Novel mechanisms of early defense against virus infections

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Data Management Plan (DMP)

For the Data Management Plan I will use httpsdmponlinedeicdkprojects The DMP will describe1 The typenature of the data sets including whom it may be useful for 2 Information on the disciplinary norms we will adopt in data generation and what the data will be about The DMP will also provide information on who generated data made publcally available and the form in which they are available3 Criteria for what type of data to share and what data that will not be shared in ENVISION 4 Details on the sites of data archiving and preservation indclusion the duration of the archiving period

Pubblicazioni

TMEFF1 is a neuron-specific restriction factor for herpes simplex virus

Autori: Yao Dai, Manja Idorn, Manutea C. Serrero, Xiaoyong Pan, Emil A. Thomsen, Ryo Narita, Muyesier Maimaitili, Xiaoqing Qian, Marie B. Iversen, Line S. Reinert, Rasmus K. Flygaard, Muwan Chen, Xiangning Ding, Bao-cun Zhang, Madalina E. Carter-Timofte, Qing Lu, Zhuofan Jiang, Yiye Zhong, Shuhui Zhang, Lintai Da, Jinwei Zhu, Mark Denham, Poul Nissen, Trine H. Mogensen, Jacob Giehm Mikkelsen, Shen-Ying Zh
Pubblicato in: Nature, Numero 632, 2024, Pagina/e 383-389, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-024-07670-z

TREM2 is down-regulated by HSV1 in microglia and involved in antiviral defense in the brain

Autori: Stefanie Fruhwrth, Line S. Reinert, Carl berg, Marcelina Sakr, Marcus Henricsson, Henrik Zetterberg, Sren R. Paludan
Pubblicato in: Science Advances, Numero 9, 2024, Pagina/e eadf5808, ISSN 2375-2548
Editore: American Association for the Advancement of Science (
DOI: 10.1126/sciadv.adf5808

The STING inhibitor (ISD-017) reduces glomerulonephritis in 129.B6.Fcgr2b-deficient mice

Autori: Isara Alee, Papasara Chantawichitwong, Asada Leelahavanichkul, Sren R. Paludan, Trairak Pisitkun, Prapaporn Pisitkun
Pubblicato in: Scientific Reports, Numero 14, 2024, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-024-61597-z

The HIF transcription network exerts innate antiviral activity in neurons and limits brain inflammation

Autori: Ensieh Farahani, Line S. Reinert, Ryo Narita, Manutea C. Serrero, Morten Kelder Skouboe, Demi van der Horst, Sonia Assil, Baocun Zhang, Marie B. Iversen, Eugenio Gutierrez, Hossein Hazrati, Mogens Johannsen, David Olagnier, Reiner Kunze, Mark Denham, Trine H. Mogensen, Michael Lappe, Sren R. Paludan
Pubblicato in: Cell Reports, Numero 43, 2024, Pagina/e 113792, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2024.113792

Brain immune cells undergo cGAS/STING-dependent apoptosis during herpes simplex virus type 1 infection to limit type I IFN production

Autori: Line S. Reinert, Ahmad S. Rashidi, Diana N. Tran, Georgios Katzilieris-Petras, Astrid K. Hvidt, Mette Gohr, Stefanie Fruhwürth, Chiranjeevi Bodda, Martin K. Thomsen, Mikkel H. Vendelbo, Ahmad R. Khan, Brian Hansen, Petra Bergström, Lotta Agholme, Trine H. Mogensen, Maria H. Christensen, Jens R. Nyengaard, Ganes C. Sen, Henrik Zetterberg, Georges MGM Verjans, Søren R. Paludan
Pubblicato in: Journal of Clinical Investigation, Numero 131/1, 2021, ISSN 0021-9738
Editore: American Society for Clinical Investigation
DOI: 10.1172/jci136824

Targeting herpes simplex virus with CRISPR–Cas9 cures herpetic stromal keratitis in mice

Autori: Di Yin, Sikai Ling, Dawei Wang, Yao Dai, Hao Jiang, Xujiao Zhou, Soren R. Paludan, Jiaxu Hong, Yujia Cai
Pubblicato in: Nature Biotechnology, Numero 39/5, 2021, Pagina/e 567-577, ISSN 1087-0156
Editore: Nature Publishing Group
DOI: 10.1038/s41587-020-00781-8

STING is redundant for host defense and pathology of COVID-19-like disease in mice

Autori: Giorgia Marino, Baocun Zhang, Alexander Schmitz, Hanna VF Schwensen, Line S Reinert, Sren R Paludan
Pubblicato in: Life Science Alliance, Numero 6, 2024, Pagina/e e202301997, ISSN 2575-1077
Editore: EMBO Press, Rockefeller University Press and Cold Spring Harbor Laboratory Press
DOI: 10.26508/lsa.202301997

Constitutive and latent immune mechanisms exert silent control of virus infections in the central nervous system

Autori: Soren R Paludan, Trine H Mogensen
Pubblicato in: Current Opinion in Immunology, Numero 72, 2024, Pagina/e 158-166, ISSN 0952-7915
Editore: Elsevier BV
DOI: 10.1016/j.coi.2021.05.004

Capsid-like particles decorated with the SARS-CoV-2 receptor-binding domain elicit strong virus neutralization activity

Autori: Cyrielle Fougeroux, Louise Goksøyr, Manja Idorn, Vladislav Soroka, Sebenzile K. Myeni, Robert Dagil, Christoph M. Janitzek, Max Søgaard, Kara-Lee Aves, Emma W. Horsted, Sayit Mahmut Erdoğan, Tobias Gustavsson, Jerzy Dorosz, Stine Clemmensen, Laurits Fredsgaard, Susan Thrane, Elena E. Vidal-Calvo, Paul Khalifé, Thomas M. Hulen, Swati Choudhary, Michael Theisen, Susheel K. Singh, Asier Garcia-Se
Pubblicato in: Nature Communications, Numero 12/1, 2021, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-020-20251-8

TLR2 and TLR7 mediate distinct immunopathological and antiviral plasmacytoid dendritic cell responses to SARSCoV2 infection

Autori: Rene M van der Sluis, Lamin B Cham, Albert GrisOliver, Kristine R Gammelgaard, Jesper G Pedersen, Manja Idorn, Ulvi Ahmadov, Sabina Sanches Hernandez, Ena Cmalovic, Stine H Godsk, Jacob Thyrsted, Jesper D Gunst, Silke D Nielsen, Janni J Jrgensen, Tobias Wang Bjerg, Anders Laustsen, Line S Reinert, David Olagnier, Rasmus O Bak, Mads Kjolby, Christian K Holm, Martin Tolstrup, Sren R Palud
Pubblicato in: The EMBO Journal, Numero 41, 2023, Pagina/e e109622, ISSN 0261-4189
Editore: Nature Publishing Group
DOI: 10.15252/embj.2021109622

Lysyl-tRNA synthetase produces diadenosine tetraphosphate to curb STING-dependent inflammation

Autori: J. Guerra, A.-L. Valadao, D. Vlachakis, K. Polak, I. K. Vila, C. Taffoni, T. Prabakaran, A. S. Marriott, R. Kaczmarek, A. Houel, B. Auzemery, S. Déjardin, P. Boudinot, B. Nawrot, N. J. Jones, S. R. Paludan, S. Kossida, C. Langevin, N. Laguette
Pubblicato in: Science Advances, Numero 6/21, 2020, Pagina/e eaax3333, ISSN 2375-2548
Editore: Science
DOI: 10.1126/sciadv.aax3333

Identification of SARS-CoV2-mediated suppression of NRF2 signaling reveals a potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate

Autori: Antonio Alcami; Julia B. Cadanet; Jinrong Huang; Søren R. Paludan; John Hiscott; Siddharth Balachandran; Marie B. Iversen; Michelle M. Thomsen; Bruno Hernáez; Jan Rehwinkel; Alice Knudsen; Martin R. Jakobsen; Rasmus Ottosen; Trine H. Mogensen; Alon Schneider Hait; Anne L. Thielke; Ensieh Farahani; Esben B. Svenningsen; Manja Idorn; Suraj Peri; Demi van der Horst; Angela Herengt; Yonglu Luo; Vict
Pubblicato in: Nature Communications, Numero 3, 2020, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.21203/rs.3.rs-31855/v1

Essential role of autophagy in restricting poliovirus infection revealed by identification of an ATG7 defect in a poliomyelitis patient

Autori: Nanna-Sophie Brinck Andersen, Sofie Eg Jørgensen, Kristian Alsbjerg Skipper, Simon Müller Larsen, Johanna Heinz, Michelle Mølgaard Thomsen, Ensieh Farahani, Yujia Cai, Alon Schneider Hait, Lise Kay, Jacob Giehm Mikkelsen, Mariane Høgsbjerg Schleimann, Martin Kristian Thomsen, Søren R. Paludan, Trine H. Mogensen
Pubblicato in: Autophagy, 2020, Pagina/e 1-16, ISSN 1554-8627
Editore: Landes Bioscience
DOI: 10.1080/15548627.2020.1831800

Antiviral Potential of the Antimicrobial Drug Atovaquone against SARS-CoV-2 and Emerging Variants of Concern

Autori: Madalina Elena Carter-Timofte, Rozanne Arulanandam, Naziia Kurmasheva, Kathy Fu, Genevive Laroche, Zaid Taha, Demi van der Horst, Lena Cassin, Rene M. van der Sluis, Enrico Palermo, Daniele Di Carlo, David Jacobs, Glib Maznyi, Taha Azad, Ragunath Singaravelu, Fanghui Ren, Anne Louise Hansen, Manja Idorn, Christian K. Holm, Martin R. Jakobsen, Julien van Grevenynghe, John Hiscott, Sren R. Pal
Pubblicato in: ACS Infectious Diseases, Numero 7, 2023, Pagina/e 3034-3051, ISSN 2373-8227
Editore: American Chemical Society
DOI: 10.1021/acsinfecdis.1c00278

Systematic <scp>P2Y</scp> receptor survey identifies <scp>P2Y11</scp> as modulator of immune responses and virus replication in macrophages

Autori: Line Lykke Andersen, Yiqi Huang, Christian Urban, Lila Oubraham, Elena Winheim, Che Stafford, Dennis Nagl, Fionan O'Duill, Thomas Ebert, Thomas Engleitner, Sren Riis Paludan, Anne Krug, Roland Rad, Veit Hornung, Andreas Pichlmair
Pubblicato in: The EMBO Journal, Numero 42, 2023, ISSN 0261-4189
Editore: Nature Publishing Group
DOI: 10.15252/embj.2022113279

Microglia Activate Early Antiviral Responses upon Herpes Simplex Virus 1 Entry into the Brain to Counteract Development of Encephalitis-Like Disease in Mice

Autori: Georgios Katzilieris-Petras, Xin Lai, Ahmad S. Rashidi, Georges M. G. M. Verjans, Line S. Reinert, Sren R. Paludan
Pubblicato in: Journal of Virology, Numero 96, 2022, ISSN 0022-538X
Editore: American Society for Microbiology
DOI: 10.1128/jvi.01311-21

Restriction factors regulating human herpesvirus infections

Autori: Manutea C. Serrero, Sren R. Paludan
Pubblicato in: Trends in Immunology, Numero 45, 2024, Pagina/e 662-677, ISSN 1471-4906
Editore: Elsevier BV
DOI: 10.1016/j.it.2024.07.010

HSV1 VP1-2 deubiquitinates STING to block type I interferon expression and promote brain infection

Autori: Chiranjeevi Bodda, Line S. Reinert, Stefanie Fruhwürth, Timmy Richardo, Chenglong Sun, Bao-cun Zhang, Maria Kalamvoki, Anja Pohlmann, Trine H. Mogensen, Petra Bergström, Lotta Agholme, Peter O’Hare, Beate Sodeik, Mads Gyrd-Hansen, Henrik Zetterberg, Søren R. Paludan
Pubblicato in: Journal of Experimental Medicine, Numero 217/7, 2020, ISSN 0022-1007
Editore: Rockefeller University Press
DOI: 10.1084/jem.20191422

Defects in LC3B2 and ATG4A underlie HSV2 meningitis and reveal a critical role for autophagy in antiviral defense in humans

Autori: Alon Schneider Hait, David Olagnier, Vanessa Sancho-Shimizu, Kristian Alsbjerg Skipper, Marie Helleberg, Simon Muller Larsen, Chiranjeevi Bodda, Liviu Ionut Moldovan, Fanghui Ren, Nanna-Sophie Brinck Andersen, Michelle M. Thomsen, Mette Ratzer Freytag, Sathya Darmalinggam, Isobel Parkes, Darshana D. Kadekar, Stine Hess Rahbek, Demi van der Horst, Lasse Sommer Kristensen, Kristina Eriksson, Jørgen
Pubblicato in: Science Immunology, Numero 5/54, 2020, Pagina/e eabc2691, ISSN 2470-9468
Editore: Science
DOI: 10.1126/sciimmunol.abc2691

Intracellular bacteria engage a STING–TBK1–MVB12b pathway to enable paracrine cGAS–STING signalling

Autori: Ramya Nandakumar, Roland Tschismarov, Felix Meissner, Thaneas Prabakaran, Abhichart Krissanaprasit, Ensieh Farahani, Bao-cun Zhang, Sonia Assil, Amandine Martin, Wilhelm Bertrams, Christian K. Holm, Andrea Ablasser, Tanja Klause, Martin K. Thomsen, Bernd Schmeck, Kenneth A. Howard, Thomas Henry, Kurt V. Gothelf, Thomas Decker, Søren R. Paludan
Pubblicato in: Nature Microbiology, Numero 4/4, 2019, Pagina/e 701-713, ISSN 2058-5276
Editore: Nature Publishing Group
DOI: 10.1038/s41564-019-0367-z

DNA-stimulated cell death: implications for host defence, inflammatory diseases and cancer

Autori: Søren R. Paludan, Line S. Reinert, Veit Hornung
Pubblicato in: Nature Reviews Immunology, Numero 19/3, 2019, Pagina/e 141-153, ISSN 1474-1733
Editore: Nature Publishing Group
DOI: 10.1038/s41577-018-0117-0

Viral infection of the ovaries compromises pregnancy and reveals innate immune mechanisms protecting fertility

Autori: Jelena Tomac, Marija Mazor, Berislav Lisnić, Mijo Golemac, Daria Kveštak, Marina Bralić, Lidija Bilić Zulle, Melanie M. Brinkmann, Lars Dölken, Line S. Reinert, Soren R. Paludan, Astrid Krmpotić, Stipan Jonjić, Vanda Juranić Lisnić
Pubblicato in: Immunity, 2021, ISSN 1074-7613
Editore: Cell Press
DOI: 10.1016/j.immuni.2021.04.020

STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses

Autori: Isabelle K. Vila, Hanane Chamma, Alize Steer, Mathilde Saccas, Clara Taffoni, Evgenia Turtoi, Line S. Reinert, Saqib Hussain, Johanna Marines, Lei Jin, Xavier Bonnefont, Mathieu Hubert, Olivier Schwartz, Soren R. Paludan, Gaetan Van Simaeys, Gilles Doumont, Bijan Sobhian, Dimitrios Vlachakis, Andrei Turtoi, Nadine Laguette
Pubblicato in: Cell Metabolism, Numero 34, 2023, Pagina/e 125-139.e8, ISSN 1550-4131
Editore: Cell Press
DOI: 10.1016/j.cmet.2021.12.007

An IKBKE variant conferring functional cGAS/STING pathway deficiency and susceptibility to recurrent HSV-2 meningitis

Autori: Azadeh Reyahi, Marie Studahl, Morten K. Skouboe, Stefanie Fruhwrth, Ryo Narita, Fanghui Ren, Moa Bjerhem Viklund, Marie B. Iversen, Mette Christiansen, Alexandra Svensson, Trine H. Mogensen, Kristina Eriksson, Sren R. Paludan
Pubblicato in: JCI Insight, Numero 8, 2023, Pagina/e e173066, ISSN 2379-3708
Editore: American Society for Clinical Investigation
DOI: 10.1172/jci.insight.173066

Cholesterol-binding motifs in STING that control endoplasmicreticulum retention mediate anti-tumoral activity of cholesterol-lowering compounds

Autori: Bao-cun Zhang, Marlene F. Laursen, Lili Hu, Hossein Hazrati, Ryo Narita, Lea S. Jensen, Aida S. Hansen, Jinrong Huang, Yan Zhang, Xiangning Ding, Maimaitili Muyesier, Emil Nilsson, Agnieszka Banasik, Christina Zeiler, Trine H. Mogensen, Anders Etzerodt, Ralf Agger, Mogens Johannsen, Emil Kofod-Olsen, Sren R. Paludan, Martin R. Jakobsen
Pubblicato in: Nature Communications, Numero 15, 2024, Pagina/e 2760, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-024-47046-5

Constitutive immune mechanisms: mediators of host defence and immune regulation

Autori: Søren R. Paludan, Thomas Pradeu, Seth L. Masters, Trine H. Mogensen
Pubblicato in: Nature Reviews Immunology, Numero 21/3, 2021, Pagina/e 137-150, ISSN 1474-1733
Editore: Nature Publishing Group
DOI: 10.1038/s41577-020-0391-5

Identification of FDA-approved bifonazole as a SARS-CoV-2 blocking agent following a bioreporter drug screen

Autori: Zaid Taha, Rozanne Arulanandam, Glib Maznyi, Elena Godbout, Madalina E. Carter-Timofte, Naziia Kurmasheva, Line S. Reinert, Andrew Chen, Mathieu J.F. Crupi, Stephen Boulton, Genevive Laroche, Alexandra Phan, Reza Rezaei, Nouf Alluqmani, Anna Jirovec, Alexandra Acal, Emily E.F. Fekete, Ragunath Singaravelu, Julia Petryk, Manja Idorn, Kyle G. Potts, Hayley Todesco, Cini John, Douglas J. Mahoney, C
Pubblicato in: Molecular Therapy, Numero 30, 2023, Pagina/e 2998-3016, ISSN 1525-0016
Editore: Nature Publishing Group
DOI: 10.1016/j.ymthe.2022.04.025

Single-Cell Monitoring of Activated Innate Immune Signaling by a d2eGFP-Based Reporter Mimicking Time-Restricted Activation of IFNB1 Expression

Autori: Emil Aagaard Thomsen, Sofie Andersen, Mikkel Haarslev Schrder Marqvorsen, Kristian Alsbjerg Skipper, Sren R. Paludan, Jacob Giehm Mikkelsen
Pubblicato in: Frontiers in Cellular and Infection Microbiology, Numero 11, 2022, ISSN 2235-2988
Editore: Frontiers Media S. A.
DOI: 10.3389/fcimb.2021.784762

STEEP mediates STING ER exit and activation of signaling

Autori: Bao-cun Zhang, Ramya Nandakumar, Line S. Reinert, Jinrong Huang, Anders Laustsen, Zong-liang Gao, Cheng-long Sun, Sren Beck Jensen, Anne Troldborg, Sonia Assil, Martin F. Berthelsen, Carsten Scavenius, Yan Zhang, Samuel J. Windross, David Olagnier, Thaneas Prabakaran, Chiranjeevi Bodda, Ryo Narita, Yujia Cai, Cong-gang Zhang, Harald Stenmark, Christine M. Doucet, Takeshi Noda, Zheng Guo, Raphael
Pubblicato in: Nature Immunology, Numero 21, 2021, Pagina/e 868-879, ISSN 1529-2908
Editore: Nature Publishing Group
DOI: 10.1038/s41590-020-0730-5

Human TMEFF1 is a restriction factor for herpes simplex virus in the brain

Autori: Yi-Hao Chan, Zhiyong Liu, Paul Bastard, Noopur Khobrekar, Kennen M. Hutchison, Yasuhiro Yamazaki, Qing Fan, Daniela Matuozzo, Oliver Harschnitz, Nacim Kerrouche, Koji Nakajima, Param Amin, Ahmad Yatim, Darawan Rinchai, Jie Chen, Peng Zhang, Gabriele Ciceri, Jia Chen, Kerry Dobbs, Serkan Belkaya, Danyel Lee, Adrian Gervais, Krad Aydn, Ayse Kartal, Mary L. Hasek, Shuxiang Zhao, Eduardo Garcia
Pubblicato in: Nature, Numero 632, 2024, Pagina/e 390-400, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-024-07745-x

<scp>ER</scp> stress induces <scp>caspase2tBIDGSDME</scp>dependent cell death in neurons lytically infected with herpes simplex virus type 2

Autori: Fanghui Ren, Ryo Narita, Ahmad S Rashidi, Stefanie Fruhwrth, Zongliang Gao, Rasmus O Bak, Martin K Thomsen, Georges MGM Verjans, Line S Reinert, Sren R Paludan
Pubblicato in: The EMBO Journal, Numero 42, 2023, Pagina/e e113118, ISSN 0261-4189
Editore: Nature Publishing Group
DOI: 10.15252/embj.2022113118

B Cell Intrinsic STING Signaling Is Not Required for Autoreactive Germinal Center Participation

Autori: Kenneth Green, Thomas R. Wittenborn, Cecilia Fahlquist-Hagert, Ewa Terczynska-Dyla, Nina van Campen, Lisbeth Jensen, Line Reinert, Rune Hartmann, Sren R. Paludan, Sren E. Degn
Pubblicato in: Frontiers in Immunology, Numero 12, 2021, ISSN 1664-3224
Editore: Frontiers
DOI: 10.3389/fimmu.2021.782558

A STING antagonist modulating the interaction with STIM1 blocks ER-to-Golgi trafficking and inhibits lupus pathology

Autori: Thaneas Prabakaran, Anne Troldborg, Sarinya Kumpunya, Isara Alee, Emilija Marinković, Samuel J. Windross, Ramya Nandakumar, Ryo Narita, Bao-cun Zhang, Mikkel Carstensen, Pichpisith Vejvisithsakul, Mikkel H.S. Marqvorsen, Marie B. Iversen, Christian K. Holm, Lars J. Østergaard, Finn Skou Pedersen, Trairak Pisitkun, Rayk Behrendt, Prapaporn Pisitkun, Søren R. Paludan
Pubblicato in: EBioMedicine, Numero 66, 2021, Pagina/e 103314, ISSN 2352-3964
Editore: Elsevier BV
DOI: 10.1016/j.ebiom.2021.103314

SAM68 directs STING signaling to apoptosis in macrophages

Autori: Demi van der Horst, Naziia Kurmasheva, Mikkel H. S. Marqvorsen, Sonia Assil, Anna H. F. Rahimic, Christoph F. Kollmann, Leandro Silva da Costa, Qi Wu, Jian Zhao, Eleonora Cesari, Marie B. Iversen, Fanghui Ren, Trine I. Jensen, Ryo Narita, Vivien R. Schack, Bao-cun Zhang, Rasmus O. Bak, Claudio Sette, Robert A. Fenton, Jacob G. Mikkelsen, Sren R. Paludan, David Olagnier
Pubblicato in: Communications Biology, Numero 7, 2024, Pagina/e 283, ISSN 2399-3642
Editore: Nature Publishing Group
DOI: 10.1038/s42003-024-05969-1

Human ZBP1 induces cell deathindependent inflammatory signaling via RIPK3 and RIPK1

Autori: Ruoshi Peng, Chris Kedong Wang, Xuan WangKan, Manja Idorn, Majken Kjr, Felix Y Zhou, Berthe Katrine Fiil, Frederik Timmermann, Susana L Orozco, Julia McCarthy, Carol S Leung, Xin Lu, Katrin Bagola, Jan Rehwinkel, Andrew Oberst, Jonathan Maelfait, Sren R Paludan, Mads GyrdHansen
Pubblicato in: EMBO reports, Numero 23, 2023, Pagina/e e55839, ISSN 1469-221X
Editore: Nature Publishing Group
DOI: 10.15252/embr.202255839

The alpha/B.1.1.7 SARS-CoV-2 variant exhibits significantly higher affinity for ACE-2 and requires lower inoculation doses to cause disease in K18-hACE2 mice

Autori: Rafael Bayarri-Olmos, Laust Bruun Johnsen, Manja Idorn, Line S Reinert, Anne Rosbjerg, Sren Vang, Cecilie Bo Hansen, Charlotte Helgstrand, Jais Rose Bjelke, Theresa Bak-Thomsen, Sren R Paludan, Peter Garred, Mikkel-Ole Skjoedt
Pubblicato in: eLife, Numero 10, 2023, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.70002

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