MIcrobiota-Gut-BraiN EngineeRed platform to eVAluate intestinal microflora impact on brain functionality

Project Information

MINERVA

Grant agreement ID: 724734

DOI 10.3030/724734

Project closed

EC signature date 13 March 2017

Start date 1 May 2017

End date 31 October 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 999 194,00

EU contribution € 1 999 194,00

Coordinated by

POLITECNICO DI MILANO
Italy

Publications

Peer reviewed articles (14)

The microbiota-gut-brain axis and epilepsy from a multidisciplinary perspective: Clinical evidenceand technological solutions for improvement of in vitro preclinical models

Author(s): Federica Fusco, Simone Perottoni, Carmen Giordano, Antonella Riva, Luigi Francesco Iannone, Carmen De Caro, Emilio Russo, Diego Albani, Pasquale Striano
Published in: Bioengineering & Translational medicine, 2022, Page(s) e10296, ISSN 2380-6761
Publisher: John Wiley & Sons, Inc.
DOI: 10.1002/btm2.10296

3D brain tissue physiological model with co-cultured primary neurons and glial cells in hydrogels

Author(s): Ilaria Raimondi, Marta Tunesi, Gianluigi Forloni, Diego Albani, Carmen Giordano
Published in: Journal of Tissue Engineering, Issue 11, 2020, Page(s) 204173142096398, ISSN 2041-7314
Publisher: SAGE Publisher
DOI: 10.1177/2041731420963981

MINERVA: The technological project to boost research on the microbiota-gut-brain axis in chronic neurodegenerative disorders

Author(s): Carmen Giordano, Diego Albani
Published in: AGRO FOOD INDUSTRY HI-TECH, Issue 28 (6), 2017, Page(s) 48-50, ISSN 1722-6996
Publisher: Teknoscienze s.r.l.

Influence of the static magnetic field on cell response in a miniaturized optically accessible bioreactor for 3D cell culture

Author(s): Luca Izzo, Marta Tunesi, Lucia Boeri, Matteo Laganà, Carmen Giordano, Manuela Teresa Raimondi
Published in: Biomedical Microdevices, Issue 21/1, 2019, ISSN 1387-2176
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10544-019-0387-8

An Organ-On-A-Chip Engineered Platform to Study the Microbiota–Gut–Brain Axis in Neurodegeneration

Author(s): Manuela Teresa Raimondi, Diego Albani, Carmen Giordano
Published in: Trends in Molecular Medicine, Issue 25/9, 2019, Page(s) 737-740, ISSN 1471-4914
Publisher: Elsevier BV
DOI: 10.1016/j.molmed.2019.07.006

Towards bioinspired in vitro models of intestinal mucus

Author(s): Lorenzo Sardelli, Daniela Peneda Pacheco, Anna Ziccarelli, Marta Tunesi, Omar Caspani, Andrea Fusari, Francesco Briatico Vangosa, Carmen Giordano, Paola Petrini
Published in: RSC Advances, Issue 9/28, 2019, Page(s) 15887-15899, ISSN 2046-2069
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9ra02368b

Advanced Organ-on-a-Chip Devices to Investigate Liver Multi-Organ Communication: Focus on Gut, Microbiota and Brain

Author(s): Lucia Boeri, Luca Izzo, Lorenzo Sardelli, Marta Tunesi, Diego Albani, Carmen Giordano
Published in: Bioengineering, Issue 6/4, 2019, Page(s) 91, ISSN 2306-5354
Publisher: Basel : MDPI AG, 2014-
DOI: 10.3390/bioengineering6040091

CURRENT PERSPECTIVES ON THE MICROBIOTA-GUT-BRAIN AXIS IN CHRONIC NEURODEGENERATIVE DISORDERS

Author(s): Diego Albani, Carmen Giordano
Published in: Istituto Lombardo - Accademia di Scienze e Lettere - Rendiconti di Scienze, Issue 151, 2020, Page(s) 1-12, ISSN 2384-986X
Publisher: PAGEPress
DOI: 10.4081/scie.2017.641

Organ-On-A-Chip in vitro Models of the Brain and the Blood-Brain Barrier and Their Value to Study the Microbiota-Gut-Brain Axis in Neurodegeneration

Author(s): Ilaria Raimondi, Luca Izzo, Marta Tunesi, Manola Comar, Diego Albani, Carmen Giordano
Published in: Frontiers in Bioengineering and Biotechnology, Issue 7, 2020, Page(s) 1-17, ISSN 2296-4185
Publisher: Lausanne : Frontiers Editorial Office
DOI: 10.3389/fbioe.2019.00435

Human Gut-Microbiota Interaction in Neurodegenerative Disorders and Current Engineered Tools for Its Modeling

Author(s): Florencia Andrea Ceppa, Luca Izzo, Lorenzo Sardelli, Ilaria Raimondi, Marta Tunesi, Diego Albani, Carmen Giordano
Published in: Frontiers in Cellular and Infection Microbiology, Issue 10, 2020, Page(s) 1-18, ISSN 2235-2988
Publisher: Frontiers Media S. A.
DOI: 10.3389/fcimb.2020.00297

Microbiota‐Host Immunity Communication in Neurodegenerative Disorders: Bioengineering Challenges for In Vitro Modeling

Author(s): Lucia Boeri, Simone Perottoni, Luca Izzo, Carmen Giordano, Diego Albani
Published in: Advanced Healthcare Materials, Issue 2002043, 2021, Page(s) 1-17, ISSN 2192-2659
Publisher: World Scientific
DOI: 10.1002/adhm.202002043

Using integrated meta-omics to appreciate the role of the gut microbiota in epilepsy

Author(s): Lucia Boeri, Francesca Donnaloja, Marzia Campanile, Lorenzo Sardelli, Marta Tunesi, Federica Fusco, Carmen Giordano, Diego Albani
Published in: Neurobiology of Disease, Issue 164, 2022, Page(s) 105614, ISSN 0969-9961
Publisher: Academic Press
DOI: 10.1016/j.nbd.2022.105614

Technological tools and strategies for culturing human gut microbiota in engineered in vitro models

Author(s): Lorenzo Sardelli, Simone Perottoni, Marta Tunesi, Lucia Boeri, Federica Fusco, Paola Petrini, Diego Albani, Carmen Giordano
Published in: Biotechnology and Bioengineering, Issue 118/8, 2021, Page(s) 2886-2905, ISSN 0006-3592
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/bit.27816

A miniaturized hydrogel-based in vitro model for dynamic culturing of human cells overexpressing beta-amyloid precursor protein

Author(s): Marta Tunesi, Luca Izzo, Ilaria Raimondi, Diego Albani, Carmen Giordano
Published in: Journal of Tissue Engineering, Issue 11, 2020, Page(s) 204173142094563, ISSN 2041-7314
Publisher: SAGE Publisher
DOI: 10.1177/2041731420945633

Intellectual Property Rights

Patent (1)

MILLIFLUIDIC DEVICE FOR ADVANCED CULTURES OF BIOLOGICAL AGENTS

Application/Publication number: 20 20058339
Date: 2020-09-08