Objective
HIV-1 is responsible for a global pandemic of 35 million people, and continues to spread at a rate of >2 million new infections/year. It is widely acknowledged that a protective vaccine would be the most effective means to reduce HIV-1 spread and ultimately eliminate the pandemic, while a therapeutic vaccine may help mitigate the clinical course of disease and lead to strategies of viral eradication. However despite 30 years of research, we do not have a vaccine capable of protecting from HIV-1 infection or impacting on disease progression. This in part represents the challenge of identifying immunogens and vaccine modalities with reduced risk of failure in late stage development. To overcome this bottleneck some of the most competitive research groups in vaccine discovery from European public institutions and biotechs from 9 EU countries together with top Australian and Canadian groups and US collaborators, have agreed to join forces in EAVI, providing a pool of international expertise at the highest level. EAVI2020 will provide a platform for the discovery and selection of several new, diverse and novel preventive and/or therapeutic vaccine candidates for HIV/AIDS. Emphasis will be placed on early rapid, iterative, small Experimental medicine (EM) human vaccine studies to select and refine the best immunogens, adjuvants, vectors, homologous and heterologous prime–boost schedules, and determine the impact of host factors such as gender and genetics. Animal models will be used to complement human studies, and to select novel immunization technologies to be advanced to the clinic. To shift the “risk curve” in product development we will develop innovative risk prediction methods, specifically designed to reduce the risk associated with late stage preventive or therapeutic vaccine failure, increasing the chance of discovery of an effective vaccine.
Fields of science
- natural sciencesbiological sciencesgenetics
- medical and health sciencesbasic medicineimmunologyimmunisation
- medical and health scienceshealth sciencespublic healthepidemiologypandemics
- medical and health scienceshealth sciencesinfectious diseasesRNA virusesHIV
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines
Programme(s)
Funding Scheme
RIA - Research and Innovation actionCoordinator
SW7 2AZ LONDON
United Kingdom
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Participants (26)
OX1 2JD Oxford
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75654 Paris
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08916 Barcelona
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00161 Roma
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3400 Klosterneuburg
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
Participation ended
08036 Barcelona
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
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08036 Barcelona
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1081 HV Amsterdam
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75015 PARIS 15
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20132 Milano
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38058 Grenoble
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WC2R 2LS London
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17177 Stockholm
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91054 Erlangen
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N6A 3K7 Ontario -London
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1024 Budapest
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1090 Wien
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55131 Mainz
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
28029 Madrid
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1013 NH Amsterdam
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3010 Melbourne
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2052 Sydney
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CB10 1SA SAFFRON WALDEN
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10004 New York
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SO17 1BJ Southampton
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08035 Barcelona
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