CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.
Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .
Rezultaty
Mechanisms will be developed to ease the development and reduce the cost of deployment of new analysis algorithms into the data access nodes This will reduce the time taken for data access node operators in the cohorts to spend time on maintenance of algorithms available at their node
Scientific outputThe results of T6.2 will be described in at least 10 scientific papers (top 25% journals)
List of stakeholders using EUCAN-Connect M24Yearly update of the lists of partners and participants of WP61WP63 as engaged
Guidelines for data harmonizationMethodological harmonization guidelines to be used to support data harmonization process
Governance context appraisalAccount of the existing regulatory context challenges and issues including for the governance of the DataSHIELD infrastructure and stakeholder expectations of data sharing and data governance
Community can add tools to the toolboxThis deliverable is the successful creation and incorporation of community developed tools and apps to support analysis or to facilitate successful interaction with governance systems and stipulations Task 510 This work will be undertaken with WP7 and its experts in coproduction of tools and apps
List of stakeholders using EUCAN-Connect M36Yearly update of the lists of partners and participants of WP61WP63 as engaged
Communication about resultsConference workshops on the scientific potential of EUCANConnect analyses for the outcomes
Report on latest release of data access system and deployment in the cohortsThis report will detail the latest release of the data access system and provide a description of the resulting deployment in the cohorts including progress on the KPIs
List of stakeholders using EUCAN-Connect M48Yearly update of the lists of partners and participants of WP61WP63 as engaged
Sustainability plan for EUCAN-ConnectSustainability plan V10 of the developed infrastructure coordinated by BBMRIERIC
System for data deposition and federated access deployedFirst deployment of the software to facilitate federated data access and analysis is ready in cohorts required for specific analytic needs of EUCANConnect including suitable SOPs monitoring options and training materials
List of stakeholders using EUCAN-Connect M12Yearly update of the lists of partners and participants of WP6.1-WP6.3 as engaged.
Catalogue of cohorts, their data item semantic annotations, and cross-cohort mapping to harmonize these data.
Training material datashield usersComplete extension and customisation of DataSHIELD, Opal, and MOLGENIS for the specific analytic needs of EUCAN-Connect. Task T5.6 completed in all respects. N.B. In contrast to M5.2, D5.2 includes completion of the development work to enable analysis of high throughput omics data in DataSHIELD. Tasks T5.7, T5.8, and T5.9 completed.
Update core set of variablesCore information harmonized to be used to answer research questions addressed.
Core set of harmonized variablesCore information harmonized to be used to answer research questions addressed.
Bioinformatics support & training in placeEffective programs and systems for help, advice, support, and training relating to the Bioinformatics Toolbox, DataSHIELD, Opal, and MOLGENIS have been successfully developed and implemented. The key issue here is that programs and systems developed under Task 5.11 have been shown to work well within EUCAN-Connect and can now be rolled out externally.
Cohort metadata modelData model for cohort metadata/data items and their mapping/curations (publishable)
training material for the catalogue
Bioinformatics Toolbox catalogue onlineCatalogue of tools and methods for federated andor privacy protected analysis of cohort studies and biobanks is complete from the perspective of the needs of EUCANConnect and made publicly available on the external web T52T55
Framework that enables software providers to extend their software to interface with the DataSHIELD network. These capabilities will be demonstrated by implementing the API with MOLGENIS and investigating the feasibility of connecting other scientific data software.
Practical translationAt least two digital tools (software applications) that can be applied for risk estimations will be developed
Report indicating what would be required to take the bioinformatics toolbox beyond EUCAN-ConnectTask 5.12 addresses the tailoring of DataSHIELD’s functionality for analysing vertically partitioned data (where different sources hold different data on the same observational units) to enable a fully efficient Genomewide Complex Trait Analysis to be undertaken without data having to be transferred between the studies generating the data. Task 5.13 addresses an exploration of the potential to provide toolbox users with an option to use a simplified subset of analysis commands via a web-based graphical interface that can directly address a number of the tools in the toolbox.
Publikacje
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Gomez-Alonso, Monica del C.; Kretschmer, Anja; Wilson, Rory; Pfeiffer, Liliane; Karhunen, Ville; Seppala, Ilkka; Zhang, Weihua; Mittelstrass, Kirstin; Wahl, Simone; Matias-Garcia, Pamela R.; Prokisch, Holger; Horn, Sacha; Meitinger, Thomas; Serrano-Garcia, Luis R.; Sebert, Sylvain; Raitakari, Olli; Loh, Marie; Rathmann, Wolfgang; Mueller-Nurasyid, Martina; Herder, Christian; Roden, Michael; Hurme,
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Environment International, 2022, ISSN 1873-6750
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Mol Psychiatry., 2023, ISSN 1359-4184
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Nature Publishing Group
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Pediatric Allergy and Immunology, 2021, ISSN 1399-3038
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Medicine Access@ Point of Care, 2021, ISSN 2399-2026
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European Respiratory Journal, 2021, ISSN 0903-1936
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BMC Research Notes, 2023, ISSN 1756-0500
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