Protein Dynamics in Antiviral Processes

System-Based Approaches to Delineate the Antiviral Innate Immune Landscape

Autori: Karsten Krey, Aleksandra W. Babnis, Andreas Pichlmair
Pubblicato in: Viruses, Numero 12, 2024, Pagina/e 1196, ISSN 1999-4915
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v12101196

Influenza A Virus Infection Reactivates Human Endogenous Retroviruses Associated with Modulation of Antiviral Immunity

Autori: Hengyuan Liu, Valter Bergant, Goar Frishman, Andreas Ruepp, Andreas Pichlmair, Michelle Vincendeau, Dmitrij Frishman
Pubblicato in: Viruses, Numero 14, 2024, Pagina/e 1591, ISSN 1999-4915
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v14071591

Attenuation of <scp>SARS‐CoV</scp>‐2 replication and associated inflammation by concomitant targeting of viral and host cap 2'‐O‐ribose methyltransferases

Autori: Valter Bergant, Shintaro Yamada, Vincent Grass, Yuta Tsukamoto, Teresa Lavacca, Karsten Krey, Maria‐Teresa Mühlhofer, Sabine Wittmann, Armin Ensser, Alexandra Herrmann, Anja vom Hemdt, Yuriko Tomita, Shutoku Matsuyama, Takatsugu Hirokawa, Yiqi Huang, Antonio Piras, Constanze A Jakwerth, Madlen Oelsner, Susanne Thieme, Alexander Graf, Stefan Krebs, Helmut Blum, Beate M Kümmerer, Alexey Stukalov
Pubblicato in: The EMBO Journal, Numero 41, 2023, ISSN 0261-4189
Editore: Nature Publishing Group
DOI: 10.15252/embj.2022111608

Targeting genomic SARS-CoV-2 RNA with siRNAs allows efficient inhibition of viral replication and spread

Autori: Shubhankar Ambike; Cho-Chin Cheng; Martin Feuerherd; Stoyan Velkov; Domizia Baldassi; Suliman Qadir Afridi; Diana Porras-Gonzalez; Xin Wei; Philipp Hagen; Nikolaus Kneidinger; Mircea Gabriel Stoleriu; Vincent Grass; Gerald Burgstaller; Andreas Pichlmair; Olivia M Merkel; Chunkyu Ko; Thomas Michler
Pubblicato in: Nucleic Acids Research, Numero 2, 2021, ISSN 0305-1048
Editore: Oxford University Press
DOI: 10.1093/nar/gkab1248

Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.

Autori: Alexey Stukalov; Virginie Girault; Vincent Grass; Ozge Karayel; Valter Bergant; Christian Urban; Darya A. Haas; Yiqi Huang; Lila Oubraham; Anqi Wang; M. Sabri Hamad; Antonio Piras; Fynn M. Hansen; Maria C. Tanzer; Igor Paron; Luca Zinzula; Thomas Enghleitner; Maria Reinecke; Maria Reinecke; Teresa M. Lavacca; Rosina Ehmann; Roman Wölfel; Jörg Jores; Bernhard Kuster; Bernhard Kuster; Ulrike Protz
Pubblicato in: Nature/Vol 594, Numero 2, 2021, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-021-03493-4

ER-shaping atlastin proteins act as central hubs to promote flavivirus replication and virion assembly

Autori: Christopher J. Neufeldt, Mirko Cortese, Pietro Scaturro, Berati Cerikan, Jeremy G. Wideman, Keisuke Tabata, Thaís Moraes, Olga Oleksiuk, Andreas Pichlmair & Ralf Bartenschlager
Pubblicato in: Nature Microbiology, 2019, ISSN 2058-5276
Editore: Nature publishing group
DOI: 10.1038/s41564-019-0586-3

Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV

Autori: Alexey Stukalov, Virginie Girault, Vincent Grass, Ozge Karayel, Valter Bergant, Christian Urban, Darya A. Haas, Yiqi Huang, Lila Oubraham, Anqi Wang, M. Sabri Hamad, Antonio Piras, Fynn M. Hansen, Maria C. Tanzer, Igor Paron, Luca Zinzula, Thomas Engleitner, Maria Reinecke, Teresa M. Lavacca, Rosina Ehmann, Roman Wölfel, Jörg Jores, Bernhard Kuster, Ulrike Protzer, Roland Rad, John Ziebuhr, Volk
Pubblicato in: Nature, Numero 594/7862, 2021, Pagina/e 246-252, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-021-03493-4

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape

Autori: Philipp Hubel, Christian Urban, Valter Bergant, William M. Schneider, Barbara Knauer, Alexey Stukalov, Pietro Scaturro, Angelika Mann, Linda Brunotte, Heinrich H. Hoffmann, John W. Schoggins, Martin Schwemmle, Matthias Mann, Charles M. Rice, Andreas Pichlmair
Pubblicato in: Nature Immunology, Numero 20/4, 2019, Pagina/e 493-502, ISSN 1529-2908
Editore: Nature Publishing Group
DOI: 10.1038/s41590-019-0323-3

MDM2 Influences ACE2 Stability and SARS-CoV-2 Uptake

Autori: Quirin Emslander, Karsten Krey, Sabri Hamad, Susanne Maidl, Lila Oubraham, Joshua Hesse, Alexander Henrici, Katharina Austen, Julia Mergner, Vincent Grass, Andreas Pichlmair
Pubblicato in: Viruses, Numero 15, 2023, Pagina/e 1763, ISSN 1999-4915
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v15081763

Chasing Intracellular Zika Virus Using Proteomics

Autori: Pietro Scaturro, Anna Lena Kastner, Andreas Pichlmair
Pubblicato in: Viruses, Numero 11/9, 2019, Pagina/e 878, ISSN 1999-4915
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v11090878

mRNA 3’UTR lengthening by alternative polyadenylation attenuates inflammatory responses and correlates with virulence of Influenza A virus

Autori: Valter Bergant, Daniel Schnepf, Niklas de Andrade Krätzig, Philipp Hubel, Christian Urban, Thomas Engleitner, Ronald Dijkman, Bernhard Ryffel, Katja Steiger, Percy A. Knolle, Georg Kochs, Roland Rad, Peter Staeheli, Andreas Pichlmair
Pubblicato in: Nature Communications, Numero 14, 2023, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-023-40469-6

Exploring the SARS-CoV-2 virus-host-drug interactome for drug repurposing

Autori: Sepideh Sadegh, Julian Matschinske, David B. Blumenthal, Gihanna Galindez, Tim Kacprowski, Markus List, Reza Nasirigerdeh, Mhaned Oubounyt, Andreas Pichlmair, Tim Daniel Rose, Marisol Salgado-Albarrán, Julian Späth, Alexey Stukalov, Nina K. Wenke, Kevin Yuan, Josch K. Pauling and Jan Baumbach
Pubblicato in: Nature Communications, 2020, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-020-17189-2

Persistent Innate Immune Stimulation Results in IRF3-Mediated but Caspase-Independent Cytostasis

Autori: Christian Urban, Hendrik Welsch, Katharina Heine, Sandra Wüst, Darya A. Haas, Christopher Dächert, Aparna Pandey, Andreas Pichlmair and Marco Binder
Pubblicato in: Viruses, 2020, ISSN 1999-4915
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v12060635

Human cytomegalovirus-induced host protein citrullination is crucial for viral replication

Autori: Gloria Griffante, Francesca Gugliesi, Selina Pasquero, Valentina Dell’Oste, Matteo Biolatti, Ari J. Salinger, Santanu Mondal, Paul R. Thompson, Eranthie Weerapana, Robert J. Lebbink, Jasper A. Soppe, Thomas Stamminger, Virginie Girault, Andreas Pichlmair, Gábor Oroszlán, Donald M. Coen, Marco De Andrea, Santo Landolfo
Pubblicato in: Nature Communications, Numero 12/1, 2021, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-24178-6

Two cGAS-like receptors induce antiviral immunity in Drosophila

Autori: Andreas Holleufer, Kasper Grønbjerg Winther, Hans Henrik Gad, Xianlong Ai, Yuqiang Chen, Lihua Li, Ziming Wei, Huimin Deng, Jiyong Liu, Ninna Ahlmann Frederiksen, Bine Simonsen, Line Lykke Andersen, Karin Kleigrewe, Louise Dalskov, Andreas Pichlmair, Hua Cai, Jean-Luc Imler, Rune Hartmann
Pubblicato in: Nature, Numero 597/7874, 2021, Pagina/e 114-118, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-021-03800-z

Cross-species analysis of viral nucleic acid interacting proteins identifies TAOKs as innate immune regulators

Autori: Friederike L. Pennemann, Assel Mussabekova, Christian Urban, Alexey Stukalov, Line Lykke Andersen, Vincent Grass, Teresa Maria Lavacca, Cathleen Holze, Lila Oubraham, Yasmine Benamrouche, Enrico Girardi, Rasha E. Boulos, Rune Hartmann, Giulio Superti-Furga, Matthias Habjan, Jean-Luc Imler, Carine Meignin, Andreas Pichlmair
Pubblicato in: Nature Communications, Numero 12, 2023, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-27192-w

Multi-omics characterization of the monkeypox virus infection

Autori: Yiqi Huang, Valter Bergant, Vincent Grass, Quirin Emslander, M. Sabri Hamad, Philipp Hubel, Julia Mergner, Antonio Piras, Karsten Krey, Alexander Henrici, Rupert Öllinger, Yonas M. Tesfamariam, Ilaria Dalla Rosa, Till Bunse, Gerd Sutter, Gregor Ebert, Florian I. Schmidt, Michael Way, Roland Rad, Andrew G. Bowie, Ulrike Protzer, Andreas Pichlmair
Pubblicato in: Nature Communications, Numero 15, 2024, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-024-51074-6

A novel interaction between dengue virus nonstructural protein 1 and the NS4A-2K-4B precursor is required for viral RNA replication but not for formation of the membranous replication organelle

Autori: Anna Płaszczyca, Pietro Scaturro, Christopher John Neufeldt, Mirko Cortese, Berati Cerikan, Salvatore Ferla, Andrea Brancale, Andreas Pichlmair, Ralf Bartenschlager
Pubblicato in: PLOS Pathogens, Numero 15/5, 2019, Pagina/e e1007736, ISSN 1553-7366
Editore: Public Library of Science
DOI: 10.1371/journal.ppat.1007736

Systematic <scp>P2Y</scp> receptor survey identifies <scp>P2Y11</scp> as modulator of immune responses and virus replication in macrophages

Autori: Line Lykke Andersen, Yiqi Huang, Christian Urban, Lila Oubraham, Elena Winheim, Che Stafford, Dennis Nagl, Fionan O'Duill, Thomas Ebert, Thomas Engleitner, Søren Riis Paludan, Anne Krug, Roland Rad, Veit Hornung, Andreas Pichlmair
Pubblicato in: The EMBO Journal, Numero 42, 2023, ISSN 0261-4189
Editore: Nature Publishing Group
DOI: 10.15252/embj.2022113279

Engineered, nucleocytoplasmic shuttling Cas13d enables highly efficient cytosolic RNA targeting

Autori: Christoph Gruber, Lea Krautner, Valter Bergant, Vincent Grass, Zhe Ma, Lara Rheinemann, Ariane Krus, Friederike Reinhardt, Lyupka Mazneykova, Marianne Rocha-Hasler, Dong-Jiunn Jeffery Truong, Gil Gregor Westmeyer, Andreas Pichlmair, Gregor Ebert, Florian Giesert, Wolfgang Wurst
Pubblicato in: Cell Discovery, Numero 10, 2024, ISSN 2056-5968
Editore: Nature Publishing group
DOI: 10.1038/s41421-024-00672-1

NUDT2 initiates viral RNA degradation by removal of 5′-phosphates

Autori: Beatrice T. Laudenbach, Karsten Krey, Quirin Emslander, Line Lykke Andersen, Alexander Reim, Pietro Scaturro, Sarah Mundigl, Christopher Dächert, Katrin Manske, Markus Moser, Janos Ludwig, Dirk Wohlleber, Andrea Kröger, Marco Binder, Andreas Pichlmair
Pubblicato in: Nature Communications, Numero 12, 2022, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-27239-y

Bitter taste signaling in tracheal epithelial brush cells elicits innate immune responses to bacterial infection

Autori: Monika I. Hollenhorst, Rajender Nandigama, Saskia B. Evers, Igor Gamayun, Noran Abdel Wadood, Alaa Salah, Mario Pieper, Amanda Wyatt, Alexey Stukalov, Anna Gebhardt, Wiebke Nadolni, Wera Burow, Christian Herr, Christoph Beisswenger, Soumya Kusumakshi, Fabien Ectors, Tatjana I. Kichko, Lisa Hübner, Peter Reeh, Antje Munder, Sandra-Maria Wienhold, Martin Witzenrath, Robert Bals, Veit Flockerzi, Tho
Pubblicato in: Journal of Clinical Investigation, Numero 132, 2023, ISSN 1558-8238
Editore: American Society for Clinical Investigation (ASCI)
DOI: 10.1172/jci150951

eIF2B as a Target for Viral Evasion of PKR-Mediated Translation Inhibition

Autori: Jennifer Deborah Wuerth, Matthias Habjan, Markus Kainulainen, Besim Berisha, Damien Bertheloot, Giulio Superti-Furga, Andreas Pichlmair, Friedemann Weber
Pubblicato in: mBio, 2020, ISSN 2150-7511
Editore: American Society for Microbiology
DOI: 10.1128/mbio.00976-20

Genotoxic stress in constitutive trisomies induces autophagy and the innate immune response via the cGAS-STING pathway

Autori: Maria Krivega, Clara M. Stiefel, Sahar Karbassi, Line L. Andersen, Narendra K. Chunduri, Neysan Donnelly, Andreas Pichlmair, Zuzana Storchová
Pubblicato in: Communications Biology, Numero 4/1, 2021, ISSN 2399-3642
Editore: Springer Nature
DOI: 10.1038/s42003-021-02278-9

Human NLRP1 is a sensor for double-stranded RNA

Autori: Stefan Bauernfried, Matthias J. Scherr, Andreas Pichlmair, Karl E. Duderstadt, Veit Hornung
Pubblicato in: Science, Numero 371/6528, 2021, Pagina/e eabd0811, ISSN 0036-8075
Editore: American Association for the Advancement of Science
DOI: 10.1126/science.abd0811

The UFM1 Pathway Impacts HCMV US2-Mediated Degradation of HLA Class I.

Autori: Anouk B. C. Schuren; Ingrid G. J. Boer; Esther M. C. Bouma; M. L. van de Weijer; Ana I. Costa; P. Hubel; Andreas Pichlmair; Robert Jan Lebbink; Emmanuel J. H. J. Wiertz
Pubblicato in: MDPI/Volume 26, Numero 1, 2021, ISSN 1420-3049
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules26020287

Nuclear-localized human respiratory syncytial virus NS1 protein modulates host gene transcription

Autori: Jingjing Pei, Nina R. Beri, Angela J. Zou, Philipp Hubel, Hannah K. Dorando, Valter Bergant, Rebecca D. Andrews, Jiehong Pan, Jared M. Andrews, Kathleen C.F. Sheehan, Andreas Pichlmair, Gaya K. Amarasinghe, Steven L. Brody, Jacqueline E. Payton, Daisy W. Leung
Pubblicato in: Cell Reports, Numero 37/2, 2021, Pagina/e 109803, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2021.109803

Data, Reagents, Assays and Merits of Proteomics for SARS-CoV-2 Research and Testing

Autori: Jana Zecha, Chien-Yun Lee, Florian P. Bayer, Chen Meng, Vincent Grass, Johannes Zerweck, Karsten Schnatbaum, Thomas Michler, Andreas Pichlmair, Christina Ludwig, Bernhard Kuster
Pubblicato in: Molecular & Cellular Proteomics, Numero 19/9, 2020, Pagina/e 1503-1522, ISSN 1535-9476
Editore: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/mcp.ra120.002164

Zika virus remodelled ER membranes contain proviral factors involved in redox and methylation pathways

Autori: Solène Denolly, Alexey Stukalov, Uladzimir Barayeu, Alina N. Rosinski, Paraskevi Kritsiligkou, Sebastian Joecks, Tobias P. Dick, Andreas Pichlmair, Ralf Bartenschlager
Pubblicato in: Nature Communications, Numero 14, 2023, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-023-43665-6

The alternative cap-binding complex is required for antiviral defense in vivo

Autori: Anna Gebhardt,Valter Bergant,Daniel Schnepf,Markus Moser,Arno Meiler,Dieudonnée Togbe,Claire Mackowiak,Line S. Reinert,Søren R. Paludan,Bernhard Ryffel,Alexey Stukalov,Peter Staeheli,Andreas Pichlmair
Pubblicato in: PLOS Pathogens, 2019, ISSN 1553-7366
Editore: Public Library of Science
DOI: 10.1371/journal.ppat.1008155

The Cytomegalovirus Tegument Protein UL35 Antagonizes Pattern Recognition Receptor-Mediated Type I IFN Transcription

Autori: Markus Fabits, Vladimir Gonçalves Magalhães, Baca Chan ,Virginie Girault, Endrit Elbasani, Elisa Rossetti, Eirikur Saeland, Martin Messerle,Andreas Pichlmair, Vanda Juranić Lisnić and Melanie M. Brinkmann
Pubblicato in: Microorganisms, 2020, ISSN 2076-2607
Editore: MDPI
DOI: 10.3390/microorganisms8060790

A Nanoscaffolded Spike-RBD Vaccine Provides Protection against SARS-CoV-2 with Minimal Anti-Scaffold Response

Autori: Duško Lainšček, Tina Fink, Vida Forstnerič, Iva Hafner-Bratkovič, Sara Orehek, Žiga Strmšek, Mateja Manček-Keber, Peter Pečan, Hana Esih, Špela Malenšek, Jana Aupič, Petra Dekleva, Tjaša Plaper, Sara Vidmar, Lucija Kadunc, Mojca Benčina, Neža Omersa, Gregor Anderluh, Florence Pojer, Kelvin Lau, David Hacker, Bruno E. Correia, David Peterhoff, Ralf Wagner, Valter Bergant, Alexander H
Pubblicato in: Vaccines, Numero 9/5, 2021, Pagina/e 431, ISSN 2076-393X
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines9050431

ADAM10 and ADAM17 promote SARS‐CoV‐2 cell entry and spike protein‐mediated lung cell fusion

Autori: Georg Jocher, Vincent Grass, Sarah K Tschirner, Lydia Riepler, Stephan Breimann, Tuğberk Kaya, Madlen Oelsner, M Sabri Hamad, Laura I Hofmann, Carl P Blobel, Carsten B Schmidt‐Weber, Ozgun Gokce, Constanze A Jakwerth, Jakob Trimpert, Janine Kimpel, Andreas Pichlmair, Stefan F Lichtenthaler
Pubblicato in: EMBO reports, Numero 23, 2023, ISSN 1469-221X
Editore: Nature Publishing Group
DOI: 10.15252/embr.202154305

Data-driven host-directed antiviral drug repurposing against emerging pathogens

Autori: Bergant, Valter
Pubblicato in: Numero 1, 2023
Editore: TUM

Recruitment of highly functional SARS-CoV-2-specific CD8<sup>+</sup>T cell receptors mediating cytotoxicity of virus-infected target cells in non-severe COVID-19

Autori: Karolin I. Wagner, Laura M. Mateyka, Sebastian Jarosch, Vincent Grass, Simone Weber, Kilian Schober, Monika Hammel, Teresa Burrell, Behnam Kalali, Holger Poppert, Henriette Beyer, Sophia Schambeck, Stefan Holdenrieder, Andrea Strötges-Achatz, Verena Haselmann, Michael Neumaier, Johanna Erber, Alina Priller, Sarah Yazici, Hedwig Roggendorf, Marcus Odendahl, Torsten Tonn, Andrea Dick, Klaus Witter,
Pubblicato in: 2024
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2021.07.20.21260845

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