Multitasking Nanoparticles for Intracellular Bioimaging and Biosensing

Project Information

NanoIntra

Grant agreement ID: 702300

DOI 10.3030/702300

Project closed

EC signature date 18 February 2016

Start date 1 May 2017

End date 30 April 2020

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost € 258 530,40

EU contribution € 258 530,40

Coordinated by

UNIVERSITEIT GENT
Belgium

Objective

The development of specifically designed nanomaterials for advanced medical applications such as theranostics has become a major technical challenge with great potential societal and economic outcomes. Nanomedicine and related techniques hold great promises for improved diagnostic and treatment of widely spread diseases such as cancer. This project, entitled NanoIntra, aims at developing novel multitasking nanoparticles as advanced tools for highly localized and ultrasensitive intracellular imaging and biosensing. These nanoprobes should provide new insights in the spatial and temporal processes at play in live cells and therefore reveal part of their mystery. Such functional objects are achieved through the design of a complex architecture which involves quantum dots as bright and stable luminescent markers encapsulated in a protective silica matrix. These nanoparticles are combined with plasmonic nanocrystals, which offer new strategies for their photothermally induced intracellular delivery. The targeting and imaging of specific subcellular structures is then achieved thanks to proper surface functionalization of the nanoparticles. In addition, the plasmonic nanocrystals also allow these nanoparticles to be used as Surface Enhanced Raman Scattering (SERS) biosensors. Finally, for a higher control on the use of such nano-biosensors, optical tweezers are used to purposefully manipulate and position the nanoparticles inside the cells at the region of interest. Besides their application in cell labeling and biosensing, these functional nanoparticles have tremendous potential applications in the fields of theranostics, nanomedicine and nanobiophotonics, and NanoIntra constitutes a first step toward the development of a full lab-on-a-particle. Thus, through the synthesis and characterization of novel materials and their application to biotechnology, NanoIntra is a multidisciplinary research and training project at the interface between physics, chemistry and biology.

Fields of science

Not validated

• engineering and technology › environmental biotechnology › biosensing
• medical and health sciences › medical biotechnology › nanomedicine
• engineering and technology › nanotechnology › nano-materials › nanocrystals
• natural sciences › physical sciences › electromagnetism and electronics › semiconductivity
• natural sciences › chemical sciences › organic chemistry › amines

Programme(s)

• H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme
• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility

Topic(s)

• MSCA-IF-2015-GF - Marie Skłodowska-Curie Individual Fellowships (IF-GF)

Call for proposal

H2020-MSCA-IF-2015

Funding Scheme

MSCA-IF-GF - Global Fellowships

Coordinator

UNIVERSITEIT GENT

• Net EU contribution: € 258 530,40
• Address: SINT PIETERSNIEUWSTRAAT 25 ; 9000 Gent ; Belgium
• Region: Vlaams Gewest › Prov. Oost-Vlaanderen › Arr. Gent
• Activity type: Higher or Secondary Education Establishments
• Total cost: € 258 530,40

Partners (1)

Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

CORNELL UNIVERSITY

United States

• Net EU contribution: € 0,00
• Address: PINE TREE ROAD 373 ; 14850 Ithaca Ny
• Activity type: Higher or Secondary Education Establishments
• Total cost: € 172 130,40