabolism?

Author(s): Michael P. Murphy, Luke A. J. O’Neill
Published in: Nature Immunology, Issue 21/7, 2020, Page(s) 713-715, ISSN 1529-2908
Publisher: Nature Publishing Group
DOI: 10.1038/s41590-020-0691-8

The next decade of metabolism

Author(s): Fredrik Bäckhed, Elisabetta Bugianesi, Heather Christofk, Ivan Dikic, Rana Gupta, William B. Mair, Luke A. J. O’Neill, Markus Ralser, David M. Sabatini, Matthias Tschöp
Published in: Nature Metabolism, Issue 1/1, 2019, Page(s) 2-4, ISSN 2522-5812
Publisher: npg
DOI: 10.1038/s42255-018-0022-7

Immunothrombosis and the molecular control of tissue factor by pyroptosis: prospects for new anticoagulants

Author(s): Ryan TAJ, Preston RJS, O'Neill LAJ
Published in: Biochemical Journal, 2022, Page(s) 731-750, ISSN 0264-6021
Publisher: Portland Press, Ltd.
DOI: 10.1042/bcj20210522

Krebs Cycle Reborn in Macrophage Immunometabolism

Author(s): Dylan G. Ryan, Luke A.J. O'Neill
Published in: Annual Review of Immunology, Issue 38/1, 2020, Page(s) 289-313, ISSN 0732-0582
Publisher: Annual Reviews, Inc.
DOI: 10.1146/annurev-immunol-081619-104850

The Role of HIF in Immunity and Inflammation

Author(s): Anne F. McGettrick, Luke A.J. O’Neill
Published in: Cell Metabolism, Issue 32/4, 2020, Page(s) 524-536, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2020.08.002

Targeting macrophage immunometabolism to prevent atherosclerosis

Author(s): Luke A. J. O’Neill
Published in: Nature Metabolism, Issue 1/12, 2019, Page(s) 1173-1174, ISSN 2522-5812
Publisher: Springer
DOI: 10.1038/s42255-019-0154-4

4-Octyl itaconate reduces influenza A replication by targeting the nuclear export protein CRM1

Author(s): Pau Ribó-Molina and including Hauke J Weiss and Luke A J O'Neill
Published in: Journal of Virology, Issue 97(10), 2023, Page(s) e0132523, ISSN 1098-5514
Publisher: American Society for Microbiology
DOI: 10.1128/jvi.01325-23

Cytokine-like Roles for Metabolites in Immunity

Author(s): Zbigniew Zasłona, Luke A.J. O’Neill
Published in: Molecular Cell, Issue 78/5, 2020, Page(s) 814-823, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2020.04.002

Influenza A virus causes maternal and fetal pathology via innate and adaptive vascular inflammation in mice

Author(s): Stella Liong, Osezua Oseghale, Eunice E. To, Kurt Brassington, Jonathan R. Erlich, Raymond Luong, Felicia Liong, Robert Brooks, Cara Martin, Sharon O’Toole, Antony Vinh, Luke A. J. O’Neill, Steven Bozinovski, Ross Vlahos, Paris C. Papagianis, John J. O’Leary, Doug A. Brooks, Stavros Selemidis
Published in: Proceedings of the National Academy of Sciences, Issue 117/40, 2020, Page(s) 24964-24973, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2006905117

4-Octyl Itaconate and Dimethyl Fumarate Induce Secretion of the Anti-Inflammatory Protein Annexin A1 via NRF2

Author(s): Ciana Diskin, Emily A Day, Órlaith C Henry, Juliana E Toller-Kawahisa , Luke A J O'Neill
Published in: J Immunol, Issue 211(6), 2023, Page(s) 10321041, ISSN 0022-1767
Publisher: American Association of Immunologists
DOI: 10.4049/jimmunol.2200848

BCG-induced trained immunity: can it offer protection against COVID-19?

Author(s): Luke A. J. O’Neill, Mihai G. Netea
Published in: Nature Reviews Immunology, Issue 20/6, 2020, Page(s) 335-337, ISSN 1474-1733
Publisher: Nature Publishing Group
DOI: 10.1038/s41577-020-0337-y

Two for the price of one: itaconate and its derivatives as an anti-infective and anti-inflammatory immunometabolite

Author(s): Anne F McGettrick Luke AJ O'Neill
Published in: Current Opinion in Immunology, Issue 80, 2023, Page(s) 102268, ISSN 0952-7915
Publisher: Elsevier BV
DOI: 10.1016/j.coi.2022.102268

Spatial Properties of Reactive Oxygen Species Govern Pathogen-Specific Immune System Responses

Author(s): Eunice E. To, John J. O'Leary, Luke A.J. O'Neill, Ross Vlahos, Steven Bozinovski, Christopher J.H. Porter, Robert D. Brooks, Doug A. Brooks, Stavros Selemidis
Published in: Antioxidants & Redox Signaling, Issue 32/13, 2020, Page(s) 982-992, ISSN 1523-0864
Publisher: Mary Ann Liebert Inc.
DOI: 10.1089/ars.2020.8027

Pharmacological Activation of Pyruvate Kinase M2 Inhibits CD4+ T Cell Pathogenicity and Suppresses Autoimmunity

Author(s): Stefano Angiari, Marah C. Runtsch, Caroline E. Sutton, Eva M. Palsson-McDermott, Beth Kelly, Nisha Rana, Harry Kane, Gina Papadopoulou, Erika L. Pearce, Kingston H.G. Mills, Luke A.J. O'Neill
Published in: Cell Metabolism, Issue 31/2, 2020, Page(s) 391-405.e8, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2019.10.015

How neutrophil metabolism affects bacterial killing

Author(s): Juliana E Toller-Kawahisa and Luke A J O'Neill
Published in: Open Biology, Issue 12(11), 2022, Page(s) 220248, ISSN 2046-2441
Publisher: Royal Society Publishing
DOI: 10.1098/rsob.220248

The metabolic function of pyruvate kinase M2 regulates reactive oxygen species production and microbial killing by neutrophils

Author(s): Juliana E Toller-Kawahisa and including Tristram Ryan and Luke O'Neill
Published in: Nature Communications, Issue 14(1), 2023, Page(s) 4280, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-40021-6

The role of itaconate in host defense and inflammation.

Author(s): Peace C, O'Neill LA
Published in: J Clin Invest, 2022, Page(s) 132(2):e148548, ISSN 0021-9738
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci148548

Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon

Author(s): Tristram Ryan and including Juliana E Toller Emily Day Hauke Weiss and Luke O'Neill
Published in: Nature Communications, Issue 4(1), 2023, Page(s) 3513, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-39174-1

Non-peer reviewed articles (1)

Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation

Author(s): Mark M. Hughes, Alexander Hooftman, Stefano Angiari, Padmaja Tummala, Zbigniew Zaslona, Marah C. Runtsch, Anne F. McGettrick, Caroline E. Sutton, Ciana Diskin, Melissa Rooke, Shuhei Takahashi, Srinivasan Sundararaj, Marco G. Casarotto, Jane E. Dahlstrom, Eva M. Palsson-McDermott, Sinead C. Corr, Kingston H.G. Mills, Roger J.S. Preston, Nouri Neamati, Yiyue Xie, Jonathan B. Baell, Philip G. Board,
Published in: Cell Reports, Issue 29/1, 2019, Page(s) 151-161.e5, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2019.08.072