Deliverables
Design, fabrication and first characterization in EM shielded environment of a first version of a magnetic sensor formed by four LSMO based anisotropic magnetoresistance elements
Functional artificial neuronAssembly of an artificial neuron: an electronic device that will generate an electrical signal equivalent to that of a neuron in magnitude and temporal scale. This will be used as testing workbench of the magnetic-field sensors.
Bypass prototypeBypass prototype using the developed sensors and stimulating electrodes
First nanostructured electrodeFabrication of a first version of nanowire-coated elements using template-assisted electrochemical deposition
First nanostructured electrode on neuron-accesible substratesFabrication of a nanowire-coated element on a substrate suitable for accesing a neural sample
We will create a Linked-In group, and Facebook and Twitter profiles. Using as starting point the already existing networks of MFD, we will be invite representatives from the healthcare industry to join it. We will identify, join and actively contribute to other existing social-network groups related to brain-machine interfaces, especially those applied to spinal cord injuries.
Four non-specialists lecturesWe will give at least one scientific dissemination lecture per year
Organization of several events for disseminationEvery year, we will participate in several dissemination events as Open Days, Researcher’s Night, and local Science Weeks.
Website and project logoA website will be open with the project logo, and will be continuously updated
Second public report on the results of our biocompatibility studies of the magnetic sensors and nanostructured electrodes.
Public report on biocompatibility in vitro 3Third public report on the results of our biocompatibility studies of the magnetic sensors and nanostructured electrodes
Dissemination and Exploitation PlanWe will create a Dissemination and Exploitation Plan
Report on electrophysiological tests 2Updated report on the performance of the fabricated magnetic-field sensors and nanostructured contacts in organotypic cultures.
Public report on the bypass elements performance in organotypic systemsA public report on the ability to interface signalling with high resolution in organotypic systems
Public report summarizing results of the biocompatibility in vitroA public report on the biocompatibility in vitro of the fabricated nanomaterial-based devices
Public report on device developmentPublic report about the development and performance of the new neural interfaces
Report on the magnetic sensor and nanostructured electrode developmentReports on the status of the magnetic sensors and nanowire-coated electrodes development.
Public report on device development and performancePublic report about the development and performance of the new neural interfaces
Report on the bypass elements performance in vitroReport on the performance of the nanostructured electrodes for sensing and triggering synaptic signals both in individual neurons and in organotypic spinal cord cultures. A second updated report will be produced in month 48.
Public report on the magnetic sensors and nanostructured electrodes developmentA public report about the development status of both the magnetic sensors and the nanowire-coated electrodes
Public report on biocompatibility in vitro 1First public report on the results of our biocompatibility studies of the magnetic sensors and nanostructured electrodes
Publications
Author(s):
Matteo Manzati, Teresa Sorbo, Michele Giugliano, Laura Ballerini
Published in:
Molecular Brain, Issue 13/1, 2020, Page(s) 78, ISSN 1756-6606
Publisher:
BioMed Central
DOI:
10.1186/s13041-020-00619-z
Author(s):
Ana Domínguez‐Bajo, Beatriz Loreto Rodilla, Ivo Calaresu, Ana Arché‐Núñez, Ankor González‐Mayorga, Denis Scaini, Lucas Pérez, Julio Camarero, Rodolfo Miranda, Elisa López‐Dolado, María Teresa González, Laura Ballerini, María Concepción Serrano
Published in:
Advanced Biosystems, Issue 4/9, 2020, Page(s) 2000117, ISSN 2366-7478
Publisher:
Wiley Online Library
DOI:
10.1002/adbi.202000117
Author(s):
Bhimareddy Dinesh, Manuela Medelin, Denis Scaini, Federica Lareno Faccini, Federica Quici, Laura Ballerini, Alberto Bianco
Published in:
ACS Chemical Neuroscience, Issue 11/2, 2019, Page(s) 162-172, ISSN 1948-7193
Publisher:
American Chemical Society
DOI:
10.1021/acschemneuro.9b00522
Author(s):
Sadaf Usmani, Audrey Franceschi Biagioni, Manuela Medelin, Denis Scaini, Raffaele Casani, Emily R. Aurand, Daniel Padro, Ander Egimendia, Pedro Ramos Cabrer, Manuela Scarselli, Maurizio De Crescenzi, Maurizio Prato, Laura Ballerini
Published in:
Proceedings of the National Academy of Sciences, Issue 117/41, 2020, Page(s) 25212-25218, ISSN 0027-8424
Publisher:
National Academy of Sciences
DOI:
10.1073/pnas.2005708117
Author(s):
Niccolò Paolo Pampaloni, Denis Scaini, Fabio Perissinotto, Susanna Bosi, Maurizio Prato, Laura Ballerini
Published in:
Nanomedicine: Nanotechnology, Biology and Medicine, Issue 14/7, 2018, Page(s) 2521-2532, ISSN 1549-9634
Publisher:
Elsevier BV
DOI:
10.1016/j.nano.2017.01.020
Author(s):
Myriam Barrejón, Rossana Rauti, Laura Ballerini, Maurizio Prato
Published in:
ACS Nano, Issue 13/8, 2019, Page(s) 8879-8889, ISSN 1936-0851
Publisher:
American Chemical Society
DOI:
10.1021/acsnano.9b02429
Author(s):
Paolo Perna, Davide Maccariello, Fernando Ajejas, Ruben Guerrero, Laurence Méchin, Stephane Flament, Jacobo Santamaria, Rodolfo Miranda, Julio Camarero
Published in:
Advanced Functional Materials, Issue 27/26, 2017, Page(s) 1700664, ISSN 1616-301X
Publisher:
John Wiley & Sons Ltd.
DOI:
10.1002/adfm.201700664
Author(s):
Ankor González-Mayorga, Elisa López-Dolado, María C. Gutiérrez, Jorge E. Collazos-Castro, M. Luisa Ferrer, Francisco del Monte, María C. Serrano
Published in:
ACS Omega, Issue 2/11, 2017, Page(s) 8253-8263, ISSN 2470-1343
Publisher:
ACS Omega
DOI:
10.1021/acsomega.7b01354
Author(s):
Emily R. Aurand, Sadaf Usmani, Manuela Medelin, Denis Scaini, Susanna Bosi, Federica B. Rosselli, Sandro Donato, Giuliana Tromba, Maurizio Prato, Laura Ballerini
Published in:
Advanced Functional Materials, Issue 28/12, 2018, Page(s) 1700550, ISSN 1616-301X
Publisher:
John Wiley & Sons Ltd.
DOI:
10.1002/adfm.201700550
Author(s):
Sandeep Kumar Chaluvadi, Fernando Ajejas, Pasquale Orgiani, Olivier Rousseau, Giovanni Vinai, Aleksandr Yu Petrov, Piero Torelli, Alain Pautrat, Julio Camarero, Paolo Perna, Laurence Mechin
Published in:
Applied Physics Letters, Issue 113/5, 2018, Page(s) 052403, ISSN 0003-6951
Publisher:
American Institute of Physics
DOI:
10.1063/1.5020072
Author(s):
Niccolò P. Pampaloni, Ilaria Rago, Ivo Calaresu, Luca Cozzarini, Loredana Casalis, Andrea Goldoni, Laura Ballerini, Denis Scaini
Published in:
Developmental Neurobiology, Issue 80/9-10, 2020, Page(s) 316-331, ISSN 1932-8451
Publisher:
John Wiley & Sons Inc.
DOI:
10.1002/dneu.22711
Author(s):
Domínguez-Bajo, Ana
Published in:
Design and development of biomaterials for spinal cord injury repair, 2020
Publisher:
DIGITAL.CSIC
Author(s):
Olivier Rousseau, Stéphane Flament, Bruno Guillet, Marc Lam Chok Sing, Laurence Méchin
Published in:
Proceedings, Issue 1/4, 2017, Page(s) 635, ISSN 2504-3900
Publisher:
Proceedings of Eurosensors 2017
DOI:
10.3390/proceedings1040635
Author(s):
Guillet, Bruno; Flament, Stéphane; Liu, Shuang; Rousseau, Olivier; Aryan, Ammar; Lam Chok Sing, Marc; Méchin, Laurence; Routoure, Jean-Marc; enger, luiz,; Lebargy, Sylvain; Nascimento, Vanuza,; Wu, Sheng
Published in:
https://hal-normandie-univ.archives-ouvertes.fr/hal-02336146, Issue 1, 2019
Publisher:
25th International Conference on Noise and Fluctuations (ICNF 2019), 18 - 21 June 2019
DOI:
10.5075/epfl-iclab-icnf-269309
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