Novel Testing Strategies for Endocrine Disruptors in the Context of Developmental NeuroToxicity

Resultado final

1st animation

First animation video showing highlights of the project results

2nd animation

Second animation video showing highlights of the project results

Launch of Website, logo and flyer

Set of test compounds

Final list of the set of chemicals tested in WP2 and WP3.

Publicaciones

A human stem cell-derived test system for agents modifying neuronal N -methyl- d -aspartate-type glutamate receptor Ca 2+ -signalling

Autores: Stefanie Klima; Markus Brüll; Anna-Sophie Spreng; Ilinca Suciu; Tjalda Falt; Jens Christian Schwamborn; Tanja Waldmann; Christiaan Karreman; Marcel Leist
Publicado en: Archives of Toxicology, Edición 6, 2021, ISSN 1432-0738
Editor: Springer Verlag
DOI: 10.1007/s00204-021-03024-0

Prenatal exposure to phthalates and gender-specific play behavior at seven years of age in the SELMA study

Autores: Fatih Özel, Marlene Stratmann, Christian Lindh, Chris Gennings, Carl-Gustaf Bornehag, Joëlle Rüegg
Publicado en: Environment International, 2023, ISSN 0160-4120
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2023.108029

Human neuronal signaling and communication assays to assess functional neurotoxicity.

Autores: Dominik Loser; Jasmin Schaefer; Timm Danker; Clemens Möller; Markus Brüll; Ilinca Suciu; Anna-Katharina Ückert; Stefanie Klima; Marcel Leist; Udo Kraushaar
Publicado en: Archives of Toxicology, Edición 5, 2021, ISSN 1432-0738
Editor: Springer Verlag
DOI: 10.1007/s00204-020-02956-3

https://www.altex.org/index.php/altex/article/view/1339

Autores: Alice Krebs, Tanja Waldmann, Martin F. Wilks, Barbara M. A. van Vugt-Lussenburg, Bart van der Burg, Andrea Terron, Thomas Steger-Hartmann, Joelle Ruegg, Costanza Rovida, Emma Pedersen, Giorgia Pallocca, Mirjam Luijten, Sofia B. Leite, Stefan Kustermann, Hennicke Kamp, Julia Hoeng, Philip Hewitt, Matthias Herzler, Jan G. Hengstler, Tuula Heinonen, Thomas Hartung, Barry Hardy, Florian Gantner, Ellen
Publicado en: ALTEX, Edición 36(4), 2019, Página(s) 682-699, ISSN 1868-596X
Editor: Springer-Verlag Gmb
DOI: 10.14573/altex.1909271

CaFFEE: A program for evaluating time courses of Ca2+ dependent signal changes of complex cells loaded with fluorescent indicator dyes

Autores: Christiaan Karreman
Publicado en: ALTEX, Edición 37(2), 2020, Página(s) 332-336, ISSN 1868-596X
Editor: Springer-Verlag GmbH
DOI: 10.14573/altex.2003191

Organophosphate insecticides disturb neuronal network development and function via non-AChE mediated mechanisms

Autores: Lennart V.J. van Melis, Harm J. Heusinkveld, Celine Langendoen, Anouk Peters, Remco H.S. Westerink
Publicado en: NeuroToxicology, 2023, ISSN 0161-813X
Editor: Elsevier BV
DOI: 10.1016/j.neuro.2022.11.002

Endocrine Disrupting Chemicals and Hippocampal Development: The Role of Estrogen and Androgen Signalling

Autores: Diana-Ioana Lupu, Andrea Cediel Ulloa, Joëlle Rüegg
Publicado en: Neuroendocrinology, 2023, ISSN 0028-3835
Editor: S. Karger AG
DOI: 10.1159/000531669

LP-32 Comparative Transcriptomics in Developing Rat Hippocampus After Perinatal Exposure to Bisphenol F (BPF), Butylbenzylphthalate (BBzP), 1,2-Cyclohexane dicarboxylic acid diisononyl ester (DINCH), Permethrin (PMT), Perfluorooctanesulfonic acid (PFOS), and Triphenylphosphate (TPHP)

Autores: W. Lichtensteiger, C. Bassetti-Gaille, H. Rehrauer, J. Félix, B. Linillos-Pradillo, H. Idrissi, L. Miguélez-Salas, L. Rancan, S.D. Paredes, M. De la Fuente, P. Leonards, J. Rüegg, J.A.F. Tresguerres, M. Schlumpf
Publicado en: Toxicology Letters, 2022, ISSN 0378-4274
Editor: Elsevier BV
DOI: 10.1016/j.toxlet.2022.07.772

Association of per- and polyfluoroalkyl substances with thyroid homeostasis during pregnancy in the SELMA study

Autores: Arash Derakhshan, Andreas Kortenkamp, Huan Shu, Maarten A C Broeren, Christian H Lindh, Robin P Peeters, Carl-Gustaf Bornehag, Barbara Demeneix, Tim I M Korevaar
Publicado en: Environment International, 2022, ISSN 0160-4120
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2022.107420

Acute effects of the imidacloprid metabolite desnitro-imidacloprid on human nACh receptors relevant for neuronal signaling.

Autores: Dominik Loser; Dominik Loser; Karin Grillberger; Maria G. Hinojosa; Jonathan Blum; Yves Haufe; Timm Danker; Ylva Johansson; Clemens Möller; Annette Nicke; Susanne Hougaard Bennekou; Iain Gardner; Caroline Bauch; Paul Walker; Anna Forsby; Gerhard F. Ecker; Udo Kraushaar; Marcel Leist
Publicado en: Archives of Toxicology, Edición 7, 2021, ISSN 1432-0738
Editor: Springer Verlag
DOI: 10.1007/s00204-021-03168-z

Environmental influences on brain aging

Autores: Barbara A. Demeneix
Publicado en: Aging Brain,Volume 1, 2021, 100003, Edición 7, 2021, ISSN 2589-9589
Editor: Elsevier
DOI: 10.1016/j.nbas.2020.100003

Determination of benchmark concentrations and their statistical uncertainty for cytotoxicity test data and functional in vitro assays

Autores: Alice Krebs
Publicado en: ALTEX, Edición 37(1), 2019, Página(s) 155-163, ISSN 1868-596X
Editor: Springer -Verlag GmbH
DOI: 10.14573/altex.1912021

LP-33 Memory Function in Adult Rat Offspring Following Perinatal Exposure to Chemicals Affecting Gene Expression Patterns in Developing Hippocampus

Autores: M. Schlumpf, J. Félix, B. Linillos-Pradillo, H. Idrissi, L. Miguélez-Salas, L. Rancan, S.D. Paredes, M. De la Fuente, P. Leonards, J. Rüegg, J.A.F. Tresguerres, W. Lichtensteiger
Publicado en: Toxicology Letters, 2022, ISSN 0378-4274
Editor: Elsevier BV
DOI: 10.1016/j.toxlet.2022.07.773

From cohorts to molecules: Adverse impacts of endocrine disrupting mixtures

Autores: Nicolò Caporale, Michelle Leemans, Lina Birgersson, Pierre-Luc Germain, Cristina Cheroni, Gábor Borbély, Elin Engdahl, Christian Lindh, Raul Bardini Bressan, Francesca Cavallo, Nadav Even Chorev, Giuseppe Alessandro D’agostino, Steven M. Pollard, Marco Tullio Rigoli, Erika Tenderini, Alejandro Lopez Tobon, Sebastiano Trattaro, Flavia Troglio, Matteo Zanella, Åke Bergman, Pauliina Damdimopoul
Publicado en: Science, 2022, ISSN 0036-8075
Editor: American Association for the Advancement of Science
DOI: 10.1126/science.abe8244

Epigenetics of methylmercury

Autores: Andrea Cediel-Ulloa, Sabrina Lindner, Joëlle Rüegg, Karin Broberg
Publicado en: NeuroToxicology, 2023, ISSN 0161-813X
Editor: Elsevier BV
DOI: 10.1016/j.neuro.2023.05.004

Association Between Intellectual Functioning and Autistic Traits in the General Population of Children

Autores: Maria Marinopoulou, Eva Billstedt, Catrin Wessman, Carl-Gustaf Bornehag, Maria Unenge Hallerbäck
Publicado en: Child Psychiatry and Human Development, 2023, ISSN 0009-398X
Editor: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s10578-023-01562-5

Autism spectrum disorder at the crossroad between genes and environment: contributions, convergences, and interactions in ASD developmental pathophysiology

Autores: Cristina Cheroni; Cristina Cheroni; Nicolò Caporale; Nicolò Caporale; Giuseppe Testa; Giuseppe Testa
Publicado en: Molecular Autism, Vol 11, Iss 1, Pp 1-18 (2020), Edición 2, 2020, ISSN 2040-2392
Editor: BioMed Central
DOI: 10.1186/s13229-020-00370-1

Oxidative stress increases in liver of lactating rats after BPF-low-dose exposure: perinatal effects in the offspring

Autores: Beatriz Linillos-Pradillo, Lisa Rancan, Julio García Murias, Margret Schlumpf, Walter Lichtensteiger, J. A. F. Tresguerres, Elena Vara, Sergio D. Paredes
Publicado en: Scientific Reports, 2023, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-023-38434-w

Neurotoxicity and underlying cellular changes of 21 mitochondrial respiratory chain inhibitors

Autores: Johannes Delp; Andrea Cediel-Ulloa; Andrea Cediel-Ulloa; Ilinca Suciu; Petra Kranaster; Barbara M.A. van Vugt-Lussenburg; Vesna Munic Kos; Wanda van der Stel; Giada Carta; Susanne Hougaard Bennekou; Paul Jennings; Bob van de Water; Anna Forsby; Anna Forsby; Marcel Leist
Publicado en: Delp , J , Cediel-Ulloa , A , Suciu , I , Kranaster , P , van Vugt-Lussenburg , B M , Munic Kos , V , van der Stel , W , Carta , G , Bennekou , S H , Jennings , P , van de Water , B , Forsby , A & Leist , M 2021 , ' Neurotoxicity and underlying cellular changes of 21 mitochondrial respiratory chain inhibitors ' , Archives of Toxicology , vol. 95 , pp. 591–615 . https://doi.org/10.1007/s00204-020, Edición 5, 2021, ISSN 1432-0738
Editor: Springer
DOI: 10.1007/s00204-020-02970-5

DNA methylation at GRIN2B partially mediates the association between prenatal bisphenol F exposure and cognitive functions in 7-year-old children in the SELMA study

Autores: Elin Engdahl, Katherine Svensson, Ping-I Daniel Lin, Ali Alavian-Ghavaninic, Christian Lindh, Joëlle Rüegg, Carl-Gustaf Bornehag
Publicado en: Environment International, Volume 156, November 2021, 106617, 2021, ISSN 0160-4120
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2021.106617

Functional alterations by a subgroup of neonicotinoid pesticides in human dopaminergic neurons.

Autores: Dominik Loser; Maria G. Hinojosa; Jonathan Blum; Jasmin Schaefer; Markus Brüll; Ylva Johansson; Ilinca Suciu; Karin Grillberger; Timm Danker; Clemens Möller; Iain Gardner; Gerhard F. Ecker; Susanne Hougaard Bennekou; Anna Forsby; Udo Kraushaar; Marcel Leist
Publicado en: Archives of Toxicology, Edición 1, 2021, ISSN 1432-0738
Editor: Springer Verlag
DOI: 10.1007/s00204-021-03031-1

Identification of mitochondrial toxicants by combined in silico and in vitro studies : a structure-based view on the Adverse Outcome Pathway

Autores: Florentina Troger; Johannes Delp; Melina Funke; Wanda van der Stel; Claire Colas; Marcel Leist; Bob van de Water; Gerhard F. Ecker
Publicado en: Computational Toxicology, 14, Edición 8, 2020, ISSN 2468-1113
Editor: Elsevier
DOI: 10.1016/j.comtox.2020.100123

Increased Remyelination and Proregenerative Microglia Under Siponimod Therapy in Mechanistic Models

Autores: Michael Dietrich, Christina Hecker, Elodie Martin, Dominique Langui, Michael Gliem, Bruno Stankoff, Catherine Lubetzki, Joel Gruchot, Peter Göttle, Andrea Issberner, Milad Nasiri, Pamela Ramseier, Christian Beerli, Sarah Tisserand, Nicolau Beckmann, Derya Shimshek, Patrick Petzsch, David Akbar, Bodo Levkau, Holger Stark, Karl Köhrer, Hans-Peter Hartung, Patrick Küry, Sven Günther Meuth, Marc B
Publicado en: Neurology Neuroimmunology Neuroinflammation, 2022, ISSN 2332-7812
Editor: American Academy of Neurology
DOI: 10.1212/nxi.0000000000001161

Development of a neural rosette formation assay (RoFA) to identify neurodevelopmental toxicants and to characterize their transcriptome disturbances

Autores: Nadine Dreser, Katrin Madjar, Anna-Katharina Holzer, Marion Kapitza, Christopher Scholz, Petra Kranaster, Simon Gutbier, Stefanie Klima, David Kolb, Christian Dietz, Timo Trefzer, Johannes Meisig, Christoph van Thriel, Margit Henry, Michael R. Berthold, Nils Blüthgen, Agapios Sachinidis, Jörg Rahnenführer, Jan G. Hengstler, Tanja Waldmann, Marcel Leist
Publicado en: Archives of Toxicology, Edición 94/1, 2020, Página(s) 151-171, ISSN 0340-5761
Editor: Springer Verlag
DOI: 10.1007/s00204-019-02612-5

Evidenced-Based Approaches to Support the Development of Endocrine-Mediated Adverse Outcome Pathways: Challenges and Opportunities

Autores: Karine Audouze, Elias Zgheib, Khaled Abass, Asma H. Baig, Isabel Forner-Piquer, Henrik Holbech, Dries Knapen, Pim E. G. Leonards, Diana I. Lupu, Saranya Palaniswamy, Arja Rautio, Maria Sapounidou, Olwenn V. Martin
Publicado en: Front. Toxicol, 2021, ISSN 2673-3080
Editor: Frontiers
DOI: 10.3389/ftox.2021.787017

Predicting Endocrine Disruption Using Conformal Prediction – A Prioritization Strategy to Identify Hazardous Chemicals with Confidence

Autores: Maria Sapounidou, Ulf Norinder, Patrik L. Andersson
Publicado en: Chemical Research in Toxicology, 2022, ISSN 0893-228X
Editor: American Chemical Society
DOI: 10.1021/acs.chemrestox.2c00267

Profiling of Human Neural Crest Chemoattractant Activity as a Replacement of Fetal Bovine Serum for In Vitro Chemotaxis Assays

Autores: Xenia Dolde; Christiaan Karreman; Marianne Wiechers; Stefan Schildknecht; Marcel Leist
Publicado en: International Journal of Molecular Sciences, Vol 22, Iss 10079, p 10079 (2021), Edición 9, 2021, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms221810079

Methylmercury-induced DNA methylation—From epidemiological observations to experimental evidence

Autores: Andrea Cediel-Ulloa, Ximiao Yu, Maria Hinojosa, Ylva Johansson, Anna Forsby, Karin Broberg, Joëlle Rüegg
Publicado en: Frontiers in Genetics, 2022, ISSN 1664-8021
Editor: Frontiers Media
DOI: 10.3389/fgene.2022.993387

Novel in vitro Experimental Approaches to Study Myelination and Remyelination in the Central Nervous System

Autores: Davide Marangon, Nicolò Caporale, Marta Boccazzi, Maria P. Abbracchio, Giuseppe Testa, Davide Lecca
Publicado en: Frontiers in cellular neuroscience, 2021, ISSN 1662-5102
Editor: Frontiers Research Foundation
DOI: 10.3389/fncel.2021.748849

Pesticides With Potential Thyroid Hormone-Disrupting Effects: A Review of Recent Data

Autores: Michelle Leemans, Stephan Couderq, Barbara Demeneix, Jean-Baptiste Fini
Publicado en: Frontiers in Endocrinology, Edición 10, 2019, ISSN 1664-2392
Editor: Frontiers
DOI: 10.3389/fendo.2019.00743

The ENDpoiNTs Project: Novel Testing Strategies for Endocrine Disruptors Linked to Developmental Neurotoxicity

Autores: Diana Lupu, Patrik Andersson, Carl-Gustaf Bornehag, Barbara Demeneix, Ellen Fritsche, Chris Gennings, Walter Lichtensteiger, Marcel Leist, Pim E. G. Leonards, Anne-Louise Ponsonby, Martin Scholze, Giuseppe Testa, Jesus A. F. Tresguerres, Remco H. S. Westerink, Bernard Zalc, Joëlle Rüegg
Publicado en: International Journal of Molecular Sciences, Edición 21/11, 2020, Página(s) 3978, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21113978

Evidence for Prenatal Exposure to Thyroid Disruptors and Adverse Effects on Brain Development

Autores: Barbara A. Demeneix
Publicado en: European Thyroid Journal, Edición 8/6, 2019, Página(s) 283-292, ISSN 2235-0640
Editor: S. Karger AG
DOI: 10.1159/000504668

TBBPA targets converging key events of human oligodendrocyte development resulting in two novel AOPs

Autores: Jördis Klose, Julia Tigges, Stefan Masjosthusmann, Katharina Schmuck, Farina Bendt, Ulrike Hübenthal, Patrick Petzsch, Karl Köhrer, Katharina Koch, Ellen Fritsche
Publicado en: ALTEX, 2021, ISSN 1868-8551
Editor: Springer spectrum
DOI: 10.14573/altex.2007201

Handling deviating control values in concentration-response curves.

Autores: Franziska Kappenberg; Tim Brecklinghaus; Wiebke Albrecht; Jonathan Blum; Carola van der Wurp; Marcel Leist; Jan G. Hengstler; Jörg Rahnenführer
Publicado en: Archives of Toxicology, Edición 2, 2020, ISSN 1432-0738
Editor: Springer Verlag
DOI: 10.1007/s00204-020-02913-0

Culture of Rat Primary Cortical Cells for Microelectrode Array (MEA) Recordings to Screen for Acute and Developmental Neurotoxicity

Autores: Lora-Sophie Gerber, Lennart V J van Melis, Regina G D M van Kleef, Aart de Groot, Remco H S Westerink
Publicado en: Curr Protoc . 2021 Jun;1(6):e158, 2021, ISSN 2691-1299
Editor: Wiley
DOI: 10.1002/cpz1.158

Using Metrics of a Mixture Effect and Nutrition from an Observational Study for Consideration towards Causal Inference

Autores: Chris Gennings, Katherine Svensson, Alicja Wolk, Christian Lindh, Hannu Kiviranta, Carl-Gustaf Bornehag
Publicado en: International Journal of Environmental Research and Public Health, 2022, ISSN 1661-7827
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijerph19042273

Impact of endocrine disrupting chemicals on neurodevelopment: the need for better testing strategies for endocrine disruption-induced developmental neurotoxicity

Autores: Andrea Cediel-Ulloa, Diana Loana Lupu, Ylva Johansson, Maria Hinojosa, Fatih Özel, Joëlle Rüegg
Publicado en: Expert Review of Endocrinology & Metabolism, 2022, ISSN 1744-6651
Editor: Future Drugs Ltd.
DOI: 10.1080/17446651.2022.2044788

Is WISC-IV Working Memory Index associated with ADHD symptoms in 7–8-year-olds?

Autores: Maria Marinopoulou, Maria Unenge Hallerbäck, Carl-Gustaf Bornehag, Eva Billstedt
Publicado en: Applied Neuropsychology: Child, 2023, ISSN 2162-2965
Editor: Taylor and Francis Inc.
DOI: 10.1080/21622965.2023.2176232

Monitoring recovery after CNS demyelination, a novel tool to de-risk pro-remyelinating strategies

Autores: Esther Henriet, Elodie M Martin, Pauline Jubin, Dominique Langui, Abdelkrim Mannioui, Bruno Stankoff, Catherine Lubetzki, Arseny Khakhalin, Bernard Zalc
Publicado en: Brain, 2023, ISSN 0006-8950
Editor: Oxford University Press
DOI: 10.1093/brain/awad051

Low Dose of BPA Induces Liver Injury through Oxidative Stress, Inflammation and Apoptosis in Long–Evans Lactating Rats and Its Perinatal Effect on Female PND6 Offspring

Autores: Beatriz Linillos-Pradillo, Lisa Rancan, Sergio D. Paredes, Margret Schlumpf, Walter Lichtensteiger, Elena Vara, Jesús Á. F. Tresguerres
Publicado en: International Journal of Molecular Sciences, 2023, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24054585

Do Wechsler intelligence scales predict academic achievement in children with ADHD or autism? A systematic review and meta-analysis

Autores: Maria Marinopoulou, Jakob Åsberg Johnels, Carl-Gustaf Bornehag, Maria Unenge Hallerbäck, Eva Billstedt
Publicado en: Applied Neuropsychology: Child, 2024, Página(s) 1-15, ISSN 2162-2965
Editor: Taylor and Francis Inc.
DOI: 10.1080/21622965.2024.2361022

The sociability spectrum: evidence from reciprocal genetic copy number variations.

Autores: Alejandro López-Tobón; Alejandro López-Tobón; Sebastiano Trattaro; Sebastiano Trattaro; Giuseppe Testa; Giuseppe Testa
Publicado en: Molecular Autism, Vol 11, Iss 1, Pp 1-13 (2020), Edición 2, 2020, ISSN 2040-2392
Editor: BioMed Central
DOI: 10.1186/s13229-020-00347-0

Kinetic modeling of stem cell transcriptome dynamics to identify regulatory modules of normal and disturbed neuroectodermal differentiation.

Autores: Johannes Meisig; Johannes Meisig; Nadine Dreser; Marion Kapitza; Margit Henry; Tamara Rotshteyn; Jörg Rahnenführer; Jan G. Hengstler; Agapios Sachinidis; Tanja Waldmann; Marcel Leist; Nils Blüthgen; Nils Blüthgen
Publicado en: Nucleic Acids Research, Edición 1, 2020, ISSN 1362-4962
Editor: Oxford University Press
DOI: 10.1093/nar/gkaa1089

From Cohort to Cohort: A Similar Mixture Approach (SMACH) to Evaluate Exposures to a Mixture Leading to Thyroid-Mediated Neurodevelopmental Effects Using NHANES Data

Autores: Maria Sapounidou,Patrik L. Andersson ,Michelle Leemans, Jean-Baptiste Fini, Barbara Demeneix, Joëlle Rüegg, Carl-Gustaf Bornehag, Chris Gennings
Publicado en: Toxics, 2023, ISSN 2305-6304
Editor: Basel: MDPI AG, 2013-
DOI: 10.3390/toxics11040331

A human-relevant mixture of endocrine disrupting chemicals induces changes in hippocampal DNA methylation correlating with hyperactive behavior in male mice

Autores: Michela Di Criscio, Jennifer Ekholm Lodahl, Antonios Stamatakis, Efthymia Kitraki, Ioannis Bakoyiannis, Anastasia Repouskou, Carl-Gustaf Bornehag, Chris Gennings, Diana Lupu, Joëlle Rüegg
Publicado en: Chemosphere, 2022, ISSN 0045-6535
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.chemosphere.2022.137633

Human Cortical Organoids Expose a Differential Function of GSK3 on Cortical Neurogenesis

Autores: Alejandro López-Tobón, Carlo Emanuele Villa, Cristina Cheroni, Sebastiano Trattaro, Nicolò Caporale, Paola Conforti, Raffaele Iennaco, Maria Lachgar, Marco Tullio Rigoli, Berta Marcó de la Cruz, Pietro Lo Riso, Erika Tenderini, Flavia Troglio, Marco De Simone, Isabel Liste-Noya, Giuseppe Macino, Massimiliano Pagani, Elena Cattaneo, Giuseppe Testa
Publicado en: Stem Cell Reports, Edición 13/5, 2019, Página(s) 847-861, ISSN 2213-6711
Editor: Cell Press
DOI: 10.1016/j.stemcr.2019.09.005

Incorporation of stem cell-derived astrocytes into neuronal organoids to allow neuro-glial interactions in toxicological studies

Autores: Markus Brüll
Publicado en: ALTEX, Edición 37(3), 2020, Página(s) 409-428, ISSN 1868-596X
Editor: Springer-Verlag GmbH
DOI: 10.14573/altex.1911111

SOC-VI-03 Applicability of the murine neural progenitor C17.2 cell-line for assessment of developmental neurotoxicity induced by endocrine disruptors

Autores: A. Cediel-Ulloa, R. Awoga, X. Yu, A. Gliga, A. Forsby, J. Rüegg
Publicado en: Toxicology Letters, 2022, ISSN 0378-4274
Editor: Elsevier BV
DOI: 10.1016/j.toxlet.2022.07.223

Myelin replacement triggered by single-cell demyelination in mouse cortex.

Autores: Nicolas Snaidero; Martina Schifferer; Aleksandra Mezydlo; Bernard Zalc; Martin Kerschensteiner; Thomas Misgeld; Thomas Misgeld
Publicado en: Nature Communications, Edición 8, 2020, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-020-18632-0

SUIKER: Quantification of antigens in cell organelles, neurites and cellular sub-structures by imaging

Autores: Christiaan Karreman
Publicado en: ALTEX, Edición 36(3), 2019, Página(s) 518-520, ISSN 1868-596X
Editor: Springer - Verlag GMB
DOI: 10.14573/altex.1906251

Multiplexing cortical brain organoids for the longitudinal dissection of developmental traits at single cell resolution

Autores: Nicolò Caporale, Davide Castaldi, Marco Tullio Rigoli, Cristina Cheroni, Sebastiano Trattaro, Alessia Valenti, Matteo Bonfanti, Sarah Stucchi, Alejandro Lopez Tobon, Dario Ricca, Manuel Lessi, Martina Pezzali, Alessandro Vitriolo, Katharina T. Schmid, Matthias Heinig, Fabian J. Theis, Carlo Emanuele Villa, Giuseppe Testa
Publicado en: 2023
Editor: BioRxiv
DOI: 10.1101/2023.08.21.553507

Brain organoids modeling of genetic and environmental impact on neurodevelopmental traits

Autores: Nicolò Caporale, Sarah Stucchi, Cristina Cheroni, Giuseppe Testa
Publicado en: Sex, Gender, and Epigenetics, 2023, Página(s) 281-290
Editor: Elsevier
DOI: 10.1016/b978-0-12-823937-7.00023-7

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