Descripción del proyecto
Mejorar los diagnósticos «in vivo»
En los procedimientos de diagnóstico médico se aplican diversas tecnologías diferentes, incluidas las imágenes por resonancia magnética (IRM). Para minimizar el tiempo de exposición y el riesgo de radiación de tales procedimientos, los científicos del proyecto PATHOS, financiado con fondos europeos, trabajan en optimizar la resolución espectral y espacial de las IRM. Dado que los sistemas biológicos son entornos complejos y ruidosos, los investigadores están desarrollando protocolos y configuraciones de exploración novedosos basados en las IRM para mejorar la detección intramolecular e intratisular. Estos instrumentos innovadores contribuirán a revelar características bioquímicas que, de otro modo, permanecen ocultas tras la heterogeneidad de los tejidos. A su vez, el procesamiento avanzado de los datos controlará el ruido que generan los complejos sistemas biológicos.
Objetivo
We plan to develop a radically new technology for the sensing of bio-systems and in-vivo diagnostics of biomedical conditions using hitherto unexploited tools of unconventional complex-system dynamical control and information sampling/processing. They will be founded on groundbreaking concepts and challenging experiments, with the following aims: (a) Magnetic-resonance imaging (MRI) and optically-detected magnetic-resonance (ODMR) sensing will be dramatically improved by orders of magnitude through highly selective cooling/suppression of thermal noisy background in-vivo with unprecedented spectral and spatial (subnano- or submicron-) resolution. It will be based on so far unemployed (but conceptually proven) stochastic (anti-) Zeno effects and collective-spin cooling pioneered by the partners of this very interdisciplinary consortium. (b) Development of novel probing configurations and protocols: NMR intra-molecule/intra-tissue sensing and intra-cell NV-center thermometry based on dynamical control being aimed at unravelling of hitherto invisible biochemical activity features masked by inhomogeneous broadening. (c) Advanced sensing-data processing, including high-order correlation spectroscopy – innovative strategies that seek to exploit dynamically controlled/modified noise in bio-systems as a source of previously untapped information on physiological (temporal) processes and anatomical (structural) detail. This information will be obtained by treating bio-systems as complex, noisy “environments” through novel probing/estimation procedures and compressed (sparse) imagery of the spectrally and spatially structured “environment”, but reducing drastically their complexity by dynamically controlling the relevant information encoded by key noise parameters. The overarching goal will be to substantially enrich the spatial and spectral information content and robustness of diverse medical diagnostic procedures and thereby minimize the exposure time/irradiation dosage.
Ámbito científico
Palabras clave
Programa(s)
Convocatoria de propuestas
Consulte otros proyectos de esta convocatoriaConvocatoria de subcontratación
H2020-FETOPEN-2018-2019-2020-01
Régimen de financiación
RIA - Research and Innovation actionCoordinador
50121 Florence
Italia