polyValent mEsopoRous nanosystem for bone DIseases

Project Information

VERDI

Grant agreement ID: 694160

DOI 10.3030/694160

Project closed

EC signature date 5 September 2016

Start date 1 October 2016

End date 30 September 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 500 000,00

EU contribution € 2 500 000,00

Coordinated by

UNIVERSIDAD COMPLUTENSE DE MADRID
Spain

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (148)

 A versatile multicomponent mesoporous silica nanosystem with dual antimicrobial and osteogenic effects

Author(s): Elena Alvarez , Manuel Estevez , Carla Jimenez-Jimenez , Montserrat Colilla , Isabel Izquierdo-Barba , Blanca Gonzalez , Marıa Vallet-Regı
Published in: Acta Biomaterialia, 2021, Page(s) 570-581, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2021.09.027

Our Contributions to Applications of Mesoporous Silica Nanoparticles

Author(s): María Vallet-Regí
Published in: Acta Biomaterialia, 2021, Page(s) 44-52, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2021.10.011

Arabic gum plus colistin coated moxifloxacin-loaded nanoparticles for the treatment of bone infection caused by Escherichia coli

Author(s): J.J. Aguilera-Correa , M. Gisbert-Garzarán , A. Mediero , R. A. Carias-Cálix , C. Jiménez Jiménez, J. Esteban, M. Vallet-Regí
Published in: Acta Biomaterialia, 2021, Page(s) 218-234, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2021.10.014

Ipriflavone-Loaded Mesoporous Nanospheres with Potential Applications for Periodontal Treatment

Author(s): Laura Casarrubios, Natividad Gómez-Cerezo, María José Feito, María Vallet-Regí, Daniel Arcos, María Teresa Portolés
Published in: Nanomaterials, Issue 10/12, 2020, Page(s) 2573, ISSN 2079-4991
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nano10122573

Antibiotics- and heavy metals-based titanium alloy surface modifications for local prosthetic joint infections

Author(s): Jaime Esteban , María Vallet-Regí, John-Jairo Aguilera-Correa
Published in: Antibiotics-Basel, 2021, Page(s) 1270, ISSN 2079-6382
Publisher: MDPI
DOI: 10.3390/antibiotics10101270

Mesoporous Bioglasses Enriched with Bioactive Agents for Bone Repair, with a Special Highlight of María Vallet-Regí’s Contribution

Author(s): Antonio J. Salinas, Pedro Esbrit
Published in: Pharmaceutics, 2022, Page(s) 202, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics14010202

Strontium-Modified Scaffolds Based on Mesoporous Bioactive Glasses/Polyvinyl Alcohol Composites for Bone Regeneration

Author(s): Javier Jiménez-Holguín, Alvaro López-Hidalgo, Sandra Sánchez-Salcedo, Juan Peña, María Vallet-Regí, Antonio J. Salinas
Published in: Materials, Issue 13/23, 2020, Page(s) 5526, ISSN 1996-1944
Publisher: MDPI Open Access Publishing
DOI: 10.3390/ma13235526

Chronology of Global Success: 20 Years of Prof Vallet-Regí Solving Questions

Author(s): Miguel Manzano
Published in: Pharmaceutics, Issue 19994923, 2022, Page(s) 2179, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13122179

Transcriptome Analysis Identifies Novel Mechanisms Associated with the Antitumor Effect of Chitosan-Stabilized Selenium Nanoparticles

Author(s): Hector Estevez, Estefania Garcia-Calvo, Jose Rivera-Torres, María Vallet-Regí, Blanca González, Jose L. Luque-Garcia
Published in: Pharmaceutics, Issue 13/3, 2021, Page(s) 356, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13030356

Endostatin Genetically Engineered Placental Mesenchymal Stromal Cells Carrying Doxorubicin-Loaded Mesoporous Silica Nanoparticles for Combined Chemo- and Antiangiogenic Therapy

Author(s): Paz de la Torre, Juan L. Paris, Miguel Fernández-de la Torre, María Vallet-Regí, Ana I. Flores
Published in: Pharmaceutics, Issue 13/2, 2021, Page(s) 244, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13020244

Antibiotic delivery from bone-targeted mesoporous silica nanoparticles for the treatment of osteomyelitis caused by methicillin-resistant.

Author(s): J.J. Aguilera-Correa , M. Gisbert-Garzarán, A. Mediero , M.J. Fernández-Aceñero, D. de-Pablo-Velasco, D. Lozano, J. Esteban , M. Vallet-Regí
Published in: Acta Biomaterialia, Issue 17427061, 2022, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2022.10.039

Effects of Ipriflavone-Loaded Mesoporous Nanospheres on the Differentiation of Endothelial Progenitor Cells and Their Modulation by Macrophages

Author(s): Laura Casarrubios, Alberto Polo-Montalvo, María Concepción Serrano, María José Feito, María Vallet-Regí, Daniel Arcos, María Teresa Portolés
Published in: Nanomaterials, Issue 11/5, 2021, Page(s) 1102, ISSN 2079-4991
Publisher: MDPI
DOI: 10.3390/nano11051102

Cu-Doped Hollow Bioactive Glass Nanoparticles for Bone Infection Treatment

Author(s): Javier Jiménez-Holguín, Sandra Sánchez-Salcedo, Mónica Cicuéndez, María Vallet-Regí , Antonio J. Salinas
Published in: Pharmaceutics, Issue 19994923, 2022, Page(s) 845, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics14040845

Multifunctional antibiotic- and zinc-containing mesoporous bioactive glass scaffolds to fight bone infection

Author(s): C. Heras, J. Jiménez-Holguín, A.L. Doadrio, M. Vallet-Regí, S. Sánchez-Salcedo, A.J. Salinas
Published in: Acta Biomaterialia, Issue 114, 2020, Page(s) 395-406, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2020.07.044

Design of 3D Scaffolds for Hard Tissue Engineering: From Apatites to Silicon Mesoporous Materials

Author(s): Ana García, María Victoria Cabañas, Juan Peña, Sandra Sánchez-Salcedo
Published in: Pharmaceutics, Issue 19994923, 2022, Page(s) 1981, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13111981

Mesoporous silica nanoparticles containing silver as novel antimycobacterial agents against Mycobacterium tuberculosis.

Author(s): Sandra Montalvo-Quirós, Sergio Gómez-Graña, María Vallet-Regí, Rafael C. Prados-Rosales, Blanca González, Jose L. Luque-García*
Published in: Colloids and Surfaces B: Biointerfaces, 2020, Page(s) 1218, ISSN 0927-7765
Publisher: Elsevier BV
DOI: 10.1016/j.colsurfb.2020.111405

Evaluation of the penetration process of fluorescent collagenase nanocapsules in a 3D collagen gel

Author(s): Víctor M. Moreno, Alejandro Baeza, María Vallet-Regí
Published in: Acta Biomaterialia, 2020, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2020.12.022

Nanoparticles Coated with Cell Membranes for Biomedical Applications

Author(s): Carla Jiménez-Jiménez, Miguel Manzano, María Vallet-Regí
Published in: Biology, Issue 9/11, 2020, Page(s) 406, ISSN 2079-7737
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/biology9110406

Nanoparticles for human viral and bacterial infections prevention and treatment

Author(s): John Jairo Aguilera-Correa *, Jaime Esteban, María Vallet-Regí *
Published in: Nanomaterials, 2020, ISSN 2079-4991
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nano11010137

Injectable Mesoporous Bioactive Nanoparticles Regenerate Bone Tissue under Osteoporosis Conditions 

Author(s): D. Arcos , N. Gómez-Cerezo, M. Saiz-Pardo , D. de Pablo , L. Ortega , S. Enciso, B. Fernández-Tomé, I. Díaz-Güemes, F.M. Sánchez-Margallo, L. Casarrubios , M.J. Feito , M.T. Portolés , M. Vallet-Regí
Published in: Acta Biomaterialia, Issue 17427061, 2022, Page(s) 501-511, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2022.07.067

Nanoantibiotics Based in Mesoporous Silica Nanoparticles: New Formulations for Bacterial Infection Treatment.

Author(s): Elena Álvarez, Blanca González, Daniel Lozano, Antonio L. Doadrio, Montserrat Colilla, Isabel Izquierdo-Barba
Published in: Pharmaceutics, Issue 19994923, 2021, Page(s) 2033, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13122033

Production of MCM-41 Nanoparticles with Control of Particle Size and Structural Properties: Optimizing Operational Conditions during Scale-Up

Author(s): Rafael R. Castillo, Lorena de la Torre, Félix García-Ochoa, Miguel Ladero, María Vallet-Regí
Published in: International Journal of Molecular Sciences, Issue 21/21, 2020, Page(s) 7899, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21217899

Redox-Responsive Mesoporous Silica Nanoparticles for Cancer Treatment: Recent Updates

Author(s): Miguel Gisbert Garzaran, Maria Vallet Regi
Published in: Nanomaterials, 2021, Page(s) 2222, ISSN 2079-4991
Publisher: MDPI
DOI: 10.3390/nano11092222

An Immunological Approach to the Biocompatibility of Mesoporous SiO2-CaO Nanospheres

Author(s): María Montes-Casado, Adrian Sanvicente, Laura Casarrubios, María José Feito, José M. Rojo, María Vallet-Regí, Daniel Arcos, Pilar Portolés, María Teresa Portolés
Published in: International Journal of Molecular Sciences, Issue 21/21, 2020, Page(s) 8291, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21218291

Targeted Stimuli-Responsive Mesoporous Silica Nanoparticles for Bacterial Infection Treatment

Author(s): Montserrat Colilla, María Vallet-Regí
Published in: International Journal of Molecular Sciences, Issue 21/22, 2020, Page(s) 8605, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21228605

ZnO-mesoporous glass scaffolds loaded with osteostatin and mesenchymal cells improve bone healing in a rabbit bone defect.

Author(s): D. Lozano, J. Gil-Albarova, C. Heras, S. Sánchez-Salcedo, V. E. Gómez-Palacio, A. Gómez-Blasco, J. C. Doadrio, M. Vallet-Regí, A. J. Salinas
Published in: Journal of Materials Science-Materials in Medicine, 2020, Page(s) 31:100, ISSN 0957-4530
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10856-020-06439-w

Mesoporous bioactive glasses for regenerative medicine

Author(s): M. Vallet-Regi, A.J. Salinas
Published in: Materials Today Bio, Issue 11, 2021, Page(s) 100121, ISSN 2590-0064
Publisher: ELSEVIER
DOI: 10.1016/j.mtbio.2021.100121

Response of RAW 264.7 and J774A.1 macrophages to particles and nanoparticles of a mesoporous bioactive glass: A comparative study

Author(s): M.J. Feito, , L. Casarrubios , M. Oñaderra , M. Gómez-Duro , P. Arribas , A. PoloMontalvo , M. Vallet-Regí, , D. Arcos, , M.T. Portolés
Published in: Colloids and Surfaces B: Biointerfaces, 2021, Page(s) 112110, ISSN 0927-7765
Publisher: Elsevier BV
DOI: 10.1016/j.colsurfb.2021.112110

UVA-Degradable Collagenase Nanocapsules as a Potential Treatment for Fibrotic Diseases

Author(s): Víctor M. Moreno, Carolina Meroño, Alejandro Baeza, Alicia Usategui, Pablo L. Ortiz-Romero, José L. Pablos, María Vallet-Regí
Published in: Pharmaceutics, Issue 13/4, 2021, Page(s) 499, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13040499

Effect of gold nanostars plus amikacin against cabapenem-resistant Klebsiella pneumoniae biofilm.

Author(s): John Jairo Aguilera-Correa, Rafaela García-Álvarez, Aranzazu Mediero, Jaime Esteban, María Vallet-Regí.
Published in: Biology-Basel, 2021, Page(s) 162, ISSN 2079-7737
Publisher: MDPI
DOI: 10.3390/biology11020162

Emerging Strategies in Anticancer Combination Therapy Employing Silica‐Based Nanosystems

Author(s): Rafael R. Castillo, Maria Vallet‐Regí
Published in: Biotechnology Journal, 2020, Page(s) 1900438, ISSN 1860-6768
Publisher: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/biot.201900438

A novel hemocompatible core@shell nanosystem for selective targeting and apoptosis induction in cancer cells

Author(s): Guillermo Aragoneses-Cazorla, Juana Serrano-Lopez, Ines Martinez-Alfonzo, María Vallet-Regí, Blanca González, Jose L. Luque-Garcia
Published in: Inorganic Chemistry Frontiers, Issue 8/11, 2021, Page(s) 2697-2712, ISSN 2052-1553
Publisher: ROYAL SOC CHEMISTRY
DOI: 10.1039/d1qi00143d

Bacteria and cells as alternative nano-carriers for biomedical applications.

Author(s): Rafaela García-Álvarez, María Vallet Regí
Published in: Expert Opinion on Drug Delivery, 2022, Page(s) 103-108, ISSN 1744-7593
Publisher: TAYLOR & FRANCIS LTD
DOI: 10.1080/17425247.2022.2029844

Mesoporous Silica Nanoparticles for Targeting Subcellular Organelles

Author(s): Miguel Gisbert-Garzarán, Daniel Lozano, María Vallet-Regí
Published in: International Journal of Molecular Sciences, Issue 21/24, 2020, Page(s) 9696, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21249696

Recent Advances Toward the Use of Mesoporous Silica Nanoparticles for the Treatment of Bacterial Infections

Author(s): Rafael R Castillo, María Vallet-Regí
Published in: International Journal of Nanomedicine, Issue Volume 16, 2021, Page(s) 4409-4430, ISSN 1178-2013
Publisher: DOVE MEDICAL PRESS LTD
DOI: 10.2147/ijn.s273064

Novel ion-doped mesoporous glasses for bone tissue engineering: Study of their structural characteristics influenced by the presence of phosphorous oxide

Author(s): Anahí Philippart, Natividad Gómez-Cerezo, Daniel Arcos, Antonio J. Salinas, Elena Boccardi, Maria Vallet-Regi, Aldo R. Boccaccini
Published in: Journal of Non-Crystalline Solids, Issue 455, 2017, Page(s) 90-97, ISSN 0022-3093
Publisher: Elsevier BV
DOI: 10.1016/j.jnoncrysol.2016.10.031

Advances in mesoporous silica-based nanocarriers for co-delivery and combination therapy against cancer

Author(s): Rafael R. Castillo, Montserrat Colilla, María Vallet-Regí
Published in: Expert Opinion on Drug Delivery, Issue 14/2, 2016, Page(s) 229-243, ISSN 1742-5247
Publisher: Ashley Publications Ltd.
DOI: 10.1080/17425247.2016.1211637

Tuning mesoporous silica dissolution in physiological environments: a review

Author(s): Juan L. Paris, Montserrat Colilla, Isabel Izquierdo-Barba, Miguel Manzano, María Vallet-Regí
Published in: Journal of Materials Science, Issue 52/15, 2017, Page(s) 8761-8771, ISSN 0022-2461
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10853-017-0787-1

pH-Responsive Mesoporous Silica and Carbon Nanoparticles for Drug Delivery

Author(s): Miguel Gisbert-Garzarán, Miguel Manzano, María Vallet-Regí
Published in: Bioengineering, Issue 4/4, 2017, Page(s) 3, ISSN 2306-5354
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/bioengineering4010003

Recent applications of the combination of mesoporous silica nanoparticles with nucleic acids: development of bioresponsive devices, carriers and sensors

Author(s): Rafael R. Castillo, Alejandro Baeza, María Vallet-Regí
Published in: Biomaterials Science, Issue 5/3, 2017, Page(s) 353-377, ISSN 2047-4830
Publisher: Royal Society of Chemistry
DOI: 10.1039/c6bm00872k

3D scaffold with effective multidrug sequential release against bacteria biofilm

Author(s): Rafaela García-Alvarez, Isabel Izquierdo-Barba, María Vallet-Regí
Published in: Acta Biomaterialia, Issue 49, 2017, Page(s) 113-126, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2016.11.028

Molecular gates in mesoporous bioactive glasses for the treatment of bone tumors and infection

Author(s): Lorena Polo, Natividad Gómez-Cerezo, Elena Aznar, José-Luis Vivancos, Félix Sancenón, Daniel Arcos, María Vallet-Regí, Ramón Martínez-Máñez
Published in: Acta Biomaterialia, Issue 50, 2017, Page(s) 114-126, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2016.12.025

Self-immolative polymers as novel pH-responsive gate keepers for drug delivery

Author(s): M. Gisbert-Garzaran, D. Lozano, M. Vallet-Regí, M. Manzano
Published in: RSC Advances, Issue 7/1, 2017, Page(s) 132-136, ISSN 2046-2069
Publisher: Royal Society of Chemistry
DOI: 10.1039/c6ra26771h

Double Sequential Encrypted Targeting Sequence: A New Concept for Bone Cancer Treatment

Author(s): Gonzalo Villaverde, Valentina Nairi, Alejandro Baeza, María Vallet-Regí
Published in: Chemistry - A European Journal, Issue 23/30, 2017, Page(s) 7174-7179, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201605947

Electron microscopy for inorganic-type drug delivery nanocarriers for antitumoral applications: what does it reveal?

Author(s): A. Baeza, R. R. Castillo, A. Torres-Pardo, J. M. González-Calbet, M. Vallet-Regí
Published in: Journal of Materials Chemistry B, Issue 5/15, 2017, Page(s) 2714-2725, ISSN 2050-7518
Publisher: Royal Society of Chemistry
DOI: 10.1039/c6tb03062a

Mechanisms of Muscle Weakness Associated with Bone Metastases

Author(s): MIGUEL MANZANO GARCIA, Khalid S. Mohammad, Theresa A. Guise, Maria Vallet-Regi
Published in: International Journal of Cancer and Oncology, Issue 4/2, 2017, Page(s) 1-5, ISSN 2377-0902
Publisher: Sandra S. Hatch
DOI: 10.15436/2377-0902.17.1188

Management of Cancer in the Older Age Person: An Approach to Complex Medical Decisions

Author(s): María Vallet‐Regí, Miguel Manzano, Leocadio Rodriguez‐Mañas, Marta Checa López, Matti Aapro, Lodovico Balducci
Published in: The Oncologist, Issue 22/3, 2017, Page(s) 335-342, ISSN 1083-7159
Publisher: AlphaMed Press Inc
DOI: 10.1634/theoncologist.2016-0276

Copper-containing mesoporous bioactive glass nanoparticles as multifunctional agent for bone regeneration

Author(s): Alessandra Bari, Nora Bloise, Sonia Fiorilli, Giorgia Novajra, Maria Vallet-Regí, Giovanna Bruni, Almudena Torres-Pardo, José M. González-Calbet, Livia Visai, Chiara Vitale-Brovarone
Published in: Acta Biomaterialia, Issue 55, 2017, Page(s) 493-504, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2017.04.012

Prevention of bacterial adhesion to zwitterionic biocompatible mesoporous glasses

Author(s): Sandra Sánchez-Salcedo, Ana García, María Vallet-Regí
Published in: Acta Biomaterialia, Issue 57, 2017, Page(s) 472-486, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2017.05.005

Vectorization of ultrasound-responsive nanoparticles in placental mesenchymal stem cells for cancer therapy

Author(s): Juan L. Paris, Paz de la Torre, M. Victoria Cabañas, Miguel Manzano, Montserrat Grau, Ana I. Flores, María Vallet-Regí
Published in: Nanoscale, Issue 9/17, 2017, Page(s) 5528-5537, ISSN 2040-3364
Publisher: Royal Society of Chemistry
DOI: 10.1039/c7nr01070b

A novel visible light responsive nanosystem for cancer treatment

Author(s): M. Martínez-Carmona, D. Lozano, A. Baeza, M. Colilla, M. Vallet-Regí
Published in: Nanoscale, Issue 9/41, 2017, Page(s) 15967-15973, ISSN 2040-3364
Publisher: Royal Society of Chemistry
DOI: 10.1039/c7nr05050j

Proton Environments in Biomimetic Calcium Phosphates Formed from Mesoporous Bioactive CaO–SiO 2 –P 2 O 5 Glasses in Vitro : Insights from Solid-State NMR

Author(s): Renny Mathew, Claudia Turdean-Ionescu, Yang Yu, Baltzar Stevensson, Isabel Izquierdo-Barba, Ana García, Daniel Arcos, María Vallet-Regí, Mattias Edén
Published in: The Journal of Physical Chemistry C, Issue 121/24, 2017, Page(s) 13223-13238, ISSN 1932-7447
Publisher: American Chemical Society
DOI: 10.1021/acs.jpcc.7b03469

Janus Mesoporous Silica Nanoparticles for Dual Targeting of Tumor Cells and Mitochondria

Author(s): Victoria López, Maria Rocío Villegas, Verónica Rodríguez, Gonzalo Villaverde, Daniel Lozano, Alejandro Baeza, María Vallet-Regí
Published in: ACS Applied Materials & Interfaces, Issue 9/32, 2017, Page(s) 26697-26706, ISSN 1944-8244
Publisher: American Chemical Society
DOI: 10.1021/acsami.7b06906

Lectin-conjugated pH-responsive mesoporous silica nanoparticles for targeted bone cancer treatment

Author(s): Marina Martínez-Carmona, Daniel Lozano, Montserrat Colilla, María Vallet-Regí
Published in: Acta Biomaterialia, Issue 65, 2018, Page(s) 393-404, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2017.11.007

Amine-Functionalized Mesoporous Silica Nanoparticles: A New Nanoantibiotic for Bone Infection Treatment

Author(s): Daniel Pedraza, Jaime Díez, Isabel-Izquierdo-Barba, Montserrat Colilla, María Vallet-Regí
Published in: Biomedical Glasses, Issue 4/1, 2018, Page(s) 1-12, ISSN 2299-3932
Publisher: Boccaccini, Aldo R.
DOI: 10.1515/bglass-2018-0001

Mesoporous Silica Nanoparticles for Drug Delivery: Current Insights

Author(s): María Vallet-Regí, Montserrat Colilla, Isabel Izquierdo-Barba, Miguel Manzano
Published in: Molecules, Issue 23/1, 2018, Page(s) 47, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules23010047

Multifunctional pH sensitive 3D scaffolds for treatment and prevention of bone infection

Author(s): Mónica Cicuéndez, Juan C. Doadrio, Ana Hernández, M. Teresa Portolés, Isabel Izquierdo-Barba, María Vallet-Regí
Published in: Acta Biomaterialia, Issue 65, 2018, Page(s) 450-461, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2017.11.009

Multifunctional Protocells for Enhanced Penetration in 3D Extracellular Tumoral Matrices

Author(s): María Rocío Villegas, Alejandro Baeza, Achraf Noureddine, Paul N. Durfee, Kimberly S. Butler, Jacob Ongudi Agola, C. Jeffrey Brinker, María Vallet-Regí
Published in: Chemistry of Materials, Issue 30/1, 2017, Page(s) 112-120, ISSN 0897-4756
Publisher: American Chemical Society
DOI: 10.1021/acs.chemmater.7b03128

Mesoporous silica nanoparticles decorated with polycationic dendrimers for infection treatment

Author(s): Blanca González, Montserrat Colilla, Jaime Díez, Daniel Pedraza, Marta Guembe, Isabel Izquierdo-Barba, María Vallet-Regí
Published in: Acta Biomaterialia, Issue 68, 2018, Page(s) 261-271, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2017.12.041

Lysine-Grafted MCM-41 Silica as an Antibacterial Biomaterial

Author(s): María Villegas, Lorena Garcia-Uriostegui, Ofelia Rodríguez, Isabel Izquierdo-Barba, Antonio Salinas, Guillermo Toriz, María Vallet-Regí, Ezequiel Delgado
Published in: Bioengineering, Issue 4/4, 2017, Page(s) 80, ISSN 2306-5354
Publisher: Prof. Dr. Anthony Guiseppi-Elie
DOI: 10.3390/bioengineering4040080

Self-immolative chemistry in nanomedicine

Author(s): M. Gisbert-Garzarán, M. Manzano, M. Vallet-Regí
Published in: Chemical Engineering Journal, Issue 340, 2018, Page(s) 24-31, ISSN 1385-8947
Publisher: Elsevier BV
DOI: 10.1016/j.cej.2017.12.098

Interactions between bovine serum albumin and mesoporous silica nanoparticles functionalized with biopolymers

Author(s): Valentina Nairi, Sara Medda, Marco Piludu, Maria Francesca Casula, Maria Vallet-Regì, Maura Monduzzi, Andrea Salis
Published in: Chemical Engineering Journal, Issue 340, 2018, Page(s) 42-50, ISSN 1385-8947
Publisher: Elsevier BV
DOI: 10.1016/j.cej.2018.01.011

Mesoporous core-shell silica nanoparticles with anti-fouling properties for ovarian cancer therapy

Author(s): Sandra Sanchez-Salcedo, Maria Vallet-Regí, Sophia Allaf Shahin, Carlotta A. Glackin, Jeffrey I. Zink
Published in: Chemical Engineering Journal, Issue 340, 2018, Page(s) 114-124, ISSN 1385-8947
Publisher: Elsevier BV
DOI: 10.1016/j.cej.2017.12.116

Mesoporous silica nanoparticles engineered for ultrasound-induced uptake by cancer cells

Author(s): Juan L. Paris, Miguel Manzano, M. Victoria Cabañas, María Vallet-Regí
Published in: Nanoscale, 2018, ISSN 2040-3364
Publisher: Royal Society of Chemistry
DOI: 10.1039/C8NR00693H

Highly-Bioreactive Silica-Based Mesoporous Bioactive Glasses Enriched with Gallium(III)

Author(s): Sandra Sanchez-Salcedo, Gianluca Malavasi, Antonio Salinas, Gigliola Lusvardi, Luca Rigamonti, Ledi Menabue, Maria Vallet-Regi
Published in: Materials, Issue 11/3, 2018, Page(s) 367, ISSN 1996-1944
Publisher: MDPI Open Access Publishing
DOI: 10.3390/ma11030367

Ultrasound-mediated cavitation-enhanced extravasation of mesoporous silica nanoparticles for controlled-release drug delivery

Author(s): Juan L. Paris, Christophoros Mannaris, M. Victoria Cabañas, Robert Carlisle, Miguel Manzano, María Vallet-Regí, Constantin C. Coussios
Published in: Chemical Engineering Journal, Issue 340, 2018, Page(s) 2-8, ISSN 1385-8947
Publisher: Elsevier BV
DOI: 10.1016/j.cej.2017.12.051

Reversible nanogate system for Mesoporous Silica Nanoparticles based on Diels-Alder adducts.

Author(s): Rafael R. Castillo, David Henrández-Escobar, Sergio Gómez-Graña, Maria Vallet-Regi
Published in: Chemistry - A European Journal, 2018, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201706100

Recent advances in porous nanoparticles for drug delivery in antitumoral applications: inorganic nanoparticles and nanoscale metal-organic frameworks

Author(s): Alejandro Baeza, Daniel Ruiz-Molina, María Vallet-Regí
Published in: Expert Opinion on Drug Delivery, Issue 14/6, 2017, Page(s) 783-796, ISSN 1742-5247
Publisher: Ashley Publications Ltd.
DOI: 10.1080/17425247.2016.1229298

Role of the Short Distance Order in Glass Reactivity

Author(s): María Vallet-Regi, Antonio Salinas
Published in: Materials, Issue 11/3, 2018, Page(s) 415, ISSN 1996-1944
Publisher: MDPI Open Access Publishing
DOI: 10.3390/ma11030415

Beyond Traditional Hyperthermia: In Vivo Cancer Treatment with Magnetic-Responsive Mesoporous Silica Nanocarriers

Author(s): Eduardo Guisasola, Laura Asín, Lilianne Beola, Jesús M. de la Fuente, Alejandro Baeza, María Vallet-Regí
Published in: ACS Applied Materials & Interfaces, 2018, ISSN 1944-8244
Publisher: American Chemical Society
DOI: 10.1021/acsami.8b02398

Mesoporous silica nanoparticles functionalized with hyaluronic acid. Effect of the biopolymer chain length on cell internalization

Author(s): Valentina Nairi, Silvia Magnolia, Marco Piludu, Mariella Nieddu, Cristian Antonio Caria, Valeria Sogos, Maria Vallet-Regì, Maura Monduzzi, Andrea Salis
Published in: Colloids and Surfaces B: Biointerfaces, 2018, ISSN 0927-7765
Publisher: Elsevier BV
DOI: 10.1016/j.colsurfb.2018.02.019

Nanoparticles for the treatment of osteoporosis

Author(s): M. Vallet-Regí, P. Mora-Raimundo, M. Manzano
Published in: AIMS Bioengineering, Issue 4/2, 2017, Page(s) 259-274, ISSN 2375-1495
Publisher: Prof. Dr. Anthony Guiseppi-Elie
DOI: 10.3934/bioeng.2017.2.259

High glucose alters the secretome of mechanically stimulated osteocyte-like cells affecting osteoclast precursor recruitment and differentiation

Author(s): Marta Maycas, María Teresa Portolés, María Concepción Matesanz, Irene Buendía, Javier Linares, María José Feito, Daniel Arcos, María Vallet-Regí, Lilian I. Plotkin, Pedro Esbrit, Arancha R. Gortázar
Published in: Journal of Cellular Physiology, Issue 232/12, 2017, Page(s) 3611-3621, ISSN 0021-9541
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/jcp.25829

Mesoporous silica nanoparticles in nanomedicine applications

Author(s): Miguel Manzano, María Vallet-Regí
Published in: Journal of Materials Science: Materials in Medicine, Issue 29/5, 2018, Page(s) 65, ISSN 0957-4530
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10856-018-6069-x

ZnO Nanostructures for Drug Delivery and Theranostic Applications

Author(s): Marina Martínez-Carmona, Yurii Gun’ko, María Vallet-Regí
Published in: Nanomaterials, Issue 8/4, 2018, Page(s) 268, ISSN 2079-4991
Publisher: MDPI AG
DOI: 10.3390/nano8040268

Nanotechnological Strategies for Protein Delivery

Author(s): María Rocío Villegas, Alejandro Baeza, María Vallet-Regí
Published in: Molecules, Issue 23/5, 2018, Page(s) 1008, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules23051008

Heating at the Nanoscale through Drug-Delivery Devices: Fabrication and Synergic Effects in Cancer Treatment with Nanoparticles

Author(s): Eduardo Guisasola, Alejandro Baeza, Laura Asín, Jesús M. de la Fuente, María Vallet-Regí
Published in: Small Methods, 2018, Page(s) 1800007, ISSN 2366-9608
Publisher: WILEY-V C H VERLAG GMBH
DOI: 10.1002/smtd.201800007

Effects of a mesoporous bioactive glass on osteoblasts, osteoclasts and macrophages

Author(s): N. Gómez-Cerezo, L. Casarrubios, I. Morales, M.J. Feito, M. Vallet-Regí, D. Arcos, M.T. Portolés
Published in: Journal of Colloid and Interface Science, Issue 528, 2018, Page(s) 309-320, ISSN 0021-9797
Publisher: Academic Press
DOI: 10.1016/j.jcis.2018.05.099

Collagenase nanocapsules: An approach to fibrosis treatment

Author(s): M. Rocío Villegas, Alejandro Baeza, Alicia Usategui, Pablo L Ortiz-Romero, José L. Pablos, María Vallet-Regí
Published in: Acta Biomaterialia, Issue 74, 2018, Page(s) 430-438, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2018.05.007

Metabolomic response of osteosarcoma cells to nanographene oxide-mediated hyperthermia

Author(s): Mónica Cicuéndez, Joana Flores, Helena Oliveira, M. Teresa Portolés, María Vallet-Regí, Mercedes Vila, Iola F. Duarte
Published in: Materials Science and Engineering: C, Issue 91, 2018, Page(s) 340-348, ISSN 0928-4931
Publisher: Elsevier BV
DOI: 10.1016/j.msec.2018.05.057

Nanomotors for Nucleic Acid, Proteins, Pollutants and Cells Detection

Author(s): Alejandro Baeza, María Vallet-Regí
Published in: International Journal of Molecular Sciences, Issue 19/6, 2018, Page(s) 1579, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms19061579

Targeted Chemo-Photothermal Therapy: A Nanomedicine Approximation to Selective Melanoma Treatment

Author(s): Gonzalo Villaverde, Sergio Gómez-Graña, Eduardo Guisasola, Isabel García, Christoph Hanske, Luis M. Liz-Marzán, Alejandro Baeza, Maria Vallet-Regí
Published in: Particle & Particle Systems Characterization, 2018, Page(s) 1800148, ISSN 0934-0866
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/ppsc.201800148

Synthesis, Characterization and Biocompatibility of Mesolamellar Calcium Phosphate Hybrids Prepared by Anionic Surfactant Templating

Author(s): Antonio J. Salinas, José M. Blanco-Bécares, Okan Mersinlioglu, Laura Casarrubios, Daniel Fernández-Villa, María J. Feito, Teresa Portolés, Blanca González, María Vallet-Regí
Published in: ChemistrySelect, Issue 3/24, 2018, Page(s) 6880-6891, ISSN 2365-6549
Publisher: WILEY-V C H VERLAG GMBH
DOI: 10.1002/slct.201703130

The response of pre-osteoblasts and osteoclasts to gallium containing mesoporous bioactive glasses

Author(s): N. Gómez-Cerezo, E. Verron, V. Montouillout, F. Fayon, P. Lagadec, J.M. Bouler, B. Bujoli, D. Arcos, M. Vallet-Regí
Published in: Acta Biomaterialia, 2018, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2018.06.036

Osteogenic Effect of ZnO-Mesoporous Glasses Loaded with Osteostatin

Author(s): Rebeca Pérez, Sandra Sanchez-Salcedo, Daniel Lozano, Clara Heras, Pedro Esbrit, María Vallet-Regí, Antonio Salinas
Published in: Nanomaterials, Issue 8/8, 2018, Page(s) 592, ISSN 2079-4991
Publisher: MDPI AG
DOI: 10.3390/nano8080592

Features of aminopropyl modified mesoporous silica nanoparticles. Implications on the active targeting capability

Author(s): M.V. Cabañas, D. Lozano, A. Torres-Pardo, C. Sobrino, J. González-Calbet, D. Arcos, M. Vallet-Regí
Published in: Materials Chemistry and Physics, Issue 220, 2018, Page(s) 260-269, ISSN 0254-0584
Publisher: Elsevier BV
DOI: 10.1016/j.matchemphys.2018.09.005

Induction of VEGF secretion from bone marrow stromal cell line (ST-2) by the dissolution products of mesoporous silica glass particles containing CuO and SrO

Author(s): Preethi Balasubramanian, Antonio J. Salinas, Sandra Sanchez-Salcedo, Rainer Detsch, Maria Vallet-Regi, Aldo R. Boccaccini
Published in: Journal of Non-Crystalline Solids, Issue 500, 2018, Page(s) 217-224, ISSN 0022-3093
Publisher: Elsevier BV
DOI: 10.1016/j.jnoncrysol.2018.07.073

Mesoporous bioactive glasses equipped with stimuli-responsive molecular gates for the controlled delivery of levofloxacin against bacteria

Author(s): Lorena Polo, Natividad Gómez-Cerezo, Alba García-Fernández, Elena Aznar, Jose Luis Vivancos, Daniel Arcos, María Vallet-Regí, Ramón Martínez-Máñez
Published in: Chemistry - A European Journal, 2018, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201803301

From proof-of-concept material to PEGylated and modularly targeted ultrasound-responsive mesoporous silica nanoparticles

Author(s): Juan L. Paris, Gonzalo Villaverde, M. Victoria Cabañas, Miguel Manzano, María Vallet-Regí
Published in: Journal of Materials Chemistry B, Issue 6/18, 2018, Page(s) 2785-2794, ISSN 2050-7518
Publisher: Royal Society of Chemistry
DOI: 10.1039/C8TB00444G

Building Block Based Construction of Membrane-Organelle Double Targeted Nanosystem for Two-Drug Delivery

Author(s): Rafael R. Castillo, Daniel Lozano, María Vallet-Regí
Published in: Bioconjugate Chemistry, Issue 29/11, 2018, Page(s) 3677-3685, ISSN 1043-1802
Publisher: American Chemical Society
DOI: 10.1021/acs.bioconjchem.8b00603

Incorporation and effects of mesoporous SiO2-CaO nanospheres loaded with ipriflavone on osteoblast/osteoclast cocultures

Author(s): Laura Casarrubios, Natividad Gómez-Cerezo, María José Feito, María Vallet-Regí, Daniel Arcos, María Teresa Portolés
Published in: European Journal of Pharmaceutics and Biopharmaceutics, Issue 133, 2018, Page(s) 258-268, ISSN 0939-6411
Publisher: Elsevier BV
DOI: 10.1016/j.ejpb.2018.10.019

Improved connective integration of a degradable 3D-nano-apatite/agarose scaffold subcutaneously implanted in a rat model

Author(s): Natalio García-Honduvilla, Alejandro Coca, Miguel A Ortega, Cynthia Trejo, Jesús Román, Juan Peña, M Victoria Cabañas, Maria Vallet Regi, Julia Buján
Published in: Journal of Biomaterials Applications, Issue 33/5, 2018, Page(s) 741-752, ISSN 0885-3282
Publisher: SAGE Publications
DOI: 10.1177/0885328218810084

Suicide-gene transfection of tumor-tropic placental stem cells employing ultrasound-responsive nanoparticles

Author(s): Juan L. Paris, Paz de la Torre, M. Victoria Cabañas, Miguel Manzano, Ana I. Flores, María Vallet-Regí
Published in: Acta Biomaterialia, Issue 83, 2019, Page(s) 372-378, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2018.11.006

Synergistic effect of Si-hydroxyapatite coating and VEGF adsorption on Ti6Al4V-ELI scaffolds for bone regeneration in an osteoporotic bone environment

Author(s): I. Izquierdo-Barba, L. Santos-Ruiz, J. Becerra, M.J. Feito, D. Fernández-Villa, M.C. Serrano, I. Díaz-Güemes, B. Fernández-Tomé, S. Enciso, F.M. Sánchez-Margallo, D. Monopoli, H. Afonso, M.T. Portolés, D. Arcos, M. Vallet-Regí
Published in: Acta Biomaterialia, Issue 83, 2019, Page(s) 456-466, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2018.11.017

The Role of Zwitterionic Materials in the Fight against Proteins and Bacteria

Author(s): Montserrat Colilla, Isabel Izquierdo-Barba, María Vallet-Regí
Published in: Medicines, Issue 5/4, 2018, Page(s) 125, ISSN 2305-6320
Publisher: MDPI
DOI: 10.3390/medicines5040125

Mesoporous Silica Materials as Drug Delivery: “The Nightmare” of Bacterial Infection

Author(s): Marina Martínez-Carmona, Yurii Gun’ko, María Vallet-Regí
Published in: Pharmaceutics, Issue 10/4, 2018, Page(s) 279, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics10040279

Mixed-charge pseudo-zwitterionic mesoporous silica nanoparticles with low-fouling and reduced cell uptake properties

Author(s): Noemí Encinas, Mercedes Angulo, Carlos Astorga, Montserrat Colilla, Isabel Izquierdo-Barba, María Vallet-Regí
Published in: Acta Biomaterialia, Issue 84, 2019, Page(s) 317-327, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2018.12.012

Molecular Scaffolds as Double-Targeting Agents For the Diagnosis and Treatment of Neuroblastoma

Author(s): Gonzalo Villaverde, Arantzazu Alfranca, África Gonzalez-Murillo, Gustavo J. Melen, Rafael R. Castillo, Manuel Ramírez, Alejandro Baeza, María Vallet-Regí
Published in: Angewandte Chemie International Edition, 2019, Page(s) 3067-3072, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201811691

Fabrication of a nanoparticle-containing 3D porous bone scaffold with proangiogenic and antibacterial properties

Author(s): Juan L. Paris, Nuria Lafuente-Gómez, M. Victoria Cabañas, Jesús Román, Juan Peña, María Vallet-Regí
Published in: Acta Biomaterialia, Issue 86, 2019, Page(s) 441-449, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2019.01.013

Ultrasound responsive mesoporous silica nanoparticles for biomedical applications

Author(s): Miguel Manzano, María Vallet-Regí
Published in: Chemical Communications, Issue 55/19, 2019, Page(s) 2731-2740, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/c8cc09389j

Bioceramics: from bone substitutes to nanoparticles for drug delivery

Author(s): María Vallet-Regí
Published in: Pure and Applied Chemistry, Issue 0/0, 2019, ISSN 0033-4545
Publisher: International Union of Pure and Applied Chemistry
DOI: 10.1515/pac-2018-0505

Cancer cell targeting and therapeutic delivery of silver nanoparticles by mesoporous silica nanocarriers: insights into the action mechanisms using quantitative proteomics

Author(s): Sandra Montalvo-Quiros, Guillermo Aragoneses-Cazorla, Laura Garcia-Alcalde, María Vallet-Regí, Blanca González, Jose L. Luque-Garcia
Published in: Nanoscale, Issue 11/10, 2019, Page(s) 4531-4545, ISSN 2040-3364
Publisher: Royal Society of Chemistry
DOI: 10.1039/c8nr07667g

Functional Mesoporous Silica Nanocomposites: Biomedical applications and Biosafety.

Author(s): Rafael R. Castillo, María Vallet-Regí
Published in: International Journal of Molecular Sciences, Issue 20/4, 2019, Page(s) 929, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20040929

Osteostatin potentiates the bioactivity of mesoporous glass scaffolds containing Zn2+ ions in human mesenchymal stem cells

Author(s): C. Heras, S. Sanchez-Salcedo, D. Lozano, J. Peña, P. Esbrit, M. Vallet-Regi, A.J. Salinas
Published in: Acta Biomaterialia, Issue 89, 2019, Page(s) 359-371, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2019.03.033

Advances in mesoporous silica nanoparticles for targeted stimuli-responsive drug delivery: an update

Author(s): Rafael R. Castillo, Daniel Lozano, Blanca González, Miguel Manzano, Isabel Izquierdo-Barba, María Vallet-Regí
Published in: Expert Opinion on Drug Delivery, 2019, Page(s) 1-25, ISSN 1742-5247
Publisher: Ashley Publications Ltd.
DOI: 10.1080/17425247.2019.1598375

Mesoporous bioactive glass/ɛ-polycaprolactone scaffolds promote bone regeneration in osteoporotic sheep

Author(s): N. Gómez-Cerezo, L. Casarrubios, M. Saiz-Pardo, L. Ortega, D. de Pablo, I. Díaz-Güemes, B. Fernández-Tomé, S. Enciso, F.M. Sánchez-Margallo, M.T. Portolés, D. Arcos, M. Vallet-Regí
Published in: Acta Biomaterialia, Issue 90, 2019, Page(s) 393-402, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2019.04.019

Zinc oxide nanocrystals as a nanoantibiotic and osteoinductive agent

Author(s): Nadia Garino, Pasquale Sanvitale, Bianca Dumontel, Marco Laurenti, Montserrat Colilla, Isabel Izquierdo-Barba, Valentina Cauda, Maria Vallet-Regì
Published in: RSC Advances, Issue 9/20, 2019, Page(s) 11312-11321, ISSN 2046-2069
Publisher: Royal Society of Chemistry
DOI: 10.1039/c8ra10236h

Nanoparticles to Knockdown Osteoporosis-Related Gene and Promote Osteogenic Marker Expression for Osteoporosis Treatment

Author(s): Patricia Mora-Raimundo, Daniel Lozano, Miguel Manzano, María Vallet-Regí
Published in: ACS Nano, Issue 13/5, 2019, Page(s) 5451-5464, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.9b00241

Assembly of Multicomponent Nano-Bioconjugates Composed of Mesoporous Silica Nanoparticles, Proteins, and Gold Nanoparticles

Author(s): Giulia Rossella Delpiano, Maria F. Casula, Marco Piludu, Riccardo Corpino, Pier Carlo Ricci, María Vallet-Regí, Enrico Sanjust, Maura Monduzzi, Andrea Salis
Published in: ACS Omega, Issue 4/6, 2019, Page(s) 11044-11052, ISSN 2470-1343
Publisher: AMER CHEMICAL SOC
DOI: 10.1021/acsomega.9b01240

Concanavalin A-targeted mesoporous silica nanoparticles for infection treatment

Author(s): Marina Martínez-Carmona, Isabel Izquierdo-Barba, Montserrat Colilla, María Vallet-Regí
Published in: Acta Biomaterialia, 2019, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2019.07.001

Cerium (III) and (IV) containing mesoporous glasses/alginate beads for bone regeneration: Bioactivity, biocompatibility and reactive oxygen species activity

Author(s): E. Varini, S. Sánchez-Salcedo, G. Malavasi, G. Lusvardi, M. Vallet-Regí, A.J. Salinas
Published in: Materials Science and Engineering: C, Issue 105, 2019, Page(s) 109971, ISSN 0928-4931
Publisher: Elsevier BV
DOI: 10.1016/j.msec.2019.109971

Mesoporous Silica Nanoparticles for Drug Delivery.

Author(s): Miguel Manzano, María Vallet Regí
Published in: Advanced Functional Materials, 2019, Page(s) 1902634, ISSN 1616-301X
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.201902634

Nanomaterials as Promising Alternative in the Infection Treatment

Author(s): María Vallet-Regí, Blanca González, Isabel Izquierdo-Barba
Published in: International Journal of Molecular Sciences, Issue 20/15, 2019, Page(s) 3806, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20153806

Antibacterial Nanostructured Ti Coatings by Magnetron Sputtering: from Laboratory Scales to Industrial Reactors.

Author(s): Rafael Alvarez , Sandra Muñoz-Piña, María U. González, Isabel Izquierdo-Barba, Iván Fernández-Martínez, Victor Rico, Daniel Arcos, Aurelio García-Valenzuela, Alberto Palmero, María Vallet-Regi, Agustín R. , González-Elipe, José M. García-Martín
Published in: Nanomaterials, 2019, Page(s) 1217, ISSN 2079-4991
Publisher: MDPI
DOI: 10.3390/nano9091217

Overcoming the stability, toxicity, and biodegradation challenges of tumor stimuli-responsive inorganic nanoparticles for delivery of cancer therapeutics

Author(s): Juan L. Paris, Alejandro Baeza, María Vallet-Regí
Published in: Expert Opinion on Drug Delivery, Issue 16/10, 2019, Page(s) 1095-1112, ISSN 1742-5247
Publisher: Ashley Publications Ltd.
DOI: 10.1080/17425247.2019.1662786

Silicon substituted hydroxyapatite/VEGF scaffolds stimulate bone regeneration in osteoporotic sheep

Author(s): L. Casarrubios, N. Gómez-Cerezo, S. Sánchez-Salcedo, M.J. Feito, M.C. Serrano, M. Saiz-Pardo, L. Ortega, D. de Pablo, I. Díaz-Güemes, B. Fernández-Tomé, S. Enciso, F.M. Sánchez-Margallo, M.T. Portolés, D. Arcos, M. Vallet-Regí
Published in: Acta Biomaterialia, Issue 101, 2020, Page(s) 544-553, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2019.10.033

Nanoparticles for multimodal antivascular therapeutics: Dual drug release, photothermal and photodynamic therapy

Author(s): Juan L. Paris, Gonzalo Villaverde, Sergio Gómez-Graña, María Vallet-Regí
Published in: Acta Biomaterialia, Issue 101, 2020, Page(s) 459-468, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2019.11.004

Ultrasound-Activated Nanomaterials for Therapeutics

Author(s): Juan L. Paris, María Vallet-Regí
Published in: Bulletin of the Chemical Society of Japan, Issue 93/2, 2020, Page(s) 220-229, ISSN 0009-2673
Publisher: Chemical Society of Japan/Nippon Kagakukai
DOI: 10.1246/bcsj.20190346

Strontium-releasing mesoporous bioactive glasses with anti-adhesive zwitterionic surface as advanced biomaterials for bone tissue regeneration

Author(s): Carlotta Pontremoli, Isabel Izquierdo-Barba, Giorgia Montalbano, María Vallet-Regí, Chiara Vitale-Brovarone, Sonia Fiorilli
Published in: Journal of Colloid and Interface Science, Issue 563, 2020, Page(s) 92-103, ISSN 0021-9797
Publisher: Academic Press
DOI: 10.1016/j.jcis.2019.12.047

The effect of biomimetic mineralization of 3D-printed mesoporous bioglass scaffolds on physical properties and in vitro osteogenicity

Author(s): M. Natividad Gómez-Cerezo, Daniel Lozano, Daniel Arcos, María Vallet-Regí, Cedryck Vaquette
Published in: Materials Science and Engineering: C, Issue 109, 2020, Page(s) 110572, ISSN 0928-4931
Publisher: Elsevier BV
DOI: 10.1016/j.msec.2019.110572

Mesoporous Silica Nanoparticles for the Treatment of Complex Bone Diseases: Bone Cancer, Bone Infection and Osteoporosis

Author(s): Miguel Gisbert-Garzarán, Miguel Manzano, María Vallet-Regí
Published in: Pharmaceutics, Issue 12/1, 2020, Page(s) 83, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics12010083

Substituted hydroxyapatite coatings of bone implants

Author(s): Daniel Arcos, María Vallet-Regí
Published in: Journal of Materials Chemistry B, Issue 8/9, 2020, Page(s) 1781-1800, ISSN 2050-7518
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9tb02710f

Engineered pH-Responsive Mesoporous Carbon Nanoparticles for Drug Delivery

Author(s): Miguel Gisbert-Garzarán, Julia C. Berkmann, Dimitra Giasafaki, Daniel Lozano, Konstantinos Spyrou, Miguel Manzano, Theodore Steriotis, Georg N. Duda, Katharina Schmidt-Bleek, Georgia Charalambopoulou, María Vallet-Regí
Published in: ACS Applied Materials & Interfaces, Issue 12/13, 2020, Page(s) 14946-14957, ISSN 1944-8244
Publisher: American Chemical Society
DOI: 10.1021/acsami.0c01786

Bacteria as Nanoparticles Carrier for Enhancing Penetration in a Tumoral Matrix Model

Author(s): Víctor M. Moreno, Elena Álvarez, Isabel Izquierdo‐Barba, Alejandro Baeza, Juana Serrano‐López, María Vallet‐Regí
Published in: Advanced Materials Interfaces, Issue 7/11, 2020, Page(s) 1901942, ISSN 2196-7350
Publisher: Wiley Online Library
DOI: 10.1002/admi.201901942

Hybrid Injectable Sol-Gel Systems Based on Thermo-Sensitive Polyurethane Hydrogels Carrying pH-Sensitive Mesoporous Silica Nanoparticles for the Controlled and Triggered Release of Therapeutic Agents

Author(s): Monica Boffito, Alessandro Torchio, Chiara Tonda-Turo, Rossella Laurano, Miguel Gisbert-Garzarán, Julia C. Berkmann, Claudio Cassino, Miguel Manzano, Georg N. Duda, María Vallet-Regí, Katharina Schmidt-Bleek, Gianluca Ciardelli
Published in: Frontiers in Bioengineering and Biotechnology, Issue 8, 2020, Page(s) https://www.frontiersin.org/articles/10.3389/fbioe.2020.00384/full, ISSN 2296-4185
Publisher: Frontiers Media
DOI: 10.3389/fbioe.2020.00384

Influence of the Surface Functionalization on the Fate and Performance of Mesoporous Silica Nanoparticles

Author(s): Miguel Gisbert-Garzarán, María Vallet-Regí
Published in: Nanomaterials, Issue 10/5, 2020, Page(s) 916, ISSN 2079-4991
Publisher: MDPI
DOI: 10.3390/nano10050916

Antimycobacterial Effect of Selenium Nanoparticles on Mycobacterium tuberculosis

Author(s): Hector Estevez, Ainhoa Palacios, David Gil, Juan Anguita, Maria Vallet-Regi, Blanca González, Rafael Prados-Rosales, Jose L. Luque-Garcia
Published in: Frontiers in Microbiology, Issue 11, 2020, Page(s) 800, ISSN 1664-302X
Publisher: Frontiers Media
DOI: 10.3389/fmicb.2020.00800

Biomaterials against Bone Infection

Author(s): María Vallet‐Regí, Daniel Lozano, Blanca González, Isabel Izquierdo‐Barba
Published in: Advanced Healthcare Materials, Issue 9/13, 2020, Page(s) 2000310, ISSN 2192-2640
Publisher: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202000310

Mesoporous Silica Nanoparticles as Carriers for Therapeutic Biomolecules

Author(s): Rafael R. Castillo, Daniel Lozano, María Vallet-Regí
Published in: Pharmaceutics, Issue 12/5, 2020, Page(s) 432, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics12050432

Mesoporous Silica Nanoparticles for Co-Delivery of Drugs and Nucleic Acids in Oncology: A Review

Author(s): Juan L. Paris, María Vallet-Regí
Published in: Pharmaceutics, Issue 12/6, 2020, Page(s) 526, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics12060526

Amino-Functionalized Mesoporous Silica Nanoparticle-Encapsulated Octahedral Organoruthenium Complex as an Efficient Platform for Combatting Cancer

Author(s): Marina Martínez-Carmona, Quy P. Ho, Jérémy Morand, Ana García, Enrique Ortega, Luiza C. S. Erthal, Eduardo Ruiz-Hernandez, M. Dolores Santana, José Ruiz, Maria Vallet-Regí, Yurii K. Gun’ko
Published in: Inorganic Chemistry, Issue 59/14, 2020, Page(s) 10275-10284, ISSN 0020-1669
Publisher: American Chemical Society
DOI: 10.1021/acs.inorgchem.0c01436

Development and evaluation of copper-containing mesoporous bioactive glasses for bone defects therapy

Author(s): J. Jiménez-Holguín, S. Sánchez-Salcedo, M. Vallet-Regí, A.J. Salinas
Published in: Microporous and Mesoporous Materials, 2020, Page(s) 110454, ISSN 1387-1811
Publisher: Elsevier BV
DOI: 10.1016/j.micromeso.2020.110454

Impact of the antibiotic-cargo from MSNs on gram-positive and gram-negative bacterial biofilms

Author(s): Anna Aguilar-Colomer, Montserrat Colilla, Isabel Izquierdo-Barba, Carla Jiménez-Jiménez, Ignacio Mahillo, Jaime Esteban, María Vallet-Regí
Published in: Microporous and Mesoporous Materials, Issue 311, 2021, Page(s) 110681, ISSN 1387-1811
Publisher: Elsevier BV
DOI: 10.1016/j.micromeso.2020.110681

Antibacterial effect of 3D printed mesoporous bioactive glass scaffolds doped with metallic silver nanoparticles.

Author(s): Sandra Sánchez-Salcedo , Ana García, Adela González-Jiménez , María Vallet-Regí
Published in: Acta Biomaterialia, Issue 17427061, 2022, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2022.10.045

In Vitro and In Vivo Response of Zinc-Containing Mesoporous Bioactive Glasses in a Sheep Animal Model.

Author(s): Javier Jiménez-Holguín, Daniel Arcos, Daniel Lozano, Melchor, Saiz-Pardo, David De Pablo, Luis Ortega, Silvia Enciso, Blanca, Fernández-Tomé, Idoia López-Güemes, Francisco Miguel Sánchez-Margallo, Laura Casarrubios, María Teresa Portolés, María Vallet-Regí
Published in: International Journal of Molecular Sciences, Issue 14220067, 2022, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms232213918

Achievements in Mesoporous Bioactive Glasses for Biomedical Applications.

Author(s): María Vallet-Regí, Montserrat Colilla, Isabel Izquierdo-Barba, Chiara Vitale-Brovarone, Sonia Fiorilli
Published in: Pharmaceutics, 2022, Page(s) 2636, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics14122636

Designing Mesoporous Silica Nanoparticles to Overcome Biological Barriers by Incorporating Targeting and Endosomal Escape

Author(s): Miguel Gisbert-Garzarán, Daniel Lozano, Kotaro Matsumoto, Aoi Komatsu, Miguel Manzano, Fuyuhiko Tamanoi, María Vallet-Regí
Published in: ACS Applied Materials & Interfaces, Issue 13/8, 2021, Page(s) 9656-9666, ISSN 1944-8244
Publisher: American Chemical Society
DOI: 10.1021/acsami.0c21507

Advances in Laser Ablation Synthesized Silicon-Based Nanomaterials for the Prevention of Bacterial Infection

Author(s): Marina Martínez-Carmona, María Vallet-Regí
Published in: Nanomaterials, Issue 10/8, 2020, Page(s) 1443, ISSN 2079-4991
Publisher: MDPI
DOI: 10.3390/nano10081443

Multiscale porosity in mesoporous bioglass 3D-printed scaffolds for bone regeneration

Author(s): M. Natividad Gómez-Cerezo, Juan Peña, Sašo Ivanovski, Daniel Arcos, María Vallet-Regí, Cedryck Vaquette
Published in: Materials Science and Engineering: C, 2020, Page(s) 111706, ISSN 0928-4931
Publisher: Elsevier BV
DOI: 10.1016/j.msec.2020.111706

Bacteria-assisted transport of nanomaterials to improve drug delivery in cancer therapy

Author(s): Carla Jiménez-Jiménez, Víctor M. Moreno, María Vallet-Regí 
Published in: Nanomaterials, 2022, Page(s) 288, ISSN 2079-4991
Publisher: MDPI
DOI: 10.3390/nano12020288

Effects of mesoporous SiO2-CaO nanospheres on the murine peritoneal macrophages/Candidaalbicans interface

Author(s): R. Diez-Orejas, L. Casarrubios, M.J. Feito, J.M. Rojo, M. Vallet-Regí, D. Arcos, M.T. Portolés
Published in: International Immunopharmacology, Issue 94, 2021, Page(s) 107457, ISSN 1567-5769
Publisher: Elsevier BV
DOI: 10.1016/j.intimp.2021.107457

Superparamagnetic Iron Oxide Nanoparticles into Collagen Formulation for 3D Electrospun Scaffolds.

Author(s): Manuel Estévez, Giorgia Montalbano, Isabel Izquierdo-Barba *, Blanca González, Clarissa Tomasina, Lorenzo Moroni, María Vallet-Regí, Chiara Vitale Brovarone, Sonia Fiorilli *
Published in: Nanomaterials, 2021, Page(s) 181, ISSN 2079-4991
Publisher: MDPI
DOI: 10.3390/nano12020181

Osteoporosis Remission and New Bone Formation with Mesoporous Silica Nanoparticles

Author(s): Patricia Mora‐Raimundo, Daniel Lozano, Manuel Benito, Francisca Mulero, Miguel Manzano, María Vallet‐Regí
Published in: Advanced Science, 2021, Page(s) 2101107, ISSN 2198-3844
Publisher: WILEY
DOI: 10.1002/advs.202101107

Mesoporous Silica Nanoparticles as Theranostic Antitumoral Nanomedicines

Author(s): Alejandro Baeza, Maria Vallet-Regí
Published in: Pharmaceutics, Issue 12/10, 2020, Page(s) 957, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics12100957

Effective reduction of biofilm through photothermal therapy by gold core@shell based mesoporous silica nanoparticles

Author(s): Ana García, Blanca González, Catherine Harvey, Isabel Izquierdo-Barba , María Vallet-Regí
Published in: Microporous and Mesoporous Materials, 2021, Page(s) 111489, ISSN 1387-1811
Publisher: Elsevier BV
DOI: 10.1016/j.micromeso.2021.111489

Hard and Soft Protein Corona of Nanomaterials: Analysis and Relevance

Author(s): Rafaela García-Álvarez, María Vallet-Regí
Published in: Nanomaterials, Issue 11/4, 2021, Page(s) 888, ISSN 2079-4991
Publisher: MDPI
DOI: 10.3390/nano11040888

Evolution of Biomaterials

Author(s): María Vallet-Regí
Published in: Frontiers in Materials, Issue 22968016, 2022, Page(s) 804016, ISSN 2296-8016
Publisher: FRONTIERS MEDIA SA
DOI: 10.3389/fmats.2022.864016

Engineering Mesoporous Silica Nanoparticles for Drug Delivery: where are we after two decades?

Author(s): María Vallet-Regí, Ferdi Schüth, Daniel Lozano, Montserrat Colilla, and Miguel Manzano
Published in: Chemical Society Review, Issue 03060012, 2022, Page(s) 5365 -5451, ISSN 0306-0012
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1cs00659b

Other (1)

Nanoparticles for Bio-Medical Applications

Author(s): Miguel Gisbert-Garzarán, María Vallet-Regí
Published in: Nanomaterials, Issue 20794991, 2022, Page(s) 1189, ISSN 2079-4991
Publisher: MDPI
DOI: 10.3390/nano12071189

Intellectual Property Rights

Patent (1)

NANOCAPSULE COMPOSITIONS FOR THE CONTROLLED RELEASED OF AGENTS OF THERAPEUTIC INTEREST

Application/Publication number: 18 382005
Date: 2018-01-09