Mechanical control of biological function

Deliverables

Plan for the Exploitation and Dissemination of Results
Characterization of mechanical and adhesive factors driving sub-cellular behaviour

Characterization of mechanical and adhesive factors driving sub-cellular behaviour, plus publication

Updated Plan for the Exploitation and Dissemination of Results M12

Update the Plan for the Exploitation and Dissemination of Results

Characterization of mechanical and adhesive factors driving cellular behaviour

Characterization of mechanical and adhesive factors driving cellular behaviour, plus publication.

Updated Plan for the Exploitation and Dissemination of Results M48

Update the Plan for the Exploitation and Dissemination of Results

Proof of concept tested and publication: human breast cancer xenografts can be treated/controlled by controlling tissue mechanics

Proof of concept tested and publication human breast cancer xenografts can be treatedcontrolled by controlling tissue mechanics

Proof of concept tested and publication: transplantation-based syngeneic mouse breast cancer model can be treated/controlled by controlling tissue mechanics

Proof of concept tested and publication transplantationbased syngeneic mouse breast cancer model can be treatedcontrolled by controlling tissue mechanics

Updated Plan for the Exploitation and Dissemination of Results M30

Update the Plan for the Exploitation and Dissemination of Results

Proof of concept tested and publication: mechanical-control can enhance the efficacy of current breast cancer treatments

Proof of concept tested and publication mechanicalcontrol can enhance the efficacy of current breast cancer treatments

Updated Plan for the Exploitation and Dissemination of Results M60

Update the Plan for the Exploitation and Dissemination of Results

Characterization of mechanical and adhesive factors driving monolayer behaviour

Characterization of mechanical and adhesive factors driving monolayer behaviour plus publication

Characterization of mechanical and adhesive factors driving organoid behaviour

Characterization of mechanical and adhesive factors driving organoid behaviour plus publication

Set-up of the continuum model coupling adhesion, cortex, membrane and matrix
Cohesive traction-separation law based on cell doublet data and detailed modeling, and new modeling-based quantitative protocols of adhesion based on spreading

Cohesive traction-separation law based on cell doublet data and detailed modeling, and new modeling-based quantitative protocols of adhesion based on spreading.

Set-up of the specific validation experiments for bond clusters, and Predictive models for the lifetime of a cluster
Set-up of the discrete stochastic models for bond clusters

Summer school
Logo and Public website of the project
Mechanobiology Meeting

Publications

Epithelial cell cluster size affects force distribution in response to EGF-induced collective contractility

Author(s): Chiara Zambarda, Carlos Perez Gonzalez, Andreas Schoenit, Nisha Veits, Clara Schimmer, Raimund Jung, Dirk Ollech, Joel Christian, Pere Roca-Cusachs, Xavier Trepat , Elisabetta Ada Cavalcanti-Adam
Published in: European Journal of Cell Biology, 2022, ISSN 0171-9335
Publisher: Elsevier BV
DOI: 10.1016/j.ejcb.2022.151274

Caveolin-1 dolines form a distinct and rapid caveolae-independent mechanoadaptation system

Author(s): Lolo FN, Walani N, Seemann E, Zalvidea D, Pavón DM, Cojoc G, Zamai M, Viaris de Lesegno C, Martínez de Benito F, Sánchez-Álvarez M, Uriarte JJ, Echarri A, Jiménez-Carretero D, Escolano JC, Sánchez SA, Caiolfa VR, Navajas D, Trepat X, Guck J, Lamaze C, Roca-Cusachs P, Kessels MM, Qualmann B, Arroyo M, Del Pozo MA.
Published in: Nature Cell Biology, 2022, ISSN 1465-7392
Publisher: Nature Publishing Group
DOI: 10.1038/s41556-022-01034-3

Digesting the mechanobiology of the intestinal epithelium

Author(s): Carlos Pérez-González, Gerardo Ceada, Marija Matejčić, Xavier Trepat
Published in: Current Opinion in Genetics & Development, 2021, ISSN 0959-437X
Publisher: Elsevier BV
DOI: 10.1016/j.gde.2021.10.005

Competition for endothelial cell polarity drives vascular morphogenesis in the mouse retina

Author(s): Pedro Barbacena, Maria Dominguez-Cejudo, Catarina G. Fonseca, Manuel Gomez-Gonzalez, Laura M. Faure, Georgia Zarkada, Andreia Pena, Anna Pezzarossa, Daniela Ramalho, Ylenia Giarratano, Marie Ouarne, David Barata, Isabela C. Fortunato, Lenka Henao Misikova, Ian Mauldin, Yulia Carvalho, Xavier Trepat, Pere Roca-Cusachs, Anne Eichmann, Miguel O. Bernabeu, and Claudio A. Franco
Published in: Developmental Cell, 2022, ISSN 1534-5807
Publisher: Cell Press
DOI: 10.1016/j.devcel.2022.09.002

Dynamic mechanochemical feedback between curved membranes and BAR protein self-organization

Author(s): Anabel-Lise Le Roux, Caterina Tozzi, Nikhil Walani, Xarxa Quiroga, Dobryna Zalvidea, Xavier Trepat, Margarita Staykova, Marino Arroyo & Pere Roca-Cusachs
Published in: Nature Communications, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-26591-3

Thiol-Methylsulfone-Based Hydrogels for 3D Cell Encapsulation

Author(s): Julieta I. Paez, Aleeza Farrukh, Rocío Valbuena-Mendoza, Małgorzata K. Włodarczyk-Biegun, Aránzazu del Campo
Published in: ACS Applied Materials & Interfaces, Issue 12/7, 2020, Page(s) 8062-8072, ISSN 1944-8244
Publisher: American Chemical Society
DOI: 10.1021/acsami.0c00709

Positive, negative and controlled durotaxis

Author(s): Sáez Viñas, Pablo; Venturini, Chiara
Published in: Soft Matter, 2023, ISSN 1744-683X
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2sm01326f

Cardiac fibroblasts and mechanosensation in heart development, health and disease

Author(s): Maurizio Pesce, Georg N. Duda, Giancarlo Forte, Henrique Girao, Angel Raya, Pere Roca-Cusachs, Joost P. G. Sluijter, Carsten Tschöpe & Sophie Van Linthout
Published in: Nature Review Cardiology, 2022, ISSN 1759-5002
Publisher: Nature Publishing Group
DOI: 10.1038/s41569-022-00799-2

Stiffness-dependent active wetting enables optimal collective cell durotaxis

Author(s): Macià Esteve Pallarès, Irina Pi-Jaumà, Isabela Corina Fortunato, Valeria Grazu, Manuel Gómez-González, Pere Roca-Cusachs, Jesus M. de la Fuente, Ricard Alert, Raimon Sunyer, Jaume Casademunt & Xavier Trepat
Published in: Nature Physics, 2022, ISSN 1745-2473
Publisher: Nature Publishing Group
DOI: 10.1038/s41567-022-01835-1

An asymmetric junctional mechanoresponse coordinates mitotic rounding with epithelial integrity

Author(s): Jooske L. Monster, Lisa Donker, Marjolein J. Vliem, Zaw Win, Helen K. Matthews, Joleen S. Cheah, Soichiro Yamada, Johan de Rooij, Buzz Baum, Martijn Gloerich
Published in: Journal of Cell Biology, Issue 220/5, 2021, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.202001042

Active wetting of epithelial tissues

Author(s): Carlos Pérez-González, Ricard Alert, Carles Blanch-Mercader, Manuel Gómez-González, Tomasz Kolodziej, Elsa Bazellieres, Jaume Casademunt, Xavier Trepat
Published in: Nature Physics, Issue 15/1, 2019, Page(s) 79-88, ISSN 1745-2473
Publisher: Nature Publishing Group
DOI: 10.1038/s41567-018-0279-5

Peeling dynamics of fluid membranes bridged by molecular bonds: moving or breaking

Author(s): Dimitri Kaurin, Pradeep K. Bal, Marino Arroyo
Published in: Journal of the Royal Society Interface, 2022, ISSN 1742-5689
Publisher: The Royal Society
DOI: 10.1098/rsif.2022.0183

Mechanical force application to the nucleus regulates nucleocytoplasmic transport

Author(s): Ion Andreu, Ignasi Granero-Moya, Nimesh R. Chahare, Kessem Clein, Marc Molina-Jordán, Amy E. M. Beedle, Alberto Elosegui-Artola, Juan F. Abenza, Leone Rossetti, Xavier Trepat, Barak Raveh, Pere Roca-Cusachs
Published in: Nature Cell Biology, 2022, ISSN 1465-7392
Publisher: Nature Publishing Group
DOI: 10.1038/s41556-022-00927-7

A theory of ordering of elongated and curved proteins on membranes driven by density and curvature

Author(s): Caterina Tozzi, Nikhil Walani, Anabel-Lise Le Roux, Pere Roca-Cusachs, Marino Arroyo
Published in: Soft Matter, Issue 17/12, 2021, Page(s) 3367-3379, ISSN 1744-683X
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0sm01733g

Thiol-Methylsulfone-Based Hydrogels for Cell Encapsulation: Reactivity Optimization of Aryl-Methylsulfone Substrate for Fine-Tunable Gelation Rate and Improved Stability

Author(s): Julieta I. Paez, Adrián de Miguel-Jiménez, Rocío Valbuena-Mendoza, Aditi Rathore, Minye Jin, Alisa Gläser, Samuel Pearson, Aránzazu del Campo
Published in: Biomacromolecules, 2021, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/acs.biomac.1c00256

Molecular Fluctuations as a Ruler of Force-Induced Protein Conformations

Author(s): Andrew Stannard, Marc Mora, Amy E. M. Beedle, Marta Castro-López, Stephanie Board, Sergi Garcia-Manyes
Published in: Nano Letters, Issue 21/7, 2021, Page(s) 2953-2961, ISSN 1530-6984
Publisher: American Chemical Society
DOI: 10.1021/acs.nanolett.1c00051

TLN1 contains a cancer-associated cassette exon that alters talin-1 mechanosensitivity

Author(s): Gallego-Paez, L. M., Edwards, W. J. S., Chanduri, M., Guo, Y., Koorman, T., Lee, C. Y., Grexa, N., Derksen, P., Yan, J., Schwartz, M. A., Mauer, J., & Goult, B. T.
Published in: Journal of Cell Biology, 2023, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.202209010

Mechanical strain stimulates COPII‐dependent secretory trafficking via Rac1

Author(s): Santosh Phuyal, Elena Djaerff, Anabel-Lise Le Roux, Martin J Baker, Daniela Fankhauser, Sayyed Jalil Mahdizadeh, Veronika Reiterer, Amirabbas Parizadeh, Edward Felder,Jennifer C Kahlhofer, David Teis, Marcelo G Kazanietz, Stephan Geley, Leif Eriksson, Pere Roca-Cusachs & Hesso Farhan
Published in: EMBO Journal, 2022, ISSN 1460-2075
Publisher: Wiley-Blackwell
DOI: 10.15252/embj.2022110596

Atlas of Lobular Breast Cancer Models: Challenges and Strategic Directions

Author(s): George Sflomos, Koen Schipper, Thijs Koorman, Amanda Fitzpatrick, Steffi Oesterreich, Adrian V. Lee, Jos Jonkers, Valerie G. Brunton, Matthias Christgen, Clare Isacke, Patrick W. B. Derksen, and Cathrin Brisken
Published in: Cancers, 2021, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13215396

Optoregulated force application to cellular receptors using molecular motors

Author(s): Yijun Zheng, Mitchell K. L. Han, Renping Zhao, Johanna Blass, Jingnan Zhang, Dennis W. Zhou, Jean-Rémy Colard-Itté, Damien Dattler, Arzu Çolak, Markus Hoth, Andrés J. García, Bin Qu, Roland Bennewitz, Nicolas Giuseppone & Aránzazu del Campo
Published in: Nature Communications, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-23815-4

SKOR1 mediates FER kinase-dependent invasive growth of breast cancer cells

Author(s): Sluimer, L. M., Bullock, E., Rätze, M. A. K., Enserink, L., Overbeeke, C., Hornsveld, M., Brunton, V. G., Derksen, P. W. B., & Tavares, S.
Published in: Journal of cell science, 2023, ISSN 0021-9533
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/jcs.260243

Mechanical compartmentalization of the intestinal organoid enables crypt folding and collective cell migration

Author(s): Pérez-González C; Ceada G; Greco F; Matej?i? M; Gómez-González M; Castro N; Menendez A; Kale S; Krndija D; Clark AG; Gannavarapu VR; Álvarez-Varela A; Roca-Cusachs P; Batlle E; Vignjevic DM; Arroyo M; Trepat X
Published in: Nature Cell Biology, 2021, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41556-021-00699-6

The ESCRT machinery counteracts Nesprin-2G-mediated mechanical forces during nuclear envelope repair

Author(s): Wallis SS, Ventimiglia, LN, Otigbah E, Infante E, Cuesta-Geijo MA, Kidiyoor GR, Carbajal MA, Fleck RA, Foiani M, Garcia-Manyes S, Martin-Serrano J, Agromayor M
Published in: Developmental Cell, 2021, ISSN 1534-5807
Publisher: Cell Press
DOI: 10.1016/j.devcel.2021.10.022

Understanding the role of mechanics in nucleocytoplasmic transport

Author(s): Ion Andreu, Ignasi Granero-Moya, Sergi Garcia-Manyes and Pere Roca-Cusachs
Published in: APL Bioengineering, 2022, ISSN 2473-2877
Publisher: American Institute of Physics
DOI: 10.1063/5.0076034

Out-of-equilibrium mechanochemistry and self-organization of fluid membranes interacting with curved proteins

Author(s): Caterina Tozzi, Nikhil Walani, Marino Arroyo
Published in: New Journal of Physics, Issue 21/9, 2019, Page(s) 093004, ISSN 1367-2630
Publisher: Institute of Physics Publishing
DOI: 10.1088/1367-2630/ab3ad6

Loss of E-cadherin leads to Id2-dependent inhibition of cell cycle progression in metastatic lobular breast cancer

Author(s): Max A. K. Rätze, Thijs Koorman, Thijmen Sijnesael, Blessing Bassey-Archibong, Robert van de Ven, Lotte Enserink, Daan Visser, Sridevi Jaksani, Ignacio Viciano, Elvira R. M. Bakker, François Richard, Andrew Tutt, Lynda O’Leary, Amanda Fitzpatrick, Pere Roca-Cusachs, Paul J. van Diest, Christine Desmedt, Juliet M. Daniel, Clare M. Isacke and Patrick W. B. Derksen
Published in: Oncogene, 2022, ISSN 0950-9232
Publisher: Nature Publishing Group
DOI: 10.1038/s41388-022-02314-w

Surface Tension Controls the Hydraulic Fracture of Adhesive Interfaces Bridged by Molecular Bonds

Author(s): Dimitri Kaurin, Marino Arroyo
Published in: Physical Review Letters, Issue 123/22, 2019, ISSN 0031-9007
Publisher: American Physical Society
DOI: 10.1103/physrevlett.123.228102

Modelling fluid deformable surfaces with an emphasis on biological interfaces

Author(s): Alejandro Torres-Sánchez, Daniel Millán, Marino Arroyo
Published in: Journal of Fluid Mechanics, Issue 872, 2019, Page(s) 218-271, ISSN 0022-1120
Publisher: Cambridge University Press
DOI: 10.1017/jfm.2019.341

Binding of anisotropic curvature-inducing proteins onto membrane tubes

Author(s): Hiroshi Noguchi, Caterina Tozzi and Marino Arroyo
Published in: Soft Matter, 2022, ISSN 1744-683X
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2sm00274d

Force transduction by cadherin adhesions in morphogenesis

Author(s): Willem-Jan Pannekoek, Johan de Rooij, Martijn Gloerich
Published in: F1000Research, Issue 8, 2019, Page(s) 1044, ISSN 2046-1402
Publisher: F1000 Research Ltd.
DOI: 10.12688/f1000research.18779.1

The 2020 motile active matter roadmap

Author(s): Gerhard Gompper, Roland G Winkler, Thomas Speck, Alexandre Solon, Cesare Nardini, Fernando Peruani, Hartmut Löwen, Ramin Golestanian, U Benjamin Kaupp, Luis Alvarez, Thomas Kiørboe, Eric Lauga, Wilson C K Poon, Antonio DeSimone, Santiago Muiños-Landin, Alexander Fischer, Nicola A Söker, Frank Cichos, Raymond Kapral, Pierre Gaspard, Marisol Ripoll, Francesc Sagues, Amin Doostmohammadi, Julia M
Published in: Journal of Physics: Condensed Matter, Issue 32/19, 2020, Page(s) 193001, ISSN 0953-8984
Publisher: Institute of Physics Publishing
DOI: 10.1088/1361-648x/ab6348

The mechanics of single cross-links which mediate cell attachment at a hydrogel surface

Author(s): Arzu Çolak, Bin Li, Johanna Blass, Kaloian Koynov, Aranzazu del Campo, Roland Bennewitz
Published in: Nanoscale, Issue 11/24, 2019, Page(s) 11596-11604, ISSN 2040-3364
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9nr01784d

Photodegradable Hydrogels for Cell Encapsulation and Tissue Adhesion

Author(s): Maria Villiou, Julieta I. Paez, Aránzazu del Campo
Published in: ACS Applied Materials & Interfaces, Issue 12/34, 2020, Page(s) 37862-37872, ISSN 1944-8244
Publisher: American Chemical Society
DOI: 10.1021/acsami.0c08568

Rethinking organoid technology through bioengineering

Author(s): Elena Garreta, Roger D. Kamm, Susana M. Chuva de Sousa Lopes, Madeline A. Lancaster, Ron Weiss, Xavier Trepat, Insoo Hyun, Nuria Montserrat
Published in: Nature Materials, Issue 20/2, 2021, Page(s) 145-155, ISSN 1476-1122
Publisher: Nature Publishing Group
DOI: 10.1038/s41563-020-00804-4

4D hydrogel for dynamic cell culture with orthogonal, wavelength-dependent mechanical and biochemical cues

Author(s): Yijun Zheng, Mitchell Kim Liong Han, Qiyang Jiang, Bin Li, Jun Feng, Aránzazu del Campo
Published in: Materials Horizons, Issue 7/1, 2020, Page(s) 111-116, ISSN 2051-6347
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9mh00665f

Spatial collagen stiffening promotes collective breast cancer cell invasion by reinforcing extracellular matrix alignment

Author(s): Thijs Koorman, Karin A. Jansen, Antoine Khalil, Peter D. Haughton, Daan Visser, Max A. K. Rätze, Wisse E. Haakma, Gabrielè Sakalauskaitè, Paul J. van Diest, Johan de Rooij and Patrick W. B. Derksen
Published in: Oncogene, 2022, ISSN 0950-9232
Publisher: Nature Publishing Group
DOI: 10.1038/s41388-022-02258-1

Toward Light-Regulated Living Biomaterials

Author(s): Shrikrishnan Sankaran, Shifang Zhao, Christina Muth, Julieta Paez, Aránzazu del Campo
Published in: Advanced Science, Issue 5/8, 2018, Page(s) 1800383, ISSN 2198-3844
Publisher: Wiley-VCH
DOI: 10.1002/advs.201800383

The nanomechanics of individual proteins

Author(s): Marc Mora, Andrew Stannard, Sergi Garcia-Manyes
Published in: Chemical Society Reviews, Issue 49/19, 2020, Page(s) 6816-6832, ISSN 0306-0012
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0cs00426j

Self-generated gradients steer collective migration on viscoelastic collagen networks

Author(s): Andrew G. Clark, Ananyo Maitra, Cécile Jacques , Martin Bergert , Carlos Pérez-González, Anthony Simon, Luc Lederer , Alba Diz-Muñoz, Xavier Trepat, Raphaël Voituriez, Danijela Matic Vignjevic
Published in: Nature materials, 2022, ISSN 1476-1122
Publisher: Nature Publishing Group
DOI: 10.1038/s41563-022-01259-5

Exogenous supply of Hsp47 triggers fibrillar collagen deposition in skin cell cultures in vitro

Author(s): Essak S. Khan, Shrikrishnan Sankaran, Lorena Llontop, Aránzazu del Campo
Published in: BMC Molecular and Cell Biology, Issue 21/1, 2020, ISSN 2661-8850
Publisher: BioMed Central Ltd
DOI: 10.1186/s12860-020-00267-0

FER regulates endosomal recycling and is a predictor for adjuvant taxane benefit in breast cancer

Author(s): Sandra Tavares, Nalan Liv, Milena Pasolli, Mark Opdam, Max A.K. Rätze, Manuel Saornil, Lilian M. Sluimer, Rutger C.C. Hengeveld, Robert van Es, Erik van Werkhoven, Harmjan Vos, Holger Rehmann, Boudewijn M.T. Burgering, Hendrika M. Oosterkamp, Susanne M.A. Lens, Judith Klumperman, Sabine C. Linn, Patrick W.B. Derksen
Published in: Cell reports, 2022, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2022.110584

αE-catenin is a candidate tumor suppressor for the development of E-cadherin-expressing lobular-type breast cancer

Author(s): Jolien S de Groot, Max AK Ratze, Miranda van Amersfoort, Tanja Eisemann, Eva J Vlug, Mijanou T Niklaas, Suet-Feung Chin, Carlos Caldas, Paul J van Diest, Jos Jonkers, Johan de Rooij, Patrick WB Derksen
Published in: The Journal of Pathology, Issue 245/4, 2018, Page(s) 456-467, ISSN 0022-3417
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/path.5099

Near-infrared-light regulated angiogenesis in a 4D hydrogel

Author(s): Yijun Zheng, Zhijun Chen, Qiyang Jiang, Jun Feng, Si Wu, Aránzazu del Campo
Published in: Nanoscale, Issue 12/25, 2020, Page(s) 13654-13661, ISSN 2040-3364
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0nr02552f

Physical Models of Collective Cell Migration

Author(s): Ricard Alert, Xavier Trepat
Published in: Annual Review of Condensed Matter Physics, Issue 11/1, 2020, Page(s) 77-101, ISSN 1947-5454
Publisher: Annual Reviews Inc.
DOI: 10.1146/annurev-conmatphys-031218-013516

Long-lived force patterns and deformation waves at repulsive epithelial boundaries

Author(s): Pilar Rodríguez-Franco, Agustí Brugués, Ariadna Marín-Llauradó, Vito Conte, Guiomar Solanas, Eduard Batlle, Jeffrey J. Fredberg, Pere Roca-Cusachs, Raimon Sunyer, Xavier Trepat
Published in: Nature Materials, Issue 16/10, 2017, Page(s) 1029-1037, ISSN 1476-1122
Publisher: Nature Publishing Group
DOI: 10.1038/NMAT4972

Force Triggers YAP Nuclear Entry by Regulating Transport across Nuclear Pores

Author(s): Alberto Elosegui-Artola, Ion Andreu, Amy E.M. Beedle, Ainhoa Lezamiz, Marina Uroz, Anita J. Kosmalska, Roger Oria, Jenny Z. Kechagia, Palma Rico-Lastres, Anabel-Lise Le Roux, Catherine M. Shanahan, Xavier Trepat, Daniel Navajas, Sergi Garcia-Manyes, Pere Roca-Cusachs
Published in: Cell, Issue 171/6, 2017, Page(s) 1397-1410.e14, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2017.10.008

Membrane tension controls adhesion positioning at the leading edge of cells

Author(s): Bruno Pontes, Pascale Monzo, Laurent Gole, Anabel-Lise Le Roux, Anita Joanna Kosmalska, Zhi Yang Tam, Weiwei Luo, Sophie Kan, Virgile Viasnoff, Pere Roca-Cusachs, Lisa Tucker-Kellogg, Nils C. Gauthier
Published in: The Journal of Cell Biology, 2017, Page(s) jcb.201611117, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.201611117

Force loading explains spatial sensing of ligands by cells

Author(s): Roger Oria, Tina Wiegand, Jorge Escribano, Alberto Elosegui-Artola, Juan Jose Uriarte, Cristian Moreno-Pulido, Ilia Platzman, Pietro Delcanale, Lorenzo Albertazzi, Daniel Navajas, Xavier Trepat, José Manuel García-Aznar, Elisabetta Ada Cavalcanti-Adam, Pere Roca-Cusachs
Published in: Nature, 2017, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/nature24662

Binding of ZO-1 to α5β1 integrins regulates the mechanical properties of α5β1–fibronectin links

Author(s): Víctor González-Tarragó, Alberto Elosegui-Artola, Elsa Bazellières, Roger Oria, Carlos Pérez-González, Pere Roca-Cusachs
Published in: Molecular Biology of the Cell, Issue 28/14, 2017, Page(s) 1847-1852, ISSN 1059-1524
Publisher: American Society for Cell Biology
DOI: 10.1091/mbc.E17-01-0006

Amoebae as Mechanosensitive Tanks

Author(s): Alberto Elosegui-Artola, Pere Roca-Cusachs
Published in: Biophysical Journal, Issue 112/12, 2017, Page(s) 2457-2458, ISSN 0006-3495
Publisher: Biophysical Society
DOI: 10.1016/j.bpj.2017.05.020

The force-dependent mechanism of DnaK-mediated mechanical folding

Author(s): Judit Perales-Calvo, David Giganti, Guillaume Stirnemann, Sergi Garcia-Manyes
Published in: Science Advances, Issue 4/2, 2018, Page(s) eaaq0243, ISSN 2375-2548
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciadv.aaq0243

Quantifying forces in cell biology

Author(s): Pere Roca-Cusachs, Vito Conte, Xavier Trepat
Published in: Nature Cell Biology, Issue 19/7, 2017, Page(s) 742-751, ISSN 1465-7392
Publisher: Nature Publishing Group
DOI: 10.1038/ncb3564

Molecular clutch drives cell response to surface viscosity

Author(s): Mark Bennett, Marco Cantini, Julien Reboud, Jonathan M. Cooper, Pere Roca-Cusachs, Manuel Salmeron-Sanchez
Published in: Proceedings of the National Academy of Sciences, Issue 115/6, 2018, Page(s) 1192-1197, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1710653115

Sticking, steering, squeezing and shearing: cell movements driven by heterotypic mechanical forces

Author(s): Anna Labernadie, Xavier Trepat
Published in: Current Opinion in Cell Biology, Issue 54, 2018, Page(s) 57-65, ISSN 0955-0674
Publisher: Elsevier BV
DOI: 10.1016/j.ceb.2018.04.008

4D Biomaterials for Light‐Guided Angiogenesis

Author(s): Aleeza Farrukh, Julieta I. Paez, Aránzazu del Campo
Published in: Advanced Functional Materials, Issue 29/6, 2019, Page(s) 1807734, ISSN 1616-301X
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.201807734

Supracellular contraction at the rear of neural crest cell groups drives collective chemotaxis

Author(s): Adam Shellard, András Szabó, Xavier Trepat, Roberto Mayor
Published in: Science, Issue 362/6412, 2018, Page(s) 339-343, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aau3301

Active superelasticity in three-dimensional epithelia of controlled shape

Author(s): Ernest Latorre, Sohan Kale, Laura Casares, Manuel Gómez-González, Marina Uroz, Léo Valon, Roshna V. Nair, Elena Garreta, Nuria Montserrat, Aránzazu del Campo, Benoit Ladoux, Marino Arroyo, Xavier Trepat
Published in: Nature, Issue 563/7730, 2018, Page(s) 203-208, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-018-0671-4

Mechanochemical feedback control of dynamin independent endocytosis modulates membrane tension in adherent cells

Author(s): Joseph Jose Thottacherry, Anita Joanna Kosmalska, Amit Kumar, Amit Singh Vishen, Alberto Elosegui-Artola, Susav Pradhan, Sumit Sharma, Parvinder P. Singh, Marta C. Guadamillas, Natasha Chaudhary, Ram Vishwakarma, Xavier Trepat, Miguel A. del Pozo, Robert G. Parton, Madan Rao, Pramod Pullarkat, Pere Roca-Cusachs, Satyajit Mayor
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-018-06738-5

Forcing the reversibility of a mechanochemical reaction

Author(s): Amy E. M. Beedle, Marc Mora, Colin T. Davis, Ambrosius P. Snijders, Guillaume Stirnemann, Sergi Garcia-Manyes
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-018-05115-6

In Situ, Light-Guided Axon Growth on Biomaterials via Photoactivatable Laminin Peptidomimetic IK(HANBP)VAV

Author(s): Aleeza Farrukh, Shifang Zhao, Julieta I. Paez, Atria Kavyanifar, Marcelo Salierno, Adolfo Cavalié, Aránzazu del Campo
Published in: ACS Applied Materials & Interfaces, Issue 10/48, 2018, Page(s) 41129-41137, ISSN 1944-8244
Publisher: American Chemical Society
DOI: 10.1021/acsami.8b15517

A hybrid computational model for collective cell durotaxis

Author(s): Jorge Escribano, Raimon Sunyer, María Teresa Sánchez, Xavier Trepat, Pere Roca-Cusachs, José Manuel García-Aznar
Published in: Biomechanics and Modeling in Mechanobiology, Issue 17/4, 2018, Page(s) 1037-1052, ISSN 1617-7959
Publisher: Springer Verlag
DOI: 10.1007/s10237-018-1010-2

Loss of E-Cadherin-Dependent Cell–Cell Adhesion and the Development and Progression of Cancer

Author(s): Heather C. Bruner, Patrick W.B. Derksen
Published in: Cold Spring Harbor Perspectives in Biology, Issue 10/3, 2018, Page(s) a029330, ISSN 1943-0264
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/cshperspect.a029330

Re-inforcing the cell death army in the fight against breast cancer

Author(s): Clara R. L. Oudenaarden, Robert A. H. van de Ven, Patrick W. B. Derksen
Published in: Journal of Cell Science, Issue 131/16, 2018, Page(s) jcs212563, ISSN 0021-9533
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/jcs.212563

Mesoscale physical principles of collective cell organization

Author(s): Xavier Trepat, Erik Sahai
Published in: Nature Physics, Issue 14/7, 2018, Page(s) 671-682, ISSN 1745-2473
Publisher: Nature Publishing Group
DOI: 10.1038/s41567-018-0194-9

DNA Binding Induces a Nanomechanical Switch in the RRM1 Domain of TDP-43

Author(s): Yong Jian Wang, Palma Rico-Lastres, Ainhoa Lezamiz, Marc Mora, Carles Solsona, Guillaume Stirnemann, Sergi Garcia-Manyes
Published in: The Journal of Physical Chemistry Letters, Issue 9/14, 2018, Page(s) 3800-3807, ISSN 1948-7185
Publisher: American Chemical Society
DOI: 10.1021/acs.jpclett.8b01494

A Photoactivatable α 5 β 1 -Specific Integrin Ligand

Author(s): Roshna V. Nair, Aleeza Farrukh, Aránzazu del Campo
Published in: ChemBioChem, Issue 19/12, 2018, Page(s) 1280-1287, ISSN 1439-4227
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.201800180

Control of Mechanotransduction by Molecular Clutch Dynamics

Author(s): Alberto Elosegui-Artola, Xavier Trepat, Pere Roca-Cusachs
Published in: Trends in Cell Biology, Issue 28/5, 2018, Page(s) 356-367, ISSN 0962-8924
Publisher: Elsevier BV
DOI: 10.1016/j.tcb.2018.01.008

Photoactivatable Adhesive Ligands for Light-Guided Neuronal Growth

Author(s): Aleeza Farrukh, Wenqiang Fan, Shifang Zhao, Marcelo Salierno, Julieta I. Paez, Aránzazu del Campo
Published in: ChemBioChem, Issue 19/12, 2018, Page(s) 1271-1279, ISSN 1439-4227
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.201800118

Regulation of cell cycle progression by cell–cell and cell–matrix forces

Author(s): Marina Uroz, Sabrina Wistorf, Xavier Serra-Picamal, Vito Conte, Marta Sales-Pardo, Pere Roca-Cusachs, Roger Guimerà, Xavier Trepat
Published in: Nature Cell Biology, Issue 20/6, 2018, Page(s) 646-654, ISSN 1465-7392
Publisher: Nature Publishing Group
DOI: 10.1038/s41556-018-0107-2

Mechanosensing at integrin-mediated cell–matrix adhesions: from molecular to integrated mechanisms

Author(s): Nils C Gauthier, Pere Roca-Cusachs
Published in: Current Opinion in Cell Biology, Issue 50, 2018, Page(s) 20-26, ISSN 0955-0674
Publisher: Elsevier BV
DOI: 10.1016/j.ceb.2017.12.014

TRPM7 controls mesenchymal features of breast cancer cells by tensional regulation of SOX4

Author(s): Arthur J. Kuipers, Jeroen Middelbeek, Kirsten Vrenken, Carlos Pérez-González, Geert Poelmans, Jeffrey Klarenbeek, Kees Jalink, Xavier Trepat, Frank N. van Leeuwen
Published in: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Issue 1864/7, 2018, Page(s) 2409-2419, ISSN 0925-4439
Publisher: Elsevier BV
DOI: 10.1016/j.bbadis.2018.04.017

Photoactivatable Hsp47: A Tool to Regulate Collagen Secretion and Assembly

Author(s): Essak S. Khan, Shrikrishnan Sankaran, Julieta I. Paez, Christina Muth, Mitchell K. L. Han, Aránzazu del Campo
Published in: Advanced Science, Issue 6/9, 2019, Page(s) 1801982, ISSN 2198-3844
Publisher: WILEY-VCH Verlag GmbH & Co. KGaA
DOI: 10.1002/advs.201801982

Traction forces at the cytokinetic ring regulate cell division and polyploidy in the migrating zebrafish epicardium

Author(s): Marina Uroz, Anna Garcia-Puig, Isil Tekeli, Alberto Elosegui-Artola, Juan F. Abenza, Ariadna Marín-Llauradó, Silvia Pujals, Vito Conte, Lorenzo Albertazzi, Pere Roca-Cusachs, Ángel Raya, Xavier Trepat
Published in: Nature Materials, 2019, ISSN 1476-1122
Publisher: Nature Publishing Group
DOI: 10.1038/s41563-019-0381-9

The plasma membrane as a mechanochemical transducer

Author(s): Anabel-Lise Le Roux, Xarxa Quiroga, Nikhil Walani, Marino Arroyo, Pere Roca-Cusachs
Published in: Philosophical Transactions of the Royal Society B: Biological Sciences, Issue 374/1779, 2019, Page(s) 20180221, ISSN 0962-8436
Publisher: Royal Society of London
DOI: 10.1098/rstb.2018.0221

Patterning of human epidermal stem cells on undulating elastomer substrates reflects differences in cell stiffness

Author(s): Seyedeh Atefeh Mobasseri, Sebastiaan Zijl, Vasiliki Salameti, Gernot Walko, Andrew Stannard, Sergi Garcia-Manyes, Fiona M. Watt
Published in: Acta Biomaterialia, Issue 87, 2019, Page(s) 256-264, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2019.01.063

The mechanical stability of proteins regulates their translocation rate into the cell nucleus

Author(s): Elvira Infante, Andrew Stannard, Stephanie J. Board, Palma Rico-Lastres, Elena Rostkova, Amy E. M. Beedle, Ainhoa Lezamiz, Yong Jian Wang, Samuel Gulaidi Breen, Fani Panagaki, Vinoth Sundar Rajan, Catherine Shanahan, Pere Roca-Cusachs, Sergi Garcia-Manyes
Published in: Nature Physics, 2019, ISSN 1745-2473
Publisher: Nature Publishing Group
DOI: 10.1038/s41567-019-0551-3

Fine tuning the extracellular environment accelerates the derivation of kidney organoids from human pluripotent stem cells

Author(s): Elena Garreta, Patricia Prado, Carolina Tarantino, Roger Oria, Lucia Fanlo, Elisa Martí, Dobryna Zalvidea, Xavier Trepat, Pere Roca-Cusachs, Aleix Gavaldà-Navarro, Luca Cozzuto, Josep M. Campistol, Juan Carlos Izpisúa Belmonte, Carmen Hurtado del Pozo, Nuria Montserrat
Published in: Nature Materials, Issue 18/4, 2019, Page(s) 397-405, ISSN 1476-1122
Publisher: Nature Publishing Group
DOI: 10.1038/s41563-019-0287-6

Integrins as biomechanical sensors of the microenvironment

Author(s): Jenny Z. Kechagia, Johanna Ivaska, Pere Roca-Cusachs
Published in: Nature Reviews Molecular Cell Biology, Issue 20/8, 2019, Page(s) 457-473, ISSN 1471-0072
Publisher: Nature Publishing Group
DOI: 10.1038/s41580-019-0134-2

Cadherin mechanotransduction in leader-follower cell specification during collective migration

Author(s): Antoine A. Khalil, Johan de Rooij
Published in: Experimental Cell Research, Issue 376/1, 2019, Page(s) 86-91, ISSN 0014-4827
Publisher: Academic Press
DOI: 10.1016/j.yexcr.2019.01.006

The Role of Mitotic Cell-Substrate Adhesion Re-modeling in Animal Cell Division

Author(s): Christina L. Dix, Helen K. Matthews, Marina Uroz, Susannah McLaren, Lucie Wolf, Nicholas Heatley, Zaw Win, Pedro Almada, Ricardo Henriques, Michael Boutros, Xavier Trepat, Buzz Baum
Published in: Developmental Cell, Issue 45/1, 2018, Page(s) 132-145.e3, ISSN 1534-5807
Publisher: Cell Press
DOI: 10.1016/j.devcel.2018.03.009

Gelation Kinetics and Mechanical Properties of Thiol‐Tetrazole Methylsulfone Hydrogels Designed for Cell Encapsulation

Author(s): Adrián de Miguel-Jiménez, Bastian Ebeling, Julieta I. Paez, Claudia Fink-Straube, Samuel Pearson, Aránzazu del Campo
Published in: Macromolecular Bioscience, 2022, ISSN 1616-5195
Publisher: Wiley-VCH Verlag
DOI: 10.1002/mabi.202200419

Elastomeric Optical Waveguides by Extrusion Printing

Author(s): Jun Feng, Yijun Zheng, Qiyang Jiang, Małgorzata K. Włodarczyk-Biegun, Samuel Pearson, and Aránzazu del Campo
Published in: Advanced Materials Technologies, 2022, ISSN 2365-709X
Publisher: Wiley-Blackwell
DOI: 10.1002/admt.202101539

Lighting the Path: Light Delivery Strategies to Activate Photoresponsive Biomaterials In Vivo

Author(s): Samuel Pearson; Jun Feng; Jun Feng; Aránzazu del Campo; Aránzazu del Campo
Published in: Advanced Functional Materials, Issue 7, 2021, ISSN 1616-301X
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202105989

Embryonic self-fracking

Author(s): Marino Arroyo, Xavier Trepat
Published in: Science, Issue 365/6452, 2019, Page(s) 442-443, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aay2860

Enhanced statistical sampling reveals microscopic complexity in the talin mechanosensor folding energy landscape

Author(s): Tapia-Rojo, R; Mora, M; Board, S.J.; Walker, J; Boujemaa-Paterski, R.; Medalia, O; Garcia-Manyes, S.
Published in: Nature Physics, 2022, ISSN 1745-2473
Publisher: Nature Publishing Group
DOI: 10.1038/s41567-022-01808-4

The role of single-protein elasticity in mechanobiology

Author(s): Amy E. M. Beedle, Sergi Garcia-Manyes
Published in: Nature Review Materials, 2022, ISSN 2058-8437
Publisher: Nature Publishing Group
DOI: 10.1038/s41578-022-00488-z

A mechanical G2 checkpoint controls epithelial cell division through E-cadherin-mediated regulation of Wee1-Cdk1

Author(s): Donker L, Houtekamer R, Vliem M, Sipieter F, Canever H, Gómez-González M, Bosch-Padrós M, Pannekoek WJ, Trepat X, Borghi N, Gloerich M.
Published in: Cell Reports, 2022, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2022.111475

Protein nanomechanics: The power of stretching

Author(s): Marc Mora, Sergi Garcia-Manyes
Published in: Europhysics News, Issue 51/5, 2020, Page(s) 24-27, ISSN 0531-7479
Publisher: European Physical Society
DOI: 10.1051/epn/2020503

LGR6-dependent conditional inactivation of E-cadherin and p53 leads to invasive skin and mammary carcinomas in mice

Author(s): Eline J. ter Steege; Thijmen Sijnesael; Lotte Enserink; Sjoerd Klarenbeek; Wisse E. Haakma; Elvira R.M. Bakker; Patrick W.B. Derksen
Published in: Neoplasia, 2022, ISSN 1522-8002
Publisher: Elsevier BV
DOI: 10.1016/j.neo.2022.100844

Extracellular matrix anisotropy is determined by TFAP2C-dependent regulation of cell collisions

Author(s): Danielle Park, Esther Wershof, Stefan Boeing, Anna Labernadie, Robert P. Jenkins, Samantha George, Xavier Trepat, Paul A. Bates, Erik Sahai
Published in: Nature Materials, Issue 19/2, 2020, Page(s) 227-238, ISSN 1476-1122
Publisher: Nature Publishing Group
DOI: 10.1038/s41563-019-0504-3

A Single-Molecule Strategy to Capture Non-native Intramolecular and Intermolecular Protein Disulfide Bridges

Author(s): Marc Mora, Stephanie Board, Olivier Languin-Cattoën, Laura Masino, Guillaume Stirnemann, Sergi Garcia-Manyes
Published in: Nano Letters, 2022, ISSN 1530-6984
Publisher: American Chemical Society
DOI: 10.1021/acs.nanolett.2c00043

The force loading rate drives cell mechanosensing through both reinforcement and cytoskeletal softening

Author(s): Ion Andreu, Bryan Falcones, Sebastian Hurst, Nimesh Chahare, Xarxa Quiroga, Anabel-Lise Le Roux, Zanetta Kechagia, Amy E. M. Beedle, Alberto Elosegui-Artola, Xavier Trepat, Ramon Farré, Timo Betz, Isaac Almendros & Pere Roca-Cusachs
Published in: Nature Communications, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-24383-3

Possibilities and Limitations of Photoactivatable Cytochalasin D for the Spatiotemporal Regulation of Actin Dynamics

Author(s): Roshna V. Nair, Shifang Zhao, Emmanuel Terriac, Franziska Lautenschläger, Joseph H.R. Hetmanski, Patrick T. Caswell, Aranzazu del Campo
Published in: ChemRxiv, 2020, ISSN 2573-2293
Publisher: ChemRxiv
DOI: 10.26434/chemrxiv.12609545.v1

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Application/Publication number: 20 20067410
Date: 2020-06-23
Applicant(s): LEIBNIZ-INSTITUT FUER NEUE MATERIALIEN GEMEINNUETZIGE GMBH

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