CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.
I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .
Risultati finali
iQSARs for KE for common respiratory toxicity pathways: a mathematical model to relate the calculated NM descriptors and the probability of the identified MIE/KE for specific respiratory TP/AOP.
Prediction of content of NP-BM corona in lung fluidsPrediction of content of NP-BM corona in lung fluids: calculation of binding affinities for lung surfactandt proteins and lipids, affinity ranking, and prediction of concentration of seleceted molecules in the NP corona for selected nanomaterials (up to 60).
Identification of potential AOPs for pulmonary exposure to NMsResutls of data mining in GEO database and other AOP resources for known NP-related adverse outcomes.
PMFs and binding free energies for interaction of NM with building blocks of biomoleculesResults of atomistic simulations: potnetials of mean force and binding free energies for interaction of selected NMs (up to 60) with building blocks of biomolecules - lipid fragments, headgroups, aminoacids.
List of NMsList of NM to be used within the project and characterization will be compiled based on assessment of the available and most suitable materials. NM Materials (the NM series) deposited in the EC, Joint Research Centre (selected by the OECD Nanomaterials Working Party) and a series of 64 materials (the NRCWE series) available at the NRCWE (Partner 4) will be assessed for suitability for in vivo inhalation and in vitro tracking studies.
Molecular mechanisms of interactions of key molecules of each TP with NMsResults of MD simulations of interaction between the specific molecules involved in the MIE/KE as identified in WP3 for selceted NMs. Report on binding rate, orientation, conformational change.
In vivo samples for transcriptomics studies (inhalation)In vivo samples for transcriptomics studies (inhalation - rats, mice): Lung tissues collected 3, 30, 90 and 180 days after the end of animal exposure to assess short and long term effects of NMs.
A CG model of epithelial lining fluid, surfactant and mucusA coarse-grained (DPD or LB/LD) molecular simulation model of epithelial lining fluid, surfactant and mucus including all the main components – lipids, proteins and sugars, validated against experimental data (surface tension, adsorption energy, viscosity).
Report of end-localization of NPs within relevant cellsReport of end-localization of NPs within relevant cells: results of cell lines (macrophages and lung epithelium cells) and lung tissue exposure to the functionalized and labeled NPs regarding trafficking, partitioning and accumulation of the NPs.
Identify and score the pathological outcome of the in vivo exposuresList and assessment of severity of pathological outcomes of the in vivo exposures: hystopathology, transcriptomics (and targeted proteomics) analyses of in vivo and in vitro exposures of mice and rats to the NMs.
Report on surface tension experimentsReport on surface tension experiments using the Constrained Drop Surfactometer: The effect of NMs adsorbed from aerosol on lung surfactant and on lung surface tension.
Report on statistical models that predict TPs for specific NMs.Description of developed statistical models for predicting toxicity for specific NMs.
In vivo samples for transcriptomics studies (instillation)In vivo samples for transcriptomics studies (instillation - mice): Lung tissues collected at different time points following animal exposure to assess short and long term effects of NMs.
Particle specific responses and their compliance between in vivo and in vitroReport on the particle specific responses and their compliance between in vivo and in vitro as obtained fro momics analysis. Discussion of possibility of in vitro-in vivo extrapolation.
Isolation and archiving of biological samples for subsequent analysisIsolation and archiving of biological in vivo samples (exposed mice / rats) for subsequent analysis (lung lavage analysis, hematology and histology, transcriptomics).
Labelled NPs for tracking within cells and tissuesNanoparticles fluorescently or isotopically labeled to enable tracking within the cells and evaluation of the interactions with the NP coats such as protein corona or lipid wraps.
Candidate genes and pathways relevant to the AOPs for validation experimentsResults of analysis of the toxicity pathways and AOPs to identify specific biomarkers, MIEs and KEs relevant to each AOPs for validation experiments. List of identified bimarkers, MIEs, KEs.
Database of NP-BM interactionsDatabase of NP-BM interactions: new descriptors, suitable for bionano interface, (protein bindign affinities, hydration energies, band gaps, dissolution rates, etc.) for selected NMs (ip to 60) as calcualted by ab initio MD, atomistic and CG MD simulations.
Report of in vitro and in vivo toxicological properties of NMReport of in vitro and in vivo toxicological properties of NM: Cytology and biochemistry of the bronchoalveolar fluid study to assess lung inflammation and toxicity, histological analyses on lung and liver, pulmonary inflammation in terms of broncho-alveolar lavage cell composition, DNA strand break levels in lung and liver tissues. Reverse Phase Protein Array study results to characterize classical signaling pathways activated by toxic NM.
In vitro samples for transcriptomics studiesCocultures of mouse macrophage and epithelial cells will be prepared and used to study the toxicity NM and investigate the cellular uptake of NM as well as cell-specific gene expression profile and production of cytokines (P3, P4). A murine dose controlled air-liquid interface cell exposure system, provided by P12 will be applied.
List of nanomaterials and respective doses to be tested as TP benchmarkList of nanomaterials and respective doses to be tested as TP benchmark: results of literature survey, data mining, initial tests regarding the materials with well established toxic action.
NP coat compositionNP corona composition as determined by lipidomics and protomics study of the particles exposed to in vitro cell cultures and model membranes.
Report on mechanisms of corona/lipid wrap evolutionReport on mechanisms of corona/lipid wrap evolution as obtained from label-free quantitative mass-spectrometry-based proteomics and from high resolution Q-Exctive mass spectrometer for lipids.
Report the deduced toxicity-pathway specific end-pointsToxicity mechanisms (pathways) as established in statistical modelling and Bayesian analysis performed on the in vivo and in vitro proteomics and transcriptomics data.
Position paper on predictive in vitro modelshe literature will be surveyed for providing a basis for the best selection of cultured cells and effects by different NMs. A position paper will be written on the poissibilities and limiations of in vitro toxicity assessment techniques.
Classification of NPs according to ability to penetrate membranesClassification of NPs according to ability to modify, penetrate, or destroy lipid membranes (lung and epithelial cell membranes) as obtained in atomistic and CG simulations and theory.
Report on validity of the extracted TPsReport on validation tests for the extracted TP/AOPs using blocking of pathways with pharmaceutical agents, gene silencing, or KO models (if available).
Exploitation plan for the materials modelling methods, in vitro toxicity assessment techniques, in silico toxicity assessment scheme.
Organisation of international conferencesAnnual symposia around a major theme (in vivo, in vitro, in silico) of the project each year, which will also serve as a progress review for the project (Year 1 – Dublin;Year 2 – Ljubljana; Year 3 – Nancy) with invitation of other significant EU players (related H2020 projects and major EU labs).
Submission of AOPs to OECD databaseSubmission of AOPs to OECD database: novel respiratory or NM-related AOPs (up to 5), established and validated within the project.
Final Nanotox SymposiumFinal Nanotox Symposium summarizing all the progress made and considering the next steps. All the partners represented, 5-6 invited speakers.
Development of the data portalPortal for data storage, exchange, annotation and evaluation between the partners as a part of the project website with restricted access.
Establishment of a stakeholder advisory boardEstablishment of a stakeholder advisory board: invitation of top experts in toxicology, nanomaterials, software engineering, environmental safety to participate in the project advisory board.
Development of a public database of NM descriptorsDevelopment of a public database of NM descriptors: a database format for the NM descriptors upon consultation with eNanoMapper, Nanoreg 2, NanoSafe, OpenTox.
Plan for dissemination, storage and maintenance of obtained data during and after project term. List of data to be stored, formats and technologies.
Pubblicazioni
Autori:
Jérôme Devoy, Hervé Nunge, Elodie Bonfanti, Carole Seidel, Laurent Gaté, Frédéric Cosnier
Pubblicato in:
Nanotoxicology, 2020, Pagina/e 1-14, ISSN 1743-5390
Editore:
Informa Healthcare
DOI:
10.1080/17435390.2020.1814439
Autori:
Hana Kokot, Boštjan Kokot, Aleksandar Sebastijanović, Carola Voss, Rok Podlipec, Patrycja Zawilska, Trine Berthing, Carolina Ballester López, Pernille Høgh Danielsen, Claudia Contini, Mikhail Ivanov, Ana Krišelj, Petra Čotar, Qiaoxia Zhou, Jessica Ponti, Vadim Zhernovkov, Matthew Schneemilch, Zahra Doumandji, Mojca Pušnik, Polona Umek, Stane Pajk, Olivier Joubert, Otmar Schmid, Iztok Urban
Pubblicato in:
Advanced Materials, 2020, Pagina/e 2003913, ISSN 0935-9648
Editore:
United Nations Industrial Developement Organization
DOI:
10.1002/adma.202003913
Autori:
Lin Yang, Regine Gradl, Martin Dierolf, Winfried Möller, David Kutschke, Annette Feuchtinger, Lorenz Hehn, Martin Donnelley, Benedikt Günther, Klaus Achterhold, Axel Walch, Tobias Stoeger, Daniel Razansky, Franz Pfeiffer, Kaye S. Morgan, Otmar Schmid
Pubblicato in:
Small, Numero 15/49, 2019, Pagina/e 1904112, ISSN 1613-6810
Editore:
Wiley - V C H Verlag GmbbH & Co.
DOI:
10.1002/smll.201904112
Autori:
Mélanie M. Leroux, Zahra Doumandji, Laetitia Chézeau, Laurent Gaté, Sara Nahle, Romain Hocquel, Vadim Zhernovkov, Sylvie Migot, Jafar Ghanbaja, Céline Bonnet, Raphaël Schneider, Bertrand H. Rihn, Luc Ferrari, Olivier Joubert
Pubblicato in:
International Journal of Molecular Sciences, Numero 21/14, 2020, Pagina/e 4855, ISSN 1422-0067
Editore:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/ijms21144855
Autori:
Marzieh Saeedimasine, Erik G. Brandt, Alexander P. Lyubartsev
Pubblicato in:
The Journal of Physical Chemistry B, 2020, ISSN 1520-6106
Editore:
American Chemical Society
DOI:
10.1021/acs.jpcb.0c08622
Autori:
Lorenzo Agosta, Erik G. Brandt, Alexander P. Lyubartsev
Pubblicato in:
The Journal of Chemical Physics, 2017, ISSN 0021-9606
Editore:
American Institute of Physics
DOI:
10.1063/1.4991381
Autori:
Claudia Contini, Matthew Schneemilch, Simon Gaisford, Nick Quirke
Pubblicato in:
Journal of Experimental Nanoscience, 2017, Pagina/e 1-20, ISSN 1745-8080
Editore:
Taylor & Francis
DOI:
10.1080/17458080.2017.1413253
Autori:
Otmar Schmid, Flemming R. Cassee
Pubblicato in:
Particle and Fibre Toxicology, Numero 14/1, 2017, ISSN 1743-8977
Editore:
BioMed Central
DOI:
10.1186/s12989-017-0233-1
Autori:
Ulla Vogel, Flemming R. Cassee
Pubblicato in:
Particle and Fibre Toxicology, Numero 15/1, 2018, ISSN 1743-8977
Editore:
BioMed Central
DOI:
10.1186/s12989-018-0247-3
Autori:
M. Schneemilch, N. Quirke
Pubblicato in:
The Journal of Chemical Physics, Numero 148/19, 2018, Pagina/e 194704, ISSN 0021-9606
Editore:
American Institute of Physics
DOI:
10.1063/1.5028557
Autori:
Zahra M. Doumandji, Bertrand Rihn, Olivier Joubert
Pubblicato in:
Free Radical Biology and Medicine, Numero 120, 2018, Pagina/e S88, ISSN 0891-5849
Editore:
Elsevier BV
DOI:
10.1016/j.freeradbiomed.2018.04.290
Autori:
Iztok Urbančič, Maja Garvas, Boštjan Kokot, Hana Majaron, Polona Umek, Hilary Cassidy, Miha Škarabot, Falk Schneider, Silvia Galiani, Zoran Arsov, Tilen Koklic, David Matallanas, Miran Čeh, Igor Muševič, Christian Eggeling, Janez Štrancar
Pubblicato in:
Nano Letters, 2018, ISSN 1530-6984
Editore:
American Chemical Society
DOI:
10.1021/acs.nanolett.8b02291
Autori:
Kristina Bram Knudsen, Trine Berthing, Petra Jackson, Sarah Søs Poulsen, Alicja Mortensen, Nicklas Raun Jacobsen, Vidar Skaug, Józef Szarek, Karin Sørig Hougaard, Henrik Wolff, Håkan Wallin, Ulla Vogel
Pubblicato in:
Basic & Clinical Pharmacology & Toxicology, 2018, ISSN 1742-7835
Editore:
Nordic Pharmacological Society
DOI:
10.1111/bcpt.13119
Autori:
Shigeyuki Magi, Kazunari Iwamoto, Noriko Yumoto, Michio Hiroshima, Takeshi Nagashima, Rieko Ohki, Amaya Garcia-Munoz, Natalia Volinsky, Alexander Von Kriegsheim, Yasushi Sako, Koichi Takahashi, Shuhei Kimura, Boris N. Kholodenko, Mariko Okada-Hatakeyama
Pubblicato in:
Journal of Biological Chemistry, Numero 293/6, 2018, Pagina/e 2206-2218, ISSN 0021-9258
Editore:
American Society for Biochemistry and Molecular Biology Inc.
DOI:
10.1074/jbc.M117.778399
Autori:
Tapesh Santra, Oleksii Rukhlenko, Vadim Zhernovkov, Boris N. Kholodenko
Pubblicato in:
Current Opinion in Systems Biology, Numero 9, 2018, Pagina/e 11-21, ISSN 2452-3100
Editore:
Elsevier BV
DOI:
10.1016/j.coisb.2018.02.003
Autori:
Keesha E. Erickson, Oleksii S. Rukhlenko, Richard G. Posner, William S. Hlavacek, Boris N. Kholodenko
Pubblicato in:
Seminars in Cancer Biology, 2018, ISSN 1044-579X
Editore:
Academic Press
DOI:
10.1016/j.semcancer.2018.02.008
Autori:
Oleksii S. Rukhlenko, Fahimeh Khorsand, Aleksandar Krstic, Jan Rozanc, Leonidas G. Alexopoulos, Nora Rauch, Keesha E. Erickson, William S. Hlavacek, Richard G. Posner, Silvia Gómez-Coca, Edina Rosta, Cheree Fitzgibbon, David Matallanas, Jens Rauch, Walter Kolch, Boris N. Kholodenko
Pubblicato in:
Cell Systems, Numero 7/2, 2018, Pagina/e 161-179.e14, ISSN 2405-4712
Editore:
Elsevier BV
DOI:
10.1016/j.cels.2018.06.002
Autori:
Susanne Fritsch-Decker, Clarissa Marquardt, Tobias Stoeger, Silvia Diabaté, Carsten Weiss
Pubblicato in:
Archives of Toxicology, Numero 92/7, 2018, Pagina/e 2163-2174, ISSN 0340-5761
Editore:
Springer Verlag
DOI:
10.1007/s00204-018-2223-y
Autori:
Rauch N., Rukhlenko O., Kolch W., Kholodenko B.
Pubblicato in:
Current Opinion in Structural Biology, Numero 41, 2016, Pagina/e 151–158, ISSN 0959-440X
Editore:
Elsevier BV
DOI:
10.1016/j.sbi.2016.07.019
Autori:
Schneemilch M., Quirke N.
Pubblicato in:
Free energy of adsorption of supported lipid bilayers from molecular dynamics simulation, Numero 664, 2016, Pagina/e 199–204, ISSN 0009-2614
Editore:
Elsevier BV
DOI:
10.1016/j.cplett.2016.10.010
Autori:
Agosta L., Brandt e., Lyubartsev A.P.
Pubblicato in:
Nanoscale, Numero 8, 2016, Pagina/e 13385-13398, ISSN 2040-3364
Editore:
Royal Society of Chemistry
DOI:
10.1039/c6nr02791a
Autori:
Lan K. Nguyen, Boris N. Kholodenko, Alex von Kriegsheim
Pubblicato in:
Small GTPases, Numero 17, 2016, Pagina/e 1-6, ISSN 2154-1248
Editore:
Landes Bioscience
DOI:
10.1080/21541248.2016.1224399
Autori:
Fallahi E, O'Driscoll NA, Matallanas D.
Pubblicato in:
Genes (Basel), Numero 17, 2016, ISSN 2073-4425
Editore:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/genes7060028
Autori:
Laurent Gaté, Kristina Bram Knudsen, Carole Seidel, Trine Berthing, Laëtitia Chézeau, Nicklas Raun Jacobsen, Sarah Valentino, Håkan Wallin, Sébastien Bau, Henrik Wolff, Sylvie Sébillaud, Mylène Lorcin, Stéphane Grossmann, Stéphane Viton, Hervé Nunge, Christian Darne, Ulla Vogel, Frédéric Cosnier
Pubblicato in:
Toxicology and Applied Pharmacology, Numero 375, 2019, Pagina/e 17-31, ISSN 0041-008X
Editore:
Academic Press
DOI:
10.1016/j.taap.2019.05.001
Autori:
M. Schneemilch, N. Quirke
Pubblicato in:
The Journal of Chemical Physics, Numero 150/22, 2019, Pagina/e 229901, ISSN 0021-9606
Editore:
American Institute of Physics
DOI:
10.1063/1.5111197
Autori:
Vadim Zhernovkov, Tapesh Santra, Hilary Cassidy, Oleksii Rukhlenko, David Matallanas, Aleksandar Krstic, Walter Kolch, Vladimir Lobaskin, Boris N Kholodenko
Pubblicato in:
Toxicological Sciences, 2019, ISSN 1096-6080
Editore:
Oxford University Press
DOI:
10.1093/toxsci/kfz151
Autori:
Niels Hadrup, Feriel Rahmani, Nicklas R. Jacobsen, Anne T. Saber, Petra Jackson, Stefan Bengtson, Andrew Williams, Håkan Wallin, Sabina Halappanavar, Ulla Vogel
Pubblicato in:
Nanotoxicology, 2019, Pagina/e 1-18, ISSN 1743-5390
Editore:
Informa Healthcare
DOI:
10.1080/17435390.2019.1654004
Autori:
David Power, Ian Rouse, Stefano Poggio, Erik Brandt, Hender Lopez, Alexander Lyubartsev, Vladimir Lobaskin
Pubblicato in:
Modelling and Simulation in Materials Science and Engineering, Numero 27/8, 2019, Pagina/e 084003, ISSN 0965-0393
Editore:
Institute of Physics Publishing
DOI:
10.1088/1361-651x/ab3b6e
Autori:
M. Schneemilch, N. Quirke
Pubblicato in:
The Journal of Chemical Physics, Numero 151/13, 2019, Pagina/e 134707, ISSN 0021-9606
Editore:
American Institute of Physics
DOI:
10.1063/1.5120810
Autori:
Pernille Høgh Danielsen, Kristina Bram Knudsen, Janez Štrancar, Polona Umek, Tilen Koklič, Maja Garvas, Esa Vanhala, Sauli Savukoski, Yaobo Ding, Anne Mette Madsen, Nicklas Raun Jacobsen, Ingrid Konow Weydahl, Trine Berthing, Sarah Søs Poulsen, Otmar Schmid, Henrik Wolff, Ulla Vogel
Pubblicato in:
Toxicology and Applied Pharmacology, 2019, Pagina/e 114830, ISSN 0041-008X
Editore:
Academic Press
DOI:
10.1016/j.taap.2019.114830
Autori:
Sabina Halappanavar, Luna Rahman, Jake Nikota, Sarah S. Poulsen, Yaobo Ding, Petra Jackson, Hakan Wallin, Otmar Schmid, Ulla Vogel, Andrew Williams
Pubblicato in:
NanoImpact, Numero 14, 2019, Pagina/e 100158, ISSN 2452-0748
Editore:
Elsevier BV
DOI:
10.1016/j.impact.2019.100158
Autori:
Niels Hadrup, Anne T. Saber, Zdenka O. Kyjovska, Nicklas R. Jacobsen, Minnamari Vippola, Essi Sarlin, Yaobo Ding, Otmar Schmid, Håkan Wallin, Keld A. Jensen, Ulla Vogel
Pubblicato in:
Environmental Toxicology and Pharmacology, 2019, Pagina/e 103303, ISSN 1382-6689
Editore:
Elsevier BV
DOI:
10.1016/j.etap.2019.103303
Autori:
Doumandji Zahra, Safar Ramia, Lovera-Leroux Mélanie, Nahle Sara, Cassidy Hilary, Matallanas David, Rihn Bertrand, Ferrari Luc, Joubert Olivier
Pubblicato in:
Cell Biology and Toxicology, 2019, ISSN 0742-2091
Editore:
Kluwer Academic Publishers
DOI:
10.1007/s10565-019-09484-6
Autori:
Fernando Luís Barroso da Silva, Paolo Carloni, David Cheung, Grazia Cottone, Serena Donnini, E. Allen Foegeding, Muhammad Gulzar, Jean Christophe Jacquier, Vladimir Lobaskin, Donal MacKernan, Zeynab Mohammad Hosseini Naveh, Ravi Radhakrishnan, Erik E. Santiso
Pubblicato in:
Annual Review of Food Science and Technology, Numero 11/1, 2020, Pagina/e 365-387, ISSN 1941-1413
Editore:
Annual Reviews Inc.
DOI:
10.1146/annurev-food-032519-051640
Autori:
Martin Thomas Horsch, Christoph Niethammer, Gianluca Boccardo, Paola Carbone, Silvia Chiacchiera, Mara Chiricotto, Joshua D. Elliott, Vladimir Lobaskin, Philipp Neumann, Peter Schiffels, Michael A. Seaton, Ilian T. Todorov, Jadran Vrabec, Welchy Leite Cavalcanti
Pubblicato in:
Journal of Chemical & Engineering Data, Numero 65/3, 2020, Pagina/e 1313-1329, ISSN 0021-9568
Editore:
American Chemical Society
DOI:
10.1021/acs.jced.9b00739
Autori:
Hana Majaron, Boštjan Kokot, Aleksandar Sebastijanović, Carola Voss, Rok Podlipec, Patrycja Zawilska, Trine Berthing, Carolina Ballester López, Pernille Høgh Danielsen, Claudia Contini, Mikhail Ivanov, Ana Krišelj, Petra Čotar, Qiaoxia Zhou, Jessica Ponti, Vadim Zhernovkov, Matthew Schneemilch, Zahra Manel Doumandji, Mojca Pušnik, Polona Umek, Stane Pajk, Olivier Joubert, Otmar Schmid, Izto
Pubblicato in:
BioRxiv, 2020, ISSN 1943-0264
Editore:
Cold Spring Harbor Laboratory Press
DOI:
10.1101/2020.02.27.966036
Autori:
Niels Hadrup, Vadim Zhernovkov, Nicklas Raun Jacobsen, Carola Voss, Maximilian Strunz, Meshal Ansari, Herbert B. Schiller, Sabina Halappanavar, Sarah S. Poulsen, Boris Kholodenko, Tobias Stoeger, Anne Thoustrup Saber, Ulla Vogel
Pubblicato in:
Small, 2020, Pagina/e 1907476, ISSN 1613-6810
Editore:
Wiley - V C H Verlag GmbbH & Co.
DOI:
10.1002/smll.201907476
Autori:
Sabina Halappanavar, Sybille van den Brule, Penny Nymark, Laurent Gaté, Carole Seidel, Sarah Valentino, Vadim Zhernovkov, Pernille Høgh Danielsen, Andrea De Vizcaya, Henrik Wolff, Tobias Stöger, Andrey Boyadziev, Sarah Søs Poulsen, Jorid Birkelund Sørli, Ulla Vogel
Pubblicato in:
Particle and Fibre Toxicology, Numero 17/1, 2020, ISSN 1743-8977
Editore:
BioMed Central
DOI:
10.1186/s12989-020-00344-4
Autori:
James D. Ede, Vladimir Lobaskin, Ulla Vogel, Iseult Lynch, Sabina Halappanavar, Shareen H. Doak, Megan G. Roberts, Jo Anne Shatkin
Pubblicato in:
Nanomaterials, Numero 10/6, 2020, Pagina/e 1229, ISSN 2079-4991
Editore:
MDPI AG
DOI:
10.3390/nano10061229
Autori:
Jorid Sørli
Pubblicato in:
ALTEX, 2017, ISSN 1868-596X
Editore:
ALTEX
DOI:
10.14573/altex.1705181
Autori:
Lorenzo Agosta, Erik G. Brandt, Alexander P. Lyubartsev
Pubblicato in:
The Journal of Chemical Physics, Numero 147/2, 2017, Pagina/e 024704, ISSN 0021-9606
Editore:
American Institute of Physics
DOI:
10.1063/1.4991381
Autori:
Dirk Fey, Edita Aksamitiene, Anatoly Kiyatkin, Boris N. Kholodenko
Pubblicato in:
Methods Mol Biol, Numero 1636, 2017, Pagina/e 417-453, ISSN 1064-3745
Editore:
Humana Press, Inc.
DOI:
10.1007/978-1-4939-7154-1_27
Autori:
Andrea Degasperi, Dirk Fey, Boris N. Kholodenko
Pubblicato in:
npj Systems Biology and Applications, Numero 3/1, 2017, ISSN 2056-7189
Editore:
Springer Nature
DOI:
10.1038/s41540-017-0023-2
Autori:
Koustav Ganguly, Dariusch Ettehadieh, Swapna Upadhyay, Shinji Takenaka, Thure Adler, Erwin Karg, Fritz Krombach, Wolfgang G. Kreyling, Holger Schulz, Otmar Schmid, Tobias Stoeger
Pubblicato in:
Particle and Fibre Toxicology, Numero 14/1, 2017, ISSN 1743-8977
Editore:
BioMed Central
DOI:
10.1186/s12989-017-0200-x
Autori:
Christine Sattler, Franco Moritz, Shanze Chen, Beatrix Steer, David Kutschke, Martin Irmler, Johannes Beckers, Oliver Eickelberg, Philippe Schmitt-Kopplin, Heiko Adler, Tobias Stoeger
Pubblicato in:
Particle and Fibre Toxicology, Numero 14/1, 2017, ISSN 1743-8977
Editore:
BioMed Central
DOI:
10.1186/s12989-016-0181-1
Autori:
Jake Nikota, Allyson Banville, Laura Rose Goodwin, Dongmei Wu, Andrew Williams, Carole Lynn Yauk, Håkan Wallin, Ulla Vogel, Sabina Halappanavar
Pubblicato in:
Particle and Fibre Toxicology, Numero 14/1, 2017, ISSN 1743-8977
Editore:
BioMed Central
DOI:
10.1186/s12989-017-0218-0
Autori:
M. Meunier, A. Goupil, P. Lienard
Pubblicato in:
International Journal of Pharmaceutics, Numero 526/1-2, 2017, Pagina/e 157-166, ISSN 0378-5173
Editore:
Elsevier BV
DOI:
10.1016/j.ijpharm.2017.04.043
Autori:
Sara Nahle, Hilary Cassidy, Mélanie M. Leroux, Reuben Mercier, Jaafar Ghanbaja, Zahra Doumandji, David Matallanas, Bertrand H. Rihn, Olivier Joubert, Luc Ferrari
Pubblicato in:
Journal of Nanobiotechnology, Numero 18/1, 2020, ISSN 1477-3155
Editore:
BioMed Central
DOI:
10.1186/s12951-020-0587-7
Autori:
Yaobo Ding, Patrick Weindl, Anke-Gabriele Lenz, Paula Mayer, Tobias Krebs, Otmar Schmid
Pubblicato in:
Particle and Fibre Toxicology, Numero 17/1, 2020, ISSN 1743-8977
Editore:
BioMed Central
DOI:
10.1186/s12989-020-00376-w
Autori:
Carole Seidel, Vadim Zhernovkov, Hilary Cassidy, Boris Kholodenko, David Matallanas, Frédéric Cosnier, Laurent Gaté
Pubblicato in:
Nanotoxicology, 2020, Pagina/e 1-19, ISSN 1743-5390
Editore:
Informa Healthcare
DOI:
10.1080/17435390.2020.1851418
Autori:
Shada A. Alsharif, David Power, Ian Rouse, Vladimir Lobaskin
Pubblicato in:
Nanomaterials, Numero 10/10, 2020, Pagina/e 1967, ISSN 2079-4991
Editore:
MDPI AG
DOI:
10.3390/nano10101967
Autori:
Claudia Contini, James W. Hindley, Tom Macdonald, Joseph Barritt, Oscar Ces, Nick Quirke
Pubblicato in:
ChemRxiv, 2019, ISSN 2573-2293
Editore:
American Chemical Society (ACS)
DOI:
10.26434/chemrxiv.10246928
Autori:
Power D, Poggio S, Lopez H, Lobaskin V.
Pubblicato in:
2019, ISBN 978-9814-800648
Editore:
Jenny Stanford Publishing
Autori:
Joubert O., Rihn,P., Rihn B.H.
Pubblicato in:
Biomedical Application of Nanoparticles, 2017, ISBN 9781-498750011
Editore:
CRC Press
Autori:
Krebs T., Mülhopt S., Diabaté S., Schlager C., Paur H.R., Dilger M.
Pubblicato in:
Biomedical Application of Nanoparticles, 2017, ISBN 9781-498750011
Editore:
CRC Press
Autori:
André J.C, Simon J, Rihn B.H.
Pubblicato in:
Biomedical Application of Nanoparticles, 2017, ISBN 9781-498750011
Editore:
CRC Press
Autori:
Ferrari L., Diab R., Nemos C., Safar R., Puisney C.
Pubblicato in:
Biomedical Application of Nanoparticles, 2017, ISBN 9781-498750011
Editore:
CRC Press
Autori:
Eidi H., Doumandji Z., Tomljenovic L., Rihn B.H.
Pubblicato in:
Biomedical Application of Nanoparticles, 2017, ISBN 9781-498750011
Editore:
CRC Press
Autori:
Abdel-Wahhab M.A., Joubert O., El-Nekeety A.A., Abdel-Wahhab K.G., Ronzani C., Safar R., El-Kady A.A., Hassan N.S, Mannaa F.A, Rihn B.H.
Pubblicato in:
Biomedical Application of Nanoparticles, 2017, ISBN 9781-498750011
Editore:
CRC Press
Autori:
Gaté L., Cosnier F.,Cassee F.R.
Pubblicato in:
Biomedical Application of Nanoparticles, 2017, ISBN 9781-498750011
Editore:
CRC Press
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