Immune activity Mapping of Carbon Nanomaterials

Deliverables

Report on computational models of CBMs behaviour in liquid environments and interactions with biomolecules

Trend in dispersibility of materials in dependence of functionalization and characterization of the inorganicbio interfaces in terms of interaction mechanisms

Computational modelling training

Training of seconded scientists on classical molecular dynamics simulation techniques

Immune genomic analysis training

Training of seconded scientists on experimental methods for gene expression profile and bioinformatics data analysis

Carbon nanotube fibers

Size controlled and well characterised CNTf suitable for biological applications

Final Report submitted to EU Commission

Final Reports submitted to EU Commission for periodic reporting

Progress report submitted to EU Commission

Progress Reports submitted to EU Commission for periodic reporting

Feedback on the immune-phenotypic and immune-genotypic impact of the different materials

Cytotoxicity phenotypic analysis and immunegenomic analysis for different materials

Immune cell-culture and multiparametric analysis training

Training of seconded scientists on experimental methods to prepare and characterize immune cells by highthroughput techniques

Functionalized graphenes oxides, exfoliated graphenes and graphenes nanoribbons

Size-controlled and well-characterised exfoliated graphenes, graphene oxide conjugates selectively functionalised with amino groups and GNRs functionalized with hydrophilic polymers of various structures

Materials Training

Training of seconded scientists on experimental methods to purify and characterize well reproducible and stable carbon nanomaterials

Progress reports submitted to EU Commission

Progress Reports submitted to EU Commission for periodic reporting

Minute conference calls for coordination of visiting periods

Report on information shared to coordinate the scientists secondments

Functionalized carbon nanotubes

size controlled and well characterized functionalized carbon nanotubes

Project website and seminars

Communication and dissemination tools gathering project website publications and seminars

Publications

Degradation of Structurally Defined Graphene Nanoribbons by Myeloperoxidase and the Photo-Fenton Reaction.

Author(s): Xiangfeng Luan; Cristina Martín; Pengfei Zhang; Qian Li; Isabella Anna Vacchi; Lucia Gemma Delogu; Yiyong Mai; Alberto Bianco
Published in: Angewandte Chemie - International Edition, 2020, ISSN 0570-0833
Publisher: Wiley
DOI: 10.1002/anie.202008925

Photodynamic Therapy Based on Graphene and MXene in Cancer Theranostics.

Author(s): Arianna Gazzi; Arianna Gazzi; Laura Fusco; Laura Fusco; Laura Fusco; Anooshay Khan; Davide Bedognetti; Barbara Zavan; Barbara Zavan; Flavia Vitale; Flavia Vitale; Acelya Yilmazer; Acelya Yilmazer; Lucia Gemma Delogu; Lucia Gemma Delogu
Published in: Frontiers in Bioengineering and Biotechnology, 2019, ISSN 2296-4185
Publisher: Lausanne: Frontiers Media
DOI: 10.3389/fbioe.2019.00295

Graphene oxide activates B cells with upregulation of granzyme B expression: evidence at the single-cell level for its immune-modulatory properties and anticancer activity

Author(s): Marco Orecchioni; Laura Fusco; Laura Fusco; Laura Fusco; Raghvendra Mall; Valentina Bordoni; Claudia Fuoco; Darawan Rinchai; Shi Guo; Raquel Sainz; Martina Zoccheddu; Cansu Gurcan; Açelya Yilmazer; Barbara Zavan; Cécilia Ménard-Moyon; Alberto Bianco; Wouter Hendrickx; Wouter Hendrickx; Davide Bedognetti; Davide Bedognetti; Davide Bedognetti; Lucia Gemma Delogu; Lucia Gemma Delogu
Published in: Nanoscale, Issue 1, 2022, ISSN 2040-3364
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1nr04355b

Impact of the surface functionalization on nanodiamond biocompatibility: a comprehensive view on human blood immune cells

Author(s): Fusco, Laura; Avitabile, Elisabetta; Armuzza, Valentina; Orecchioni, Marco; Istif, Akcan; Bedognetti, Davide; Da Ros, Tatiana; Delogu, Lucia Gemma
Published in: Carbon, 2020, ISSN 0008-6223
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.carbon.2020.01.003

2D MXenes with antiviral and immunomodulatory properties: A pilot study against SARS-CoV-2

Author(s): Unal, M.A., Bayrakdar, F., Fusco, L., Besbinar, O., Shuck, C.E., Yalcin, S., Erken, M.T., Ozkul, A., Gurcan, C., Panatli, O., Summak, G.Y., Gokce, C., Orecchioni, M., Gazzi, A., Vitale, F., Somers, J., Demir, E., Yildiz, S.S., Nazir, H., Grivel, J.-C., Bedognetti, D., Crisanti, A., Akcali, K.C., Gogotsi, Y., Delogu, L.G., Yilmazer, A.
Published in: Nano Today, 2021, ISSN 1748-0132
Publisher: Elsevier BV
DOI: 10.1016/j.nantod.2021.101136

Graphene, other carbon nanomaterials and the immune system: toward nanoimmunity-by-design

Author(s): Arianna Gazzi; Arianna Gazzi; Laura Fusco; Marco Orecchioni; Marco Orecchioni; Silvia Ferrari; Giulia Franzoni; J. Stephen Yan; Matthias Rieckher; Guotao Peng; Matteo Andrea Lucherelli; Isabella Anna Vacchi; Ngoc Do Quyen Chau; Alejandro Criado; Akcan Istif; Donato Mancino; Antonio Dominguez; Hagen Eckert; Ester Vázquez; Tatiana Da Ros; Paola Nicolussi; Vincenzo Palermo; Bjoern Schumacher; Gianau
Published in: Journal Phys Materials, 2020, ISSN 2515-7639
Publisher: IOP Publishing
DOI: 10.1088/2515-7639/ab9317

Graphene quantum dots: From efficient preparation to safe renal excretion

Author(s): Caroline Hadad; Jose M. González-Domínguez; Jose M. González-Domínguez; Silvia Armelloni; Deborah Mattinzoli; Masami Ikehata; Akcan Istif; Adrian Ostric; Francesco Cellesi; Carlo Alfieri; Carlo Alfieri; Piergiorgio Messa; Piergiorgio Messa; Belén Ballesteros; Tatiana Da Ros
Published in: Nano Research, 2021, ISSN 1998-0124
Publisher: Tsinghua Univ Press
DOI: 10.1007/s12274-020-3096-y

A closer look at the genotoxicity of graphene based materials

Author(s): Gurcan, Cansu; Taheri, Hadiseh; Bianco, Alberto; Delogu, Lucia Gemma; Yilmazer, Acelya
Published in: Journal of Physics: Materials, 2020, ISSN 2515-7639
Publisher: IOP Publishing
DOI: 10.1088/2515-7639/ab5844

Functionalization of filled radioactive multi-walled carbon nanocapsules by arylation reaction forin vivodelivery of radio-therapy

Author(s): Gajewska, A., Wang, J.T., Klippstein, R., Martincic, M., Pach, E., Feldman, R., Saccavini, J.-C., Tobias, G., Ballesteros, B., Al-Jamal, K.T., Da Ros, T
Published in: Journal of Materials Chemistry B, 2022, ISSN 2050-7518
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1tb02195h

Electrochemically controlled cleavage of imine bonds on a graphene platform: towards new electro-responsive hybrids for drug release

Author(s): Hui-Lei Hou; Lucia Cardo; Donato Mancino; Blanca Arnaiz; Alejandro Criado; Maurizio Prato; Maurizio Prato
Published in: Nanoscale, 2020, ISSN 2040-3364
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0nr04102e

Highly sensitive room temperature ammonia gas sensor using pristine graphene: The role of biocompatible stabilizer

Author(s): Huang, S., Panes-Ruiz, L.A., Croy, A., Löffler, M., Khavrus, V., Bezugly, V., Cuniberti, G.
Published in: Carbon, 2021, ISSN 0008-6223
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.carbon.2020.11.001

Enhanced visible-light photodegradation of fluoroquinolone-based antibiotics and E. coli growth inhibition using Ag-TiO2 nanoparticles

Author(s): Jiao Wang; Ladislav Svoboda; Zuzana Němečková; Massimo Sgarzi; Jiří Henych; Nadia Licciardello; Gianaurelio Cuniberti
Published in: RSC Advances, 2021, ISSN 2046-2069
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0ra10403e

Lateral dimension and amino-functionalization on the balance to assess the single-cell toxicity of graphene on fifteen immune cell types

Author(s): Fusco, L., Orecchioni, M., Reina, G., Bordoni, V., Fuoco, C., Gurcan, C., Guo, S., Zoccheddu, M., Collino, F., Zavan, B., Treossi, E., Yilmazer, A., Palermo, V., Bianco, A., Delogu, L.G.
Published in: NanoImpact, 2021, ISSN 2452-0748
Publisher: Elsevier
DOI: 10.1016/j.impact.2021.100330

Toxicological evaluation of highly water dispersible few-layer graphene in vivo

Author(s): Amalia Ruiz; Matteo Andrea Lucherelli; Diane Murera; Delphine Lamon; Cécilia Ménard-Moyon; Alberto Bianco
Published in: Carbon, 2020, ISSN 0008-6223
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.carbon.2020.08.023

Nanocytometer for smart analysis of peripheral blood and acute myeloid leukemia: a pilot study

Author(s): Julian Schütt; Julian Schütt; Diana Isabel Sandoval Bojorquez; Elisabetta Avitabile; Eduardo Sergio Oliveros Mata; Eduardo Sergio Oliveros Mata; Gleb Milyukov; Juliane Colditz; Lucia Gemma Delogu; Lucia Gemma Delogu; Martina Rauner; Anja Feldmann; Stefanie Koristka; Jan Moritz Middeke; Katja Sockel; Jürgen Fassbender; Michael Bachmann; Martin Bornhäuser; Gianaurelio Cuniberti; Larysa Baraban
Published in: Nano Letters, 2020, ISSN 1530-6984
Publisher: American Chemical Society
DOI: 10.1021/acs.nanolett.0c02300

Toward High-Dimensional Single-Cell Analysis of Graphene Oxide Biological Impact: Tracking on Immune Cells by Single-Cell Mass Cytometry.

Author(s): Marco Orecchioni; Valentina Bordoni; Claudia Fuoco; Giacomo Reina; Hazel Lin; Martina Zoccheddu; Açelya Yilmazer; Barbara Zavan; Gianni Cesareni; Davide Bedognetti; Alberto Bianco; Lucia Gemma Delogu; Lucia Gemma Delogu
Published in: Small, 2020, ISSN 1613-6829
Publisher: Wiley
DOI: 10.1002/smll.202000123

Carbon nanotubes for cardiac tissue regeneration: State of the art and perspectives

Author(s): Barrejón, M., Marchesan, S., Alegret, N., Prato, M.
Published in: Carbon, 2021, ISSN 0008-6223
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.carbon.2021.08.059

Toward Nanotechnology-Enabled Approaches against the COVID-19 Pandemic.

Author(s): Carsten Weiss; Marie Carrière; Laura Fusco; Laura Fusco; Ilaria Capua; Jose Angel Regla-Nava; Matteo Pasquali; James A. Scott; Flavia Vitale; Flavia Vitale; Mehmet Ünal; Cecilia Mattevi; Davide Bedognetti; Arben Merkoçi; Arben Merkoçi; Ennio Tasciotti; Ennio Tasciotti; Açelya Yilmazer; Yury Gogotsi; Francesco Stellacci; Lucia Gemma Delogu
Published in: ACS Nano, 2020, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.0c03697

Bioinspired Scaffold Action Under the Extreme Physiological Conditions of Simulated Space Flights: Osteogenesis Enhancing Under Microgravity

Author(s): Avitabile, E., Fusco, L., Minardi, S., Orecchioni, M., Zavan, B., Yilmazer, A., Rauner, M., Pippia, P., Tasciotti, E., Delogu, L.G.
Published in: Frontiers in Bioengineering and Biotechnology, 2020, ISSN 2296-4185
Publisher: Lausanne: Frontiers Media S.A.
DOI: 10.3389/fbioe.2020.00722

Stimulation of bone formation by monocyte-activator functionalized graphene oxide in vivo

Author(s): Bordoni, Valentina; Reina, Giacomo; Orecchioni, Marco; Furesi, Giulia; Thiele, Stefanie; Gardin, Chiara; Zavan, Barbara; Cuniberti, Gianaurelio; Bianco, Alberto; Rauner, Martina; Delogu, Lucia G.
Published in: Nanoscale, 2019, ISSN 2040-3364
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9nr03975a

Single-cell mass cytometry and transcriptome profiling reveal the impact of graphene on human immune cells

Author(s): Marco Orecchioni, Davide Bedognetti, Leon Newman, Claudia Fuoco, Filomena Spada, Wouter Hendrickx, Francesco M. Marincola, Francesco Sgarrella, Artur Filipe Rodrigues, Cécilia Ménard-Moyon, Gianni Cesareni, Kostas Kostarelos, Alberto Bianco, Lucia G Delogu
Published in: Nature Communications, Issue 8/1, 2017, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-017-01015-3

The reactivity of reduced graphene depends on solvation

Author(s): Hui-Lei Hou, Juan Pedro Merino, Alejandro Criado, Andreas Hirsch, Maurizio Prato
Published in: 2D Materials, Issue 6/2, 2019, Page(s) 025009, ISSN 2053-1583
Publisher: IOP Science
DOI: 10.1088/2053-1583/aafd9b

How can nanotechnology help the fight against breast cancer?

Author(s): Elisabetta Avitabile, Davide Bedognetti, Gianni Ciofani, Alberto Bianco, Lucia Gemma Delogu
Published in: Nanoscale, Issue 10/25, 2018, Page(s) 11719-11731, ISSN 2040-3364
Publisher: Royal Society of Chemistry
DOI: 10.1039/c8nr02796j

Silica and carbon decorated silica nanosheet impact on primary human immune cells

Author(s): Rola Mohammad Al Soubaihi, Giulia Furesi, Khaled Mohammad Saoud, Shaheen A. Al-Muhtaseb, Ahmed El Khatat, Lucia Gemma Delogu, Joydeep Dutta
Published in: Colloids and Surfaces B: Biointerfaces, Issue 172, 2018, Page(s) 779-789, ISSN 0927-7765
Publisher: Elsevier BV
DOI: 10.1016/j.colsurfb.2018.09.022

Controlled derivatization of hydroxyl groups of graphene oxide in mild conditions

Author(s): Isabella A Vacchi, Jésus Raya, Alberto Bianco, Cécilia Ménard-Moyon
Published in: 2D Materials, Issue 5/3, 2018, Page(s) 035037, ISSN 2053-1583
Publisher: IOP Science
DOI: 10.1088/2053-1583/aac8a9

Immune Profiling of Polysaccharide Submicron Vesicles

Author(s): Chiara C. Toma, Alessandra Aloisi, Valentina Bordoni, Riccardo Di Corato, Martina Rauner, Gianaurelio Cuniberti, Lucia G. Delogu, Rosaria Rinaldi
Published in: Biomacromolecules, Issue 19/8, 2018, Page(s) 3560-3571, ISSN 1525-7797
Publisher: American Chemical Society
DOI: 10.1021/acs.biomac.8b00832

2D and 3D Immobilization of Carbon Nanomaterials into PEDOT via Electropolymerization of a Functional Bis-EDOT Monomer.

Author(s): Antonio Dominguez-Alfaro; I. Jennifer Gomez; Nuria Alegret; David Mecerreyes; Maurizio Prato
Published in: Polymers, 2021, ISSN 2073-4360
Publisher: MDPI
DOI: 10.3390/polym13030436

Toward Spontaneous Neuronal Differentiation of SH-SY5Y Cells Using Novel Three-Dimensional Electropolymerized Conductive Scaffolds.

Author(s): Antonio Dominguez-Alfaro; Nuria Alegret; Nuria Alegret; Blanca Arnaiz; Maitane Salsamendi; David Mecerreyes; David Mecerreyes; Maurizio Prato; Maurizio Prato
Published in: ACS Applied Materials and Interfaces, 2020, ISSN 1944-8244
Publisher: American Chemical Society
DOI: 10.1021/acsami.0c16645

Tailored Methodology Based on Vapor Phase Polymerization to Manufacture PEDOT/CNT Scaffolds for Tissue Engineering

Author(s): Dominguez-Alfaro, Antonio; Alegret, Nuria; Arnaiz, Blanca; González-Domínguez, Jose M.; Martin-Pacheco, Ana; Cossío, Unai; Porcarelli, Luca; Bosi, Susanna; Vázquez, Ester; Mecerreyes, David; Prato, Maurizio
Published in: ACS Biomaterials Science and Engineering, 2020, ISSN 2373-9878
Publisher: ACS
DOI: 10.1021/acsbiomaterials.9b01316

Strategies for the Controlled Covalent Double Functionalization of Graphene Oxide.

Author(s): Isabella Anna Vacchi; Shi Guo; Jésus Raya; Alberto Bianco; Cécilia Ménard-Moyon
Published in: Chemistry - a European journal, 2020, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201905785

Biocompatibility studies of macroscopic fibers made from carbon nanotubes: Implications for carbon nanotube macrostructures in biomedical applications

Author(s): J. Stephen Yan; Marco Orecchioni; Marco Orecchioni; Flavia Vitale; Flavia Vitale; Julia A. Coco; Guillaume Duret; Salvatore Antonucci; Sushma Sri Pamulapati; Lauren W. Taylor; Oliver S. Dewey; Moises Di Sante; Anna Maria Segura; Cansu Gurcan; Fabio Di Lisa; Fabio Di Lisa; Açelya Yilmazer; Mark McCauley; Jacob T. Robinson; Mehdi Razavi; Klaus Ley; Lucia Gemma Delogu; Lucia Gemma Delogu; Matteo Pas
Published in: Carbon, 2021, ISSN 0008-6223
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.carbon.2020.10.077

Stabilization of aqueous graphene dispersions utilizing a biocompatible dispersant: a molecular dynamics study.

Author(s): Huang, Shirong; Croy, Alexander; Bezugly, Viktor; Cuniberti, Gianaurelio
Published in: Physical Chemistry Chemical Physics, 2019, ISSN 1463-9076
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9cp04742e

Deliverables

Publications

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