Exploring the bacterial cell cycle to re-sensitize antibiotic-resistant bacteria

Pubblicazioni

DeepBacs for multi-task bacterial image analysis using open-source deep learning approaches

Autori: Christoph Spahn, Estibaliz Gómez-de-Mariscal, Romain F. Laine, Pedro M. Pereira, Lucas von Chamier, Mia Conduit, Mariana G. Pinho, Guillaume Jacquemet, Séamus Holden, Mike Heilemann, Ricardo Henriques
Pubblicato in: Communications Biology, Numero 23993642, 2022, Pagina/e 688, ISSN 2399-3642
Editore: Nature Portfolio
DOI: 10.1038/s42003-022-03634-z

BPEI-Induced Delocalization of PBP4 Potentiates β-lactams Against MRSA.

Autori: Hill, Melissa A.; Lam, Anh K.; Reed, Patricia; Harney, Madeline C.; Wilson, Beatrice A.; Moen, Erika L.; Wright, Summer N.; Pinho, Mariana G.; Rice, Charles V.
Pubblicato in: Biochemistry, Numero 2, 2019, ISSN 0006-2960
Editore: American Chemical Society
DOI: 10.1021/acs.biochem.9b00523

Staphylococcus aureus cell growth and division are regulated by an amidase that trims peptides from uncrosslinked peptidoglycan

Autori: Truc Do, Kaitlin Schaefer, Ace George Santiago, Kathryn A. Coe, Pedro B. Fernandes, Daniel Kahne, Mariana G. Pinho, Suzanne Walker
Pubblicato in: Nature Microbiology, Numero 5/2, 2020, Pagina/e 291-303, ISSN 2058-5276
Editore: Springer Nature
DOI: 10.1038/s41564-019-0632-1

eHooke: A tool for automated image analysis of spherical bacteria based on cell cycle progression

Autori: Bruno M. Saraiva; Ludwig Krippahl; Sergio R. Filipe; Ricardo Henriques; Mariana G. Pinho
Pubblicato in: Biological Imaging, Numero 1, 2021, ISSN 2633-903X
Editore: Cambridge University Press
DOI: 10.1017/s2633903x21000027

The pentaglycine bridges of Staphylococcus aureus peptidoglycan are essential for cell integrity

Autori: João M. Monteiro, Gonçalo Covas, Daniela Rausch, Sérgio R. Filipe, Tanja Schneider, Hans-Georg Sahl, Mariana G. Pinho
Pubblicato in: Scientific Reports, Numero 9/1, 2019, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-019-41461-1

SEDS–bPBP pairs direct lateral and septal peptidoglycan synthesis in Staphylococcus aureus

Autori: Nathalie T. Reichmann, Andreia C. Tavares, Bruno M. Saraiva, Ambre Jousselin, Patricia Reed, Ana R. Pereira, João M. Monteiro, Rita G. Sobral, Michael S. VanNieuwenhze, Fábio Fernandes, Mariana G. Pinho
Pubblicato in: Nature Microbiology, Numero 4/8, 2019, Pagina/e 1368-1377, ISSN 2058-5276
Editore: Nature Research
DOI: 10.1038/s41564-019-0437-2

Revisiting the Role of VraTSR in Staphylococcus aureus Response to Cell Wall-Targeting Antibiotics

Autori: Pedro B. Fernandes, Patricia Reed, João M. Monteiro, Mariana G. Pinho
Pubblicato in: Journal of Bacteriology, Numero 00219193, 2022, Pagina/e e0016222, ISSN 0021-9193
Editore: American Society for Microbiology
DOI: 10.1128/jb.00162-22

Identification of 5-(Aryl/Heteroaryl)amino-4-quinolones as Potent Membrane-Disrupting Agents to Combat Antibiotic-Resistant Gram-Positive Bacteria

Autori: John R. Schultz; Stephen K. Costa; Gorakhnath R. Jachak; Pooja Hegde; Matthew Zimmerman; Yan Pan; Michaele Josten; Chinedu Ejeh; Travis Hammerstad; Hans Georg Sahl; Pedro M. Pereira; Mariana G. Pinho; Véronique Dartois; Ambrose Cheung; Courtney C. Aldrich
Pubblicato in: J Med Chem, Numero 2, 2022, ISSN 0022-2623
Editore: American Chemical Society
DOI: 10.1021/acs.jmedchem.2c01151

Reassessment of the distinctive geometry of Staphylococcus aureus cell division

Autori: Bruno M. Saraiva, Moritz Sorg, Ana R. Pereira, Mário J. Ferreira, Léo C. Caulat, Nathalie T. Reichmann, Mariana G. Pinho
Pubblicato in: Nature Communications, Numero 11/1, 2020, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-020-17940-9

Encapsulation of the septal cell wall protects Streptococcus pneumoniae from its major peptidoglycan hydrolase and host defenses

Autori: Figueiredo J, Henriques MX, Catalão MJ, Pinheiro S, Narciso AR, Mesquita F, Saraiva BM, Carido M, Cabanes D, Pinho MG, Filipe SR.
Pubblicato in: PLoS Pathogens, 2022, ISSN 1553-7366
Editore: Public Library of Science
DOI: 10.1371/journal.ppat.1010516

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