Deliverables
We will study the associations of individual earlylife stressors and the integrated earlylife exposome with cardiometabolic phenotypes at various ages across the life course and with trajectories of those phenotypes
Report on differences in DNA methylation loci that mediate the associations of early-life exposures with mental health and psychopathology life course trajectoriesWe will identify DNA methylation loci that mediate the relationships of earlylife stressors and the integrated earlylife exposome with mental health and disease trajectories
Report on the associations of DNA methylation loci related to early-life stressors with functional outcomes, including RNA expressionWe will explore associations of differences in DNA methylation at specific CpG sites discovered in EWAS with RNA expression levels methylationtranscription analyses using RNA expression data measured in some of the participating cohorts at various ages in childhood
Report on impact of early-life policies and interventions based on dynamic microsimulation modelsDynamic microsimulation modelling involves the generation of simulated data on individual units and is particularly suited for policy evaluations and scenario analyses It is a multiprocess simulation model in which each process is estimated at an individual level and feeds back into the other processes In LIFECYCLE the analytical framework and the specific models will be informed with populationspecific exposure prevalences and effect estimates of distal earlylife stressors and intermediates obtained from the EU Child Cohort Network and external data
Report on the associations of early-life stressors during preconception, pregnancy, infancy and early childhood with lung function developmental trajectories and the risk of asthma from childhood until young adulthoodWe will use individual participant data from the EU Child Cohort Network to identify earlylife stressors individually and integrated in the earlylife exposome with lung function trajectories and symptoms diagnosis and medication related to asthma Main outcomes include lung function FEV1 FEV1FVC FEF2575 FEF75 bronchial hyperresponsiveness and symptoms and diseases respiratory infections wheezing asthma
Report on internalizing and externalizing behavior and other mental health trajectories from birth to childhood, and their associations with psychopathology outcomesWe will model longitudinal life course trajectories of mental function from early life to adulthood using data from the EU Child Cohort Network These trajectories will include both tracking and stability of internalizing and externalizing behavioural indicators measured with the Child Behaviour Check List CBCL throughout childhood and the relationships of these behavioural indicators with psychopathology indicators in adolescence and adulthood
Report on associations of early-life stressors with DNA methylation at birthWe will use an EWAS approach to study the associations of the main indicators of early-life stressors and the integrated early-life exposome, before and during pregnancy on DNA methylation at birth measured in cord blood. We will also explore the associations of the overall early-life exposome, developed in WP3, during pregnancy, on cord blood methylation at birth.
Report on review of interventions focused on lifestyle stressors, to improve life course health trajectoriesWe will perform literature searches and reviews based on the developed strategies from deliverable 9.1. We will review evidence focused on interventions on lifestyle stressors of parents and young children. In line with WP3, these stressors will include parental smoking, alcohol consumption, illicit drug use, sleep, physical activity and parent and childhood nutritional intake and status.
Report on exposome models based on proof-of-principle studiesWe will develop protocols for analysis of associations of a fully integrated earlylife stressor model the earlylife exposome with lifecycle health outcomes and test these in proofofprinciple studies As input we will use the main earlylife stressors WP1 WP3 Deliverable 31 34 Proofofprinciple datasets will be those of the EUFP7 funded HELIX project wwwprojecthelixeu including six cohorts across Europe n1200 plus the Generation R Study n7000 and DNBC n70000
Report on review of interventions focused on migration stressors, to improve life course health trajectoriesWe will perform literature searches and reviews based on the developed strategies from deliverable 9.1. We will review evidence on interventions on stressors related to migration. In line with WP3, the stressors will include indicators at individual, neighbourhood and macro-levels such as country of origin of the individual, its parents, or grandparents, generation after migration, measurements of integration.
Report on approaches to analyse multiple stressor data in the context of longitudinal modellingIn WP3 we will develop models to analyse associations of multiple stressors many of which are multidimensional with health outcomes This task will further develop these methods by assessing approaches to analyse multiple correlated stressor data in the context of longitudinal modelling
Report on the persistence of DNA methylation differences related to early-life stressorsTo establish the role of DNA methylation differences on later life health outcomes in more detail and to better understand how these differences may exert effects, we will examine DNA methylation differences from birth to early adulthood in relation to early-life stressors.
Report on review of interventions focused on urban environment stressors, to improve life course health trajectoriesWe will perform literature searches and reviews based on the developed strategies from deliverable 9.1. We will review evidence focused on interventions on urban environment stressors. In line with WP3, these stressors will include measurements of air pollution, noise, green space, connectivity and walkability.
Report on the effects of early-life stressors on mental health and psychopathology life course trajectoriesWe will use data from the EU Child Cohort Network to study the associations of earlylife stressors including socioeconomic migrant urban environment and lifestyle related indicators and the integrated earlylife exposome with mental development mental health and risk factors for psychiatric diseases at various ages across the life course
Recommendations for public health strategies focused on future parents and young children to improve life course health trajectories from early life onwardsWe will develop recommendations for public health strategies based on findings from LIFECYCLE and systematic reviews of literature on interventions about modifications of earlylife stressors WP9
Report on early-life stressors that are related to both asthma throughout childhood and lung function and COPD in adulthoodWe will explore whether individual earlylife stressors and the integrated earlylife exposome related to impaired respiratory health at younger age also affect lung function and risk of COPD in adulthood
Report on review of interventions focused on socio-economic stressors, to improve life course health trajectoriesWe will perform literature searches and reviews based on the developed strategies from deliverable 9.1. We will review evidence focused on interventions on socio-economic inequalities In line with WP3, socio-economic related stressors will include parental education, occupation, type of employment contract, family income, family size, child care and house property and size.
Report on cardiovascular developmental trajectories during fetal life, infancy and early childhood, and the relationship with early-life exposures and cardiovascular risk factors in childhoodWe will use data from the EU Child Cohort Network partners that collected data before or during pregnancy and have detailed fetal and infant growth and cardiovascular development data. We will study associations of early-life stressors and the early-life exposome with adiposity and cardio-metabolic developmental trajectories in fetal life, infancy and early childhood (fetal and placental blood flow, cardiac and vascular dimensions, adiposity), and subsequently associations of these trajectories with risk factors for childhood for cardio-metabolic disease.
Report on the relationship of early-life exposures with differences in metabolic profiles and the extent to which these mediate associations of early-life exposures with cardio-metabolic risk factors and diseaseWe will explore the associations of individual earlylife stressors and the integrated earlylife exposome with a wide range of metabolites reflecting systemic metabolism that might mediate associations of earlylife exposures with subsequent cardiometabolic disease
Report on various life course models for the effects of early-life exposures on later cardio-metabolic risk factors and diseaseIn line with deliverable 41 and WP7 we will compare various potential life course models to best explain the relationships of earlylife stressors and potential mediators with trajectories of cardiometabolic risk factors and disease All EU Child Cohort Network cohorts will contribute to one or more of these trajectories
Report on DNA methylation changes as measures of early-life exposuresWe will explore if DNA methylation patterns can be used as markers for earlylife stressors Building on deliverables 8184 we will assess if DNA methylation sites or patterns that are related to earlylife stressors are able to accurately identify those exposed ie specific enough to the exposure in question
Report on to what extent differences in DNA methylation mediate the associations between early-life stressors and subsequent life course chronic obstructive respiratory health and disease trajectoriesWe will identify DNA methylation loci that mediate the relationships of earlylife stressors with chronic obstructive respiratory health and disease throughout the life course We will use data from studies that have epigenomewide data on DNA methylation which can be used for epigenomewide association studies EWAS metaanalyses to identify epigenetic markers associated with respiratory outcomes
Integrated summary report on recommendations on potential interventions focused on modification of early-life stressorsWe will integrate results from the reviews from deliverables 92 95 for recommendations for feasible effective and efficient interventions before or during pregnancy in infancy or in early childhood Specific subgroups of interest include socioeconomic and ethnic groups or subgroups identified at increased risk based on other parental or infant characteristics
Report on the relationships of early-life stressors with transient and persistent common allergies, and the extent to which these mediate associations of early-life stressors with life course chronic obstructive respiratory health and disease trajectoriesWe will relate individual earlylife stressors and the integrated earlylife exposome with common allergies from birth to young adulthood We will also examine if we can identify subgroups based on allergic and nonallergic pathways
Report on differences in DNA methylation loci that mediate the associations of early-life exposures with cardio-metabolic risk factors and diseaseWe will identify DNA methylation loci that mediate the associations of individual earlylife stressors and the integrated earlylife exposome with cardiometabolic risk factor trajectories and disease We will use data from studies that have epigenomewide data on DNA methylation which can be used for epigenomewide association studies EWAS metaanalyses to identify epigenetic markers associated with cardiometabolic outcomes
Report on approaches for longitudinal data/health trajectories in the context of life course analysesWe will provide a detailed description of analytical options to analyse repeated measurements data. We will cover theoretical biostatical aspects, the link between statistical modelling and the underlying biological frameworks and more practical applications dealing with issues of implementation and interpretation.
Report on patterns of core and integrated socio-economic, migration, urban environment and lifestyle related stressors across EuropeWe will use all core and integrated data from WP3 deliverables 3.1 - 3.4 and apply factor analysis and model-based latent class analysis to uncover the nature of the underlying dependencies between stressors and to define stressor patterns. Participating partner cohorts are those that have collected key variables in each of the areas. Particular attention will be paid to comparing of stressor patterns between regions
Report on approaches for causal inference in the context of life course trajectory analysesWe will develop an analysis plan providing a detailed description of options in study design and statistical analyses to apply causal inference methods to life course research. This will integrate theoretical and applied aspects, focusing on implementation and interpretation.
Report on the impact of early-life stressors on population and individual economic outcomesWe will identify links between earlylife stressors and economically related later life outcomes and elucidate mechanisms underlying these links We will use longitudinal data from the EU Child Cohort Network by linking earlylife stressors to economicallyrelated outcomes in childhood adolescence and adulthood Next we will use registrybased data from Statistics Netherlands CBS and Statistics Finland to relate earlylife stressors such as recessions to economically related outcomes later in life
Report on the relationship of early-life stressors with fetal and childhood brain developmental outcomes and the extent to which these mediate associations of early-life exposures with mental health and psychopathology life course trajectoriesWe will study brain development from the fetal period and childhood onwards by means of advanced imaging studies including repeated fetal ultrasound and childhood MRI brain studies We will first study the role of brain developmental adaptations in fetal life or childhood Generation R Generation R Next INMA ALSPAC BIB NFBC1986 RAINE and subsequently try to replicate the findings in adults NFBC1966 This deliverable will provide insights to the role of developmental structural and functional brain developmental adaptations in the relationships between earlylife stressors and mental health trajectories
We will use data from the EU Child Cohort Network to develop models (1) to predict from pregnancy and early childhood stressor data the onset of risk factors for cardio-metabolic, respiratory and mental outcomes throughout the life course (infant prediction models) and (2) to predict persistence of childhood cardio-metabolic, respiratory and mental outcomes (childhood prediction models).
Training course on causal inference methods and longitudinal modeling in the context of life course trajectory analysesThe courses will be developed to answer the main demands for theoretical and applied knowledge emerging from the interaction with WP4, WP5 and WP6.
E-learning module available onlineWe will develop an e-learning module, consolidating the scientific evidence base and status of recommendations of LIFECYCLE topics and outcomes. This e-learning module will be targeted to international AHPs and researchers working in the field and will be implemented and made publically available on the ENeA platform without access restriction (www.enea.moodle.elearning.lmu.de).
Tutorials on the implementation of causal inference methods and longitudinal modelling in the context of life course trajectory analysesWe will develop, in collaboration with WP4, WP5 and WP6, tutorials on selected outcomes to demonstrate the implementation of the analysis strategy in specific contexts. The main focus of the tutorials will be on the comparison of approaches and the interpretation of the resulting estimates.
We will maximize the impact of the main results for individuals by developing a website and mobile applications for individually customized advice to women and men before pregnancy and for pregnant women and young children
External project website launchedProject website accessible for general public and specific public. The website will be multi-layered. The homepage will be accessible to everyone; it will be based mainly on visual communication (videoclips, data visualisations, etc.); and it will link to specific pages for various stakeholder or target groups, including researchers, health care providers, patient organizations, patients and policymakers.
Publications
Author(s):
S. Sammallahti, M. E. Koopman-Verhoeff, A. C. Binter, R. H. Mulder, A. Cabre-Riera, T. Kvist, et al.
Published in:
Clin Epigenetics, Issue 18687075, 2022, ISSN 1868-7075
Publisher:
Springer Verlag
DOI:
10.1186/s13148-022-01298-4
Author(s):
S. Sammallahti, E. Holmlund-Suila, R. Zou, S. Valkama, J. Rosendahl, M. Enlund-Cerullo, et al.
Published in:
Eur Child Adolesc Psychiatry, Issue 10188827, 2021, ISSN 1018-8827
Publisher:
Dr. Dietrich Steinkopff Verlag
DOI:
10.1007/s00787-021-01894-4
Author(s):
S. M. Mensink-Bout, M. R. Jahangir, J. C. de Jongste, H. Raat, V. W. V. Jaddoe and L. Duijts
Published in:
Pediatr Allergy Immunol, Issue 09056157, 2022, ISSN 0905-6157
Publisher:
Blackwell Publishing Inc.
DOI:
10.1111/pai.13811
Author(s):
Florianne O L Vehmeijer, Susana Santos, Yolanda B de Rijke, Erica L T van den Akker, Janine F Felix, Elisabeth F C van Rossum, Vincent W V Jaddoe
Published in:
The Journal of Clinical Endocrinology & Metabolism, Issue 106/9, 2021, Page(s) e3400-e3413, ISSN 0021-972X
Publisher:
The Endocrine Society
DOI:
10.1210/clinem/dgab379
Author(s):
J. Auvinen, J. Tapio, V. Karhunen, J. Kettunen, R. Serpi, E. Y. Dimova, et al.
Published in:
Sci Adv, Issue 23752548, 2021, ISSN 2375-2548
Publisher:
American Association for the Advancement of Science
DOI:
10.1126/sciadv.abi4822
Author(s):
S. D. Poeran-Bahadoer, E. R. van Meel, R. Gaillard, V. W. V. Jaddoe and L. Duijts
Published in:
Pediatr Pulmonol, Issue 10990496, 2022, ISSN 1099-0496
Publisher:
Wiley-Liss Inc.
DOI:
10.1002/ppul.25747
Author(s):
S. Vogelezang, J. P. Bradfield, C. Early Growth Genetics, S. F. A. Grant, J. F. Felix and V. W. V. Jaddoe
Published in:
BMC Med Genomics, Issue 17558794, 2022, ISSN 1755-8794
Publisher:
BioMed Central
DOI:
10.1186/s12920-022-01281-1
Author(s):
V. Karhunen, T. A. Bond, V. Zuber, T. Hurtig, I. Moilanen, M. R. Jarvelin, et al.
Published in:
Transl Psychiatry, Issue 21583188, 2021, ISSN 2158-3188
Publisher:
Nature Publishing Group
DOI:
10.1038/s41398-021-01584-4
Author(s):
Maria Elisabeth Koopman‐Verhoeff, Rosa H. Mulder, Jared M. Saletin, Irwin Reiss, Gijsbertus T.J. Horst, Janine F. Felix, Mary A. Carskadon, Henning Tiemeier, Charlotte A.M. Cecil
Published in:
Journal of Child Psychology and Psychiatry, Issue 61/10, 2020, Page(s) 1061-1069, ISSN 0021-9630
Publisher:
Blackwell Publishing Inc.
DOI:
10.1111/jcpp.13252
Author(s):
Z. Deng, M. Lindeboom
Published in:
Journal of Applied Econometrics, Issue 08837252, 2022, ISSN 0883-7252
Publisher:
John Wiley & Sons Inc.
DOI:
10.1002/jae.2897
Author(s):
Edwina H. Yeung, Weihua Guan, Xuehuo Zeng, Lucas A. Salas, Sunni L. Mumford, Paula de Prado Bert, Evelien R. van Meel, Anni Malmberg, Jordi Sunyer, Liesbeth Duijts, Janine F. Felix, Darina Czamara, Esa Hämäläinen, Elisabeth B. Binder, Katri Räikkönen, Jari Lahti, Stephanie J. London, Robert M. Silver, Enrique F. Schisterman
Published in:
Clinical Epigenetics, Issue 12/1, 2020, ISSN 1868-7075
Publisher:
Springer Verlag
DOI:
10.1186/s13148-020-00852-2
Author(s):
Chandni Maria Jacob, Sarah Louise Killeen, Fionnuala M. McAuliffe, Judith Stephenson, Moshe Hod, Ivonne Diaz Yamal, Jaideep Malhotra, Edgar Mocanu, H. David McIntyre, Anne B. Kihara, Ronald C. Ma, Hema Divakar, Anil Kapur, Rui Ferriani, Ernest Ng, Laurie Henry, Zephne Van Der Spuy, Zev Rosenwaks, Mark A. Hanson
Published in:
International Journal of Gynecology & Obstetrics, Issue 151/S1, 2020, Page(s) 6-15, ISSN 0020-7292
Publisher:
Elsevier BV
DOI:
10.1002/ijgo.13331
Author(s):
Giulietta S. Monasso, Leanne K. Küpers, Vincent W. V. Jaddoe, Sandra G. Heil, Janine F. Felix
Published in:
Clinical Epigenetics, Issue 13/1, 2021, ISSN 1868-7075
Publisher:
Springer Verlag
DOI:
10.1186/s13148-021-01065-x
Author(s):
P. Choudhary, J. Ronkainen, R. Nedelec, M. Tolvanen, E. Lowry, J. Miettunen, et al.
Published in:
Int J Obes (Lond), Issue 03070565, 2022, ISSN 0307-0565
Publisher:
Nature Publishing Group
DOI:
10.1038/s41366-022-01134-y
Author(s):
E. Voerman, V. W. V. Jaddoe, E. Shokry, G. J. G. Ruijter, J. F. Felix, B. Koletzko, et al.
Published in:
Pediatr Obes, Issue 20476310, 2022, ISSN 2047-6310
Publisher:
Wiley-Blackwell for the International Association for the Study of Obesity
DOI:
10.1111/ijpo.12844
Author(s):
Alexander Kurilshikov, Carolina Medina-Gomez, Rodrigo Bacigalupe, Djawad Radjabzadeh, Jun Wang, Ayse Demirkan, Caroline I. Le Roy, Juan Antonio Raygoza Garay, Casey T. Finnicum, Xingrong Liu, Daria V. Zhernakova, Marc Jan Bonder, Tue H. Hansen, Fabian Frost, Malte C. Rühlemann, Williams Turpin, Jee-Young Moon, Han-Na Kim, Kreete Lüll, Elad Barkan, Shiraz A. Shah, Myriam Fornage, Joanna Szopinska
Published in:
Nature Genetics, Issue 53/2, 2021, Page(s) 156-165, ISSN 1061-4036
Publisher:
Nature Publishing Group
DOI:
10.1038/s41588-020-00763-1
Author(s):
Justiina Ronkainen, Anni Heiskala, Florianne O.L. Vehmeijer, Estelle Lowry, Doretta Caramaschi, Guadalupe Estrada Gutierrez, Jonathan A. Heiss, Nadine Hummel, Elina Keikkala, Tuomas Kvist, Allison Kupsco, Phillip E. Melton, Giancarlo Pesce, Munawar H. Soomro, Marta Vives-Usano, Nour Baiz, Elisabeth Binder, Darina Czamara, Mònica Guxens, Sanna Mustaniemi, Stephanie J. London, Sebastian Rauschert,
Published in:
Epigenetics, 2021, Page(s) 1-13, ISSN 1559-2294
Publisher:
Landes Bioscience
DOI:
10.1080/15592294.2020.1864171
Author(s):
M. J. Taeubert, P. de Prado-Bert, M. L. Geurtsen, G. Mancano, M. J. Vermeulen, I. K. M. Reiss, et al.
Published in:
Clin Epigenetics, Issue 18687075, 2022, ISSN 1868-7075
Publisher:
Springer Verlag
DOI:
10.1186/s13148-022-01276-w
Author(s):
Alexander Neumann, Esther Walton, Silvia Alemany, Charlotte Cecil, Juan Ramon González, Dereje D. Jima, Jari Lahti, Samuli T. Tuominen, Edward D. Barker, Elisabeth Binder, Doretta Caramaschi, Ángel Carracedo, Darina Czamara, Jorunn Evandt, Janine F. Felix, Bernard F. Fuemmeler, Kristine B. Gutzkow, Cathrine Hoyo, Jordi Julvez, Eero Kajantie, Hannele Laivuori, Rachel Maguire, Léa Maitre, Susan K
Published in:
Translational Psychiatry, Issue 10/1, 2020, ISSN 2158-3188
Publisher:
Nature Publishing Group
DOI:
10.1038/s41398-020-01058-z
Author(s):
S. Fernandez-Barres, O. Robinson, S. Fossati, S. Marquez, X. Basagana, J. de Bont, et al.
Published in:
Environ Int, Issue 01604120, 2022, ISSN 0160-4120
Publisher:
Pergamon Press Ltd.
DOI:
10.1016/j.envint.2022.107319
Author(s):
Susana Larrosa, Veronica Luque, Veit Grote, Ricardo Closa-Monasterolo, Natalia Ferré, Berthold Koletzko, Elvira Verduci, Dariusz Gruszfeld, Annick Xhonneux, Joaquin Escribano
Published in:
Nutrients, Issue 13/1, 2021, Page(s) 12, ISSN 2072-6643
Publisher:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/nu13010012
Author(s):
R.C. Huang, P.E. Melton, M.A. Burton, L.J. Beilin, R Clarke-Harris, E Cook, K.M. Godfrey, G.C. Burdge, T.A. Mori, D Anderson, S. Rauschert, J. M. Craig, M.S. Kobor, J.L. MacIsaac, A.M. Morin, W.H. Oddy, C.E. Pennell, J.D. Holbrook, K.A. Lillycrop
Published in:
Epigenetics, 2021, Page(s) 1-18, ISSN 1559-2294
Publisher:
Landes Bioscience
DOI:
10.1080/15592294.2021.1876297
Author(s):
D. Caramaschi, A. Neumann, A. Cardenas, G. Tindula, S. Alemany, L. Zillich, et al.
Published in:
Mol Psychiatry, Issue 13594184, 2022, ISSN 1359-4184
Publisher:
Nature Publishing Group
DOI:
10.1038/s41380-022-01441-w
Author(s):
Susana Santos, Léa Maitre, Charline Warembourg, Lydiane Agier, Lorenzo Richiardi, Xavier Basagaña, Martine Vrijheid
Published in:
European Journal of Epidemiology, Issue 35/3, 2020, Page(s) 193-204, ISSN 0393-2990
Publisher:
Kluwer Academic Publishers
DOI:
10.1007/s10654-020-00625-4
Author(s):
C. M. Jacob, H. M. Inskip, W. Lawrence, C. McGrath, F. M. McAuliffe, S. L. Killeen, et al.
Published in:
Nutrients, Issue 20726643, 2022, ISSN 2072-6643
Publisher:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/nu14173623
Author(s):
Sara M. Mensink-Bout, Trudy Voortman, Marsela Dervishaj, Irwin K. M. Reiss, Johan C. De Jongste, Vincent W. V. Jaddoe, Liesbeth Duijts
Published in:
Nutrients, Issue 12/10, 2020, Page(s) 3057, ISSN 2072-6643
Publisher:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/nu12103057
Author(s):
Costanza Pizzi, Matteo Richiardi, Marie-Aline Charles, Barbara Heude, Jean-Louis Lanoe, Sandrine Lioret, Sonia Brescianini, Virgilia Toccaceli, Martine Vrijheid, Franco Merletti, Daniela Zugna, Lorenzo Richiardi
Published in:
International Journal of Environmental Research and Public Health, Issue 17/5, 2020, Page(s) 1700, ISSN 1660-4601
Publisher:
MDPI
DOI:
10.3390/ijerph17051700
Author(s):
Brigitte Brands, Ngoc Nhan Tran, Erin Baudendistel-Happ, Marina Sanchez-Garcia, Martin R. Fischer, Berthold Koletzko
Published in:
Nutrients, Issue 13/3, 2021, Page(s) 775, ISSN 2072-6643
Publisher:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/nu13030775
Author(s):
Ling-Wei Chen, Adrien M. Aubert, Nitin Shivappa, Jonathan Y. Bernard, Sara M. Mensink-Bout, Aisling A. Geraghty, John Mehegan, Matthew Suderman, Kinga Polanska, Wojciech Hanke, Agnieszka Jankowska, Caroline L. Relton, Sarah R. Crozier, Nicholas C. Harvey, Cyrus Cooper, Mark Hanson, Keith M. Godfrey, Romy Gaillard, Liesbeth Duijts, Barbara Heude, James R. Hébert, Fionnuala M. McAuliffe, Cecily C.
Published in:
BMC Medicine, Issue 19/1, 2021, ISSN 1741-7015
Publisher:
BioMed Central
DOI:
10.1186/s12916-021-01908-7
Author(s):
C. Hu, L. Duijts, N.S. Erler, N.J. Elbert, C. Piketty, V. Bourdès, S. Blanchet‐Réthoré, J.C. Jongste, S.G.M.A. Pasmans, J.F. Felix, T. Nijsten
Published in:
British Journal of Dermatology, Issue 181/6, 2019, Page(s) 1190-1197, ISSN 0007-0963
Publisher:
Blackwell Publishing Inc.
DOI:
10.1111/bjd.17879
Author(s):
Mannan Luo, Alan J. Meehan, Esther Walton, Stefan Röder, Gunda Herberth, Ana C. Zenclussen, Marta Cosín‐Tomás, Jordi Sunyer, Rosa H. Mulder, Andrea P. Cortes Hidalgo, Marian J. Bakermans‐Kranenburg, Janine F. Felix, Caroline Relton, Matthew Suderman, Irene Pappa, Rianne Kok, Henning Tiemeier, Marinus H. IJzendoorn, Edward D. Barker, Charlotte A. M. Cecil
Published in:
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Issue 186/4, 2021, Page(s) 228-241, ISSN 1552-4841
Publisher:
Wiley-Liss Inc
DOI:
10.1002/ajmg.b.32862
Author(s):
B Penova-Veselinovic, P E Melton, R C Huang, J L Yovich, P Burton, L A Wijs, R J Hart
Published in:
Human Reproduction, Issue 36/7, 2021, Page(s) 2035-2049, ISSN 0268-1161
Publisher:
Oxford University Press
DOI:
10.1093/humrep/deab078
Author(s):
Chandni Maria Jacob, Despina D Briana, Gian Carlo Di Renzo, Neena Modi, Flavia Bustreo, Gabriella Conti, Ariadne Malamitsi-Puchner, Mark Hanson
Published in:
The Lancet Public Health, Issue 5/11, 2020, Page(s) e624-e627, ISSN 2468-2667
Publisher:
Elsevier Ltd.
DOI:
10.1016/s2468-2667(20)30200-0
Author(s):
Hugo G. Quezada-Pinedo, Florian Cassel, Liesbeth Duijts, Martina U. Muckenthaler, Max Gassmann, Vincent W. V. Jaddoe, Irwin K. M. Reiss, Marijn J. Vermeulen
Published in:
Nutrients, Issue 13/7, 2021, Page(s) 2221, ISSN 2072-6643
Publisher:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/nu13072221
Author(s):
Neena Modi, Mark Hanson
Published in:
BMJ, 2021, Page(s) n899, ISSN 1756-1833
Publisher:
BMJ
DOI:
10.1136/bmj.n899
Author(s):
C. M. Jacob, M. Hanson
Published in:
Practical Diabetes, Issue 20472897, 2022, ISSN 2047-2897
Publisher:
John Wiley & Sons Inc.
DOI:
10.1002/pdi.2404
Author(s):
Kathrin Guerlich, Dariusz Gruszfeld, Justyna Czech-Kowalska, Natàlia Ferré, Ricardo Closa-Monasterolo, Françoise Martin, Pascale Poncelet, Elvira Verduci, Berthold Koletzko, Veit Grote
Published in:
European Child & Adolescent Psychiatry, 2021, ISSN 1018-8827
Publisher:
Dr. Dietrich Steinkopff Verlag
DOI:
10.1007/s00787-021-01731-8
Author(s):
Kurt Taylor, Ahmed Elhakeem, Johanna Lucia Thorbjørnsrud Nader, Tiffany C. Yang, Elena Isaevska, Lorenzo Richiardi, Tanja Vrijkotte, Angela Pinot de Moira, Deirdre M. Murray, Daragh Finn, Dan Mason, John Wright, Sam Oddie, Nel Roeleveld, Jennifer R. Harris, Anne‐Marie Nybo Andersen, Massimo Caputo, Deborah A. Lawlor
Published in:
Journal of the American Heart Association, Issue 10/11, 2021, ISSN 2047-9980
Publisher:
Wiley-Blackwell
DOI:
10.1161/jaha.120.020051
Author(s):
Talat Bashir Ahmed, Merete Eggesbø, Rachel Criswell, Olaf Uhl, Hans Demmelmair, Berthold Koletzko
Published in:
Nutrients, Issue 20726643, 2022, ISSN 2072-6643
Publisher:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/nu14010158
Author(s):
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