Descrizione del progetto
Somministrazione controllata di farmaci grazie alla nanotecnologia
I farmaci chemioterapici sono caratterizzati da effetti indesiderati nei tessuti sani e spesso da una minore biodistribuzione nel tumore. Il progetto SMARTRIOX, finanziato dall’UE, ha sviluppato un sistema basato su nanoparticelle che può essere programmato per rilasciare il farmaco richiesto al suo bersaglio. Questa specificità si basa su molecole di DNA che rispondono a determinati stimoli nei tessuti bersaglio e rilasciano il farmaco. I ricercatori utilizzeranno questo sistema per il trattamento del cancro al seno triplo negativo, un tipo di carcinoma mammario aggressivo e difficile da trattare. Il vantaggio principale del sistema è che può essere personalizzato in base alle esigenze della paziente in ospedale, offrendo un mezzo facilmente accessibile di somministrazione dei farmaci.
Obiettivo
Although there are Triple Negative Breast Cancer (TNBC), the most aggressive type of Breast Cancer (BC), accounts for 15-25% of all BCs. Yearly 200,000 women are diagnosed with TNBC, of which 100,000 are diagnosed with metastatic disease at the primary diagnosis. TNBC lacks a recognized molecular target, making it an orphan disease: no effective treatment is available to date. The poor prognosis of patients suffering from TNBC makes it extremely challenging for both oncologists and patients. TNBC is more aggressive because all its receptors (Estrogen/Progesterone/Herceptin) are negative, and targeted and endocrine therapies are not helpful. TNBC shows a shortened disease-free interval in the neoadjuvant and adjuvant settings and a more aggressive course in the metastatic setting.The mainstay treatment for TNBC is Doxorubicin, a potent anthracycline chemotherapy, which nonetheless, has substantial toxicities (cardiac, immune, digestive and epithelial) that limit its maximal dose and render the tumour cells resistant to it. As a result, patients cannot be treated with a high enough and effective dose.In response, Triox Nano has developed TXN770: an innovative bionanoparticle based anticancer treatment. TXN770 has a DNAzyme machine cap that recognizes cancer cells and releases the chemotherapy exclusively inside them, responding to pre-programmed threshold levels of Mg2+ and ATP that are present primarily at the target TNBC cells. This allows using 4 times lower concentrations of Doxorubicin, which in turn causes less side effects and achieves a higher effectiveness. It also prevents cancer cells from becoming resistant to Doxorubicin.TrioxNano will address a BC world market of $10.4 billion, expected to grow to $17.2 billion in 2021. TrioxNano projects €547M in profit, with a ROI of €15 per euro invested in the project and in turn will help ease the economic burden of TNBC in National Health Services while positioning itself as a leading company in treatment of TNBC.
Campo scientifico
CORDIS classifica i progetti con EuroSciVoc, una tassonomia multilingue dei campi scientifici, attraverso un processo semi-automatico basato su tecniche NLP.
CORDIS classifica i progetti con EuroSciVoc, una tassonomia multilingue dei campi scientifici, attraverso un processo semi-automatico basato su tecniche NLP.
- engineering and technologymechanical engineeringmanufacturing engineering
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugs
- medical and health sciencesclinical medicineoncologybreast cancer
- medical and health sciencesbasic medicinepharmacology and pharmacypharmacokinetics
- engineering and technologynanotechnologynano-materials
Parole chiave
Programma(i)
Argomento(i)
Invito a presentare proposte
Vedi altri progetti per questo bandoBando secondario
H2020-SMEInst-2018-2020-2
Meccanismo di finanziamento
SME-2 - SME instrument phase 2Coordinatore
9518705 Jerusalem
Israele
L’organizzazione si è definita una PMI (piccola e media impresa) al momento della firma dell’accordo di sovvenzione.