Risultati finali
Yearly update of the main project contacts and to external subscribers
Press releases (M24)Outline what CUPIDO is, what it will do, who it is intended to, the innovation it will bring and its benefits.
Visual identity kit (M36)Creation of a visual identity for the project, including the project logo and document templates, with the development of promotional and informational materials contributing to the overall perception of the project and its uniform impression.
Extended model, describing relationship between FeCaPs and deposition site when exposed to an external magnetic field (M30)Definition of FeCaP deposition and flow at multiple scales taking into account various physico-chemical parameters such as particle size distribution, shape, magnetic susceptibility, etc
Validation of therapeutic efficiency of drug-loaded dpCaP/FedpCaPs in HFrEF mouse modelDefinition of Proof of Concept that administration of dpCaP (and FedpCaP) therapeutic formulations exert beneficial cardiac effects in small animal model of cardiac disease.
E-newsletter (M24)Yearly update of the main project contacts and to external subscribers
Summary of annual workshops and networking events building communities (M36)Generation of period report regarding CUPIDO major results and activites
Aptamer-mediated guidance of CaP (M12)CaP functionalized with aptamers for improved myocardial-specific targeting
In vivo assessment of the studied nanopartilces using different imaging modalities (M30)In vivo assessment of loaded and unloaded dpCaPs and FedpCaPs for a full spectrum of biocompatibility, toxicity, blood-interaction, air/blood flow-interaction at pulmonary barrier, inflammatory responses, and pharmacokinetics.
Summary of annual workshops and networking events building communities (M12)Generation of period report regarding CUPIDO major results and activites
Demonstration of the therapeutic effect of formulation for the treatment of cardiovascular function in mini-pigsDefinition of Proof of Concept that administration of dpCaP (and FedpCaP) therapeutic formulations exert beneficial cardiac effects in large animal model of cardiac disease.
Project videos (M48)Interviews on key project figures produced and posted on YouTube and other networks to provide a basis for communication to a large audience
Data on the efficiency of wearable device for continuous remote monitoring of cardiopulmonary activity of mini-pigsValidation of the efficacy of wearable device on continuous remote monitoring of cardiopulmonary activity of diseased mini-pigs upon inhalation treatment
Extended model, describing relationship between FeCaPs and deposition site when exposed to an external magnetic field (M12)Definition of FeCaP deposition and flow at multiple scales taking into account various physico-chemical parameters such as particle size distribution, shape, magnetic susceptibility, etc
Extension of open-source flow simulation framework to also include porous media flow. Establish relationship between different nanoparticles and deposition sites in both small and large animal models (M36)Definition of CaP deposition and flow at multiple scales taking into account various physico-chemical parameters such as particle size distribution, shape, magnetic susceptibility, etc
Validation of nanoparticle biodistribution in large animalsDemonstration of efficacy of nanoparticle biodistribution in large animals (mini-pigs).
Extension of open-source flow simulation framework to also include porous media flow. Establish relationship between different nanoparticles and deposition sites in both small and large animal models (M18)Definition of CaP deposition and flow at multiple scales taking into account various physico-chemical parameters such as particle size distribution, shape, magnetic susceptibility, etc
EMD-mediated guidance of FeCaP (M24)Optimized FeCaPs for electromagnetic-mediated guidance to the heart via an electromagnetic device.
Distribution of electromagnetic fields in the target area due to the drug targeting systemsComparison of different system solutions able to generate the magnetic field gradient (or the magnetic field) needed to guide the FeCaPs at the level of the heart tissues
Press releases (M12)Outline what CUPIDO is, what it will do, who it is intended to, the innovation it will bring and its benefits.
In vitro assessment of nanoparticle behavior at/across the pulmonary barrier (M24)In vitro assessment of loaded and unloaded dpCaPs for a full spectrum of biocompatibility, toxicity, and air/blood flow-interaction at pulmonary barrier.
Training satisfaction questionnairesGeneration of training satisfaction questionnaires in regard of training topics and contents organized during the project
EMD-mediated guidance of FeCaP (M12)Optimized FeCaPs for electromagnetic-mediated guidance to the heart via an electromagnetic device.
E-newsletter (M12)Yearly update of the main project contacts and to external subscribers
Aptamer-mediated guidance of CaP (M20)CaP functionalized with aptamers for improved myocardial-specific targeting
Press releases (M48)Outline what CUPIDO is, what it will do, who it is intended to, the innovation it will bring and its benefits.
Visual identity kit (M12)Creation of a visual identity for the project, including the project logo and document templates, with the development of promotional and informational materials contributing to the overall perception of the project and its uniform impression.
In vitro assessment of nanoparticle behavior at/across the pulmonary barrier (M12)In vitro assessment of loaded and unloaded dpCaPs for a full spectrum of biocompatibility, toxicity, and air/blood flow-interaction at pulmonary barrier.
Web portal, social mediaFacilitate the communication of information to the media and through the media to become the key multiplier to reach the wider public.
Wearable devices for usage on mini-pigs (M24)Delivery of wearable garments designed and validated or a continuous and non-invasive monitoring of pig heart and respiratory activity
In vivo assessment of the studied nanopartilces using different imaging modalities (M12)In vivo assessment of loaded and unloaded dpCaPs and FedpCaPs for a full spectrum of biocompatibility, toxicity, blood-interaction, air/blood flow-interaction at pulmonary barrier, inflammatory responses, and pharmacokinetics.
Summary of annual workshops and networking events building communities (M18)Generation of period report regarding CUPIDO major results and activites
Summary of annual workshops and networking events building communities (M48)Generation of period report regarding CUPIDO major results and activites
Project videos (M24)Interviews on key project figures produced and posted on YouTube and other networks to provide a basis for communication to a large audience
Press releases (M3)Outline what CUPIDO is, what it will do, who it is intended to, the innovation it will bring and its benefits.
Functional assessment (compatibility, physic-chemical and biological stability) of CaP restoration and drug releaseThe biological activity of the powders and the reconstitution of CaP population will be thoroughly evaluated in vitro in cardiomyocyte lines (HL-1), adult primary mouse cardiomyocytes and human induced pluripotent stem cells (hiPS)-derived cardiomyocytes.
Functional assessment (compatibility, physic-chemical and biological stability) of FeCaP restoration and drug releaseThe biological activity of the powders and the reconstitution of FeCaP population will be thoroughly evaluated in vitro in cardiomyocyte lines (HL-1), adult primary mouse cardiomyocytes and human induced pluripotent stem cells (hiPS)-derived cardiomyocytes.
Visual identity kit (M48)Creation of a visual identity for the project, including the project logo and document templates, with the development of promotional and informational materials contributing to the overall perception of the project and its uniform impression.
Wearable devices for usage on mini-pigs (M36)Delivery of wearable garments designed and validated or a continuous and non-invasive monitoring of pig heart and respiratory activity
Pubblicazioni
Autori:
Lorenzo Degli Esposti, Alessandro Dotti, Alessio Adamiano, Claudia Fabbi, Eride Quarta, Paolo Colombo, Daniele Catalucci, Claudio De Luca, Michele Iafisco
Pubblicato in:
Crystals, Numero 10/10, 2020, Pagina/e 953, ISSN 2073-4352
Editore:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/cryst10100953
Autori:
Dawud Abawi, Alessandro Faragli, Michael Schwarzl, Martin Manninger, David Zweiker, Karl-Patrik Kresoja, Jochen Verderber, Birgit Zirngast, Heinrich Maechler, Paul Steendijk, Burkert Pieske, Heiner Post, Alessio Alogna
Pubblicato in:
BMC Cardiovascular Disorders, Numero 19/1, 2019, ISSN 1471-2261
Editore:
BioMed Central
DOI:
10.1186/s12872-019-1212-2
Autori:
Michele Miragoli, Paola Ceriotti, Michele Iafisco, Marco Vacchiano, Nicolò Salvarani, Alessio Alogna, Pierluigi Carullo, Gloria Belén Ramirez-Rodríguez, Tatiana Patrício, Lorenzo Degli Esposti, Francesca Rossi, Francesca Ravanetti, Silvana Pinelli, Rossella Alinovi, Marco Erreni, Stefano Rossi, Gianluigi Condorelli, Heiner Post, Anna Tampieri, Daniele Catalucci
Pubblicato in:
Science Translational Medicine, Numero 10/424, 2018, Pagina/e eaan6205, ISSN 1946-6234
Editore:
American Association for the Advancement of Science
DOI:
10.1126/scitranslmed.aan6205
Autori:
Vittoria Di Mauro, Maria Barandalla-Sobrados, Daniele Catalucci
Pubblicato in:
Non-coding RNA Research, 2018, ISSN 2468-0540
Editore:
Elsevier
DOI:
10.1016/j.ncrna.2018.02.001
Autori:
Lorenzo Fassina, Giacomo Rozzi, Stefano Rossi, Simone Scacchi, Maricla Galetti, Francesco Paolo Lo Muzio, Fabrizio Del Bianco, Piero Colli Franzone, Giuseppe Petrilli, Giuseppe Faggian, Michele Miragoli
Pubblicato in:
Scientific Reports, Numero 7, 2017, Pagina/e 46143, ISSN 2045-2322
Editore:
Nature Publishing Group
DOI:
10.1038/srep46143
Autori:
Alessandra Marrella, Michele Iafisco, Alessio Adamiano, Stefano Rossi, Maurizio Aiello, Maria Barandalla-Sobrados, Pierluigi Carullo, Michele Miragoli, Anna Tampieri, Silvia Scaglione, Daniele Catalucci
Pubblicato in:
Journal of The Royal Society Interface, Numero 15/144, 2018, Pagina/e 20180236, ISSN 1742-5689
Editore:
The Royal Society
DOI:
10.1098/rsif.2018.0236
Autori:
Lorenzo Degli Esposti, Francesca Carella, Alessio Adamiano, Anna Tampieri, Michele Iafisco
Pubblicato in:
Drug Development and Industrial Pharmacy, Numero 44/8, 2018, Pagina/e 1223-1238, ISSN 0363-9045
Editore:
Marcel Dekker Inc.
DOI:
10.1080/03639045.2018.1451879
Autori:
Alexandra K. Diem, Kristian Valen-Sendstad
Pubblicato in:
Biophysical Journal, Numero 117/12, 2019, Pagina/e 2316-2323, ISSN 0006-3495
Editore:
Biophysical Society
DOI:
10.1016/j.bpj.2019.09.029
Autori:
Syver Agdestein, Kristian Valen-Sendstad, Alexandra Diem
Pubblicato in:
Journal of Open Source Software, Numero 3/32, 2018, Pagina/e 1107, ISSN 2475-9066
Editore:
Journal of Open Source Software
DOI:
10.21105/joss.01107
Autori:
Alessio Adamiano, Michele Iafisco, Monica Sandri, Martina Basini, Paolo Arosio, Tamara Canu, Giovanni Sitia, Antonio Esposito, Vincenzo Iannotti, Giovanni Ausanio, Eirini Fragogeorgi, Maritina Rouchota, George Loudos, Alessandro Lascialfari, Anna Tampieri
Pubblicato in:
Acta Biomaterialia, Numero 73, 2018, Pagina/e 458-469, ISSN 1742-7061
Editore:
Elsevier BV
DOI:
10.1016/j.actbio.2018.04.040
Autori:
Michele Iafisco, Alessio Alogna, Michele Miragoli, Daniele Catalucci
Pubblicato in:
Nanomedicine, Numero 14/18, 2019, Pagina/e 2391-2394, ISSN 1743-5889
Editore:
Future Medicine Ltd.
DOI:
10.2217/nnm-2019-0228
Autori:
Alessio Adamiano, Victoria M Wu, Francesca Carella, Gianrico Lamura, Fabio Canepa, Anna Tampieri, Michele Iafisco, Vuk Uskoković
Pubblicato in:
Nanomedicine, Numero 14/10, 2019, Pagina/e 1267-1289, ISSN 1743-5889
Editore:
Future Medicine Ltd.
DOI:
10.2217/nnm-2018-0372
Autori:
Karl-Patrik Kresoja, Alessandro Faragli, Dawud Abawi, Oliver Paul, Burkert Pieske, Heiner Post, Alessio Alogna
Pubblicato in:
PLOS ONE, Numero 14/12, 2019, Pagina/e e0226561, ISSN 1932-6203
Editore:
Public Library of Science
DOI:
10.1371/journal.pone.0226561
Autori:
Pietro Ameri, Gabriele Giacomo Schiattarella, Lia Crotti, Margherita Torchio, Edoardo Bertero, Daniele Rodolico, Maurizio Forte, Vittoria Di Mauro, Roberta Paolillo, Cristina Chimenti, Daniele Torella, Daniele Catalucci, Sebastiano Sciarretta, Cristina Basso, Ciro Indolfi, Cinzia Perrino
Pubblicato in:
International Journal of Molecular Sciences, Numero 21/4, 2020, Pagina/e 1192, ISSN 1422-0067
Editore:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/ijms21041192
Autori:
Alexandra Diem, Kristian Valen-Sendstad
Pubblicato in:
2019 Computing in Cardiology Conference (CinC), 2019, ISBN 978-1-7281-6936-1
Editore:
Computing in Cardiology
DOI:
10.22489/cinc.2019.291
Autori:
S. Fiocchi, E. Chiaramello, M. Bonato, G. Tognola, D. Catalucci, M. Parazzini, P. Ravazzani
Pubblicato in:
2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2019, Pagina/e 5674-5677, ISBN 978-1-5386-1311-5
Editore:
IEEE
DOI:
10.1109/embc.2019.8857364
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