Descripción del proyecto
Reparación encefálica mediante integración de la medicina regenerativa con un método neuroprotésico
Los trastornos encefálicos tienen un impacto significativo en la sociedad y en los sistemas de salud. La medicina regenerativa (MR, o RM por sus siglas en inglés) intenta restaurar la función encefálica mediante la reconstrucción del tejido encefálico. El reto más complicado de la reparación encefálica es el control de la integración de las células o tejido injertados en el encéfalo hospedador. Las neuroprótesis inspiradas en el encéfalo son dispositivos controlables innovadores para la sustitución de la función encefálica, pero no pueden reconstruir la materia encefálica. El equipo del proyecto HERMES, financiado con fondos europeos, pretende crear un nuevo campo de MR mejorada y ofrecer una prueba de concepto de que es posible establecer y controlar la integración de tejido encefálico de mamíferos diseñado mediante bioingeniería, curando así los daños encefálicos. Esta solución innovadora incluye biohíbridos inteligentes, fabricados mediante la integración de tejido encefálico creado por bioingeniería, microelectrónica neuromórfica e inteligencia artificial.
Objetivo
Brain disorders are the most invalidating condition, exceeding HIV, cancer and heart ischemia, with significant impact on society and public health. Regenerative medicine is a promising branch of health science that aims at restoring brain function by rebuilding brain tissue. However, repairing the brain is one of the hardest challenges and we are still unable to effectively rebuild brain matter. Epilepsy is particularly challenging due to its dynamic nature caused by the relentless brain damage and aberrant rearrangements of brain rewiring. To overcome the biological uncertainty of canonical regenerative approaches, we propose an innovative solution based on intelligent biohybrids, made by the symbiotic integration of bioengineered brain tissue, neuromorphic microelectronics and artificial intelligence, to effectively drive self-repair of dysfunctional brain circuits and we validate it against animal models of epilepsy. HERMES fosters the emergence of a novel biomedical paradigm, rooted in the use of biohybrid neuronics (neural electronics), which we name enhanced regenerative medicine. To this end, HERMES will promote interdisciplinary cross-fertilization within and outside the consortium; it will extend the concepts of enhanced brain regeneration to philosophy, ethics, policy and society to foster the emergence of a new innovation eco-system. Intelligent biohybrids will represent a major breakthrough to advance brain repair research beyond regenerative medicine and neurotechnology alone; it will bring new knowledge in neurobiology, cognitive neuroscience and philosophy, and new neuromorphic technology and AI algorithms. HERMES will bring a giant conceptual leap that will shift the concept of biomedical interventions from treating to healing. In turn, it will potentially generate major returns on health care and society at large by bringing previously unimaginable possibilities to defeat disorders that represent today a global major burden of disease.
Ámbito científico
- medical and health sciencesbasic medicineneurologyepilepsy
- medical and health scienceshealth sciencespublic health
- medical and health scienceshealth sciencesinfectious diseasesRNA virusesHIV
- medical and health sciencesclinical medicineoncology
- natural sciencesphysical scienceselectromagnetism and electronicsmicroelectronics
Palabras clave
Programa(s)
Convocatoria de propuestas
Consulte otros proyectos de esta convocatoriaConvocatoria de subcontratación
H2020-FETPROACT-2018-01
Régimen de financiación
RIA - Research and Innovation actionCoordinador
16163 Genova
Italia