Autocatalysis: A bottom-up approach to understanding the origins of life

Project Information

Autocat

Grant agreement ID: 681491

DOI 10.3030/681491

Project closed

EC signature date 27 March 2016

Start date 1 May 2016

End date 31 January 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 278 073,00

EU contribution € 2 278 073,00

Coordinated by

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom

Publications

Peer reviewed articles (12)

Oligomerization Driven by Phase Separation

Author(s): Iuliia Myrgorodska, Ignacio Colomer, Stephen P. Fletcher
Published in: ChemSystemsChem, Issue 2/5, 2020, ISSN 2570-4206
Publisher: Wiley-VCH
DOI: 10.1002/syst.201900059

A molecular assembler that produces polymers

Author(s): Anthonius H. J. Engwerda, Stephen P. Fletcher
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-17814-0

Coupled Metabolic Cycles Allow Out‐of‐Equilibrium Autopoietic Vesicle Replication

Author(s): Anthonius H. J. Engwerda, Josh Southworth, Maria A. Lebedeva, Robert J. H. Scanes, Philipp Kukura, Stephen P. Fletcher
Published in: Angewandte Chemie International Edition, Issue 59/46, 2020, Page(s) 20361-20366, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202007302

Dissipative self-assembly, competition and inhibition in a self-reproducing protocell model

Author(s): Elias A. J. Post, Stephen P. Fletcher
Published in: Chemical Science, Issue 11/35, 2020, Page(s) 9434-9442, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0sc02768e

A transient self-assembling self-replicator

Author(s): Ignacio Colomer, Sarah M. Morrow, Stephen P. Fletcher
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-018-04670-2

A chemically fuelled self-replicator

Author(s): Sarah M. Morrow, Ignacio Colomer, Stephen P. Fletcher
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-08885-9

Controlling the Kinetics of Self-Reproducing Micelles by Catalyst Compartmentalization in a Biphasic System

Author(s): Elias A. J. Post, Stephen P. Fletcher
Published in: The Journal of Organic Chemistry, Issue 84/5, 2019, Page(s) 2741-2755, ISSN 0022-3263
Publisher: American Chemical Society
DOI: 10.1021/acs.joc.8b03149

Potential for minimal self-replicating systems in a dynamic combinatorial library of equilibrating imines

Author(s): Sarah M. Morrow, Andrew J. Bissette, Stephen P. Fletcher
Published in: Tetrahedron, Issue 73/33, 2017, Page(s) 5005-5010, ISSN 0040-4020
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.tet.2017.06.045

Self-reproducing micelles coupled to a secondary catalyst

Author(s): Elias A. J. Post, Andrew J. Bissette, Stephen P. Fletcher
Published in: Chemical Communications, Issue 54/63, 2018, Page(s) 8777-8780, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/c8cc02136h

Visualization of the spontaneous emergence of a complex, dynamic, and autocatalytic system

Author(s): Jaime Ortega-Arroyo, Andrew J. Bissette, Philipp Kukura, Stephen P. Fletcher
Published in: Proceedings of the National Academy of Sciences, Issue 113/40, 2016, Page(s) 11122-11126, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1602363113

Selection from a pool of self-assembling lipid replicators

Author(s): Ignacio Colomer, Arseni Borissov, Stephen P. Fletcher
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-13903-x

Emergence and Rearrangement of Dynamic Supramolecular Aggregates Visualized by Interferometric Scattering Microscopy

Author(s): Maria A. Lebedeva, Elena Palmieri, Philipp Kukura, Stephen P. Fletcher
Published in: ACS Nano, Issue 14/9, 2020, Page(s) 11160-11168, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.0c02414