Integrating the tissue-specificity and chronology of hereditary renal cancer predisposition

Publicaciones

TCA cycle signalling and the evolution of eukaryotes

Autores: Dylan G Ryan, Christian Frezza, Luke AJ O’Neill
Publicado en: Current Opinion in Biotechnology, Edición 68, 2021, Página(s) 72-88, ISSN 0958-1669
Editor: Elsevier BV
DOI: 10.1016/j.copbio.2020.09.014

Fumarate induces vesicular release of mtDNA to drive innate immunity

Autores: Vincent Zecchini, Vincent Paupe, Irene Herranz-Montoya, Joëlle Janssen, Inge M. N. Wortel, Jordan L. Morris, Ashley Ferguson, Suvagata Roy Chowdury, Marc Segarra-Mondejar, Ana S. H. Costa, Gonçalo C. Pereira, Laura Tronci, Timothy Young, Efterpi Nikitopoulou, Ming Yang, Dóra Bihary, Federico Caicci, Shun Nagashima, Alyson Speed, Kalliopi Bokea, Zara Baig, Shamith Samarajiwa, Maxine Tran, Thomas
Publicado en: Nature, 2023, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-023-05770-w

Hypoxia promotes osteogenesis by facilitating acetyl-CoA-mediated mitochondrial–nuclear communication

Autores: Andromachi Pouikli Monika Maleszewska Swati Parekh Ming Yang Chrysa Nikopoulou Juan Jose Bonfiglio Constantine Mylonas Tonantzi Sandoval Anna-Lena Schumacher Yvonne Hinze Ivan Matic Christian Frezza Peter Tessarz
Publicado en: The EMBO Journal, 2022, ISSN 1460-2075
Editor: EMBOpress
DOI: 10.15252/embj.2022111239

Fumarate hydratase (FH) and cancer: a paradigm of oncometabolism

Autores: Lorea Valcarcel-Jimenez & Christian Frezza
Publicado en: British Journal of Cancer (BJC), 2023, ISSN 0007-0920
Editor: Nature Publishing Group
DOI: 10.1038/s41416-023-02412-w

HIRA loss transforms FH-deficient cells

Autores: Lorea Valcarcel-Jimenez, Connor Rogerson, Cissy Yong, Christina Schmidt, Ming Yang, Monica Cremades-Rodelgo, Victoria Harle, Victoria Offord, Kim Wong, Ariane Mora, Alyson Speed, Veronica Caraffini, Maxine Gia Binh Tran, Eamonn R. Maher, Grant D. Stewart, Sakari Vanharanta, David J. Adams, Christian Frezza
Publicado en: Science Advances, 2022, ISSN 2375-2548
Editor: American Association for the Advancement of Science
DOI: 10.1126/sciadv.abq8297

Targeting Metabolic Plasticity and Flexibility Dynamics for Cancer Therapy

Autores: Sarah-Maria Fendt, Christian Frezza, Ayelet Erez
Publicado en: Cancer Discovery, Edición 10/12, 2020, Página(s) 1797-1807, ISSN 2159-8274
Editor: American Association for Cancer Research Inc.
DOI: 10.1158/2159-8290.cd-20-0844

The context-specific roles of urea cycle enzymes in tumorigenesis

Autores: Emma Hajaj, Marco Sciacovelli, Christian Frezza, Ayelet Erez
Publicado en: Molecular Cell, 2021, ISSN 1097-2765
Editor: Cell Press
DOI: 10.1016/j.molcel.2021.08.005

Metabolic symbiosis in pancreatic cancer.

Autores: Ryan DG, Frezza C.
Publicado en: Nature Cancer, 2022, ISSN 2662-1347
Editor: Springer nAture Limited
DOI: 10.1038/s43018-022-00454-2

Dynamic partitioning of branched-chain amino acids-derived nitrogen supports renal cancer progression

Autores: Marco Sciacovelli , Aurelien Dugourd , Lorea Valcarcel Jimenez , Ming Yang , Efterpi Nikitopoulou , Ana S. H. Costa , Laura Tronci , Veronica Caraffini , Paulo Rodrigues , Christina Schmidt , Dylan Gerard Ryan , Timothy Young , Vincent R. Zecchini , Sabrina H. Rossi , Charlie Massie , Caroline Lohoff , Maria Masid , Vassily Hatzimanikatis , Christoph Kuppe , Alex Von Kriegsheim , Rafael Kr
Publicado en: Nature Communications, 2022, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-022-35036-4

FOXA2 controls the anti-oxidant response in FH-deficient cells

Autores: Connor Rogerson , Marco Sciacovelli , Lucas A Maddalena , Andromachi Pouikli , Marc Segarra-Mondejar , Lorea Valcarcel-Jimenez , Christina Schmidt , Ming Yang , Elena Ivanova , Joshua Kent , Ariane Mora , Danya Cheeseman , Jason S Carroll , Gavin Kelsey , Christian Frezza
Publicado en: Cell Reports, 2023, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2023.112751

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