Combatting the CardioRenal Syndrome: towards an integrative Analysis to reduce cardiovascular burden in chronic kidney disease

Informations projet

CaReSyAn

N° de convention de subvention: 764474

DOI 10.3030/764474

Projet clôturé

Date de signature de la CE 10 Août 2017

Date de début 1 Janvier 2018

Date de fin 31 Decembre 2021

Financé au titre de

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coût total € 2 795 346,00

Contribution de l’UE € 2 795 346,00

Coordonné par

UNIVERSITAETSKLINIKUM AACHEN
Germany

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (2)

List of awarded doctoral degrees

A list of awarded doctoral degrees will be provided

ESR recruitment call for distribution

The MT will advertise for all ESR positions simultaneously within Europe to recruit the best possible candidates, and this through i) websites of CaReSyAn partners and Nature-jobs; ii) websites of related consortia (e.g. iMODE-CKD) and scientific foundations of which partners are members of (ERA-EDTA; EUTox); iii) active recruitment within own networks; and iv) targeting the peer-to-peer International Student Congress of (bio)Medical Sciences (ISCOMS) and its European partners in the International Federation of Medical Students Associations (IFMSA). The advertisements will give a broad description of knowledge and competencies required, but will not be so specialized to discourage suitable applicants. A transparent description of procedures of admission, supervision, awarding of doctoral degree, working conditions and career development prospects will be included.

Other (1)

Videoclips for the lay public

We will prepare an educational video clip on CRS pathology and risk factors, as well as video clip explaining each ESR project for the lay public. These video clips will become freely available on the CaReSyAn website.

Websites, patent fillings, videos etc. (2)

Frontiers Review Topics Series end eBook by CaReSyAn partners on CRS

A special Frontiers Review Topics Series and associated eBook is planned within the Open Access Journal Frontiers with contributions of the CaReSyAn partners and ESRs on the burden pathology and open research question of the CRS and with reference to the CaReSyAn Consortium

CaReSyAn website, Facebook profile and Twitter account

We will install a website, Facebook profile and Twitter account as important means of dissemination and outreach.

Publications

Peer reviewed articles (20)

Reduction of protein-bound uraemic toxins in plasma of chronic renal failure patients: A systematic review

Auteurs: V. Saar-Kovrov, W. Zidek, S. Orth-Alampour, D. Fliser, V. Jankowski, E. A. L. Biessen, J. Jankowski
Publié dans: Journal of Internal Medicine, 2021, ISSN 1365-2796
Éditeur: John Wiley & Sons Ltd
DOI: 10.1111/joim.13248

Serum and urinary biomarkers of collagen type-I turnover predict prognosis in patients with heart failure

Auteurs: Tianlin He, Jesus D Melgarejo, Andrew L Clark, Yu-Ling Yu, Lutgarde Thijs, Javier Díez, Begoña López, Arantxa González, John G Cleland, Joost P Schanstra, Antonia Vlahou, Agnieszka Latosinska, Harald Mischak, Jan A Staessen, Zhen-Yu Zhang, Vera Jankowski
Publié dans: Clinical and translational medicine, 2021, ISSN 2001-1326
Éditeur: John Wiley & Sons Ltd
DOI: 10.1002/ctm2.267

Urine peptidome analysis in cardiorenal syndrome reflects molecular processes

Auteurs: Eleni Petra, Tianlin He, Vasiliki Lygirou, Agnieszka Latosinska, Harald Mischak, Antonia Vlahou, Joachim Jankowski
Publié dans: Scientific Reports, 2021, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-021-95695-z

Development of the BioHybrid Assay: Combining Primary Human Vascular Smooth Muscle Cells and Blood to Measure Vascular Calcification Propensity

Auteurs: Armand M G Jaminon, Asim C Akbulut, Niko Rapp, Rafael Kramann, Erik A L Biessen, Lieve Temmerman, Barend Mees, Vincent Brandenburg, Robert Dzhanaev, Willi Jahnen-Dechent, Juergen Floege, Jouni Uitto, Chris P Reutelingsperger, Leon J Schurgers
Publié dans: Cells, 2021, ISSN 2073-4409
Éditeur: MDPI
DOI: 10.3390/cells10082097

Hepatic and Vascular Vitamin K Status in Patients with High Cardiovascular Risk

Auteurs: Nikolas Rapp; Vincent Brandenburg; Nadine Kaesler; Stephan J. L. Bakker; Robert Stöhr; Alexander Schuh; Pieter Evenepoel; Leon J. Schurgers; Leon J. Schurgers
Publié dans: Nutrients, Numéro 1, 2021, ISSN 2072-6643
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu13103490

Menaquinone-7 Supplementation Improves Osteogenesis in Pluripotent Stem Cell Derived Mesenchymal Stem Cells

Auteurs: Asim Cengiz Akbulut, Grzegorz B. Wasilewski, Nikolas Rapp, Francesco Forin, Heike Singer, Katrin J. Czogalla-Nitsche and Leon J. Schurgers
Publié dans: Frontiers in Cell and Developmental Biology, 2021, ISSN 2296-634X
Éditeur: Frontiers Media SA
DOI: 10.3389/fcell.2020.618760

Uremic Toxins and Vascular Calcification–Missing the Forest for All the Trees

Auteurs: Nikolas Rapp, Pieter Evenepoel, Peter Stenvinkel, Leon Schurgers
Publié dans: Toxins, 2020, ISSN 2072-6651
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/toxins12100624

The Role of Vascular Smooth Muscle Cells in Arterial Remodeling: Focus on Calcification-Related Processes.

Auteurs: Jaminon, Armand; Reesink, Koen; Kroon, Abraham; Schurgers, Leon
Publié dans: International Journal of Molecular Sciences, Numéro 1, 2019, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20225694

Associations of urinary polymeric immunoglobulin receptor peptides in the context of cardio-renal syndrome.

Auteurs: Tianlin He; Justyna Siwy; Jochen Metzger; William Mullen; Harald Mischak; Joost P. Schanstra; Joost P. Schanstra; Petra Zürbig; Vera Jankowski
Publié dans: Scientific Reports, Numéro 1, 2020, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-020-65154-2

Collagen-Derived Peptides in CKD: A Link to Fibrosis

Auteurs: Emmanouil Mavrogeorgis; Harald Mischak; Agnieszka Latosinska; Antonia Vlahou; Joost P. Schanstra; Justyna Siwy; Vera Jankowski; Joachim Beige; Joachim Jankowski
Publié dans: Toxins; Volume 14; Numéro 1; Pages: 10, Numéro 1, 2022, ISSN 2072-6651
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/toxins14010010

Shedding of Klotho: Functional Implications in Chronic Kidney Disease and Associated Vascular Disease

Auteurs: Valeria Saar-Kovrov, Marjo M. P. C. Donners and Emiel P. C. van der Vorst
Publié dans: Frontiers in Cardiovascular Medicine, 2021, ISSN 2297-055X
Éditeur: Frontiers Media SA
DOI: 10.3389/fcvm.2020.617842

Uremic Toxins Affecting Cardiovascular Calcification: A Systematic Review

Auteurs: Jana Holmar, Sofia de la Puente-Secades, Jürgen Floege, Heidi Noels, Joachim Jankowski, Setareh Orth-Alampour
Publié dans: Cells, 2020, ISSN 2073-4409
Éditeur: MDPI
DOI: 10.3390/cells9112428

Urine peptidome in combination with transcriptomics analysis highlights MMP7, MMP14 and PCSK5 for further investigation in chronic kidney disease

Auteurs: Eleni Petra, Justyna Siwy, Antonia Vlahou, Joachim Jankowski
Publié dans: Plos One, 2022, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0262667

Senescent Cells in Early Vascular Ageing and Bone Disease of Chronic Kidney Disease—A Novel Target for Treatment

Auteurs: Sam Hobson, Samsul Arefin, Karolina Kublickiene, Paul Shiels, Peter Stenvinkel
Publié dans: Toxins, Numéro 11/2, 2019, Page(s) 82, ISSN 2072-6651
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/toxins11020082

Urinary peptides in heart failure: a link to molecular pathophysiology

Auteurs: Tianlin He; Michaela Mischak; Andrew L. Clark; Ross T. Campbell; Christian Delles; Javier Díez; Gerasimos Filippatos; Alexandre Mebazaa; John J.V. McMurray; Arantxa González; Julia Raad; Rafael Stroggilos; Helle Bosselmann; Archie Campbell; Shona M. Kerr; Colette E. Jackson; Jane A. Cannon; Morten Schou; Nicolas Girerd; Patrick Rossignol; Alex McConnachie; Kasper Rossing; Joost P. Schanstra; Fai
Publié dans: European Journal of Heart Failure, Numéro 1, 2021, ISSN 1879-0844
Éditeur: John Wiley & Sons Ltd
DOI: 10.1002/ejhf.2195

Editorial on the Special Issue “Comorbidities in Chronic Kidney Disease”

Auteurs: Heidi Noels, Joachim Jankowski
Publié dans: Toxins, 2020, ISSN 2072-6651
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/toxins12060384

Peptides in Plasma, Urine, and Dialysate: Toward Unravelling Renal Peptide Handling

Auteurs: Tianlin He, Martin Pejchinovski, William Mullen, Joachim Beige, Harald Mischak, Vera Jankowski
Publié dans: Proteomics Clinical Applications, 2020, ISSN 1862-8354
Éditeur: John Wiley & Sons Ltd
DOI: 10.1002/prca.202000029

Development, establishment and validation of in vitro and ex vivo assays of vascular calcification

Auteurs: Jana Holmar, Heidi Noels, Michael Böhm, Shruti Bhargava, Joachim Jankowski, Setareh Orth-Alampour
Publié dans: Biochem Biophys Res Commun, 2020, ISSN 0006-291X
Éditeur: Academic Press
DOI: 10.1016/j.bbrc.2020.05.085

PRYNT: a tool for prioritization of disease candidates from proteomics data using a combination of shortest-path and random walk algorithms.

Auteurs: Franck Boizard; Bénédicte Buffin-Meyer; Bénédicte Buffin-Meyer; Julien Aligon; Olivier Teste; Joost P. Schanstra; Joost P. Schanstra; Julie Klein; Julie Klein
Publié dans: Scientific Reports, Numéro 1, 2021, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-021-85135-3

Reproducibility Evaluation of Urinary Peptide Detection Using CE-MS

Auteurs: Emmanouil Mavrogeorgis; Harald Mischak; Agnieszka Latosinska; Justyna Siwy; Vera Jankowski; Joachim Jankowski
Publié dans: Molecules, Numéro 1, 2021, ISSN 1420-3049
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules26237260