Metabolic regulation of metastatic growth

Metabolism – A cornerstone of cancer initiation, progression, immune evasion and treatment response

Author(s): Sophia Y. Lunt, Sarah-Maria Fendt
Published in: Current Opinion in Systems Biology, Issue 8, 2018, Page(s) 67-72, ISSN 2452-3100
Publisher: Elsevier
DOI: 10.1016/j.coisb.2017.12.006

Targeting Metabolic Plasticity and Flexibility Dynamics for Cancer Therapy

Author(s): Sarah-Maria Fendt, Christian Frezza, Ayelet Erez
Published in: Cancer Discovery, Issue 10/12, 2020, Page(s) 1797-1807, ISSN 2159-8274
Publisher: American Association for Cancer Research Inc.
DOI: 10.1158/2159-8290.cd-20-0844

Lipid metabolism in cancer: New perspectives and emerging mechanisms

Author(s): Lindsay A. Broadfield, Antonino Alejandro Pane, Ali Talebi, Johannes V. Swinnen, and Sarah-Maria Fendt
Published in: Developmental Cell, Issue 15345807, 2021, ISSN 1534-5807
Publisher: Cell Press
DOI: 10.1016/j.devcel.2021.04.013

Age-induced accumulation of methylmalonic acid promotes tumour progression

Author(s): Ana P. Gomes, Didem Ilter, Vivien Low, Jennifer E. Endress, Juan Fernández-García, Adam Rosenzweig, Tanya Schild, Dorien Broekaert, Adnan Ahmed, Melanie Planque, Ilaria Elia, Julie Han, Charles Kinzig, Edouard Mullarky, Anders P. Mutvei, John Asara, Rafael de Cabo, Lewis C. Cantley, Noah Dephoure, Sarah-Maria Fendt, John Blenis
Published in: Nature, Issue 585/7824, 2020, Page(s) 283-287, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-020-2630-0

Macrophages are metabolically heterogeneous within the tumor microenvironment

Author(s): Xenia Geeraerts, Juan Fernández-Garcia, Felix J.Hartmann, Kyra E.de Goede, Liesbet Martens, Yvon Elkrim, Ayla Debraekeleer, Benoit Stijlemans, Anke Vandekeere, Gianmarco Rinaldi, Riet De Rycke, Mélanie Planque, Dorien Broekaert, Elisa Meinster, Emile Clappaert, Pauline Bardet, Aleksandar Murgaski, Conny Gysemans, Frank Aboubakar Nana, Yvan Saeys, Sean C. Bendall, Damya Laoui, Jan Van den Bossche
Published in: Cell Reports, Issue 22111247, 2021, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2021.110171

Statins affect cancer cell plasticity with distinct consequences for tumor progression and metastasis

Author(s): Madeleine Dorsch, Manuela Kowalczyk, Mélanie Planque, Geronimo Heilmann, Sebastian Urban, Philip Dujardin, Jan Forster, Kristina Ueffing, Silke Nothdurft, Sebastian Oeck, Annika Paul, Sven T. Liffers, Farnusch Kaschani, Markus Kaiser, Alexander Schramm, Jens T. Siveke, Monte M. Winslow, Sarah-Maria Fendt, Perihan Nalbant, Barbara M. Grüner
Published in: Cell Reports, Issue 22111247, 2021, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2021.110056

Molecular differences of angiogenic versus vessel co-opting colorectal cancer liver metastases at single-cell resolution

Author(s): Johannes Robert Fleischer, Alexandra Maria Schmitt, Gwendolyn Haas, Xingbo Xu, Elisabeth Maria Zeisberg, Hanibal Bohnenberger, Stefan Küffer, Laure-Anne Teuwen, Philipp Johannes Karras, Tim Beißbarth, Annalen Bleckmann, Mélanie Planque, Sarah-Maria Fendt, Peter Vermeulen, Michael Ghadimi, Joanna Kalucka, Tiago De Oliveira & Lena-Christin Conradi
Published in: Molecular Cancer, Issue 22, 2023, ISSN 1476-4598
Publisher: BioMed Central
DOI: 10.1186/s12943-023-01713-1

The metabolism of cancer cells during metastasis

Author(s): Gabriele Bergers, Sarah-Maria Fendt
Published in: Nature Reviews Cancer, Issue 21/3, 2021, Page(s) 162-180, ISSN 1474-175X
Publisher: Nature Publishing Group
DOI: 10.1038/s41568-020-00320-2

Stable Isotopes for Tracing Mammalian-Cell Metabolism In Vivo

Author(s): Juan Fernández-García, Patricia Altea-Manzano, Erica Pranzini, Sarah-Maria Fendt
Published in: Trends in Biochemical Sciences, Issue 45/3, 2020, Page(s) 185-201, ISSN 0968-0004
Publisher: Elsevier BV
DOI: 10.1016/j.tibs.2019.12.002

CD40 signal rewires fatty acid and glutamine metabolism for stimulating macrophage anti-tumorigenic functions

Author(s): Pu-Ste Liu, Yi-Ting Chen, Xiaoyun Li, Pei-Chun Hsueh, Sheue-Fen Tzeng, Hsi Chen, Pei-Zhu Shi, Xin Xie, Sweta Parik, Mélanie Planque, Sarah-Maria Fendt & Ping-Chih Ho
Published in: Nature Immunology, Issue 24, 2023, Page(s) 452-462, ISSN 1548-7091
Publisher: Nature Publishing Group
DOI: 10.1038/s41590-023-01430-3

In Vivo Evidence for Serine Biosynthesis-Defined Sensitivity of Lung Metastasis, but Not of Primary Breast Tumors, to mTORC1 Inhibition

Author(s): Gianmarco Rinaldi, Erica Pranzini, Joke Van Elsen, Dorien Broekaert, Cornelius M. Funk, Mélanie Planque, Ginevra Doglioni, Patricia Altea-Manzano, Matteo Rossi, Vincent Geldhof, Shao Thing Teoh, Christina Ross, Kent W. Hunter, Sophia Y. Lunt, Thomas G.P. Grünewald, Sarah-Maria Fendt
Published in: Molecular Cell, 2020, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2020.11.027

Nutrient metabolism and cancer in the in vivo context: a metabolic game of give and take

Author(s): Patricia Altea‐Manzano, Alejandro M Cuadros, Lindsay A Broadfield, Sarah‐Maria Fendt
Published in: EMBO reports, Issue 21/10, 2020, ISSN 1469-221X
Publisher: Nature Publishing Group
DOI: 10.15252/embr.202050635

Endothelial Lactate Controls Muscle Regeneration from Ischemia by Inducing M2-like Macrophage Polarization

Author(s): Jing Zhang, Jonathan Muri, Gillian Fitzgerald, Tatiane Gorski, Roberto Gianni-Barrera, Evi Masschelein, Gommaar D’Hulst, Paola Gilardoni, Guillermo Turiel, Zheng Fan, TongTong Wang, Mélanie Planque, Peter Carmeliet, Luc Pellerin, Christian Wolfrum, Sarah-Maria Fendt, Andrea Banfi, Christian Stockmann, Inés Soro-Arnáiz, Manfred Kopf, Katrien De Bock
Published in: Cell Metabolism, Issue 31/6, 2020, Page(s) 1136-1153.e7, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2020.05.004

PCK2 opposes mitochondrial respiration and maintains the redox balance in starved lung cancer cells

Author(s): Gabriele Bluemel, Mélanie Planque, Corina T. Madreiter-Sokolowski, Theresa Haitzmann, Andelko Hrzenjak, Wolfgang F. Graier, Sarah-Maria Fendt, Horst Olschewski, Katharina Leithner
Published in: FREE RADICAL BIOLOGY AND MEDICINE, Issue 08915849, 2021, ISSN 0891-5849
Publisher: Elsevier BV
DOI: 10.1016/j.freeradbiomed.2021.09.007

Mitochondria metabolism sets the species-specific tempo of neuronal development

Author(s): Iwata R, Casimir P, Erkol E, Boubakar L, Gallego López IM, Planque M, Ditkowska M, Gaspariunaite V, Beckers S, Remans D, Vints K, Vandekeere A, Poovathingal S, Bird M, Corthout N, Vermeersch P, Carpentier S, Davie K, Mazzone M, Gounko NV, Aerts S, Ghesquiere B, Fendt S-M, Vanderhaeghen P
Published in: Science, Issue 379/6632, 2023, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.abn4705

Altered propionate metabolism contributes to tumour progression and aggressiveness

Author(s): Ana P. Gomes, Didem Ilter, Vivien Low, Stanislav Drapela, Tanya Schild, Edouard Mullarky, Julie Han, Ilaria Elia, Dorien Broekaert, Adam Rosenzweig, Michal Nagiec, Joana B. Nunes, Bethany E. Schaffer, Anders P. Mutvei, John M. Asara, Lewis C. Cantley, Sarah-Maria Fendt, John Blenis
Published in: Nature Metabolism, Issue 25225812, 2022, ISSN 2522-5812
Publisher: Nature Research
DOI: 10.1038/s42255-022-00553-5

In crystallo screening for proline analog inhibitors of the proline cycle enzyme PYCR1

Author(s): Emily M. Christensen, Alexandra N. Bogner, Anke Vandekeere, Gabriela S. Tam, Sagar M. Patel, Donald F. Becker, Sarah-Maria Fendt, John J. Tanner
Published in: Journal of Biological Chemistry, Issue 295/52, 2020, Page(s) 18316-18327, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.ra120.016106

Nuclear PHGDH protects cancer cells from nutrient stress

Author(s): Daniela Annibali, Sarah-Maria Fendt
Published in: NATURE METABOLISM, Issue 25225812, 2021, ISSN 2522-5812
Publisher: NATURE PORTFOLIO
DOI: 10.1038/s42255-021-00448-x

mTOR Signaling and SREBP Activity Increase FADS2 Expression and Can Activate Sapienate Biosynthesis

Author(s): Mouna Triki, Gianmarco Rinaldi, Melanie Planque, Dorien Broekaert, Alina M. Winkelkotte, Carina R. Maier, Sudha Janaki Raman, Anke Vandekeere, Joke Van Elsen, Martin F. Orth, Thomas G.P. Grünewald, Almut Schulze, Sarah-Maria Fendt
Published in: Cell Reports, Issue 31/12, 2020, Page(s) 107806, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2020.107806

Metabolite-derived protein modifications modulating oncogenic signaling

Author(s): Yawen Liu, Anke Vandekeere, Min Xu, Sarah-Maria Fendt, Patricia Altea-Manzano
Published in: Frontiers in Oncology, 2022, ISSN 2234-943X
Publisher: Frontiers Media S. A.
DOI: 10.3389/fonc.2022.988626

Breast cancer cells rely on environmental pyruvate to shape the metastatic niche

Author(s): Ilaria Elia, Matteo Rossi, Steve Stegen, Dorien Broekaert, Ginevra Doglioni, Marit van Gorsel, Ruben Boon, Carmen Escalona-Noguero, Sophie Torrekens, Catherine Verfaillie, Erik Verbeken, Geert Carmeliet, Sarah-Maria Fendt
Published in: Nature, Issue 568/7750, 2019, Page(s) 117-121, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-019-0977-x

Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity

Author(s): Kim Vriens, Stefan Christen, Sweta Parik, Dorien Broekaert, Kazuaki Yoshinaga, Ali Talebi, Jonas Dehairs, Carmen Escalona-Noguero, Roberta Schmieder, Thomas Cornfield, Catriona Charlton, Laura Romero-Pérez, Matteo Rossi, Gianmarco Rinaldi, Martin F. Orth, Ruben Boon, Axelle Kerstens, Suet Ying Kwan, Brandon Faubert, Andrés Méndez-Lucas, Charlotte C. Kopitz, Ting Chen, Juan Fernandez-Garcia, Jo
Published in: Nature, Issue 566/7744, 2019, Page(s) 403-406, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-019-0904-1

Metabolic Hallmarks of Metastasis Formation

Author(s): Ilaria Elia, Ginevra Doglioni, Sarah-Maria Fendt
Published in: Trends in Cell Biology, Issue 28/8, 2018, Page(s) 673-684, ISSN 0962-8924
Publisher: Elsevier BV
DOI: 10.1016/j.tcb.2018.04.002

Interactions in the (Pre)metastatic Niche Support Metastasis Formation

Author(s): Ginevra Doglioni, Sweta Parik, Sarah-Maria Fendt
Published in: Frontiers in Oncology, Issue 9, 2019, ISSN 2234-943X
Publisher: Frontiers Media S. A.
DOI: 10.3389/fonc.2019.00219

Navigating metabolic pathways to enhance antitumour immunity and immunotherapy

Author(s): Xiaoyun Li, Mathias Wenes, Pedro Romero, Stanley Ching-Cheng Huang, Sarah-Maria Fendt, Ping-Chih Ho
Published in: Nature Reviews Clinical Oncology, Issue 16/7, 2019, Page(s) 425-441, ISSN 1759-4774
Publisher: Nature Publishing Group
DOI: 10.1038/s41571-019-0203-7

CD8+ T cell metabolic rewiring defined by scRNA-seq identifies a critical role of ASNS expression dynamics in T cell differentiation

Author(s): Juan Fernández-García, Fabien Franco, Sweta Parik, Patricia Altea-Manzano, Antonino Alejandro Pane, Dorien Broekaert, Joke van Elsen, Ines Vermeire, Tessa Schalley, Mélanie Planque, Thomas van Brussel, Rogier Schepers, Elodie Modave, Tobias K. Karakach, Peter Carmeliet, Diether Lambrechts, Ping-Chih Ho, Sarah-MariaFendt
Published in: Cell Reports, Issue 41/7, 2022, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2022.111639

A palmitate-rich metastatic niche enables metastasis growth via p65 acetylation resulting in pro-metastatic NF-kB signaling

Author(s): Altea-Manzano P, Doglioni G, Liu Y, Cuadros AM, Nolan E, Fernández-García J, Wu Q, Planque M, Laue KJ, Cidre-Aranaz F, Liu X, Marin-Bejar O, Van Elsen J, Vermeire I, Broekaert D, Demeyer S, Spotbeen X, Idkowiak J, Montagne A, Demicco M, Alkan HF, Rabas N, Riera-Domingo C, Richard F, Geukens T, De Schepper M, Leduc S, Hatse S, Lambrechts Y, Kay EJ, Lilla S, Alekseenko A, Geldhof V, Boeckx B, de l
Published in: Nature Cancer, Issue 4, 2023, Page(s) 344-364, ISSN 2662-1347
Publisher: Nature Cancer
DOI: 10.1038/s43018-023-00513-2

Skeletal progenitors preserve proliferation and self-renewal upon inhibition of mitochondrial respiration by rerouting the TCA cycle

Author(s): Guillaume Tournaire, Shauni Loopmans, Steve Stegen, Gianmarco Rinaldi, Guy Eelen, Sophie Torrekens, Karen Moermans, Peter Carmeliet, Bart Ghesquière, Bernard Thienpont, Sarah-Maria Fendt, Nick van Gastel, Geert Carmeliet
Published in: Cell reports, Issue 22111247, 2022, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2022.111105

Fat Induces Glucose Metabolism in Nontransformed Liver Cells and Promotes Liver Tumorigenesis

Author(s): Lindsay A. Broadfield, João André Gonçalves Duarte, Roberta Schmieder, Dorien Broekaert, Koen Veys, Mélanie Planque, Kim Vriens, Yasuaki Karasawa, Francesco Napolitano, Suguru Fujita, Masashi Fujii, Miki Eto, Bryan Holvoet, Roman Vangoitsenhoven, Juan Fernandez-Garcia, Joke Van Elsen, Jonas Dehairs, Jia Zeng, James Dooley, Rebeca Alba Rubio, Jos van Pelt, Thomas G.P. Grünewald, Adrian Liston,
Published in: Cancer Research, Issue 81/8, 2021, Page(s) 1988-2001, ISSN 0008-5472
Publisher: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-20-1954

PHGDH heterogeneity potentiates cancer cell dissemination and metastasis

Author(s): Rossi M, Altea-Manzano P, Demicco M, Doglioni G, Bornes L, Fukano M, Vandekeere A, Cuadros AM, Fernandez-Garcia J, Riera-Domingo C, Jauset C, Planque M, Alkan HF, Nittner D, Zuo D, Broadfield LA, Parik S, Pane AA, Rizzollo F, Rinaldi G, Zhang T, Teoh ST, Aurora AB, Karras P, Vermeire I, Broekaert D, Van Elsen J, Knott MML, Orth MF, Demeyer S, Eelen G, Dobrolecki LE, Bassez A, Van Brussel T, Sotlar
Published in: Nature, Issue 00280836, 2022, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-022-04758-2

Pharmacological induction of membrane lipid poly-unsaturation sensitizes melanoma to ROS inducers and overcomes acquired resistance to targeted therapy

Author(s): Ali Talebi, Vincent de Laat, Xander Spotbeen, Jonas Dehairs, Florian Rambow, Aljosja Rogiers, Frank Vanderhoydonc, Lara Rizotto, Mélanie Planque, Ginevra Doglioni, Sahar Motamedi, David Nittner, Tania Roskams, Patrizia Agostinis, Oliver Bechter, Veerle Boecxstaens, Marjan Garmyn, Marie O’Farrell, Alan Wagman, George Kemble, Eleonora Leucci, Sarah-Maria Fendt, Jean-Christophe Marine & Johannes V
Published in: Journal of experimental and clinical cancer research, Issue 42, 2023, ISSN 0392-9078
Publisher: BioMed Central
DOI: 10.1186/s13046-023-02664-7

Serine metabolism remodeling after platinum-based chemotherapy identifies vulnerabilities in a subgroup of resistant ovarian cancers

Author(s): Tom Van Nyen, Mélanie Planque, Lilian van Wagensveld, Joao A. G. Duarte, Esther A. Zaal, Ali Talebi, Matteo Rossi, Pierre-René Körner, Lara Rizzotto, Stijn Moens, Wout De Wispelaere, Regina E. M. Baiden-Amissah, Gabe S. Sonke, Hugo M. Horlings, Guy Eelen, Emanuele Berardi, Johannes V. Swinnen, Celia R. Berkers, Peter Carmeliet, Diether Lambrechts, Ben Davidson, Reuven Agami, Sarah-Maria Fendt,
Published in: Nature Communications, Issue 20411723, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-32272-6

In Crystallo Screening for Proline Analog Inhibitors of the Proline Cycle Enzyme PYCR1

Author(s): Emily M. Christensen, Alexandra N. Bogner, Anke Vandekeere, Gabriela S. Tam, Sagar M. Patel, Donald F. Becker, Sarah-Maria Fendt, John J. Tanner
Published in: Journal of Biological Chemistry, 2020, Page(s) jbc.RA120.016106, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.ra120.016106

GBM tumors are heterogeneous in their fatty acid metabolism and modulating fatty acid metabolism sensitizes cancer cells derived from recurring GBM tumors to temozolomidefmetas

Author(s): Sweta Parik, Juan Fernández-García, Francesca Lodi, Karen De Vlaminck, Marleen Derweduwe, Steven De Vleeschouwer, Raf Sciot, Wietse Geens, Linqian Weng, Francesca Maria Bosisio, Gabriele Bergers, Johnny Duerinck, Frederick De Smet, Diether Lambrechts, Jo A. Van Ginderachter and Sarah-Maria Fendt
Published in: Frontiers in oncology, Issue 2234943X, 2022, ISSN 2234-943X
Publisher: Frontiers Media S. A.
DOI: 10.3389/fonc.2022.988872

In vivo CRISPR screen defines Slc25a37 as an organ-specific regulator of antioxidant metabolism in metastasis

Author(s): Alejandro M. Cuadros, Juan Fernández-Garcia, Mélanie Planque, Patricia Altea-Manzano, Tessa Schalley, Ines Vermeire, Dorien Broekaert, Qi Wu, Thomas Van Brussel, Sophia Leduc, Marion Maetens, Ha-Linh Nguyen, Karen Van Baelen, Naama Darzi, Giuseppe Floris, Hans Wildiers, Christine Desmedt, Diether Lambrechts, Sarah-Maria Fendt
Published in: BioRxiv, 2022
Publisher: BioRxiv
DOI: 10.1101/2022.09.03.506468

Dynamic ROS Regulation by TIGAR: Balancing Anti-cancer and Pro-metastasis Effects

Author(s): Sarah-Maria Fendt, Sophia Y. Lunt
Published in: Cancer Cell, Issue 37/2, 2020, Page(s) 141-142, ISSN 1535-6108
Publisher: Cell Press
DOI: 10.1016/j.ccell.2020.01.009

Metabolic vulnerabilities of metastasizing cancer cells

Author(s): Sarah-Maria Fendt
Published in: BMC Biology, Issue 17/1, 2019, ISSN 1741-7007
Publisher: BioMed Central
DOI: 10.1186/s12915-019-0672-2

Assessing the Impact of the Nutrient Microenvironment on the Metabolism of Effector CD8+ T Cells

Author(s): Juan Fernández-García, Sarah-Maria Fendt
Published in: Metabolic Signaling - Methods and Protocols, Issue 1862, 2019, Page(s) 187-216, ISBN 978-1-4939-8768-9
Publisher: Springer New York
DOI: 10.1007/978-1-4939-8769-6_14

Measuring In Vivo Tissue Metabolism Using 13C Glucose Infusions in Mice

Author(s): Dorien Broekaert, Sarah-Maria Fendt
Published in: Metabolic Signaling - Methods and Protocols, Issue 1862, 2019, Page(s) 67-82, ISBN 978-1-4939-8768-9
Publisher: Springer New York
DOI: 10.1007/978-1-4939-8769-6_5

13C Tracer Analysis and Metabolomics in 3D Cultured Cancer Cells

Author(s): Marit van Gorsel, Ilaria Elia, Sarah-Maria Fendt
Published in: Metabolic Signaling - Methods and Protocols, Issue 1862, 2019, Page(s) 53-66, ISBN 978-1-4939-8768-9
Publisher: Springer New York
DOI: 10.1007/978-1-4939-8769-6_4

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