Rezultaty
Longitudinal data is so far not used to infer and report unobserved challenges We will describe a method that from repeated phenotypic data milk yield litter size will identify critical points challenging events such as unobserved infections in the lifespan of animals The method will be able to evaluate and identify superior animals for resilience to such events
Paper on genome-wide association studies (GWAS) for at least 10 new resilience traits in 6 breedsUsing existing genomic data and new genomic information, genomic regions affecting survival and health traits will be identified. Putative candidate genes will be searched in these regions in order to propose causative mutations.
Paper on farmer and breeder preferences for breeding and geneticsOutcomes from semi-structured interviews (T7.2) summarising the benefits, barriers and challenges for breeding programs and improving resilience and efficiency of animals and farms
Report on demography and genetic diversity of underutilized sheep and goat breedsGenetic diversity and demographic history of hardy and/or underutilised breeds will be estimated, with the objective to contribute to the full characterisation of European small ruminant populations.
Document specifying the exchange of pedigree, phenotypes and genotypesIt describes the specifications of the way to exchange and store the pedigree, phenotypes and genotypes from the different countries involved in the across country evaluation. It is intended to describe a common international pedigree file with all aliases, as well as file formats for exchanging genotypes/phenotypes
ICAR guidelines and recommendations for phenotyping efficiency and resilience traits in sheep and goats.The document is the ICAR guidelines and recommendations for phenotyping efficiency and resilience traits in sheep and goats. These recommendations will be published in ICAR guidelines and are in the scope of the sheep, goat and small camelids working group. All the traits proposed by WP1 and WP3 to be implemented on farm or on station will have specific recommendations.
New prototype and report for industry on GPS- generated phenotypes for behavioural adaptations to extensive grazing systems; artificial rearing adaptation phenotypes; lamb vigour scores linked to lamb survival; new foetal and neonatal survival phenotypesThe use of new technologic tools (like temperature measured with ruminal bolus, animal movement measured with GPS, artificial rearing measured with automates, lamb survival measured using ultrasound scan at key time…), will allow to identify new phenotypes to measure on farm.
Paper on quantification (genetic and phenotypic parameters) of new disease biomarkers linked to production. New disease phenotypes for endemic disease (proxies for foot rot, mastitis, parasites) linked to key production traits phenotypesPhenotypic and genetic relationship between disease resistance and production traits will be studied in order to advise the building of selection index in WP7.
Report on cost-effectiveness of harmonization in phenotyping and of international evaluationThis is a report on cost-effectiveness of harmonization in phenotyping and of international evaluation. This deliverable will be a tool to promote international evaluation by showing how cost-effective sharing information, especially in the genomic area.
Paper on economic, labour and environmental trade-offs for breeding for R&E traitsOutputs from the modelling in task 7.1 presenting the economic, labour and environmental values for production and R&E traits. Propose how to combine all traits into a balanced breeding goal
Report on dissemination, communication and exploitation activitiesImplemented dissemination, communication and exploitation activities
Report of the final scientific conferenceReport including the presentations, discussions, and conclusions of the project final conference
Report of novel phenotypes related to feed efficiencyList of phenotypes related to the efficient use of feed resources that can be routinely measured in commercial populations.
Report on identified pleiotropic QTLs and potential underlying genes and pathways associated efficiency, resilience and reproduction related traitsIn this deliverable, genomic and phenotypic data will be used to perform genome wide association analyses and identify QTLs that are associated with both efficiency- and resilience- related traits. Results will provide possible candidate genes and mechanism responsible for synergy and/or trade-offs under genetic control.
Report on the characterization of efficiency and resilience in lines of sheep and goat divergently selectedIn this deliverable, we will report the result from 4 experiments in genetically selected sheep and goat which will undergo both nutritional and infectious challenges. We thus will characterize the effect of genetic background and environmental stress (nutrition, infection) on a comprehensive set of efficiency- and resilience- related phenotypes.
Report on recommendations for breedingSummary of whole work package including recommendations for breeders for how to use balanced breeding goals.
A report for optimum contribution to manage diversity at critical regions and to assist mating design to maximise heterozygosity and expression of heterosis and evaluation of level inbreeding rate across genomic regions and their impact on performanceGenomic selection requires genomic management of diversity We will describe a method to first assess critical regions possibly carriers of deleterious recessive mutations and second maximize diversity in particular in those regions using optimal contributions and mate allocation
Report on G*E interactions for resource use efficiency traits in meat and dairy small ruminantsA table describing the genetic correlations between resource use efficiency traits in extensive and intensive conditions in Romane breed, in different countries (France/Greece) in lacaune dairy breed, and in different farm conditions in dairy goats.
Peer-reviewed paper on the genetic basis of feed resource use efficiency phenotypesPublication of at least one scientific paper with the general objective of assessing the genetic architecture of the complex trait of resource use efficiency.
Scientific publication on the genetic characterisation, demography and adaptation of local small ruminants breeds using results from Tasks 4.2 and 4.3Results from Tasks 4.2 and 4.3 will be integrated into at least one paper aimed at describing the demographic history of hardy and underutilized breeds, and how environmental selective pressure shaped their genome.
Schedule and program of the summer school, eLearning and training sessions and multi-actor round tablesList and preprograms of the training sessions and round tables to schedule until the end of the project
A report of an improved method to calculate genomic relationship across individuals of different purebred and crossbred populationsJoint multiple breed and crossbred genomic evaluations are not fully developed in small ruminants We will create a method to compute joint genomic relationships across individuals within a single breed across multiple breeds and across all possible crosses in a manner that genomic evaluations can generate the most accurate estimates of breeding values within and across populations profiting the information of all populations
Report on genetic correlations for feed efficiency and other economically important traitsGenetic correlations of the novel phenotypes with the productive traits will be estimated. The objective is to evaluate the consequences of the implementation in selection programs.
Report on trajectory characteristics of resilient animals, and strategies to manipulate theseIn this deliverable, we will provide a report that lists trajectory characteristics that discriminate animals with high and low resilience to nutritional and infectious challenges (identified from model and data analyses), and describes the effect of diverse control strategies on these, based on model predictions
Paper on economic/social and environmental valuesPaper describing the non-market valuation and how they can contribute to balanced breeding goals for different farm and breed types.
Method for assessing potential bias due to design of cross-validation analysisCrossvalidation studies in small ruminants may underestimate benefit accuracy and genetic progress of genomic selection due to short size of studies and the use of selected animals We will describe a crossvalidation method that generates meaningful estimates of accuracy and expected genetic progress from genomic selection
A manuscript on the development and testing of genomic evaluation tools to improve resilience and efficiency accounting for the impact of environmental challenge and using novel phenotypesEnvironmental challenges and new phenotypes related to resilience and efficiency can now be measured, but methods for their inclusion in genomic evaluation are still scarce. We will develop such methods to include environmental measures and novel phenotypes, and test them in real life data sets.
Signatures of selection for adaptation to the environment in underutilized breedsState-of-the-art methods will be used to detect signature of selection in hardy or underutilized breeds, to understand how environmental pressures shaped their genome.
First batch of practice abstract for end-users"The resulting innovative knowledge and easy accessible end-user material from this project will feed into the EIP-AGRI (The agricultural European Innovation Partnership) website for broad dissemination. The end-user material to be produced contains a substantial number of summaries for practitioners in the EIP common format (""practice abstracts""), including the characteristics of the project (e.g. contact details of partners, etc). A full package of practice abstracts will be produced by the project, containing all the outcomes/recommendations which are ready for practice. A ""practice abstract"" is a short summary of around 1000-1500 characters (word count – no spaces; see below) which describes the main information/recommendation/practice that can serve the end-users in their daily practice. Guidance and templates for these practice abstracts are available on the EIP-AGRI web site: http://ec.europa.eu/eip/agriculture/en/content/eip-agri-common-format. A total target number of 10 practice abstracts is foreseen for the project. Five ares expected to be delivered in the first batch. "
Second batch of practice abstract for end-users"The resulting innovative knowledge and easy accessible end-user material from this project will feed into the EIP-AGRI (The agricultural European Innovation Partnership) website for broad dissemination. The end-user material to be produced contains a substantial number of summaries for practitioners in the EIP common format (""practice abstracts""), including the characteristics of the project (e.g. contact details of partners, etc). A full package of practice abstracts will be produced by the project, containing all the outcomes/recommendations which are ready for practice.A ""practice abstract"" is a short summary of around 1000-1500 characters (word count – no spaces; see below) which describes the main information/recommendation/practice that can serve the end-users in their daily practice. Guidance and templates for these practice abstracts are available on the EIP-AGRI web site: http://ec.europa.eu/eip/agriculture/en/content/eip-agri-common-format. A total target number of 10 practice abstracts is foreseen for the project."
Submitted scientific publication on the variance components for pilot ruminants breeds in a pilot selection of countriesThe document includes one or several scientific publication on the variance components estimated in pilot ruminants breeds in a pilot panel of countries. The variance components are the genetic parameters required to carry out international evaluation. In particular, the genetic correlation between countries will be published.
Submitted scientific publication on the genetic parameters between efficiency, resilience and reproduction related traits in sheep and goatsThis deliverable will provide genetic correlations between efficiency and resilience related traits in order to identify synergy andor tradeoffs under genetic control Additional traits related to reproduction will also be considered To do so a set of existing data from partners SRUC INRAE INIA UNILEON will be used as well as data produced in WP1 and WP2
Business and operation model for international evaluation of rams and bucksIt describes the business and operation model for international evaluation of rams and bucks. This deliverable consists in a specification of a ready-to-implement routine international evaluation infrastructure. This deliverable also describes the outline, expectations and organisations of a reference centre for small ruminants.
Paper and report for industry on new breeding goal traits for lifetime resilience for maternal sheep breeding programmes. New traits for productive longevity, fertility and body tissue mobilisationUsing large data sets from industry and long-term experimental flocks with detailed culling and death information, genetic and genomic analyses will be perform to propose new selection criteria for resilience.
Compilation of training session reportsDocument including all the minutes of the different training sessions organised within SMARTER framework.
Following parasite infections, antibody response, Fecal egg count, anaemia and haematocrit will be measured in several breed in order to identify the best criteria to evaluate the resistance and the resilience of animals.
Development and launching of the project website and creation of main communication supports
In this deliverable, we will provide the source code and a draft paper consisting of detailed descriptions of model scope, assumptions, methodology and predictions of resilience trajectories for two types of trade-offs, generated by either nutritional or infectious challenges
Publikacje
Autorzy:
Marc Teissier, Luiz F. Brito, Flavio S. Schenkel, Guido Bruni, Pancrazio Fresi, Beat Bapst, Christèle Robert-Granie and Hélène Larroque
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Frontiers in Genetics, Numer Vol. 13, n°862838, 2022, ISSN 1664-8021
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Frontiers Media
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10.3389/fgene.2022.862838
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S. Mucha, F. Tortereau, A. Doeschl-Wilson, R. Rupp, J. Conington,
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Animal, Numer Volume 16, Numer 3,, 2022, Strona(/y) 100456, ISSN 1751-7311
Wydawca:
Cambridge University Press
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10.1016/j.animal.2022.100456
Autorzy:
Morales-González E, Fernández J, Pong-Wong R, Toro MA and Villanueva B
Opublikowane w:
Genetic Selection Evolution, 2021, ISSN 0999-193X
Wydawca:
BioMed Central
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10.3390/genes12050673
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Zully Ramos, Dorian J. Garrick, Hugh T. Blair, Brenda Vera, Gabriel Ciappesoni and Paul R. Kenyon
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Genes, Numer 14(1),, 2023, Strona(/y) 167, ISSN 2073-4425
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Multidisciplinary Digital Publishing Institute (MDPI)
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10.3390/genes14010167
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Pablo A. S. Fonseca; Aroa Suárez-Vega; Rocio Pelayo; Hector Marina; María Alonso-García; Beatriz Gutiérrez-Gil; Juan-José Arranz
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Scientific reports, Numer 13, 2023, Strona(/y) 4351, ISSN 2045-2322
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Nature Publishing Group
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10.1038/s41598-023-31546-3
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Karolina Kaseja, Sebastian Mucha, Ed Smith, John Yates, Georgios Banos, Joanne Conington
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Journal of Animal Breeding and Genetics, Numer J Anim Breed Genet. 2023;140:462–471, 2023, Strona(/y) 462-471, ISSN 6790-4823
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International Journal of Animal Breeding and Genetics
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10.1111/jbg.12771
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Carracelas, E.A. Navajas, B. Vera, G. Ciappesoni
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Genes, Numer 13 (9), 2022, ISSN 2073-4425
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Multidisciplinary Digital Publishing Institute (MDPI)
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10.3390/genes13091548
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Macedo, F. L., Astruc, J. M., Meuwissen, T. H. E., & Legarra, A.
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Journal of Dairy Science, Numer 105, 2022, ISSN 0022-0302
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American Dairy Science Association
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Massender, L. F. Brito, L. Maignel, H. R. Oliveira, M. Jafarikia, C. F. Baes, B. Sullivan, F.S. Schenkel
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American Dairy Science Association
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Fitzmaurice, S., Conington, J., McDermott, K., McHugh, N., & Banos, G.
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Journal of Animal Breeding and Genetics, Numer 139, 2022, Strona(/y) 342– 350, ISSN 6790-4823
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International Journal of Animal Breeding and Genetics
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JDS Communications, Numer 2 (3), 2021, Strona(/y) 132-136, ISSN 2666-9102
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Masoud Ghaderi Zefreh1*, Andrea B. Doeschl-Wilson1,Valentina Riggio1, Oswald Matika1,2and Ricardo Pong-Wong
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Frontiers in Genetics, Numer 10.3389/fgene.2023.1127530, 2023, Strona(/y) 1127530, ISSN 1664-8021
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Biology, Numer Vol 12, issue 3, 2023, Strona(/y) 386, ISSN 2079-7737
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F.L. Macedo, A. Reverter, A. Legarra
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Macedo F., Christensen O., Legarra A.
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S. Werne a, K. Schwarz a, S. Thüer a, B. Bapst b
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