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Physiologically Anchored Tools for Realistic nanOmateriaL hazard aSsessment

Obiettivo

Nanotechnology promises significant scientific, economic and societal benefits, but commercialization and growth are threatened by safety uncertainties. Classical hazard testing strategies to define the human and environmental health impact of engineered nanomaterials (ENM) commonly apply unrealistic acute, high-doses to models that do not reflect the in vivo environment. Furthermore, existing in vitro and in silico hazard detection methods are not accurately predictive. PATROLS addresses these limitations by establishing and standardizing the next generation of advanced safety assessment tools for improved prediction of the adverse effects caused by chronic ENM exposure in human and environmental systems. PATROLS will deliver: 1) physiologically representative multi-cellular in vitro 3D lung, gastrointestinal tract and liver models; 2) cross-species models integrating human and environmental safety testing; 3) innovative ecotoxicity bioassays in several organisms across a food chain; 4) robust in silico models for dosimetry, interspecies toxicity extrapolation and hazard prediction. ENM characterization under physiologically relevant experimental conditions will be integral to this realistic, exposure driven strategy. A systems biology approach will also be adopted to identify key events linked to adverse outcome pathways, informing mechanism-based endpoints associated with real-life ENM exposures. These objectives will be achieved by an international network of world-leading academic, governmental, industrial, SME, risk assessment agency and NGO partners. The innovative in vitro and in silico nanosafety testing tools developed by PATROLS will balance speed, cost and biological complexity, while reducing uncertainty via improved predictive power. The smart targeted testing approach will drive a paradigm shift in (eco)toxicology towards mechanism-based ENM hazard assessment to support policy development in human and environmental nanosafety regulatory frameworks.

Campo scientifico

CORDIS classifica i progetti con EuroSciVoc, una tassonomia multilingue dei campi scientifici, attraverso un processo semi-automatico basato su tecniche NLP.

Programma(i)

Argomento(i)

Invito a presentare proposte

H2020-NMBP-2016-2017

Vedi altri progetti per questo bando

Bando secondario

H2020-NMBP-2017-two-stage

Meccanismo di finanziamento

RIA - Research and Innovation action

Coordinatore

SWANSEA UNIVERSITY
Contribution nette de l'UE
€ 1 511 623,50
Indirizzo
SINGLETON PARK
SA2 8PP Swansea
Regno Unito

Mostra sulla mappa
Tipo di attività
Higher or Secondary Education Establishments
Collegamenti
Costo totale
€ 1 511 623,50

Partecipanti (23)

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Ultimo aggiornamento: 6 Settembre 2024

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Permalink: https://cordis.europa.eu/project/id/760813/it

European Union, 2025