Periodic Reporting for period 2 - CAPICE (Childhood and Adolescence Psychopathology: unravelling the complex etiology by a large Interdisciplinary Collaboration in Europe)
Reporting period: 2019-02-01 to 2021-01-31
Both genetic and non-genetic factors play a role in mental health symptoms. Depending on age, gender and type of mental health symptoms, the heritability is between 40% and 80%, implying a larger contribution of environmental factors for some syndromes than for others.
CAPICE brings together eight European cohorts. These cohorts have followed children and their families, often from birth and collected data on on lifestyle, family environment, health, and emotional and behavioral problems. Phenotypic and genome-wide genotypic data are available for over 60,000 children, in addition to genome-wide genotypes for over 20,000 mothers and epigenome-wide data for over 6,000 children.
This wealth of data provides an excellent opportunity to elucidate the role of genetic and environmental factors, and their interplay in the occurrence of childhood psychopathology, its persistence, and its comorbidities. The focus will be on common mental health symptoms, such as anxiety, depression, and Attention Deficit Hyperactivity Disorder (ADHD).
The network will also build capacity of allround researchers in psychiatric genetics that, from the start of their training work in an international network, as is nowadays the rule in this type of research, ensuring the sustainability of the consortium.
At the end of this project, a stable international and interdisciplinary research network with a good data infrastructure will exist, enabling continuation of the high quality research. The results will provide targets for prevention and intervention, improving the health prospects for those young people with mental health symptoms