Deliverables
A theoretical description of the suite of stratified and individualised cost-effectiveness analysis models that incorporate real-world data and open-access software code
A theoretical description of the suite of stratified and individualised costeffectiveness analysis models that incorporate realworld data and openaccess software code
. Reviews on applicable patients and models for proton therapy for patients with head and neck cancerReviews on applicable patients and models for proton therapy for patients with head and neck cancer
Report on real-word health outcomes (on population average and in subgroups) under different drug options for patients with relapsing-remitting MSReport on realword health outcomes on population average and in subgroups under different drug options for patients with relapsingremitting MS
Overview of the development of the use of RWD including a review of international consensus methods currently developedReport on the use of AI to predict treatment effect of orphan diseases. Experiments on how artificial data can be used to build better models when the available data set is small
Report on trade-off between treatment effectiveness and cost. Report and experiments how Pareto optimal results can be used to estimate the trade-off between treatment effectiveness and cost. (M60). These results also include a comparison to the results o
Report on trade-off between treatment effectiveness and cost. Report and experiments how Pareto optimal results can be used to estimate the trade-off between treatment effectiveness and cost. (M60). These results also include a comparison to the results of the health econometric analysis used in WP2
Dissemination plan, development of a corporate image and Project websiteDissemination plan development of a corporate image and Project website
Report on comparison of treatment models with real life in MDS patients using the EUMDS registryOntology on HTx Project
HTx Ontology
Systematic reviewSystematic review on how cost effectiveness of combinations of health technologies individualisedpersonalised treatments and treatment pathways is currently being assessed by HTA bodies
Report on the comparative (cost-) effectiveness of proton therapy for patients with head and neck cancerReport on the comparative (cost-) effectiveness of proton therapy for patients with head and neck cancer.
Reports outlining the acceptability and usefulness of the topics considered in the policy sandbox events, inclusive of recommendations on how project work can be translated into HTA policies and practices.. Report on the relevant treatment combinations for the T1DM and T2DM patients
Report on the relevant treatment combinations for the T1DM and T2DM patients
Report of explanatory factors for treatment effectiveness based on the data from the case study. This includes experimental results using different machine learning methods showing which signals and factors are most importantReport of explanatory factors for treatment effectiveness based on the data from the case study This includes experimental results using different machine learning methods showing which signals and factors are most important
A theoretical description of the suite of network meta-analysis models for real-world effectiveness within patient subgroups and open-access software codeA theoretical description of the suite of network metaanalysis models for realworld effectiveness within patient subgroups and openaccess software code
Report describing the available data sources in MSReport describing the available data sources in MS the parameters that they can estimate and an evaluation of their agreement and disagreement with respect to the evidence they provide on treatment effects
Review on the outcomes of synergies between regulatory agencies and HTA agenciesPolicy paper on transferability of payment models throughout Europe (including low- and middle-income countries
Policy paper on transferability of payment models throughout Europe including low and middleincome countries
Review on treatment modalities for patients with myelodysplastic syndrome (MDS)Review on treatment modalities for patients with myelodysplastic syndrome MDS
Review on suitable payment models for co-dependent technologies, combination technologies and advanced therapy medicinal products (ATMP's) and provide suggestions of alternative modelsReview on suitable payment models for codependent technologies combination technologies and advanced therapy medicinal products ATMPs and provide suggestions of alternative models
Report on the prediction of treatment effectiveness. Experimental results using different machine learning methods showing how well explanatory factors can predict treatment effectivenessReport on the prediction of treatment effectiveness Experimental results using different machine learning methods showing how well explanatory factors can predict treatment effectiveness
Review of change models methods for multi-lateral, multi-stakeholder initiativesinformed framework for realising change and commitment in the context of multilateral multistakeholder collaboration
Web application enabling users to select PROMs
Report of workshops to identify activities to increase the synergies with guideline developers
Report of Workshops to identify activities to increase the synergies with guideline developers
A theoretical description of the suite of network meta-analysis models for real-world effectiveness and open-access software codeA theoretical description of the suite of network metaanalysis models for realworld effectiveness and openaccess software code
Report of workshops alignment with other H2020 and IMI projectsReport on the assessment of transferability study cases
A theoretical description of the statistical prediction model that predicts health outcomes and costs for treatments and treatment pathways in real world, the associated open-access software code
Report of workshop on how clinicians and patients can use RWE to explore expectations regarding the outcome(s) of treatment and to make shared decisions
Report of workshop on how clinicians and patients can use RWE to explore expectations regarding the outcomes of treatment and to make shared decisions
Report on how AI can help patients and healthcare professionals in decision-making on optimal treatment strategy. Report on how and what results should be visualised and presented to healthcare professionals. This report will also include a comparison witReport on how AI can help patients and healthcare professionals in decision-making on optimal treatment strategy. Report on how and what results should be visualised and presented to healthcare professionals. This report will also include a comparison with the toolkit that is developed in WP2
Publications
Author(s):
Maria Kamusheva, Konstantin Tachkov, Maria Dimitrova, Zornitsa Mitkova, Gema García-Sáez, M. Elena Hernando, Wim Goettsch, Guenka Petrova
Published in:
Frontiers in endocrinology, 2020, ISSN 1664-2392
Publisher:
Frontiers Media
DOI:
10.3389/fendo.2021.636959
Author(s):
Hogervorst, M. A., Pontén, J., Vreman, R. A., Mantel-Teeuwisse, A. K., Goettsch W. G
Published in:
Frontiers in Pharmacology, 2022, ISSN 1663-9812
Publisher:
Frontiers Media S.A.
DOI:
10.3389/fphar.2022.837302
Author(s):
Dimitrova, M., Jakab, I., Mitkova, Z., Kamusheva, M., Tachkov, K., Németh, B., Zemplényi, A., Dawoud, D., Delnoij, D. M. J., Houýez, F., Kaló, Z
Published in:
Frontiers in Public Health, 2023, ISSN 1471-6348
Publisher:
Frontiers Media S.A
DOI:
10.3389/fpubh.2022.922708
Author(s):
Oana Stoicescu, Eija Ferreira, Satu Tamminen, Pekka Siirtola, Gunjan Chandra, Riitta Veijola, Juha Röning
Published in:
Public Health and Informatics, 2021, ISSN 1947-2579
Publisher:
Chicago IL
DOI:
10.3233/shti210162
Author(s):
Leeuwenberg AM, Reitsma JB, Van den Bosch LGLJ, Hoogland J, van der Schaaf A , Hoebers FJP, Wijers OB, Langendijk JA, Moons KGM, Schuit E
Published in:
Journal of the European Society for Therapeutic Radiology and Oncology, 2022, ISSN 0167-8140
Publisher:
Elsevier BV
DOI:
10.1016/j.radonc.2022.109449
Author(s):
Daly, M-J., Elvidge, J., Chantler, T., Dawoud, D
Published in:
Frontiers in Pharmacology, 2022, ISSN 1663-9812
Publisher:
Frontiers Media S.A.
DOI:
10.3389/fphar.2022.887298
Author(s):
Kamusheva, M., Németh, B., Zemplényi, A., Kaló, Z., Elvidge, J., Dimitrova, M., Pontén, J., Tachkov, K., Mitkova, Z.
Published in:
Journal of Comparative Effectiveness Research, 2022, ISSN 2042-6305
Publisher:
Future Medicine Ltd.
DOI:
10.2217/cer-2022-0065
Author(s):
Leeuwenberg, Artuur M.; van Smeden, Maarten; Langendijk, Johannes A.; van der Schaaf, Arjen; Mauer, Murielle E.; Moons, Karel G. M.; Reitsma, Johannes B.; Schuit, Ewoud
Published in:
Diagnostic and Prognostic Research, Issue 5, 2022, ISSN 2397-7523
Publisher:
BioMed Central
DOI:
10.1186/s41512-021-00115-5
Author(s):
Chalkou, K., Vickers, A.J., Pellegrini, F., Manca, A., Salanti, G
Published in:
Society for Medical Decision Making, 2023, ISSN 0272-989X
Publisher:
Sage Science Press
DOI:
10.1177/0272989x221143058
Author(s):
Chandra, G., Siirtola, P., Tamminen, S., Knip, M.J., Veijola, R., Röning, J
Published in:
Data, 2022, ISSN 2306-5729
Publisher:
MDPI
DOI:
10.3390/data7120178
Author(s):
Li Jiu, Milou A. Hogervorst, Rick A. Vreman, Rick A. Vreman, Aukje K. Mantel-Teeuwisse, Wim G. Goettsch
Published in:
Technology Assessment in Health Care, 2022, ISSN 0266-4623
Publisher:
Cambridge University Press
DOI:
10.1017/s0266462322000010
Author(s):
Elvidge, J., Summerfield, A., Knies, S., Németh, B., Kaló, Z., Goettsch, W., Dawoud, D. (2023).
Published in:
International Journal of Technology Assessment in Health Care, 2023, ISSN 1471-6348
Publisher:
Cambridge University Press
DOI:
10.1017/s0266462323000223
Author(s):
Callenbach, M.H. E., Ádám, I., Vreman, R. A., Németh, B., Kaló, Z., Goettsch, W. G
Published in:
Drug Discovery Today, 2023, ISSN 1359-6446
Publisher:
Elsevier BV
DOI:
10.1016/j.drudis.2022.103433
Author(s):
Zemplényi, A., Tachkov, K., Balkanyi, L., Németh, B., Petykó, Zs. I., Petrova, G., Czech, M., Dawoud, D., Goettsch, W., Gutierrez, I. I., Hren, R., Knies, S., Lorenzovici, L., Maravic, Z., Piniazhko, O., Savova, A., Manova, M., Tesar, T., Zerovnik, S., Kaló, Z
Published in:
Frontiers in Public Health, 2023, ISSN 1664-8714
Publisher:
Frontiers Media S.A
DOI:
10.3389/fpubh.2023.1088121
Author(s):
Hogervorst, M. A., Vreman, R. A., Zawada, A., Zielińska, M., Dawoud, D. M., de Jong, B. A., Mantel- Teeuwisse, A. K., Goettsch, W. G. (2023).
Published in:
Clinical and Translational Science, 2023, ISSN 1752-8062
Publisher:
Wiley-Blackwell
DOI:
10.1111/cts.13492
Author(s):
Ádám, I., Callenbach, M., Németh, B., Vreman, R. A., Pontén, J., Strbad, T., Dawoud, D., Kostyuk, A., Seyam, A., Nagy, L., Goettsch, W. G., Kaló, Z.
Published in:
Frontiers in Medicine, 2022, ISSN 2296-858X
Publisher:
Frontiers Media S.A
DOI:
10.3389/fmed.2022.940371
Author(s):
Milou A. Hogervorst; Rick A. Vreman; Aukje K. Mantel-Teeuwisse; Wim G. Goettsch
Published in:
Value in Health, Issue 1, 2021, ISSN 1098-3015
Publisher:
Blackwell Publishing Inc.
DOI:
10.1016/j.jval.2021.11.1356
Author(s):
Emily Leckenby, Dalia Dawoud, Jacoline Bouvy, Páll Jónsson
Published in:
Applied health economics and health policy, 2021, ISSN 1175-5652
Publisher:
Open Mind Journals
DOI:
10.1007/s40258-021-00665-1
Author(s):
Chalkou, Konstantina; Steyerberg, Ewout; Bossuyt, Patrick; Subramanian, Suvitha; Benkert, Pascal; Kuhle, Jens; Disanto, Giulio; Kappos, Ludwig; Egger, Matthias; Salanti, Georgia
Published in:
Diagnostic and Prognostic Research, Issue 3, 2021, ISSN 2397-7523
Publisher:
BioMed Central
DOI:
10.1186/s41512-021-00106-6
Author(s):
Lavikainen, P., Chandra, G., Siirtola, P., Tamminen, S., Ihalapathirana, A.T., Röning, J., Laatikainen, T., Martikainen, J
Published in:
Journal of Clinical Epidemiology, 2023, ISSN 1878-5921
Publisher:
Elsevier
DOI:
10.2147/clep.s380828
Author(s):
Hamza, T., Chalkou, K., Pellegrini, F., Kuhle, J., Benkert, P., Lorscheider, J., Zecca, C., Iglesias-Urrutia, C. P., Manca, A., Furukawa, T. A., Cipriani, A., Salanti, G. (2023).
Published in:
Research Synthesis Methods, 2023, ISSN 1759-2887
Publisher:
Wiley
DOI:
10.1002/jrsm.1619
Author(s):
Jamie Elvidge; Dalia Dawoud; Dalia Dawoud
Published in:
Pharmacoeconomics, Issue 1, 2021, ISSN 1170-7690
Publisher:
Adis International Ltd.
DOI:
10.1007/s40273-021-01097-4
Author(s):
Jakab, I., Dimitrova, M., Houÿez, F., Bereczky, T., Fövényes, M., Maravic, Z., Belina, I., Andriciuc, C., Tóth, K., Piniazhko, O., Hren, R., Gutierrez-Ibarluzea, I., Czech, M., Tesar, T., Niewada, M., Lorenzovici, L., Kamusheva, M., Manova, M., Savova, A., Mitkova, Z., Tachkov, K., Németh, B., Petykó, Zs. I., Dawoud, D., Delnoij, D., Knies, S., Goettsch, W., Kaló, Z. (2023).
Published in:
Frontiers in Public Health, 2023, ISSN 1664-8714
Publisher:
Frontiers Media S.A
DOI:
10.3389/fpubh.2023.1176200
Author(s):
Tasnim Hamza; Andrea Cipriani; Toshi A. Furukawa; Matthias Egger; Nicola Orsini; Georgia Salanti
Published in:
Statistical Methods in Medical Research, Issue 3, 2021, ISSN 0962-2802
Publisher:
SAGE Publications
DOI:
10.1177/0962280220982643
Author(s):
Tachkov, K., Zemplenyi, A., Kamusheva, M., Dimitrova, M., Siirtola, P., Pontén, J., Németh, B., Kaló, Z., Petrova, G
Published in:
Frontiers in Public Health, 2022, ISSN 1471-6348
Publisher:
Frontiers Media S.A
DOI:
10.3389/fpubh.2022.921226
Author(s):
Jamie Elvidge, Ashley Summerfield, David Nicholls, Dalia Dawoud
Published in:
Value in Health, 2022, ISSN 1098-3015
Publisher:
Blackwell Publishing Inc.
DOI:
10.1016/j.jval.2022.01.001
Author(s):
Xinyu Li, Junfeng Wang, James Altunkaya, Francisco Javier Somolinos-Simón, Anoukh van Giessen, Li Jiu et al
Published in:
Diabetes care journal, 2023, ISSN 0149-5992
Publisher:
American Diabetes Association
DOI:
10.2337/dc22-2170
Author(s):
Richard Ofori-Asenso, Christine E. Hallgreen, Marie Louise De Bruin
Published in:
Frontiers in Medicine, 2020, ISSN 2296-858X
Publisher:
Frontiers Media S.A.
DOI:
10.3389/fmed.2020.582634
Author(s):
Németh, B., Kamusheva, M., Mitkova, Z., Petykó, Zs. I., Zemplényi, A., Dimitrova, M., Tachkov, K., Balkányi, L., Czech, M., Dawoud, D., Goettsch, W., Hren, R., Knies, S., Lorenzovici, L., Maravic, Z., Piniazhko, O., Zerovnik, S., Kaló, Z
Published in:
Journal of Comparative Effectiveness Research, 2023, ISSN 2042-6305
Publisher:
Future Medicine Ltd.
DOI:
10.57264/cer-2022-0157
Author(s):
Konstantina Chalkou, Ewout Steyerberg, Matthias Egger, Andrea Manca, Fabio Pellegrini, Georgia Salanti
Published in:
Statistics in Medicine, 2021, ISSN 0277-6715
Publisher:
John Wiley & Sons Inc.
DOI:
10.1002/sim.9034
Author(s):
Ádám, I., Callenbach, M., Németh, B., Vreman, R.A., Tollin, C., Pontén, J., Dawoud, D., Elvidge, J., Crabb, N., van Waalwijk van Doorn-Khosrovani, S.B., Pisters-van Roy, A., Vincziczki, Á., Almomani, E., Vajagic, M., Oner, Z.G., Matni, M., Fürst, J., Kahveci, R., Goettsch, W.G., Kaló, Z
Published in:
Frontiers in Medicine, 2022, ISSN 2296-858X
Publisher:
Frontiers Media S.A
DOI:
10.3389/fmed.2022.940886
Author(s):
Quik, E
Published in:
International Journal of Technology Assessment in Health Care, 2022, ISSN 1471-6348
Publisher:
Cambridge University Pres
DOI:
10.1017/s0266462322001428
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