HARNESSING PML NUCLEAR BODIES FOR LEUKAEMIA THERAPY

Project Information

PML-THERAPY

Grant agreement ID: 785917

DOI 10.3030/785917

Project closed

EC signature date 6 August 2018

Start date 1 April 2019

End date 30 June 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 500 000,00

EU contribution € 2 500 000,00

Coordinated by

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (7)

Exploration of nuclear body-enhanced sumoylation reveals that PML represses 2-cell features of embryonic stem cells

Author(s): Sarah Tessier, Omar Ferhi, Marie-Claude Geoffroy, Román González-Prieto, Antoine Canat, Samuel Quentin, Marika Pla, Michiko Niwa-Kawakita, Pierre Bercier, Domitille Rérolle, Marilyn Tirard, Pierre Therizols, Emmanuelle Fabre, Alfred C. O. Vertegaal, Hugues de Thé, Valérie Lallemand-Breitenbach
Published in: Nature Communications, Issue 13, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-33147-6

Actinomycin D targets NPM1c-primed mitochondria to restore PML-driven senescence in AML therapy

Author(s): Hsin-Chieh Wu, Domitille Rerolle, Caroline Berthier, Rita Hleihel, Takashi Sakamoto, Samuel Quentin, Shirine Benhenda, Claudia Morganti, Chengchen Wu, Lidio Conte, Sylvie Rimsky, Marie Sebert, Emmanuelle Clappier, Sylvie Souquere, Stephanie Gachet, Jean Soulier, Sylvere Durand, Jennifer J Trowbridge, Paule Benit, Pierre Rustin, Hiba El Hajj, Emmanuel Raffoux, Lionel Ades, Raphael Itzykson, Herve D
Published in: Cancer Discovery, 2021, Page(s) candisc.0177.2021, ISSN 2159-8274
Publisher: American Association for Cancer Research Inc.
DOI: 10.1158/2159-8290.cd-21-0177

PML/RARα Destabilization by Hyperthermia: A New Model for Oncogenic Fusion Protein Degradation?

Author(s): Hsin-Chieh Wu; Hsin-Chieh Wu; Domitille Rérolle; Domitille Rérolle
Published in: PML/RARα Destabilization by Hyperthermia: A New Model for Oncogenic Fusion Protein Degradation?, Issue 1, 2021, ISSN 2643-3230
Publisher: AACR
DOI: 10.1158/2643-3230.bcd-21-0071

Structural Basis of PML-RARA Oncoprotein Targeting by Arsenic Unravels a Cysteine Rheostat Controlling PML Body Assembly and Function

Author(s): Pierre Bercier, Qian Qian Wang, Ning Zang, Jie Zhang, Chang Yang, Yasen Maimaitiyiming, Majdouline Abou-Ghali, Caroline Berthier, Chengchen Wu, Michiko Niwa-Kawakita, Thassadite Dirami, Marie-Claude Geoffroy, Omar Ferhi, Samuel Quentin, Shirine Benhenda, Yasumitsu Ogra, Zoher Gueroui, Chun Zhou, Hua Naranmandura, Hugues de Thé, Valérie Lallemand-Breitenbach
Published in: Cancer Discovery, Issue 13, 2023, Page(s) 2548-2565, ISSN 2159-8274
Publisher: American Association for Cancer Research Inc.
DOI: 10.1158/2159-8290.cd-23-0453

PML Nuclear bodies: the cancer connection and beyond

Author(s): Majdouline Abou-Ghali, Valérie Lallemand-Breitenbach
Published in: Nucleus, Issue 15, 2024, ISSN 1949-1034
Publisher: Landes Bioscience
DOI: 10.1080/19491034.2024.2321265

The PML hub: An emerging actor of leukemia therapies

Author(s): Domitille Rérolle; Hugues de Thé
Published in: The PML hub: An emerging actor of leukemia therapies, Issue 2, 2023, ISSN 0022-1007
Publisher: Rockefeller University Press
DOI: 10.1084/jem.20221213

JAK2V617F myeloproliferative neoplasm eradication by a novel interferon/arsenic therapy involves PML

Author(s): Tracy Dagher, Nabih Maslah, Valérie Edmond, Bruno Cassinat, William Vainchenker, Stéphane Giraudier, Florence Pasquier, Emmanuelle Verger, Michiko Niwa-Kawakita, Valérie Lallemand-Breitenbach, Isabelle Plo, Jean-Jacques Kiladjian, Jean-Luc Villeval, Hugues de Thé
Published in: Journal of Experimental Medicine, Issue 218/2, 2021, ISSN 0022-1007
Publisher: Rockefeller University Press
DOI: 10.1084/jem.20201268