AGE-RELATED CHANGES IN HEMATOPOIESIS

Livrables

Online booklet on ARCH activity

Documented yearly participation of ARCH partners and ESRs in local outreach events

Documented yearly participation of ARCH partners and ESRs in local Outreach Events

List of recruited fellows
News and Press Releases: ARCH launch and final report, scientific publications, patents, other achievements

News and Press Releases ARCH launch and final report scientific publications patents other achievements

At minimum of four educational cartoons for lay public and high school students
At minimum of four microvideos and podcasts for broad audiences (general public, funding agencies, putative transfer targets);

List of participation in international external training events
Completion of Network Training Module events

Publications

β-Hemoglobinopathies: The Test Bench for Genome Editing-Based Therapeutic Strategies

Auteurs: Gloria Barbarani, Agata Łabedz, Antonella Ellena Ronchi
Publié dans: Frontiers in Genome Editing, Numéro 2, 2020, ISSN 2673-3439
Éditeur: Frontiers Media
DOI: 10.3389/fgeed.2020.571239

Hyaluronic acid–GPRC5C signalling promotes dormancy in haematopoietic stem cells

Auteurs: Yu Wei Zhang, Julian Mess, Nadim Aizarani, Pankaj Mishra, Carys Johnson , Mari Carmen Romero-Mulero, Jasmin Rettkowski, Katharina Schönberger, Nadine Obier, Karin Jäcklein, Nadine M Woessner, Maria-Eleni Lalioti, Talia Velasco-Hernandez , Katarzyna Sikora, Ralph Wäsch, Bernhard Lehnertz, Guy Sauvageau, Thomas Manke, Pablo Menendez, Sebastian Gottfried Walter, Susana Minguet, Elisa Laurenti, Ste
Publié dans: Nature Cell Biology, 2022, ISSN 1465-7392
Éditeur: Nature Publishing Group
DOI: 10.1038/s41556-022-00931-x

Definition and Prognostic Value of Ph-like and IKZF1plus Status in Children With Down Syndrome and B-cell Precursor Acute Lymphoblastic Leukemia

Auteurs: Chiara Palmi, Silvia Bresolin, Stefanie Junk, Grazia Fazio, Daniela Silvestri, Marketa Zaliova, Athanasios Oikonomou, Katerina Scharov, Martin Stanulla, Anja Moericke, Martin Zimmermann, Martin Schrappe, Barbara Buldini, Sanil Bhatia, Arndt Borkhardt, Claudia Saitta, Marta Galbiati, Michela Bardini, Luca Lo Nigro, Valentino Conter, Maria Grazia Valsecchi, Andrea Biondi, Geertruy Te Kronnie, Gunnar
Publié dans: Hemasphere, 2023, ISSN 2572-9241
Éditeur: Wolters Kluwer Health
DOI: 10.1097/hs9.0000000000000892

Helios represses megakaryocyte priming in hematopoietic stem and progenitor cells.

Auteurs: Giovanni Cova; Chiara Taroni; Marie-Céline Deau; Qi Cai; Vincent Mittelheisser; Muriel Philipps; Matthieu Jung; Marie Cerciat; Stephanie Gras; Christelle Thibault-Carpentier; Bernard Jost; Leif Carlsson; Angela M. Thornton; Ethan M. Shevach; Peggy Kirstetter; Philippe Kastner; Susan Chan
Publié dans: Journal of Experimental Medicine, Numéro 2, 2021, ISSN 1540-9538
Éditeur: Rockefeller University Press
DOI: 10.1084/jem.20202317

A redox-based characterization of human immune cell subsets by polychromatic flow cytometry

Auteurs: Christina Pitsillidou, Ivan Muradore, Elena Pontarini, Milena Bertolotti, Alessandra Roberto
Publié dans: Star Protocols, Numéro Volume 4, Numéro 4, 2023, ISSN 2666-1667
Éditeur: Cell Press
DOI: 10.1016/j.xpro.2023.102632

A comprehensive transcriptome signature of murine hematopoietic stem cell aging

Auteurs: Arthur Flohr Svendsen, Daozheng Yang, KyungMok Kim, Seka Lazare, Natalia Skinder, Erik Zwart, Anna Mura-Meszaros, Albertina Ausema, Björn von Eyss, Gerald de Haan, Leonid Bystrykh
Publié dans: Blood, 2021, ISSN 0006-4971
Éditeur: American Society of Hematology
DOI: 10.1182/blood.2020009729

JAK-STAT in Early Hematopoiesis and Leukemia

Auteurs: Eirini Sofia Fasouli, Eleni Katsantoni
Publié dans: Frontiers in Cell and Developmental Biology, Numéro 9, 2021, ISSN 2296-634X
Éditeur: Frontiers Media
DOI: 10.3389/fcell.2021.669363

An instructive role for Interleukin-7 receptor α in the development of human B-cell precursor leukemia

Auteurs: Ifat Geron; Angela Maria Savino; Hila Fishman; Noa Tal; John Brown; Virginia A. Turati; Chela James; Jolanda Sarno; Michal Hameiri-Grossman; Yu Nee Lee; Avigail Rein; Hillary Maniriho; Yehudit Birger; Anna Zemlyansky; Inna Muler; Kara L. Davis; Victoria Marcu-Malina; Nicole Mattson; Oren Parnas; Rabea Wagener; Ute Fischer; João T. Barata; Catriona H. M. Jamieson; Markus Müschen; Chun-Wei Chen; A
Publié dans: Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022), Numéro 1, 2022, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-022-28218-7

Role of Nuclear Receptors in Controlling Erythropoiesis

Auteurs: Valentina Pastori, Serena Pozzi, Agata Labedz, Sajeela Ahmed, Antonella Ellena Ronchi
Publié dans: International Journal of Molecular Sciences, 2022, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23052800

High-throughput screening as a drug repurposing strategy for poor outcome subgroups of pediatric B-cell precursor Acute Lymphoblastic Leukemia

Auteurs: Athanasios Oikonomou, Luigia Valsecchi, Manuel Quadri, Titus Watrin, Katerina Scharov, Simona Procopio, Jia-Wey Tu, Melina Vogt, Angela Maria Savino, Daniela Silvestri, Maria Grazia Valsecchi, Andrea Biondi, Arndt Borkhardt, Sanil Bhatia, Giovanni Cazzaniga, Grazia Fazio, Michela Bardini, Chiara Palmi
Publié dans: Biochemical Pharmacology, 2023, ISSN 0006-2952
Éditeur: Elsevier BV
DOI: 10.1016/j.bcp.2023.115809

Arrayed CRISPR/Cas9 Screening for the Functional Validation of Cancer Genetic Dependencies

Auteurs: Ludovica Proietti, Gabriele Manhart, Elizabeth Heyes, Selina Troester, Florian Grebien
Publié dans: Bio Protocol, 2022, ISSN 2331-8325
Éditeur: Bio Protocol
DOI: 10.21769/bioprotoc.4577

Multilayer omics analysis reveals a non-classical retinoic acid signaling axis that regulates hematopoietic stem cell identity

Auteurs: Katharina Schoenberger, Nadine Obier, Mari Carmen Romero-Mulero, Pierre Cauchy, Julian Mess, Polina V. Pavlovich, Yu Wei Zhang, Michael Mitterer, Jasmin Rettkowski, Maria-Eleni Lalioti, Karin Jacklein, Jonathan D. Curtis, Betty Feret, Pia Sommerkamp, Claudia Morganti, Keisuke Ito, Norbert B. Ghyselinck, Eirini Trompouki, Joerg M. Buescher, Erika L. Pearce, and Nina Cabezas-Wallscheid
Publié dans: Cell Stem Cell, 2022, ISSN 1934-5909
Éditeur: Cell Press
DOI: 10.1016/j.stem.2021.10.002

Multiple Roles of m6A RNA Modification in Translational Regulation in Cancer

Auteurs: Guillermo Fernandez Rodriguez, Bianca Cesaro, Alessandro Fatica
Publié dans: International Journal of Molecular Sciences, 2022, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23168971

CD61 identifies a superior population of aged murine HSCs and is required to preserve quiescence and self-renewal

Auteurs: Natalia Skinder, Irene Sanz Fernández, Albertien Dethmers-Ausema, Ellen Weersing, Gerald de Haan
Publié dans: Blood Advances, 2023, ISSN 2473-9529
Éditeur: American Society of Hematology
DOI: 10.1182/bloodadvances.2023011585

A journey into the unknown: PhD students in a european training network on age-related changes in hematopoiesis conduct their project during a global pandemic

Auteurs: Pitsillidou, Christina; Alonso-Rubido, Sandra; Ávila-Ávila, Andrea; Romero-Mulero, Mari Carmen; Labedz, Agata; Oikonomou, Athanasios; Proietti, Ludovica; Psychoyiou, Maria Eleni; Tellez-Quijorna, Clara; Hillary, Manirio; Fasouli, Eirini Sofia; Fernández-Rodríguez, Guillermo; Giner-Laguarda, Natalia; Skinder, Natalia; Taroni, Chiara; Strouboulis, John; Katsantoni, Eleni; Ronchi, Antonella Ellen
Publié dans: HemaSphere, 2022, ISSN 2572-9241
Éditeur: Wolters Kluwer Health, Inc. o
DOI: 10.1097/hs9.0000000000000763

GPRC5C Drives Branched-Chain Amino Acid Metabolism in Leukemogenesis

Auteurs: Yu Wei Zhang, Talia Velasco-Hernandez, Julian Mess, Maria-Eleni Lalioti, Mari Carmen Romero-Mulero, Nadine Obier, Nikolaos Karantzelis, Jasmin Rettkowski, Katharina Schönberger, Noémie Karabacz, Karin Jäcklein, Tatsuya Morishima, Juan Luis Trincado, Paola Romecin, Alba Martinez-Moreno, Hitoshi Takizawa, Khalid Shoumariyeh, Simon Renders, Robert Zeiser, Heike L. Pahl, François Béliveau, Josée
Publié dans: Blood Advances, 2023, ISSN 2473-9537
Éditeur: Elsevier
DOI: 10.1182/bloodadvances.2023010460

Functions of Polycomb Proteins on Active Targets

Auteurs: Natalia Giner-Laguarda, Miguel Vidal
Publié dans: Epigenomes, Numéro 4/3, 2020, Page(s) 17, ISSN 2075-4655
Éditeur: MDPI
DOI: 10.3390/epigenomes4030017

Mouse multipotent progenitor 5 cells are located at the interphase between hematopoietic stem and progenitor cells

Auteurs: Pia Sommerkamp, Mari Carmen Romero-Mulero, Andreas Narr*, Luisa Ladel*, Lucie Hustin, Katharina Schonberger, Simon Renders, Sandro Altamura, Petra Zeisberger, Karin Jacklein, Daniel Klimmeck, Alejo Rodriguez-Fraticelli, Fernando D. Camargo, Leïla Perie, Andreas Trumpp, and Nina Cabezas-Wallscheid.
Publié dans: Blood, 2021, ISSN 0006-4971
Éditeur: American Society of Hematology
DOI: 10.1182/blood.2020007876

Physiological and Aberrant γ-Globin Transcription During Development

Auteurs: Gloria Barbarani, Agata Labedz, Sarah Stucchi, Alessia Abbiati, Antonella E. Ronchi
Publié dans: Frontiers in Cell and Developmental Biology, Numéro 9, 2021, ISSN 2296-634X
Éditeur: Frontiers Media
DOI: 10.3389/fcell.2021.640060

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