Nanoscale Effects within Biological Membranes caused by Radiation

Informations projet

NanoMembR

N° de convention de subvention: 706072

DOI 10.3030/706072

Projet clôturé

Date de signature de la CE 15 Mars 2016

Date de début 16 Mai 2017

Date de fin 15 Juillet 2019

Financé au titre de

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coût total € 171 460,80

Contribution de l’UE € 171 460,80

Coordonné par

FREIE UNIVERSITAET BERLIN
Germany

Objectif

The NanoMembR project will elucidate key elements of membrane stability under the influence of UV radiation. The stability of biological membranes is of great importance for the structure, homeostasis and functioning of all living systems. Membrane molecules have also attracted, due to their robustness and longevity, strong interest from planetary and space scientists as potential biomarkers for life detection missions to other planets. Membrane damage, perturbation, instability and fragmentation upon UV exposure will be investigated on the nanoscale using cutting-edge infrared nanoscopy. Scattering-type scanning near-field microscopy (s-SNOM) combined with Fourier transform infrared (FTIR) spectroscopy allows to combine spatial information of nanometre resolution with chemical mapping. This novel technique will enable us to study subtle changes in the structural integrity of model membranes and monitor changes in the micro- and nano-domains. In addition, we will be able to correlate membrane stability and membrane composition by intercalating structural and functional modifiers such as sterols, hopanoids and pigments. Upon radiation in oxic environments, the lipid structure of a membrane is known to be altered by peroxidation chain reactions. Under anoxic conditions radiation induced changes in lipid alteration could vary significantly, with intriguing implications for the stability of membrane molecules under different environmental conditions than found on Earth. Understanding fragmentation patterns of membranes and identifying final break-down products will provide scientific support and a database for key biomarkers detectable in remote environments. Results from this work will feed directly into planned experiments on the International Space Station (ISS), which are scheduled on new nanosatellite-technology-based exposure platforms with in-situ infrared spectroscopic capabilities, monitoring membrane stability under the influence of solar and cosmic radiation.

Champ scientifique (EuroSciVoc)

CORDIS classe les projets avec EuroSciVoc, une taxonomie multilingue des domaines scientifiques, grâce à un processus semi-automatique basé sur des techniques TLN.

• sciences naturelles › sciences chimiques › chimie physique › photochimie
• sciences naturelles › sciences physiques › optique › microscopie
• sciences naturelles › sciences physiques › astronomie › science planétaire › planètes
• sciences naturelles › sciences biologiques › biochimie › biomolécule › lipides
• sciences naturelles › sciences physiques › optique › spectroscopie › spectrométrie d’absorption

Vous devez vous identifier ou vous inscrire pour utiliser cette fonction

Programme(s)

• H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme
• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility

Thème(s)

• MSCA-IF-2015-EF - Marie Skłodowska-Curie Individual Fellowships (IF-EF)

Appel à propositions

H2020-MSCA-IF-2015

Régime de financement

MSCA-IF-EF-ST - Standard EF

Coordinateur

FREIE UNIVERSITAET BERLIN

• Contribution nette de l'UE: € 171 460,80
• Adresse: KAISERSWERTHER STRASSE 16-18 ; 14195 Berlin ; Allemagne
• Région: Berlin › Berlin › Berlin
• Type d’activité: Higher or Secondary Education Establishments
• Coût total: € 171 460,80