Establishing a Nanotechnology Risk Governance Framework

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Deliverables

Report on the verification of the models
Detailed text modules outlining initiative on how the RGF and NRGC can function in relation to the international stakeholders' requirements.

Detailed text modules outlining initiative on how the RGF and NRGC can function in relation to the international stakeholders requirements

Development of an Organisational Form for Nanotechnology Risk Governance (NRGOF) in the context of present policy goals (joint deliverable G4N-D5.5 –T5.3)

Development of an Organisational Form for Nanotechnology Risk Governance NRGOF in the context of present policy goals joint deliverable G4ND55 T53

Evaluation of the identified governance tools for their inclusion in the RGF
Publication on economic benefits from implementing the RGF, based on case studies.

Publication on economic benefits from implementing the RGF based on case studies

1st. virtual Conference and proceedings

1st virtual Conference and proceedings

Report: Case study on TiO2

Report Case study on TiO2

Options for the harmonization of existing international standards and guidelines with for integrating new risk governance tools
Mandate, composition and structure of NRGC

Mandate composition and structure of NRGC

Inventory of effective organizational forms in support of CSS.

Inventory of effective organizational forms in support of CSS

Integrative prospective on user / stakeholder needs

Integrative prospective on user stakeholder needs

Report: Case study on the impact of the RGF in Dutch industries

Report Case study on the impact of the RGF in Dutch industries

Detailed list of how the RGF has contributed to ongoing international activities, including. Brochures, webinares targeted the global audience

Detailed list of how the RGF has contributed to ongoing international activities including Brochures webinares targeted the global audience

List of contributions to EU, EU-US, ISO/CEN and OECD on TG and standardization.

List of contributions to EU EUUS ISOCEN and OECD on TG and standardization

Report on how to integrate views and needs from insurers and expectations from stakeholders regarding role from insurance
Report on multidisciplinary and multi-stakeholder dialogue

Report of the integration of NRGC with social sciences and humanities

Potential mandate, composition and structure of NRGC
Report: Case study on setting up a workplace

Report Case study on setting up a workplace

The NANORIGO database
Report: Case study on risk management

Report Case study on risk management

Report outlining the compliance of the performance and RGF tools with legislation
Training materials for students, early stage researchers and experts

Training materials for students early stage researchers and experts

Final report on dissemination and engagement activities.

Final report on dissemination and engagement activities

Report: Case study on training

Report Case study on training

Virtual NRGC workshop no.2 and proceedings

Webinar for NRGC workshop for Global Partners

Virtual NRGC workshop no.1 and proceedings

Intermediate report on all case studies, produced as a video combined with factsheets

Intermediate report on all case studies produced as a video combined with factsheets

Multimedia presentation on results of the case studies

Website and social media presence.

Publications

Defining Quality Criteria for Nanoplastic Hazard Evaluation: The Case of Polystyrene Nanoplastics and Aquatic Invertebrate Daphnia spp.

Author(s): Jemec Kokalj, Anita; Heinlaan, Margit; Novak, Sara; Drobne, Damjana; Kühnel, Dana
Published in: Nanomaterials, Issue 1, 2023, ISSN 2079-4991
Publisher: Basel MDPI AG 2011-
DOI: 10.3390/nano13030536

The Impact of Nanoparticles on Innate Immune Activation by Live Bacteria.

Author(s): Benjamin J, Swartzwelter; Alexandra C, Fux; Litty, Johnson; Elmer, Swart; Sabine, Hofer; Norbert, Hofstätter; Mark, Geppert; Paola, Italiani; Diana, Boraschi; Albert, Duschl; Martin, Himly
Published in: International Journal of Molecular Sciences, Vol 21, Iss 9695, p 9695 (2020), 2020, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21249695

Children’s Privilege in COVID-19: The Protective Role of the Juvenile Lung Morphometry and Ventilatory Pattern on Airborne SARS-CoV-2 Transmission to Respiratory Epithelial Barriers and Disease Severity

Author(s): Hofstätter Norbert, Sabine Hofer, Albert Duschl, and Martin Himly
Published in: Biomedicines, Issue 2021-10-08, 9, 1414, 2021, ISSN 2227-9059
Publisher: MDPI
DOI: 10.3390/biomedicines9101414

Plastic pollution – A case study with Enchytraeus crypticus – From micro-to nanoplastics

Author(s): M.J.B. Amorim, J.J. Scott-fordsmand
Published in: Environmental Pollution -Elsevier, 2021, Page(s) 116363, ISSN 0269-7491
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envpol.2020.116363

SARS-CoV-2-Laden Respiratory Aerosol Deposition in the Lung Alveolar-Interstitial Region Is a Potential Risk Factor for Severe Disease: A Modeling Study

Author(s): Hofer, S.; Hofstätter, N.; Duschl, A.; Himly Martin,
Published in: Journal of Personalized Medicine, 2021, Page(s) 2021-05-19, 11,431, ISSN 2075-4426
Publisher: MDPI
DOI: 10.3390/jpm11050431

Iron Oxide Nanoparticles in Bioimaging – An Immune Perspective

Author(s): Mark Gppert and Martin Himly
Published in: Frontiers in Immunology, 2021, ISSN 1664-3224
Publisher: Lausanne Frontiers Media S.A. 2010-
DOI: 10.3389/fimmu.2021.688927

Alternative test methods for (nano)materials hazards assessment: Challenges and recommendations for regulatory preparedness

Author(s): Susana I.L.Gomes, Janeck J.Scott-Fordsmand , Monica J.B.Amorima
Published in: Elsevier, 2021, ISSN 1748-0132
Publisher: Elsevier BV
DOI: 10.1016/j.nantod.2021.101242

Tyre wear nanoparticles as test for a nano risk governance framework.

Author(s): van Broekhuizen P., Säämänen A., Schuurbiers D., Isigonis P., Jensen K.A., Kühnel D. and Le Blansch K.
Published in: Frontiers in Environmental Sciences, Issue 12 December 2022, vol 10, 2022, ISSN 2296-665X
Publisher: Frontiers
DOI: 10.3389/fenvs.2022.1045246

Metadata stewardship in nanosafety research: Community-driven organisation of metadata schemas to support FAIR nanoscience data

Author(s): """Anastasios G Papadiamantis, Frederick C Klaessig, Thomas E Exner, Sabine Hofer, Norbert Hofstaetter, Martin Himly, Marc A Williams, Philip Doganis, Mark D Hoover, Antreas Afantitis, Georgia Melagraki, Tracy S Nolan, John Rumble, Dieter Maier, Iseult Lynch"""
Published in: Nanomaterials, 2020, ISSN 2079-4991
Publisher: MDPI
DOI: 10.3390/nano10102033

Ecotoxicological and Regulatory Aspects of Environmental Sustainability of Nanopesticides

Author(s): R. Grillo, L.F. Fraceto, M.J.B. Amorim, J.J. Scott-Fordsmand, R. Schoonjans, Q. Chaudhry
Published in: Journal of Hazardous Materials, 2021, Page(s) 124148, ISSN 1873-3336
Publisher: Elsevier
DOI: 10.1016/j.jhazmat.2020.124148

Microbial Population Dynamics in Model Sewage Treatment Plants and the Fate and Effect of Gold Nanoparticles

Author(s): Schlich, K.; Díaz, C.; Gomez Pizarro, B.; Knopf, B.; Schlinkert, R.; Wege, F.F.; Jurack, A.; Hund-Rinke, K.
Published in: Toxics, 2021, Page(s) 2021-3-10; 9, 54, ISSN 2305-6304
Publisher: MDPI
DOI: 10.3390/toxics9030054

"""Immunotoxicity of nanomaterials in health and disease: Current challenges and emerging approaches for identifying immune modifiers in susceptible populations"""

Author(s): Sabine Hofer, Norbert Hofstätter, Benjamin Punz, Ingrid Hasenkopf, Litty Johnson, Martin Himly
Published in: WIREs Nanomedicine and Nanobiotechnology, 2022, ISSN 1939-0041
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/wnan.1804

When Would Immunologists Consider a Nanomaterial to be Safe? Recommendations for Planning Studies on Nanosafety

Author(s): Martin Himly, Mark Geppert, Sabine Hofer, Norbert Hofstätter, Jutta Horejs‐Höck, Albert Duschl
Published in: Small, Issue 16/21, 2020, Page(s) 1907483, ISSN 1613-6810
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.201907483

In vitro-based human toxicity effect factors: challenges and opportunities for nanomaterial impact assessment

Author(s): D. Romeo, R. Hischier, B. Nowack, O. Jolliet, P. Fantke, P. Wick
Published in: Environmental Science: nano, 2022, Page(s) 1913-1925, ISSN 2051-8161
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1en01014j

Systems toxicology to advance human and environmental hazard assessment : A roadmap for advanced materials

Author(s): Amorim, M. J.B.; Peijnenburg, W.; Greco, D.; Saarimäki, L. A.; Dumit, V. I.; Bahl, A.; Haase, A.; Tran, L.; Hackermüller, J.; Canzler, S.; Scott-Fordsmand, J. J.
Published in: Nano Today, Issue 1, 2023, ISSN 1878-044X
Publisher: Science Direct
DOI: 10.1016/j.nantod.2022.101735

Molecular mechanisms of zinc toxicity in the potworm Enchytraeus crypticus, analysed by high-throughput gene expression profiling

Author(s): S.I.L. Gomes, T.E. de Boer, C.A.M. van Gestel, N.M. van Straalen, A.M.V.M. Soares, D. Roelofs, M.J.B. Amorim,
Published in: Science of the Total Environment, 2022, Page(s) 153875, ISSN 0048-9697
Publisher: Elsevier BV
DOI: 10.1016/j.scitotenv.2022.153975

Reliable Surface Analysis Data of Nanomaterials in Support of Risk Assessment Based on Minimum Information Requirements.

Author(s): Jörg Radnik; Reinhard Kersting; Birgit Hagenhoff; Francesca Bennet; Dmitri Ciornii; Penny Nymark; Roland C. Grafström; Vasile-Dan Hodoroaba
Published in: Nanomaterials, Vol 11, Iss 639, p 639 (2021), Issue 1, 2021, ISSN 2079-4991
Publisher: Basel MDPI AG 2011-
DOI: 10.3390/nano11030639

Environmental hazard testing of nanobiomaterials

Author(s): M. J. B. Amorim, M. L. Fernández-Cruz, K. Hund-Rinke, J. J. Scott-Fordsmand
Published in: Environmental Sciences Europe, Issue 32/1, 2020, ISSN 2190-4707
Publisher: Springer Verlag
DOI: 10.1186/s12302-020-00369-8

High-throughput transcriptomics reveals the mechanisms of nanopesticides – nanoformulation, commercial formulation, active ingredient – finding safe and sustainable-by-design (SSbD) options for the environment

Author(s): Susana I. L. Gomes; Estefânia V. R. Campos; Leonardo F. Fraceto; Renato Grillo; Janeck J. Scott-Fordsmand; Mónica J. B. Amorim
Published in: Environmental Science: Nano, 2022, ISSN 2051-8161
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1en00735a

Annelid genomes: Enchytraeus crypticus, a soil model for the innate (and primed) immune system

Author(s): M.J.B. Amorim, Y. Gansemans, S.I.L. Gomes, F. Van Nieuwerburgh, J.J. Scott-Fordsmand,
Published in: Lab Animal, 2021, Page(s) 285–294., ISSN 1548-4475
Publisher: Nature
DOI: 10.1038/s41684-021-00831-x

Impacts of Longer-Term Exposure to AuNPs on Two Soil Ecotoxicological Model Species

Author(s): B. Guimarães, S.I.L. Gomes, J.J. Scott-fordsmand, M.J.B. Amorim
Published in: Toxics, 2022, ISSN 2305-6304
Publisher: MDPI
DOI: 10.3390/toxics10040153

An integrated pathway based on in vitro data for the human hazard assessment of nanomaterials

Author(s): Daina Romeo, Beatrice Salieri, Roland Hischier, Bernd Nowack, Peter Wick
Published in: Environment International, Issue 137, 2020, Page(s) 105505, ISSN 0160-4120
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2020.105505

Approach toward In Vitro-Based Human Toxicity Effect Factors for the Life Cycle Impact Assessment of Inhaled Low-Solubility Particles

Author(s): D. Romeo, R. Hischier, B. Nowack, P. Wick
Published in: Environmental Science & Technology, 2022, ISSN 0013-936X
Publisher: American Chemical Society
DOI: 10.1021/acs.est.2c01816

Combined in vitro-in vivo dosimetry enables the extrapolation of in vitro doses to human exposure levels: A proof of concept based on a meta-analysis of in vitro and in vivo titanium dioxide toxicity data

Author(s): Daina Romeo, Bernd Nowack, Peter Wick
Published in: Elsevier, 2022, ISSN 2452-0748
Publisher: Elsevier
DOI: 10.1016/j.impact.2021.100376

Current status and future challenges of genotoxicity OECD Test Guidelines for nanomaterials: a workshop report

Author(s): Shareen H Doak; Cristina Andreoli; Michael J Burgum; Qasim Chaudhry; Eric A J Bleeker; Cecilia Bossa; Josefa Domenech; Damjana Drobne; Valérie Fessard; Nina Jeliazkova; Eleonora Longhin; Elise Rundén-Pran; Maciej Stępnik; Naouale El Yamani; Julia Catalán; Maria Dusinska
Published in: "Mutagenesis, 2023, pp.1-9. ⟨10.1093/mutage/gead017⟩", Issue 1, 2023, ISSN 1464-3804
Publisher: Oxford University Press
DOI: 10.1093/mutage/gead017

Toxicokinetics of Ag (nano)materials in the soil model Enchytraeus crypticus (Oligochaeta) – impact of aging and concentration

Author(s): F.C.F. Santos, P.S. Tourinho, J.J. Scott-Fordsmand, C.A.M. van Gestel, M.J.B. Amorim, T , Environ. Sci. Nano.
Published in: Environmental Science: nano, 2021, ISSN 1473-7604
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1en00338k

Reactive Oxygen Species Detection Using Fluorescence in Enchytraeus crypticus—Method Implementation through Ag NM300K Case Study

Author(s): Gomes, S.I.L.; Neves, A.B.; Scott-Fordsmand, J.J.; Amorim, M.J.B
Published in: Toxics, 2021, Page(s) 1-12, ISSN 2305-6304
Publisher: MDPI
DOI: 10.3390/toxics9100232

Attachment Efficiency of Nanomaterials to Algae as an Important Criterion for Ecotoxicity and Grouping.

Author(s): Kerstin, Hund-Rinke; Tim, Sinram; Karsten, Schlich; Carmen, Nickel; Hanna Paula, Dickehut; Matthias, Schmidt; Dana, Kühnel
Published in: Nanomaterials, 2020, ISSN 2079-4991
Publisher: Basel MDPI AG 2011-
DOI: 10.3390/nano10061021

Environmental hazards of nanopesticides to non-target soil species - commercial nanoformulation versus its active substance (Karate Zeon® and lambda-cyhalothrin)

Author(s): Susana I.L. Gomes; Sekerani B. Chidiamassamba; Janeck J. Scott-Fordsmand; Mónica J.B. Amorim
Published in: Science of The Total Environment, 2023, ISSN 1879-1026
Publisher: Science Direct
DOI: 10.1016/j.scitotenv.2023.164664

Machine learning and materials modelling interpretation of in vivo toxicological response to TiO2 nanoparticles library (UV and non-UV exposure)

Author(s): Susana I. L. Gomes, Mónica J. B. Amorim, Suman Pokhrel, Lutz Mädler, Matteo Fasano, Eliodoro Chiavazzo, Pietro Asinari, Jaak Jänes, Kaido Tämm, Jaanus Burkf and Janeck J. Scott-Fordsmand
Published in: Royal Society of Chemistry, 2021, Page(s) 13, ISSN 2040-3372
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1nr03231c

(Re)Conceptualizing decision-making tools in a risk governance framework for emerging technologies—the case of nanomaterials

Author(s): Martin Mullins, Martin Himly, Isabel Rodríguez Llopis, Irini Furxhi, Sabine Hofer, Norbert Hofstätter, Peter Wick, Daina Romeo, Dana Küehnel, Kirsi Siivola, Julia Catalán, Kerstin Hund-Rinke, Ioannis Xiarchos, Shona Linehan, Daan Schuurbiers, Amaia García Bilbao, Leire Barruetabeña & Damjana Drobne
Published in: Environment Systems and Decisions, 2022, ISSN 2194-5411
Publisher: Springer
DOI: 10.1007/s10669-022-09870-2

Precaution as a Risk in Data Gaps and Sustainable Nanotechnology Decision Support Systems: a Case Study of Nano-Enabled Textiles Production

Author(s): Irini Furxhi; Finbarr Murphy; Craig A. Poland; Martin Cunneen; Martin Mullins
Published in: NanoEthics, 2021, ISSN 1871-4765
Publisher: Springer
DOI: 10.1007/s11569-021-00400-z

Toxicity of fungicides to terrestrial non-target fauna – Formulated products versus active ingredients (azoxystrobin, cyproconazole, prothioconazole, tebuconazole) – A case study with Enchytraeus crypticus (Oligochaeta)

Author(s): Susana I.L. Gomes, Anna Ammendola, Silvia Casini, Mónica J.B. Amorim
Published in: Science of The Total Environment, Issue 754, 2021, Page(s) 142098, ISSN 0048-9697
Publisher: Elsevier BV
DOI: 10.1016/j.scitotenv.2020.142098

Embryotoxicity of silver nanomaterials (Ag NM300k) in the soil invertebrate Enchytraeus crypticus – Functional assay detects Ca channels shutdown

Author(s): R.C. Bicho, A.M.R. Faustino, F. Carvalho, A.M.V.M. Soares, J.J. Scott-Fordsmand, M.J.B. Amorim
Published in: Nanoimpact, 2021, ISSN 2452-0748
Publisher: Elsevier
DOI: 10.1016/j.impact.2021.100300

Nano-pesticides: the lunch-box principle—deadly goodies (semio-chemical functionalised nanoparticles that deliver pesticide only to target species)

Author(s): J.J. Scott-Fordsmand, L.F. Fraceto, M.J.B. Amorim
Published in: Journal of Nanobiotechnology, 2022, ISSN 1477-3155
Publisher: BioMed Central
DOI: 10.1186/s12951-021-01216-5

Avoidance Behaviour of Six Collembolan Species Shows Species-Specific Sensitivity—Impact of Ag NM300K

Author(s): Janeck Scott-Fordsmand; Mónica Amorim; Marija Kovačević; Branimir Hackenberger
Published in: Nanomaterials, 2022, ISSN 2079-4991
Publisher: Basel MDPI AG 2011-
DOI: 10.3390/nano12193276

Nanopharmaceuticals (Au-NPs) after use: Experiences with a complex higher tier test design simulating environmental fate and effect

Author(s): Kerstin Hund-Rinke, Cecilia Diaz, Anne Jurack, Judith Klein, Burkhard Knopf, Karsten Schlich, María Luisa Fernández-Cruz, David Hernández-Moreno, Nicolas Manier, Pascal Pandard, Bruno Guimarães, Susana I.L. Gomes, Janeck Scott-Fordsmand, Mónica J.B. Amorim.
Published in: Elsevier, 2021, Page(s) 14, ISSN 0147-6513
Publisher: Academic Press
DOI: 10.1016/j.ecoenv.2021.112949

Proceedings of the NANORIGO Special Scientific Coordination Meeting

Author(s): Reuther, Rudolf & Tobin, Lesley
Published in: 2023
Publisher: Zenodo

Integrating societal considerations in nanotechnology risk governance

Author(s): D. Schuurbiers
Published in: 2020
Publisher: Zenodo OpenAIRE
DOI: 10.5281/zenodo.4277549

Risk assessment with social dimension: how does risk governance differ from risk assessment or management?

Author(s): Martin Himly; Sabine Hofer; Norbert Hofstaetter; Dmitri Ciornii; Daan Schuurbiers
Published in: Zenodo OpenAIRE, 2021
Publisher: Zenodo
DOI: 10.5281/zenodo.5057543

From Principles to Reality. FAIR Implementation in the Nanosafety Community

Author(s): Dumit, Verónica I.; Ammar, Ammar; Bakker, Martine; Bañares, Miguel A.; Bossa, Cecilia; Costa, Anna; Cowie, Hilary; Drobne, Damjana; Exner, Thomas E.; Farcal, Lucian; Friedrichs, Steffi; Furxhi, Irini; Grafström, Roland; Haase, Andrea; Himly, Martin; Jeliazkova, Nina; Lynch, Iseult; Maier, Dieter; Noorlander, Cornelle W.; Shin, Hyun Kil; Soler-Illia, Galo J.A.A.; Suarez-Merino, Blanca; Willighag
Published in: Issue 1, 2023
Publisher: OpenAIRE
DOI: 10.5281/zenodo.7614989

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