Mechanisms of recovery after severe spinal cord injury

Project Information

HOW2WALKAGAIN

Grant agreement ID: 682999

DOI 10.3030/682999

Project closed

EC signature date 29 April 2016

Start date 1 July 2016

End date 30 June 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 998 715,00

EU contribution € 1 998 715,00

Coordinated by

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Switzerland

Publications

Peer reviewed articles (12)

Cell type prioritization in single-cell data

Author(s): Michael A. Skinnider, Jordan W. Squair, Claudia Kathe, Mark A. Anderson, Matthieu Gautier, Kaya J. E. Matson, Marco Milano, Thomas H. Hutson, Quentin Barraud, Aaron A. Phillips, Leonard J. Foster, Gioele La Manno, Ariel J. Levine, Grégoire Courtine
Published in: Nature Biotechnology, Issue 39/1, 2021, Page(s) 30-34, ISSN 1087-0156
Publisher: Nature Publishing Group
DOI: 10.1038/s41587-020-0605-1

Neuroprosthetic baroreflex controls haemodynamics after spinal cord injury

Author(s): Jordan W. Squair, Matthieu Gautier, Lois Mahe, Jan Elaine Soriano, Andreas Rowald, Arnaud Bichat, Newton Cho, Mark A. Anderson, Nicholas D. James, Jerome Gandar, Anthony V. Incognito, Giuseppe Schiavone, Zoe K. Sarafis, Achilleas Laskaratos, Kay Bartholdi, Robin Demesmaeker, Salif Komi, Charlotte Moerman, Bita Vaseghi, Berkeley Scott, Ryan Rosentreter, Claudia Kathe, Jimmy Ravier, Laura McCracken,
Published in: Nature, Issue 590/7845, 2021, Page(s) 308-314, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-020-03180-w

Prioritization of cell types responsive to biological perturbations in single-cell data with Augur

Author(s): Jordan W. Squair, Michael A. Skinnider, Matthieu Gautier, Leonard J. Foster, Grégoire Courtine
Published in: Nature Protocols, 2021, ISSN 1754-2189
Publisher: Nature Publishing Group
DOI: 10.1038/s41596-021-00561-x

Advantages of soft subdural implants for the delivery of electrochemical neuromodulation therapies to the spinal cord

Author(s): Marco Capogrosso, Jerome Gandar, Nathan Greiner, Eduardo Martin Moraud, Nikolaus Wenger, Polina Shkorbatova, Pavel Musienko, Ivan Minev, Stephanie Lacour, Grégoire Courtine
Published in: Journal of Neural Engineering, Issue 15/2, 2018, Page(s) 026024, ISSN 1741-2560
Publisher: Institute of Physics Publishing
DOI: 10.1088/1741-2552/aaa87a

Closed-loop control of trunk posture improves locomotion through the regulation of leg proprioceptive feedback after spinal cord injury

Author(s): Eduardo Martin Moraud, Joachim von Zitzewitz, Jenifer Miehlbradt, Sophie Wurth, Emanuele Formento, Jack DiGiovanna, Marco Capogrosso, Grégoire Courtine, Silvestro Micera
Published in: Scientific Reports, Issue 8/1, 2018, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-017-18293-y

Cortico–reticulo–spinal circuit reorganization enables functional recovery after severe spinal cord contusion

Author(s): Leonie Asboth, Lucia Friedli, Janine Beauparlant, Cristina Martinez-Gonzalez, Selin Anil, Elodie Rey, Laetitia Baud, Galyna Pidpruzhnykova, Mark A. Anderson, Polina Shkorbatova, Laura Batti, Stephane Pagès, Julie Kreider, Bernard L. Schneider, Quentin Barraud, Gregoire Courtine
Published in: Nature Neuroscience, Issue 21/4, 2018, Page(s) 576-588, ISSN 1097-6256
Publisher: Nature Publishing Group
DOI: 10.1038/s41593-018-0093-5

Brain-controlled modulation of spinal circuits improves recovery from spinal cord injury

Author(s): Marco Bonizzato, Galyna Pidpruzhnykova, Jack DiGiovanna, Polina Shkorbatova, Natalia Pavlova, Silvestro Micera, Grégoire Courtine
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-018-05282-6

Electrical spinal cord stimulation must preserve proprioception to enable locomotion in humans with spinal cord injury

Author(s): Emanuele Formento, Karen Minassian, Fabien Wagner, Jean Baptiste Mignardot, Camille G. Le Goff-Mignardot, Andreas Rowald, Jocelyne Bloch, Silvestro Micera, Marco Capogrosso, Gregoire Courtine
Published in: Nature Neuroscience, Issue 21/12, 2018, Page(s) 1728-1741, ISSN 1097-6256
Publisher: Nature Publishing Group
DOI: 10.1038/s41593-018-0262-6

Configuration of electrical spinal cord stimulation through real-time processing of gait kinematics

Author(s): Marco Capogrosso, Fabien B. Wagner, Jerome Gandar, Eduardo Martin Moraud, Nikolaus Wenger, Tomislav Milekovic, Polina Shkorbatova, Natalia Pavlova, Pavel Musienko, Erwan Bezard, Jocelyne Bloch, Grégoire Courtine
Published in: Nature Protocols, Issue 13/9, 2018, Page(s) 2031-2061, ISSN 1754-2189
Publisher: Nature Publishing Group
DOI: 10.1038/s41596-018-0030-9

Required growth facilitators propel axon regeneration across complete spinal cord injury

Author(s): Mark A. Anderson, Timothy M. O’Shea, Joshua E. Burda, Yan Ao, Sabry L. Barlatey, Alexander M. Bernstein, Jae H. Kim, Nicholas D. James, Alexandra Rogers, Brian Kato, Alexander L. Wollenberg, Riki Kawaguchi, Giovanni Coppola, Chen Wang, Timothy J. Deming, Zhigang He, Gregoire Courtine, Michael V. Sofroniew
Published in: Nature, Issue 561/7723, 2018, Page(s) 396-400, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-018-0467-6

Cbp-dependent histone acetylation mediates axon regeneration induced by environmental enrichment after spinal cord injury in rodents

Author(s): Ilaria Palmisano; Thomas H. Hutson; Tapas K. Kundu; Jose P. Lopez-Atalaya; Anne Laurence Boutillier; Claudia Kathe; John L. Bixby; Sarmistha Halder Sinha; Guiping Komg; Akash K. Singh; Quentin Barraud; Angel Barco; Francesco De Virgiliis; Matt C. Danzi; Simone Di Giovanni; Arnau Hervera; Luming Zhou; Lawrence D. F. Moon; Piyush Chaturbedy; Grégoire Courtine; Alejandro Medrano-Fernandez; Eilidh Mc
Published in: Science Translational Medicine, Issue Vol. 11, Issue 487, 2019, ISSN 1946-6234
Publisher: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.aaw2064

Multi-pronged neuromodulation intervention engages the residual motor circuitry to facilitate walking in a rat model of spinal cord injury

Author(s): Marco Bonizzato, Nicholas D. James, Galyna Pidpruzhnykova, Natalia Pavlova, Polina Shkorbatova, Laetitia Baud, Cristina Martinez-Gonzalez, Jordan W. Squair, Jack DiGiovanna, Quentin Barraud, Silvestro Micera, Gregoire Courtine
Published in: Nature Communications, Issue 12/1, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-22137-9

Intellectual Property Rights

Patent (7)

SYSTEM FOR PLANNING AND/OR PROVIDING NEUROMODULATION, ESPECIALLY NEUROSTIMULATION

Application/Publication number: 18 807369
Date: 2018-11-29

A SYSTEM FOR PROVIDING NEUROMODULATION, ESPECIALLY NEUROSTIMULATION

Application/Publication number: 20 20053381
Date: 2020-02-11

A SENSORY INFORMATION COMPLIANT SPINAL CORD STIMULATION SYSTEM FOR THE REHABILITATION OF MOTOR FUNCTIONS

Application/Publication number: 17 826212
Date: 2017-12-19

TWO-PHASE CALIBRATION OF A NEUROPROSTHETIC SYSTEM

Application/Publication number: 17 197913
Date: 2017-10-24

A SYSTEM FOR PLANNING AND/OR PROVIDING NEUROMODULATION

Application/Publication number: 18 807366
Date: 2018-11-29

SYSTEM FOR CLOSED LOOP CONTROL OF AUTONOMIC FUNCTION

Application/Publication number: 20 20063563
Date: 2020-05-14

A SYSTEM FOR PLANNING AND/OR PROVIDING NEUROSTIMULATION FOR A PATIENT

Application/Publication number: 17 205362
Date: 2017-12-05

Other (1)

SYSTEM AND METHOD FOR CONTROL OF AUTONOMIC FUNCTION

Application/Publication number: 20 20063564
Date: 2020-05-14