An integrative approach for the exploration of melanoma genetic and immunological interactions

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

NRas activity is regulated by dynamic interactions with nanoscale signaling clusters at the plasma membrane

Autores: Oren Yakovian, Julia Sajman, Michal Alon, Rand Arafeh, Yardena Samuels, Eilon Sherman*
Publicado en: iScience, Edición 25/11, 2022, ISSN 2589-0042
Editor: Cell Press
DOI: 10.1016/j.isci.2022.105282

Anti-tumour immunity induces aberrant peptide presentation in melanoma

Autores: Osnat Bartok, Abhijeet Pataskar, Remco Nagel, Maarja Laos, Eden Goldfarb, Deborah Hayoun, Ronen Levy, Pierre-Rene Körner, Inger Z M Kreuger, Julien Champagne, Esther A Zaal, Onno B Bleijerveld, Xinyao Huang, Juliana Kenski, Jennifer Wargo, Alexander Brandis, Yishai Levin, Orel Mizrahi, Michal Alon, Sacha LebonWeiwen Yang, Morten M Nielsen, Noam Stern-Ginossar, Maarten Altelaar, Celia R Berkers, T
Publicado en: Nature, Edición 590/7845, 2021, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-020-03054-1

Cross-Talk between Receptor Tyrosine Kinases AXL and ERBB3 Regulates Invadopodia Formation in Melanoma Cells

Autores: Or-Yam Revach; Oded Sandler; Yardena Samuels; Benjamin Geiger
Publicado en: Cancer research , Edición 3, 2019, ISSN 0008-5472
Editor: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-18-2316

Cancer research in the era of immunogenomics

Autores: Yochai Wolf, Yardena Samuels*
Publicado en: ESMO Open, Edición 3/7, 2018, ISSN 2059-7029
Editor: Elsevier
DOI: 10.1136/esmoopen-2018-000475

The proteasome regulator PSME4 modulates proteasome activity and antigen diversity to abrogate antitumor immunity in NSCLC

Autores: Aaron Javitt, Merav D. Shmueli*, Matthias P. Kramer, Aleksandra A. Kolodziejczyk, Ivan J. Cohen, Lihi Radomir, Daoud Sheban, Iris Kamer, Kevin Litchfield, Elizabeta Bab-Dinitz, Oranit Zadok, Vanessa Neiens, Adi Ulman, Hila Wolf-Levy, Avital Eisenberg-Lerner, Assaf Kacen, Michal Alon, Ana Toste Rêgo, Elvira Stacher-Priehse, Michael LindnerIna Koch, Jair Bar, Charles Swanton, Yardena Samuels, Yisha
Publicado en: Nature Cancer, Edición 4/5, 2023, ISSN 2662-1347
Editor: Nature Research
DOI: 10.1038/s43018-023-00557-4

Large-Scale Immuno-Peptidome Analysis Reveals Recurrent Post-Translational Splicing of Cancer and Immune-Associated Genes

Autores: Ronen Levy, Tal Alter Regev, Wayne Paes, Nofar Gumpert, Sapir Cohen Shvefel, Osnat Bartok, Maria Dayan-Rubinov, Michal Alon, MeravD Shmueli, Yishai Levin, Yifat Merbl, Nicola Ternette, Yardena Samuels*
Publicado en: Molecular & Cellular Proteomics, Edición 22/4, 2023, ISSN 1535-9484
Editor: American Society for Biochemistry and Molecular Biology
DOI: 10.1016/j.mcpro.2023.100519

Identification of presented SARS-CoV-2 HLA class I and HLA class II peptides using HLA peptidomics

Autores: Adi Nagler, Shelly Kalaora, Chaya Barbolin, Anastasia Gangaev, Steven L.C Ketelaars, Michal Alon, Joy Pai, Gil Benedek, Yfat Yahalom-Ronen, Noam Erez, Polina Greenberg, Gal Yagel, Aviyah Peri, Yishai Levin, Ansuman T Satpathy, Erez Bar-Haim, Nir Paran, Pia Kvistborg, Yardena Samuels*
Publicado en: Cell reports, Edición 35/13, 2021, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2021.109305

PhISCS-BnB: a fast branch and bound algorithm for the perfect tumor phylogeny reconstruction problem.

Autores: Erfan Sadeqi Azer; Farid Rashidi Mehrabadi; Farid Rashidi Mehrabadi; Salem Malikic; Xuan Cindy Li; Xuan Cindy Li; Osnat Bartok; Kevin Litchfield; Kevin Litchfield; Ronen Levy; Yardena Samuels; Alejandro A. Schäffer; E. Michael Gertz; Chi-Ping Day; Eva Pérez-Guijarro; Kerrie L. Marie; Maxwell P. Lee; Glenn Merlino; Funda Ergün; S. Cenk Sahinalp
Publicado en: Azer , E S , Mehrabadi , F R , Malikić , S , Li , X C , Bartok , O , Litchfield , K , Levy , R , Samuels , Y , Schäffer , A A , Gertz , M E , Day , C-P , Pérez-Guijarro , E , Marie , K , Lee , M P , Merlino , G , Ergun , F & Sahinalp , S C 2020 , ' PhISCS-BnB : a fast branch and bound algorithm for the perfect tumor phylogeny reconstruction problem ' , Bioinformatics , vol. 36 , no. 1 , pp. i16, Edición 36/1, 2020, ISSN 1367-4811
Editor: Oxford University Press
DOI: 10.1093/bioinformatics/btaa464

Neoantigens in cancer immunotherapy: quantity vs. quality

Autores: Yochai Wolf*, Yardena Sameuls*
Publicado en: Molecular Oncology, Edición 17/8, 2023, ISSN 1574-7891
Editor: Elsevier BV
DOI: 10.1002/1878-0261.13483

PIK3CA in cancer: The past 30 years

Autores: Rand Arafeh, Yardena Samuels
Publicado en: Seminars in Cancer Biology, Edición 29, 2019, ISSN 1044-579X
Editor: Academic Press
DOI: 10.1016/j.semcancer.2019.02.002

Combined presentation and immunogenicity analysis reveals a recurrent RAS.Q61K neoantigen in melanoma

Autores: Aviyah Peri, Erez Greenstein, Michal Alon, Joy A Pai, Tamir Dingjan, Shlomit Reich-Zeliger, Eilon Barnea, Chaya Barbolin, Ronen Levy, Claudia Arnedo-Pac, Shelly Kalaora, Bareket Dassa, Ester Feldmesser, Ping Shang, Polina Greenberg, Yishai Levin, Gil Benedek, Mitchell P Levesque, David J Adams, Michal LotemJames S Wilmott, Richard A Scolyer, Göran B Jönsson, Arie Admon, Steven A Rosenberg, Cyril
Publicado en: The Journal of Clinical Investigation, Edición 131/20, 2021, ISSN 0021-9738
Editor: American Society for Clinical Investigation
DOI: 10.1172/jci129466

Identification of bacteria-derived HLA-bound peptides in melanoma

Autores: Shelly Kalaora, Adi Nagler, Deborah Nejman, Michal Alon, Chaya Barbolin, Eilon Barnea, Steven L C Ketelaars, Kuoyuan Cheng, Kevin Vervier, Noam Shental, Yuval Bussi, Ron Rotkopf, Ronen Levy, Gil Benedek, Sophie Trabish, Tali Dadosh, Smadar Levin-Zaidman, Leore T Geller, Kun Wang, Polina GreenbergGal Yagel, Aviyah Peri, Garold Fuks, Neerupma Bhardwaj, Alexandre Reuben, Leandro Hermida, Sarah B John
Publicado en: Nature, Edición 592/7852, 2021, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-021-03368-8

The landscape of T cell antigens for cancer immunotherapy

Autores: Aviyah Peri, Nadja Salomon, Yochai Wolf*, Sebastian Kreiter*, Mustafa Diken*, Yardena Samuels*
Publicado en: Nature Cancer, Edición 4/7, 2023, ISSN 2662-1347
Editor: Nature Research
DOI: 10.1038/s43018-023-00588-x

Post-translational modifications reshape the antigenic landscape of the MHC I immunopeptidome in tumors

Autores: Kacen, A., A. Javitt, M.P. Kramer, D. Morgenstern, T. Tsaban, M.D. Shmueli, G.C. Teo, F. da Veiga Leprevost, E. Barnea, F. Yu, A. Admon, L. Eisenbach, Y. Samuels, O. Schueler-Furman, Y. Levin, A.I. Nesvizhskii, and Y. Merbl.
Publicado en: Nature Biotechnology, Edición 41/2, 2022, ISSN 1087-0156
Editor: Nature Publishing Group
DOI: 10.1038/s41587-022-01464-2

Exome Sequencing of ABCB5 Identifies Recurrent Melanoma Mutations that Result in Increased Proliferative and Invasive Capacities

Autores: Géraldine Sana, James P. Madigan, Jared J. Gartner, Marie Fourrez, Jimmy Lin, Nouar Qutob, Jitendra Narayan, Suneet Shukla, Suresh V. Ambudkar, Di Xia, Steven A. Rosenberg, Michael M. Gottesman, Yardena Samuels, Jean-Pierre Gillet
Publicado en: Journal of Investigative Dermatology, Edición 139/9, 2019, Página(s) 1985-1992.e10, ISSN 0022-202X
Editor: Blackwell Publishing Inc.
DOI: 10.1016/j.jid.2019.01.036

A genome‐wide CRISPR screen identifies FBXO42 involvement in resistance toward MEK inhibition in NRAS ‐mutant melanoma

Autores: Adi Nagler, David W. Vredevoogd, Michal Alon, Phil F. Cheng, Sophie Trabish, Shelly Kalaora, Rand Arafeh, Victoria Goldin, Mitchell P. Levesque, Daniel S. Peeper, Yardena Samuels
Publicado en: Pigment Cell & Melanoma Research, Edición 33/2, 2020, Página(s) 334-344, ISSN 1755-1471
Editor: Basil Blackwell
DOI: 10.1111/pcmr.12825

UVB-Induced Tumor Heterogeneity Diminishes Immune Response in Melanoma

Autores: Yochai Wolf, Osnat Bartok, Sushant Patkar, Gitit Bar Eli, Sapir Cohen, Kevin Litchfield, Ronen Levy, Alejandro Jiménez-Sánchez, Sophie Trabish, Joo Sang Lee, Hiren Karathia, Eilon Barnea, Chi-Ping Day, Einat Cinnamon, Ilan Stein, Adam Solomon, Lital Bitton, Eva Pérez-Guijarro, Tania Dubovik, Shai S. Shen-Orr, Martin L. Miller, Glenn Merlino, Yishai Levin, Eli Pikarsky, Lea Eisenbach, Arie Admon
Publicado en: Cell, Edición 179/1, 2019, Página(s) 219-235.e21, ISSN 0092-8674
Editor: Cell Press
DOI: 10.1016/j.cell.2019.08.032

Immunoproteasome expression is associated with better prognosis and response to checkpoint therapies in melanoma

Autores: Shelly Kalaora, Joo Sang Lee, Eilon Barnea, Ronen Levy, Polina Greenberg, Michal Alon, Gal Yagel, Gitit Bar Eli, Roni Oren, Aviyah Peri, Sushant Patkar, Lital Bitton, Steven A. Rosenberg, Michal Lotem, Yishai Levin, Arie Admon, Eytan Ruppin, Yardena Samuels
Publicado en: Nature Communications, Edición 11/1, 2020, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-020-14639-9

Mechanisms of immune activation and regulation: lessons from melanoma

Autores: Shelly Kalaora, Adi Nagler, Jennifer A Wargo, Yardena Samuels*
Publicado en: Nature reviews. Cancer, Edición 22/4, 2022, ISSN 1474-175X
Editor: Nature Publishing Group
DOI: 10.1038/s41568-022-00442-9

MEK inhibition reverses aberrant signaling in melanoma cells through reorganization of NRas and BRAF in self nano-clusters

Autores: Oren Yakovian; Julia Sajman; Rand Arafeh; Yair Neve-Oz; Michal Alon; Yardena Samuels; Eilon Sherman
Publicado en: Cancer Research, Edición 81/5, 2021, ISSN 0008-5472
Editor: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-20-1205

Melanoma models for the next generation of therapies

Autores: E. Elizabeth Patton*, Kristen L. Mueller, David J. Adams, Niroshana Anandasabapathy, Andrew E. Aplin, Corine Bertolotto, Marcus Bosenberg, Craig J. Ceol, Ping Chi, Meenhard Herlyn, Sheri L. Holmen, Florian A. Karreth, Charles K. Kaufman, Shaheen Khan, Sebastian Kobold, Eleonora Leucci, Carmit Levy, David B. Lombard, Amanda W. Lund, Kerrie L. MarieJean Christophe Marine, Richard Marais, Martin McMa
Publicado en: Cancer Cell, 2021, ISSN 1535-6108
Editor: Cell Press
DOI: 10.1016/j.ccell.2021.01.011

Intratumor heterogeneity and anti-tumor immunity shape one another bidirectionally

Autores: Yochai Wolf*, Yardena Samuels*
Publicado en: Clinical Cancer Research, Edición 28/14, 2022, ISSN 1078-0432
Editor: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-21-1355

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