Periodic Reporting for period 3 - Brain Health Toolbox (The Brain Health Toolbox: Facilitating personalized decision-making for effective dementia prevention)
Período documentado: 2022-02-01 hasta 2023-07-31
The Brain Health Toolbox is designed to create a seamless continuum from accurate dementia prediction to effective prevention by i) developing disease models and prediction tools for multimodal prevention; ii) testing in actual multimodal prevention trials; and iii) bridging the gap between nonpharmacological and pharmacological interventions by designing a combined multimodal prevention trial.
2. Testing in multimodal lifestyle prevention trials. Three test scenarios have been considered: selecting target populations, assessing heterogeneity of intervention effects, and trial outcomes. Results so far have been used for the development of the first global network of multimodal lifestyle-based dementia prevention trials (World-Wide FINGERS). The results have directly contributed to the harmonized design of intervention trials in the network (e.g. aspects related to participant selection process and enrolment criteria, intervention design, outcome definitions).
3. Designing a combined prevention trial (multimodal non-pharmacological and pharmacological). With several AD drug trial failures during 2019-2020, we started with drug repurposing. A protocol has been developed for the first randomized controlled trial combining a multimodal lifestyle intervention with a repurposed putative disease-modifying drug.
Several measures have also been taken to mitigate the impact of the COVID-19 pandemic on project work.