Dissecting the crosstalk between metabolism and transcriptional regulation in pluripotent stem cells.

Mitochondrial fission links ECM mechanotransduction to metabolic redox homeostasis and metastatic chemotherapy resistance.

Autores: Romani P, Nirchio N, Arboit M, Barbieri V, Tosi A, Michielin F, Shibuya S, Benoist T, Wu D, Hindmarch CCT, Giomo M, Urciuolo A, Giamogante F, Roveri A, Chakravarty P, Montagner M, Calì T, Elvassore N, Archer SL, De Coppi P, Rosato A, Martello G, Dupont S
Publicado en: Nature Cell Biology, Edición 24, 2022, Página(s) 168-180, ISSN 1465-7392
Editor: Nature Publishing Group
DOI: 10.1038/s41556-022-00843-w

3D ECM-rich environment sustains the identity of naive human iPSCs.

Autores: Cesare E, Urciuolo A, Stuart HT, Torchio E, Gesualdo A, Laterza C, Gagliano O, Martewicz S, Cui M, Manfredi A, Di Filippo L, Sabatelli P, Squarzoni S, Zorzan I, Betto RM, Martello G, Cacchiarelli D, Luni C, Elvassore N
Publicado en: Cell Stem Cell, Edición 29, 2022, Página(s) 1703-1717, ISSN 1934-5909
Editor: Cell Press
DOI: 10.1016/j.stem.2022.11.011

Metabolic control of DNA methylation in naive pluripotent cells

Autores: Betto RM, Diamante L, Perrera V, Audano M, Rapelli S, Lauria A, Incarnato D, Arboit M, Pedretti S, Rigoni G, Guerineau V, Touboul D, Stirparo GG, Lohoff T, Boroviak T, Grumati P, Soriano ME, Nichols J, Mitro N, Oliviero S, Martello G.
Publicado en: Nature Genetics, Edición 53, 2021, Página(s) 215-229, ISSN 1061-4036
Editor: Nature Publishing Group
DOI: 10.1038/s41588-020-00770-2

PsiNorm: a scalable normalization for single-cell RNA-seq data.

Autores: Borella M, Martello G, Risso D, Romualdi C.
Publicado en: Bioinformatics, Edición 38, 2021, Página(s) 164-172, ISSN 1367-4811
Editor: Oxford Academic
DOI: 10.1093/bioinformatics/btab641

BrewerIX enables allelic expression analysis of imprinted and X-linked genes from bulk and single-cell transcriptomes.

Autores: Martini P, Sales G, Diamante L, Perrera V, Colantuono C, Riccardo S, Cacchiarelli D, Romualdi C, Martello G.
Publicado en: Communications Biology, Edición 5, 2022, Página(s) 146, ISSN 2399-3642
Editor: Springer Nature
DOI: 10.1038/s42003-022-03087-4

STAT3 and HIF1α cooperatively mediate the transcriptional and physiological responses to hypoxia

Autores: Dinarello A, Betto RM, Diamante L, Tesoriere A, Ghirardo R, Cioccarelli C, Meneghetti G, Peron M, Laquatra C, Tiso N, Martello G, Argenton F.
Publicado en: Cell Death Discovery, Edición 9, 2023, Página(s) 226, ISSN 2058-7716
Editor: Springer Nature
DOI: 10.1038/s41420-023-01507-w

Y705 and S727 are required for the mitochondrial import and transcriptional activities of STAT3, and for regulation of stem cell proliferation.

Autores: Peron M, Dinarello A, Meneghetti G, Martorano L, Betto RM, Facchinello N, Tesoriere A, Tiso N, Martello G, Argenton F.
Publicado en: Development, Edición 148, 2021, Página(s) dev199477, ISSN 1477-9129
Editor: The Company of Biologists
DOI: 10.1242/dev.199477

Metabolic regulation in pluripotent stem cells

Autores: Diamante L, Martello G.
Publicado en: Current Opinion in Genetics & Development, Edición 75, 2022, Página(s) 101923, ISSN 0959-437X
Editor: Elsevier BV
DOI: 10.1016/j.gde.2022.101923

Direct generation of human naive induced pluripotent stem cells from somatic cells in microfluidics

Autores: Stefano Giulitti, Marco Pellegrini, Irene Zorzan, Paolo Martini, Onelia Gagliano, Margherita Mutarelli, Michael Johannes Ziller, Davide Cacchiarelli, Chiara Romualdi, Nicola Elvassore, Graziano Martello
Publicado en: Nature Cell Biology, Edición 21/2, 2019, Página(s) 275-286, ISSN 1465-7392
Editor: Nature Publishing Group
DOI: 10.1038/s41556-018-0254-5

A common molecular logic determines embryonic stem cell self‐renewal and reprogramming

Autores: Sara‐Jane Dunn, Meng Amy Li, Elena Carbognin, Austin Smith, Graziano Martello
Publicado en: The EMBO Journal, Edición 38/1, 2019, Página(s) e100003, ISSN 0261-4189
Editor: Nature Publishing Group
DOI: 10.15252/embj.2018100003

How Does Reprogramming to Pluripotency Affect Genomic Imprinting?

Autores: Valentina Perrera, Graziano Martello
Publicado en: Frontiers in Cell and Developmental Biology, Edición 7, 2019, ISSN 2296-634X
Editor: Frontiers Media
DOI: 10.3389/fcell.2019.00076

The transcriptional regulator ZNF398 mediates pluripotency and epithelial character downstream of TGF-beta in human PSCs

Autores: Irene Zorzan, Marco Pellegrini, Mattia Arboit, Danny Incarnato, Mara Maldotti, Mattia Forcato, Guidantonio Malagoli Tagliazucchi, Elena Carbognin, Marco Montagner, Salvatore Oliviero, Graziano Martello
Publicado en: Nature Communications, Edición 11/1, 2020, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-020-16205-9

Chemical conversion of human conventional PSCs to TSCs following transient naive gene activation

Autores: Zorzan I, Betto RM, Rossignoli G, Arboit M, Drusin A, Corridori C, Martini P, Martello G.
Publicado en: EMBO reports, Edición 24, 2023, Página(s) e55235, ISSN 1469-3178
Editor: EMBO Press
DOI: 10.15252/embr.202255235

Esrrb guides naive pluripotent cells through the formative transcriptional programme.

Autores: Carbognin E, Carlini V, Panariello F, Chieregato M, Guerzoni E, Benvegnù D, Perrera V, Malucelli C, Cesana M, Grimaldi A, Mutarelli M, Carissimo A, Tannenbaum E, Kugler H, Hackett JA, Cacchiarelli D, Martello G
Publicado en: Nature Cell Biology, Edición 25, 2023, Página(s) 643-657, ISSN 1476-4679
Editor: springer Nature
DOI: 10.1038/s41556-023-01131-x

Genome-wide screening in pluripotent cells identifies Mtf1 as a suppressor of mutant huntingtin toxicity.

Autores: Ferlazzo GM, Gambetta AM, Amato S, Cannizzaro N, Angiolillo S, Arboit M, Diamante L, Carbognin E, Romani P, La Torre F, Galimberti E, Pflug F, Luoni M, Giannelli S, Pepe G, Capocci L, Di Pardo A, Vanzani P, Zennaro L, Broccoli V, Leeb M, Moro E, Maglione V, Martello G.
Publicado en: Nature Communications, Edición 14, 2023, Página(s) 3962, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-023-39552-9

Using Microfluidics to Generate Human Naïve and Primed Pluripotent Stem Cells

Autores: Zorzan I, Gagliano O, Elvassore N, Martello G
Publicado en: Methods in Molecular Biology, Edición 2416, 2021, Página(s) 53-71, ISBN 978-1-0716-1907-0
Editor: Humana
DOI: 10.1007/978-1-0716-1908-7_5

Mitochondrial STAT3 regulates proliferation of tissue stem cells

Autores: Margherita Peron, Giacomo Meneghetti, Alberto Dinarello, Laura Martorano, Riccardo M. Betto, Nicola Facchinello, Natascia Tiso, Graziano Martello, Francesco Argenton
Publicado en: www.biorXiv.org, 2020
Editor: Cold Spring Harbor Press
DOI: 10.1101/2020.07.17.208264

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