Obiettivo
Cardiovascular diseases cause over 14 million deaths worldwide each year, particularly in the form of heart attacks and strokes. Such diseases have been commonly studied by employing in vitro and in vivo models which are not able to completely recapitulate the human physiology/disease, therefore undermining the search for efficient new treatments. High resolution 3D printing has the potential to revolutionize the study of cardiovascular diseases by means of organ-on-chip approaches. Unlike conventional 2D wafer-based microfabrication techniques, 3D printing can generate truly 3D, organically shaped, highly accurate microfluidic replicas of blood vessels. These replicas can further be lined with cells and perfused with blood, disease-like events can be studied in detail, and therapeutic molecules can be tested. In this project, the potential of such methodology will be explored by developing a software tool that enables automated application-specific customization of the on-chip study platform and by utilizing more complex and biologically relevant materials in the devices' fabrication. The added value of the devices will be further testified by comparison with well-established protocols/methods in the study of angiogenesis, namely in high throughput screening settings. Finally, the commercial viability of such approach will also be assessed, and translation to market will be pursued.
Campo scientifico
CORDIS classifica i progetti con EuroSciVoc, una tassonomia multilingue dei campi scientifici, attraverso un processo semi-automatico basato su tecniche NLP.
CORDIS classifica i progetti con EuroSciVoc, una tassonomia multilingue dei campi scientifici, attraverso un processo semi-automatico basato su tecniche NLP.
- medical and health sciencesclinical medicinecardiologycardiovascular diseases
- medical and health sciencesbasic medicinephysiology
- medical and health sciencesbasic medicineneurologystroke
- engineering and technologymechanical engineeringmanufacturing engineeringadditive manufacturing
- engineering and technologyother engineering and technologiesmicrotechnologyorgan on a chip
Programma(i)
Argomento(i)
Meccanismo di finanziamento
MSCA-IF-EF-SE - Society and Enterprise panelCoordinatore
4200-135 Porto
Portogallo
L’organizzazione si è definita una PMI (piccola e media impresa) al momento della firma dell’accordo di sovvenzione.