New siRNA Nanotherapy for Inflammatory Bowel Diseases, targeting Janus kinases

Project Information

NEW DEAL

Grant agreement ID: 720905

DOI 10.3030/720905

Project closed

EC signature date 9 November 2016

Start date 1 January 2017

End date 30 September 2021

Funded under

• INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Nanotechnologies

Total cost € 5 999 178,75

EU contribution € 5 999 178,75

Coordinated by

COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
France

Deliverables

Websites, patent fillings, videos etc. (3)

Outcomes video

SCS will produce a video to showcase the key outcomes of the project to be shown at the final conference and to be distributed by partners and via social platforms

Basic communication tools

SPARKS will provide Logo, leaflet, poster, presentation template and infographics to present the project; the website is online

Project video

SCS will produce a video to communicate the global concept and objectives of the project distribute it to the partners and publish it via social platforms

Publications

Peer reviewed articles (6)

Tuning the Immunostimulation Properties of Cationic Lipid Nanocarriers for Nucleic Acid Delivery

Author(s): Arindam K. Dey, Adrien Nougarède, Flora Clément, Carole Fournier, Evelyne Jouvin-Marche, Marie Escudé, Dorothée Jary, Fabrice P. Navarro, Patrice N. Marche
Published in: Frontiers in Immunology, Issue 12, 2021, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2021.722411

Therapeutic siRNAs targeting JAK/STAT signalling pathway in inflammatory bowel diseases

Author(s): Flora Clément, Adrien Nougarède, Stéphanie Combe, Frédérique Kermarrec, Arindam K Dey, Patricia Obeid, Fabrice P Navarro, Patrice N Marche, Eric Sulpice, Xavier Gidrol
Published in: Journal of Crohn's and Colitis, 2021, ISSN 1873-9946
Publisher: Elsevier Science
DOI: 10.1093/ecco-jcc/jjab129

Impact of Gold Nanoparticles on the Functions of Macrophages and Dendritic Cells

Author(s): Arindam K. Dey, Alexis Gonon, Eve-Isabelle Pécheur, Mylène Pezet, Christian Villiers, Patrice N. Marche
Published in: Cells, Issue 10/1, 2021, Page(s) 96, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells10010096

Macro- and Microrheological Properties of Mucus Surrogates in Comparison to Native Intestinal and Pulmonary Mucus

Author(s): Benedikt C. Huck, Olga Hartwig, Alexander Biehl, Konrad Schwarzkopf, Christian Wagner, Brigitta Loretz, Xabier Murgia, Claus-Michael Lehr
Published in: Biomacromolecules, Issue 20/9, 2019, Page(s) 3504-3512, ISSN 1525-7797
Publisher: American Chemical Society
DOI: 10.1021/acs.biomac.9b00780

Surfactant-Free Glibenclamide Nanoparticles: Formulation, Characterization and Evaluation of Interactions with Biological Barriers

Author(s): Eva C. Arrua, Olga Hartwig, Duy-Khiet Ho, Brigitta Loretz, Xabier Murgia, Claudio J. Salomon, Claus-Michael Lehr
Published in: Pharmaceutical Research, Issue 38/6, 2021, Page(s) 1081-1092, ISSN 0724-8741
Publisher: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s11095-021-03056-2

Synthesis and use of an amphiphilic dendrimer for siRNA delivery into primary immune cells

Author(s): Jiaxuan Chen, Aleksandra Ellert-Miklaszewska, Stefano Garofalo, Arindam K. Dey, Jingjie Tang, Yifan Jiang, Flora Clément, Patrice N. Marche, Xiaoxuan Liu, Bozena Kaminska, Angela Santoni, Cristina Limatola, John J. Rossi, Jiehua Zhou, Ling Peng
Published in: Nature Protocols, Issue 16/1, 2021, Page(s) 327-351, ISSN 1754-2189
Publisher: Nature Publishing Group
DOI: 10.1038/s41596-020-00418-9

Intellectual Property Rights

Patent (1)

GASTROINTESTINAL TRACT SIMULATION SYSTEM, COMPARTMENTS THEREFOR, AND METHOD

Application/Publication number: 17 174613
Date: 2017-06-06
Applicant(s): PRODIGEST