European HIV Vaccine Alliance (EHVA): a EU platform for the discovery and evaluation of novel prophylactic and therapeutic vaccine candidates

Deliverables

Draft EHVA dissemination and exploitation plan

The Exploitation Plan will outline how EHVA results will be further exploited beyond project lifespan for the use by the field, and to accelerate the development of promising vaccine candidates through engaging with the EDCTP and/or IMI and other donors and partners .

First EHVA newsletter and fact sheet developed and published

Public newsletter and a multilingual fact sheet on the consortium and the project

EHVA website and branding launched

Public website online. EHVA Graphic identity and tools

Posting EHVA-T-1 results in the study registry

Posting EHVA-T-1 trial results on the study registry

Publications

Inversed Ratio of CD39/CD73 Expression on γδ T Cells in HIV Versus Healthy Controls Correlates With Immune Activation and Disease Progression

Author(s): Katharina, Kolbe; Melanie, Wittner; Philip, Hartjen; Anja-Dorothee, Hüfner; Olaf, Degen; Christin, Ackermann; Leon, Cords; Hans-Jürgen, Stellbrink; Friedrich, Haag; Julian, Schulze Zur Wiesch
Published in: Front Immunol., Issue vol 13, 2022, ISSN 1664-3224
Publisher: Lausanne: Frontiers Media
DOI: 10.3389/fimmu.2022.867167

Frequent Anti-V1V2 Responses Induced by HIV-DNA Followed by HIV-MVA with or without CN54rgp140/GLA-AF in Healthy African Volunteers.

Author(s): Frank Msafiri; Agricola Joachim; Kathrin Held; Yuka Nadai; Raquel Matavele Chissumba; Christof Geldmacher; Said Aboud; Wolfgang Stöhr; Edna Viegas; Arne Kroidl; Muhammad Bakari; Patricia Munseri; Britta Wahren; Eric Sandström; Merlin L. Robb; Sheena McCormack; Sarah Joseph; Ilesh V. Jani; Guido Ferrari; Mangala Rao; Gunnel Biberfeld; Eligius Lyamuya; Charlotta Nilsson
Published in: Microorganisms, Issue vol 8, 2020, ISSN 2076-2607
Publisher: MDPI AG
DOI: 10.3390/microorganisms8111722

Potency and durability of T and B cell immune responses after homologous and heterologous vector delivery of a trimer-stabilized, membrane-displayed HIV-1 clade ConC Env protein

Author(s): Beatriz Perdiguero, Alexandra Hauser, Carmen Elena Gómez, David Peterhoff, Elefthéria Sideris, Carlos Óscar S Sorzano, Sarah Wilmschen , Marion Schaber , Laura Stengel, Benedikt Asbach , Song Ding, Dorothee Von Laer, Yves Levy, Giuseppe Pantaleo , Janine Kimpel, Mariano Esteban, Ralf Wagner
Published in: Front Immunol, 2023, ISSN 1664-3224
Publisher: Frontiers Media S.A
DOI: 10.3389/fimmu.2023.1270908

An MVA-based vector expressing cell-free ISG15 increases IFN-I production and improves HIV-1-specific CD8 T cell immune responses

Author(s): Michela, Falqui; Beatriz, Perdiguero; Rocio, Coloma; Manuel, Albert; Laura, Marcos-Villar; Joseph Patrick, McGrail; Carlos Óscar S, Sorzano; Mariano, Esteban; Carmen Elena, Gómez; Susana, Guerra
Published in: Front. Cell. Infect. Microbiol., Issue vol 13, 2023, ISSN 2235-2988
Publisher: Frontiers Media S. A.
DOI: 10.3389/fcimb.2023.1187193

A phase 1 human immunodeficiency virus vaccine Trial for cross-profiling the kinetics of serum and mucosal antibody responses to CN54gp140 modulated by two homologous prime-boost vaccine regimens

Author(s): Sven Kratochvil; Paul F. McKay; Jakub T. Kopycinski; Cynthia Bishop; Peter John Hayes; Luke Muir; Christopher L. Pinder; Deniz Cizmeci; Deborah King; Yoann Aldon; Bruce D. Wines; P. Mark Hogarth; Amy W. Chung; Stephen J. Kent; Stephen J. Kent; Stephen J. Kent; Kathrin Held; Christof Geldmacher; Len Dally; Nelson S. Santos; Tom Cole; Jill Gilmour; Sarah Fidler; Robin J. Shattock
Published in: Frontiers in Immunology, Issue 6, 2017, ISSN 1664-3224
Publisher: Frontiers Media SA
DOI: 10.3389/fimmu.2017.00595

Inducible HIV-1 Reservoir Quantification: Clinical Relevance, Applications and Advancements of TILDA

Author(s): Cynthia Lungu, Riddhima Banga, Rob A. Gruters, Francesco A. Procopio
Published in: Frontiers in Microbiology, Issue 12, 2021, ISSN 1664-302X
Publisher: Frontiers Media
DOI: 10.3389/fmicb.2021.686690

Comparison of Safety and Vector-Specific Immune Responses in Healthy and HIV-Infected Populations Vaccinated with MVA-B

Author(s): Elvira Couto, Vicenç Diaz-Brito, Beatriz Mothe, Alberto C. Guardo, Irene Fernandez, Ainoa Ugarte, Flor Etcheverry, Carmen E. Gómez, Mariano Esteban, Judit Pich, Joan Albert Arnaiz, Juan Carlos López Bernaldo de Quirós, Christian Brander, Montserrat Plana, Felipe García, Lorna Leal
Published in: Vaccines, Issue 7/4, 2019, Page(s) 178, ISSN 2076-393X
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines7040178

Multi-arm, multi-stage randomised controlled trials for evaluating therapeutic HIV cure interventions

Author(s): Cecilia L Moore, Wolfgang Stöhr, Angela M Crook, Laura Richert, Jean-Daniel Leliévre, Giuseppe Pantaleo, Felipe García, Stefano Vella, Yves Lévy, Rodolphe Thiébaut, Sheena McCormack
Published in: The Lancet HIV, Issue 6/5, 2019, Page(s) e334-e340, ISSN 2352-3018
Publisher: Elsevier Limited
DOI: 10.1016/s2352-3018(19)30082-7

Augmenting the Immune Response against a Stabilized HIV-1 Clade C Envelope Trimer by Silica Nanoparticle Delivery

Author(s): David Peterhoff, Stefanie Thalhauser, Jan M. Sobczak, Mona O. Mohsen, Christoph Voigt, Nicole Seifert, Patrick Neckermann, Alexandra Hauser, Song Ding, Quentin Sattentau, Martin F. Bachmann, Miriam Breunig, Ralf Wagner
Published in: Vaccines, Issue 9/6, 2021, Page(s) 642, ISSN 2076-393X
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines9060642

Measuring the success of HIV-1 cure strategies

Author(s): J Thomas, A Ruggiero, WA Paxton, G Pollakis
Published in: Frontiers in Cellular and Infection Microbiology, 2020, ISSN 2235-2988
Publisher: Frontiers Media S. A.
DOI: 10.3389/fcimb.2020.00134

Assessing immunogenicity barriers of the HIV-1 envelope trimer

Author(s): Liridona Maliqi, Nikolas Friedrich, Matthias Glögl, Stefan Schmutz, Daniel Schmidt, Peter Rusert, Merle Schanz, Maryam Zaheri, Chloé Pasin, Cyrille Niklaus, Caio Foulkes, Thomas Reinberg, Birgit Dreier, Irene Abela, David Peterhoff, Alexandra Hauser, Roger D. Kouyos, Huldrych F. Günthard, Marit J. van Gils, Rogier W. Sanders, Ralf Wagner, Andreas Plückthun, Alexandra Trkola
Published in: npj vaccines, 2023, ISSN 2059-0105
Publisher: Springer Nature
DOI: 10.1038/s41541-023-00746-3

Measuring Proviral HIV-1 DNA: Hurdles and Improvements to an Assay Monitoring Integration Events Utilising Human Alu Repeat Sequences

Author(s): Eva Malatinkova ,Jordan Thomas ,Ward De Spiegelaere, Sofie Rutsaert,Anna Maria Geretti ,Georgios Pollakis ,William A. Paxton ,Linos Vandekerckhove , and Alessandra Ruggiero
Published in: Life, 2021, ISSN 2075-1729
Publisher: MDPI
DOI: 10.3390/life11121410

In-depth virological and immunological characterization of HIV-1 cure after CCR5Δ32/Δ32 allogeneic hematopoietic stem cell transplantation

Author(s): Björn-Erik Ole Jensen; Elena Knops; Leon Cords; Nadine Lübke; Maria Salgado; Kathleen Busman-Sahay; Jacob D. Estes; Laura E. P. Huyveneers; Federico Perdomo-Celis; Melanie Wittner; Cristina Gálvez; Christiane Mummert; Caroline Passaes; Johanna M. Eberhard; Carsten Münk; Ilona Hauber; Joachim Hauber; Eva Heger; Jozefien De Clercq; Linos Vandekerckhove; Silke Bergmann; Gábor A. Dunay; Florian K
Published in: Nature Medicine, Issue 29, 2023, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-023-02213-x

SARS-CoV-2 S Glycoprotein Stabilization Strategies

Author(s): Borys Pedenko; Guidenn Sulbaran; Delphine Guilligay; Gregory Effantin; Winfried Weissenhorn
Published in: viruses, Issue 15, 2023, Page(s) 558, ISSN 1999-4915
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v15020558

Therapeutic Efficacy of a VSV-GP-based Human Papilloma Virus Vaccine in a Murine Cancer Model

Author(s): Lydia Riepler, Laura-Sophie Frommelt , Sarah Wilmschen-Tober, Wilbert Mbuya, Kathrin Held , André Volland, Dorothee von Laer , Christof Geldmacher , Janine Kimpel
Published in: J Mol Biol, Issue Volume 435, Issue 13, 2023, ISSN 0022-2836
Publisher: Academic Press
DOI: 10.1016/j.jmb.2023.168096

The BAF complex inhibitor pyrimethamine reverses HIV-1 latency in people with HIV-1 on antiretroviral therapy

Author(s): Prins HAB, Crespo R, Lungu C, Rao S, Li L, Overmars RJ, Papageorgiou G, Mueller YM, Stoszko M, Hossain T, Kan TW, Rijnders BJA, Bax HI, van Gorp ECM, Nouwen JL, de Vries-Sluijs TEMS, Schurink CAM, de Mendonça Melo M, van Nood E, Colbers A, Burger D, Palstra RJ, van Kampen JJA, van de Vijver DAMC, Mesplède T, Katsikis PD, Gruters RA, Koch BCP, Verbon A, Mahmoudi T, Rokx C.
Published in: Science advances, 2023, ISSN 2375-2548
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciadv.ade6675

cytometree: A binary tree algorithm for automatic gating in cytometry analysis

Author(s): Commenges, D., Alkhassim, C., Gottardo, R., Hejblum, B. and Thiébaut, R.
Published in: Cytometry, 2018, ISSN 1552-4930
Publisher: Wiley
DOI: 10.1002/cyto.a.23601

Simultaneous Quantification of Anti-vector and Anti-transgene-Specific CD8+ T Cells Via MHC I Tetramer Staining After Vaccination with a Viral Vector

Author(s): Sarah Wilmschen, Zoltan Banki , Dorothee von Laer , Janine Kimpel
Published in: J Vis Exp, 2018, ISSN 1940-087X
Publisher: MYJoVE Corporation
DOI: 10.3791/58680

The route of vaccine administration determines whether blood neutrophils undergo long-term phenotypic modifications

Author(s): Yanis Feraoun; Jean-Louis Palgen; Candie Joly; Nicolas Tchitchek; Ernesto Marcos-Lopez; Nathalie Dereuddre-Bosquet; Anne-Sophie Gallouet; Vanessa Contreras; Yves Lévy; Yves Lévy; Frédéric Martinon; Roger Le Grand; Anne-Sophie Beignon
Published in: "Frontiers in Immunology, Frontiers, 2022, 12, pp.784813. ⟨10.3389/fimmu.2021.784813⟩", Issue 5, 2022, ISSN 1664-3224
Publisher: Frontiers Media SA
DOI: 10.1101/2021.10.26.465872

Selective cell death in HIV-1-infected cells by DDX3 inhibitors leads to depletion of the inducible reservoir

Author(s): Shringar Rao, Cynthia Lungu, Raquel Crespo, Thijs H. Steijaert, Alicja Gorska, Robert-Jan Palstra, Henrieke A. B. Prins, Wilfred van Ijcken, Yvonne M. Mueller, Jeroen J. A. van Kampen, Annelies Verbon, Peter D. Katsikis, Charles A. B. Boucher, Casper Rokx, Rob A. Gruters, Tokameh Mahmoudi
Published in: Nature Communications, Issue 12/1, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-22608-z

Distinct conformations of the HIV-1 V3 loop crown are targetable for broad neutralization

Author(s): Nikolas Friedrich, Emanuel Stiegeler, Matthias Glögl, Thomas Lemmin, Simon Hansen, Claus Kadelka, Yufan Wu, Patrick Ernst, Liridona Maliqi, Caio Foulkes, Mylène Morin, Mustafa Eroglu, Thomas Liechti, Branislav Ivan, Thomas Reinberg, Jonas V. Schaefer, Umut Karakus, Stephan Ursprung, Axel Mann, Peter Rusert, Roger D. Kouyos, John A. Robinson, Huldrych F. Günthard, Andreas Plückthun & Alexandra
Published in: nature communications, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-27075-0

Induction of Identical IgG HIV-1 Envelope Epitope Recognition Patterns After Initial HIVIS-DNA/MVA-CMDR Immunization and a Late MVA-CMDR Boost

Author(s): Agricola Joachim, Mohamed I. M. Ahmed, Georgios Pollakis, Lisa Rogers, Verena S. Hoffmann, Patricia Munseri, Said Aboud, Eligius F. Lyamuya, Muhammad Bakari, Merlin L. Robb, Britta Wahren, Eric Sandstrom, Charlotta Nilsson, Gunnel Biberfeld, Christof Geldmacher, Kathrin Held
Published in: Frontiers in Immunology, Issue 11, 2020, ISSN 1664-3224
Publisher: Front. Immunol
DOI: 10.3389/fimmu.2020.00719

Novel chimeric proteins mimicking SARS-CoV-2 spike epitopes with broad inhibitory activity

Author(s): Cano-Muñoz, Mario; Polo-Megías, Daniel; Cámara-Artigas, Ana; Gavira Gallardo, J. A.; López-Rodríguez, María J.; Laumond, Géraldine; Schmidt, Sylvie; Demiselle, Julien; Bahram, Seiamak; Moog, Christiane; Conejero-Lara, Francisco
Published in: International Journal of Biological Macromolecules, Issue vol 222 part B, 2022, Page(s) 2467-2478, ISSN 0141-8130
Publisher: Elsevier BV
DOI: 10.1016/j.ijbiomac.2022.10.031

Identification of early-induced broadly neutralizing activities against transmitted founder HIV strains

Author(s): Julie, Lucas; Li-Yun, Lin; Nicodème, Paul; Géraldine, Laumond; Jéromine, Klingler; Sylvie, Schmidt; Julia, Frappier; Asma, Essat; Laurence, Meyer; Alicia Castro, Gordon; C É Cile, Goujard; Seiamak, Bahram; Christiane, Moog
Published in: AIDS. Official journal of the international AIDS Society, Issue AIDS 37(1), 2023, Page(s) p 43-49, ISSN 1758-2652
Publisher: International AIDS Society
DOI: 10.1097/qad.0000000000003371

Non-Neutralizing Antibodies Directed against HIV and Their Functions

Author(s): Luzia M. Mayr, Bin Su, Christiane Moog
Published in: Frontiers in Immunology, Issue 8, 2017, ISSN 1664-3224
Publisher: Front Immunol
DOI: 10.3389/fimmu.2017.01590

NK cell immune responses differ after prime and boost vaccination

Author(s): Jean‐Louis Palgen, Nicolas Tchitchek, Nicolas Huot, Jamila Elhmouzi‐Younes, Cécile Lefebvre, Pierre Rosenbaum, Nathalie Dereuddre‐Bosquet, Frédéric Martinon, Hakim Hocini, Antonio Cosma, Michaela Müller‐Trutwin, Yves Lévy, Roger Grand, Anne‐Sophie Beignon
Published in: Journal of Leukocyte Biology, Issue 105/5, 2019, Page(s) 1055-1073, ISSN 0741-5400
Publisher: Federation of American Societies for Experimental Biology
DOI: 10.1002/jlb.4a1018-391rr

Comparative analysis and generation of a robust HIV-1 DNA quantification assay.

Author(s): Thomas, J.; Ruggiero, A.; Procopio, F.A.; Pantaleo, G.; Paxton, W.A.; Pollakis, G.
Published in: J Virol Methods, Issue vol 263, 2019, Page(s) pages 24-31, ISSN 0166-0934
Publisher: Elsevier BV
DOI: 10.1016/j.jviromet.2018.10.010

Effective HIV vaccine

Author(s): Ralf Wagner
Published in: Current Opinion in HIV and AIDS, Issue 12/3, 2017, Page(s) 191-194, ISSN 1746-630X
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/coh.0000000000000371

Dürfen wir noch auf eine HIV-Impfung hoffen?

Author(s): Ralf Wagner, Benedikt Asbach
Published in: MMW - Fortschritte der Medizin, Issue 160/S2, 2018, Page(s) 24-27, ISSN 1438-3276
Publisher: Urban und Vogel Medien und Medizin Verlagsgesellschaft mbH
DOI: 10.1007/s15006-018-0649-z

Guiding the long way to broad HIV neutralization

Author(s): David Peterhoff, Ralf Wagner
Published in: Current Opinion in HIV and AIDS, Issue 12/3, 2017, Page(s) 257-264, ISSN 1746-630X
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/coh.0000000000000356

Stabilized HIV-1 envelope glycoprotein trimers for vaccine use

Author(s): Max Medina-Ramírez, Rogier W. Sanders, Quentin J. Sattentau
Published in: Current Opinion in HIV and AIDS, 2017, Page(s) 1, ISSN 1746-630X
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/COH.0000000000000363

Particle-based delivery of the HIV envelope protein

Author(s): Benedikt Asbach, Ralf Wagner
Published in: Current Opinion in HIV and AIDS, Issue 12/3, 2017, Page(s) 265-271, ISSN 1746-630X
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/coh.0000000000000366

Comparison of the integrin α4β7 expression pattern of memory T cell subsets in HIV infection and ulcerative colitis

Author(s): Melanie Wittner, Veronika Schlicker, Jana Libera, Jan-Hendrik Bockmann, Thomas Horvatits, Oliver Seiz, Silke Kummer, Carolin F. Manthey, Anja Hüfner, Marcus Kantowski, Thomas Rösch, Olaf Degen, Samuel Huber, Johanna M. Eberhard, Julian Schulze zur Wiesch
Published in: PLOS ONE, Issue 14/7, 2019, Page(s) e0220008, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0220008

A Novel MVA-Based HIV Vaccine Candidate (MVA-gp145-GPN) Co-Expressing Clade C Membrane-Bound Trimeric gp145 Env and Gag-Induced Virus-Like Particles (VLPs) Triggered Broad and Multifunctional HIV-1-Specific T Cell and Antibody Responses

Author(s): Beatriz Perdiguero, Cristina Sánchez-Corzo, Carlos Sorzano, Lidia Saiz, Pilar Mediavilla, Mariano Esteban, Carmen Gómez
Published in: Viruses, Issue 11/2, 2019, Page(s) 160, ISSN 1999-4915
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v11020160

The Envelope-Based Fusion Antigen GP120C14K Forming Hexamer-Like Structures Triggers T Cell and Neutralizing Antibody Responses Against HIV-1

Author(s): Suresh C. Raman, Ernesto Mejías-Pérez, Carmen E. Gomez, Juan García-Arriaza, Beatriz Perdiguero, Aneesh Vijayan, Mar Pérez-Ruiz, Ana Cuervo, César Santiago, Carlos Oscar S. Sorzano, Cristina Sánchez-Corzo, Christiane Moog, Judith A. Burger, Anna Schorcht, Rogier W. Sanders, José L. Carrascosa, Mariano Esteban
Published in: Frontiers in Immunology, Issue 10, 2019, ISSN 1664-3224
Publisher: n/a
DOI: 10.3389/fimmu.2019.02793

Heterologous Combination of VSV-GP and NYVAC Vectors Expressing HIV-1 Trimeric gp145 Env as Vaccination Strategy to Induce Balanced B and T Cell Immune Responses

Author(s): Beatriz Perdiguero, Carmen Elena Gómez, Juan García-Arriaza, Cristina Sánchez-Corzo, Carlos Óscar S. Sorzano, Sarah Wilmschen, Dorothee von Laer, Benedikt Asbach, Christina Schmalzl, David Peterhoff, Song Ding, Ralf Wagner, Janine Kimpel, Yves Levy, Giuseppe Pantaleo, Mariano Esteban
Published in: Frontiers in Immunology, Issue 10, 2019, ISSN 1664-3224
Publisher: N/a
DOI: 10.3389/fimmu.2019.02941

An MVA Vector Expressing HIV-1 Envelope under the Control of a Potent Vaccinia Virus Promoter as a Promising Strategy in HIV/AIDS Vaccine Design

Author(s): Patricia Pérez, María Q. Marín, Adrián Lázaro-Frías, Carlos Óscar S. Sorzano, Mauro Di Pilato, Carmen E. Gómez, Mariano Esteban, Juan García-Arriaza
Published in: Vaccines, Issue 7/4, 2019, Page(s) 208, ISSN 2076-393X
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines7040208

Envelope-Specific Recognition Patterns of HIV Vaccine-Induced IgG Antibodies Are Linked to Immunogen Structure and Sequence

Author(s): Yuka Nadai, Kathrin Held, Sarah Joseph, Mohamed I. M. Ahmed, Verena S. Hoffmann, David Peterhoff, Marco Missanga, Asli Bauer, Agricola Joachim, Ulf Reimer, Johannes Zerweck, Sheena McCormack, Alethea V. Cope, Roger Tatoud, Robin J. Shattock, Merlin Lee Robb, Eric G. Sandstroem, Michael Hoelscher, Leonard Maboko, Muhammad Bakari, Arne Kroidl, Ralf Wagner, Jonathan Weber, Georgios Pollakis, Christof
Published in: Frontiers in Immunology, Issue 10, 2019, ISSN 1664-3224
Publisher: n/a
DOI: 10.3389/fimmu.2019.00717

Induction of Tier 1 HIV Neutralizing Antibodies by Envelope Trimers Incorporated into a Replication Competent Vesicular Stomatitis Virus Vector

Author(s): C. Bresk, Tamara Hofer, Sarah Wilmschen, Marina Krismer, Anja Beierfuß, Grégory Effantin, Winfried Weissenhorn, Michael Hogan, Andrea Jordan, Rebecca Gelman, David Montefiori, Hua-Xin Liao, Joern Schmitz, Barton Haynes, Dorothee von Laer, Janine Kimpel
Published in: Viruses, Issue 11/2, 2019, Page(s) 159, ISSN 1999-4915
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v11020159

Viral Vectors for the Induction of Broadly Neutralizing Antibodies against HIV

Author(s): Sarah Wilmschen, Joern E. Schmitz, Janine Kimpel
Published in: Vaccines, Issue 7/3, 2019, Page(s) 119, ISSN 2076-393X
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines7030119

Vaccine Inoculation Route Modulates Early Immunity and Consequently Antigen-Specific Immune Response.

Author(s): Lev Stimmer; Frédéric Martinon; Antonio Cosma; Nicolas Tchitchek
Published in: Front. Immunol., Issue 1, 2021, ISSN 1664-3224
Publisher: Frontiers Media S.A
DOI: 10.3389/fimmu.2021.645210

High Metabolic Function and Resilience of NKG2A-Educated NK Cells

Author(s): Andrew J. Highton, Björn-Philipp Diercks, Franziska Möckl, Gloria Martrus, Jürgen Sauter, Alexander H. Schmidt, Madeleine J. Bunders, Christian Körner, Andreas H. Guse, and Marcus Altfeld *
Published in: Frontiers in Immunology, 2020, ISSN 1664-3224
Publisher: Frontiers Media SA
DOI: 10.3389/fimmu.2020.559576

Update on Fc-Mediated Antibody Functions Against HIV-1 Beyond Neutralization

Author(s): Su, Bin; Dispinseri, Stefania; Iannone, Valeria; Zhang, Tong; Wu, Hao; Carapito, Raphael; Bahram, Seiamak; Scarlatti, Gabriella; Moog, Christiane
Published in: Frontiers in Immunology, Issue 3, 2019, ISSN 1664-3224
Publisher: Frontiers Media SA
DOI: 10.3389/fimmu.2019.02968

Trapping the HIV-1 V3 loop in a helical conformation enables broad neutralization

Author(s): Matthias Glögl, Nikolas Friedrich, Gabriele Cerutti, Thomas Lemmin, Young D. Kwon, Jason Gorman, Liridona Maliqi, Peer R. E. Mittl, Maria C. Hesselman, Daniel Schmidt, Jacqueline Weber, Caio Foulkes, Adam S. Dingens, Tatsiana Bylund, Adam S. Olia, Raffaello Verardi, Thomas Reinberg, Nicolas S. Baumann, Peter Rusert, Birgit Dreier, Lawrence Shapiro, Peter D. Kwong, Andreas Plückthun, Alexandra Tr
Published in: Nature Structural and Molecular Biology, 2023, ISSN 1545-9993
Publisher: Nature Publishing Group
DOI: 10.1038/s41594-023-01062-z

Natural Killer Cell Education Is Associated With a Distinct Glycolytic Profile

Author(s): Caroline Pfeifer, Andrew J. Highton, Sven Peine, Jürgen Sauter, Alexander H. Schmidt, Madeleine J. Bunders, Marcus Altfeld, Christian Körner
Published in: Frontiers in Immunology, Issue 9, 2018, ISSN 1664-3224
Publisher: Front.Immunol.
DOI: 10.3389/fimmu.2018.03020

Combined Skin and Muscle DNA Priming Provides Enhanced Humoral Responses to a Human Immunodeficency Virus Type 1 Clade C Envelope Vaccine

Author(s): Cheeseman, Hannah Mary; Day, Suzanne; McFarlane, Leon Robert; Fleck, Sue; Miller, Aleisha; Cole, Tom; Sousa-Santos, Nelson; Cope, Alethea; Cizmeci, Deniz; Tolazzi, Monica; Hwekwete, Edith; Hannaman, Drew; Kratochvil, Sven; McKay, Paul Francis; Chung, Amy,; Kent, Stephen,; Cook, Adrian; Scarlatti, Gabriella; Abraham, Sonya; Combadière, Behazine; McCormack, Sheena; Lewis, David John; Shattock, Robi
Published in: 1028, Issue 6, 2018, ISSN 0893-5068
Publisher: Mary Ann Liebert Inc
DOI: 10.1089/hum.2018.075

Immunoglobulin G1 Allotype Influences Antibody Subclass Distribution in Response to HIV gp140 Vaccination.

Author(s): Sven Kratochvil; Paul F. McKay; Amy W. Chung; Stephen J. Kent; Stephen J. Kent; Stephen J. Kent; Jill Gilmour; Robin J. Shattock
Published in: Frontiers in Immunology, Issue 6, 2017, ISSN 1664-3224
Publisher: Frontiers Media SA
DOI: 10.3389/fimmu.2017.01883

New challenges in therapeutic vaccines against HIV infection

Author(s): Lorna Leal; Constanza Lucero; Josep M. Gatell; Teresa Gallart; Montserrat Plana; Felipe García
Published in: Expert Review of Vaccines, Issue 5, 2017, Page(s) 587-600, ISSN 1744-8395
Publisher: Taylor & Francis
DOI: 10.1080/14760584.2017.1322513

Prime and Boost Vaccination Elicit a Distinct Innate Myeloid Cell Immune Response

Author(s): Palgen, Jean-Louis; Tchitchek, Nicolas; Elhmouzi-Younes, Jamila; Delandre, Simon; Namet, Inana; Rosenbaum, Pierre; Dereuddre-Bosquet, Nathalie; Martinon, Frédéric; Cosma, Antonio; Lévy, Yves; Le Grand, Roger; Beignon, Anne-Sophie
Published in: https://hal.archives-ouvertes.fr/hal-02385941, Issue 5, 2018, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-018-21222-2

Vulnerability to reservoir reseeding due to high immune activation after allogeneic hematopoietic stem cell transplantation in individuals with HIV-1

Author(s): Johanna M. Eberhard; Mathieu Angin; Caroline Passaes; Maria Cristina O. Salgado; Valérie Monceaux; Elena Knops; Guido Kobbe; Björn Jensen; Maximilian Christopeit; Nicolaus Kröger; Linos Vandekerckhove; Jon Badiola; Alessandra Bandera; Kavita Raj; Jan van Lunzen; Jan van Lunzen; Gero Hütter; Jürgen Kuball; Carolina Martínez-Laperche; Pascual Balsalobre; Mi Kwon; José Luis Díez-Martín; Moni
Published in: https://hal-pasteur.archives-ouvertes.fr/pasteur-02870497, Issue 1, 2020, ISSN 1946-6234
Publisher: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.aay9355

Stepwise conformational stabilization of a HIV-1 clade C consensus envelope trimer immunogen impacts the profile of vaccine-induced antibody responses

Author(s): Hauser, Alexandra; Carnell, George; Held, Kathrin; Sulbaran, Guidenn; Tischbierek, Nadine; Rogers, Lisa; Pollakis, Georgios; Tonks, Paul; Hoelscher, Michael; Ding, Song; Sanders, Rogier; Geldmacher, Christof; Sattentau, Quentin; Weissenhorn, Winfried; Heeney, Jonathan; Peterhoff, David; Wagner, Ralf
Published in: VACCINES, Issue 3, 2021, ISSN 2076-393X
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines9070750

Immunization with synthetic SARS-CoV-2 S glycoprotein virus-like particles protects Macaques from infection

Author(s): Guidenn Sulbaran; Pauline Maisonnasse; Axelle Amen; Gregory Effantin; Delphine Guilligay; Nathalie Dereuddre-Bosquet; Judith A. Burger; Meliawati Poniman; Marloes Grobben; Marlyse Buisson; Sebastian Dergan Dylon; Thibaut Naninck; Julien Lemaître; Wesley Gros; Anne-Sophie Gallouët; Romain Marlin; Camille Bouillier; Vanessa Contreras; Francis Relouzat; Daphna Fenel; Michel Thepaut; Isabelle Bally;
Published in: Cell Reports Medicine,. Cell Press, Issue 1 3(2):100528, 2022, ISSN 2666-3791
Publisher: Cell Pres Elsevier Inc
DOI: 10.1016/j.xcrm.2022.100528

Neutralizing Antibody-Based Prevention of Cell-Associated HIV-1 Infection.

Author(s): Matthew S. Parsons; Roger Le Grand; Stephen J. Kent; Stephen J. Kent
Published in: Viruses, Vol 10, Iss 6, p 333 (2018), Issue 5, 2018, ISSN 1999-4915
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v10060333

Inter-Laboratory Reproducibility of Inducible HIV-1 Reservoir Quantification by TILDA

Author(s): Cynthia Lungu, Francesco A. Procopio, Ronald J. Overmars, Rob J. J. Beerkens, Jolanda J. C. Voermans, Shringar Rao, Henrieke A. B. Prins, Casper Rokx, Giuseppe Pantaleo, David A. M. C. van de Vijver, Tokameh Mahmoudi, Charles A. B. Boucher, Rob A. Gruters, Jeroen J. A. van Kampen
Published in: Viruses, Issue 12/9, 2020, Page(s) 973, ISSN 1999-4915
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v12090973

Manufacturing of convalescent plasma of COVID-19 patients: Aspects of quality.

Author(s): Christian Johnson
Published in: PLoS ONE, Issue 15, 2020, ISSN 1544-9173
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0243967

Guiding the humoral response against HIV-1 toward a MPER adjacent region by immunization with a VLP-formulated antibody-selected envelope variant

Author(s): Carolina Beltran-Pavez; Carolina B. Ferreira; Alberto Merino-Mansilla; Amanda Fabra-Garcia; Maria Casadellà; Marc Noguera-Julian; Roger Paredes; Alex Olvera; Isabel Haro; Christian Brander; Felipe García; José M. Gatell; Eloisa Yuste; Victor Sanchez-Merino
Published in: PLoS ONE, 2018, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0208345

Autologous DC vaccination followed by analytical treatment interruption induced distinct shifts in the HIV-1 proviral landscape in vivo.

Author(s): Lungu, C., Hossain, T., Prins, H.A.B., Hensley, K.S., Crespo, R., Rokx, C., Rao, S., van Kampen, J.J.A., van de Vijver, D.A.M.C., Mesplède, T., Gruters, R.A. and Mahmoudi, T
Published in: Nature Microbiology, 2024, ISSN 2058-5276
Publisher: Nature microbiology

Innate and secondary humoral responses are improved by increasing the time between MVA vaccine immunizations.

Author(s): Jean-Louis Palgen; Nicolas Tchitchek; André Rodriguez-Pozo; Quentin Jouhault; Hadjer Abdelhouahab; Nathalie Dereuddre-Bosquet; Vanessa Contreras; Frédéric Martinon; Antonio Cosma; Yves Levy; Roger Le Grand; Anne-Sophie Beignon
Published in: https://hal.archives-ouvertes.fr/hal-03079492, Issue 5, 2020, ISSN 2059-0105
Publisher: Nature Publishing Group
DOI: 10.1038/s41541-020-0175-8

Systematic comparison of HIV-1 Envelope-specific IgG responses induced by different vaccination regimens: Can we steer IgG recognition towards regions of viral vulnerability?

Author(s): Horvath A, Rogers L, Pollakis G, Baranov O, Pieroth N, Joseph S, Chachage M, Heitzer A, Maganga L, Msafiri F, Joachim A, Viegas E, Eller LA, Kibuuka H, Rerks-Ngarm S, Pitisuttithum P, Nitayapan S, Dhitavat J, Premsri N, Fidler S, Shattock RJ, Robb ML, Weber J, McCormack S, Munseri PJ, Lyamuya E, Nilsson C, Kroidl A, Hoelscher M, Wagner R, Geldmacher C, Held K.
Published in: Frontiers in Immunology, 2023, ISSN 1664-3224
Publisher: Frontiers Media S.A
DOI: 10.3389/fimmu.2022.1075606

High‐resolution analysis of individual spike peptide‐specific CD4 + T‐cell responses in vaccine recipients and COVID‐19 patients

Author(s): Hendrik Karsten, Leon Cords, Tim Westphal, Maximilian Knapp, Thomas Theo Brehm, Lennart Hermanussen, Till Frederik Omansen, Stefan Schmiedel, Robin Woost, Vanessa Ditt, Sven Peine, Marc Lütgehetmann , Samuel Huber, Christin Ackermann, Melanie Wittner, Marylyn Martina Addo, Alessandro Sette, John Sidney, Julian Schulze Zur Wiesch
Published in: Clin Transl Immunology, 2022, ISSN 2050-0068
Publisher: Nature Publishing Group
DOI: 10.1002/cti2.1410

Evidence for broad cross-reactivity of the SARS-CoV-2 NSP12-directed CD4+ T-cell response with pre-primed responses directed against common cold coronaviruses

Author(s): Tim Westphal; Maria Mader; Hendrik Karsten; Leon Cords; Maximilian Knapp; Sophia Schulte; Lennart Hermanussen; Sven Peine; Vanessa Ditt; Alba Grifoni; Marylyn Martina Addo; Samuel Huber; Alessandro Sette; Marc Lütgehetmann; Sven Pischke; William W. Kwok; John Sidney; Julian Schulze zur Wiesch
Published in: Front. Immunol., Issue vol 14, 2023, ISSN 1664-3224
Publisher: Frontiers Media S.A
DOI: 10.3389/fimmu.2023.1182504

Exploring Highly Conserved Regions of SARS-CoV-2 Spike S2 Subunit as Targets for Fusion Inhibition Using Chimeric Proteins

Author(s): Daniel Polo-Megías; Mario Cano-Muñoz; Alberto G. Berruezo; Géraldine Laumond; Christiane Moog; Francisco Conejero-Lara
Published in: International Journal of Molecular Sciences;, Issue Volume 23; Issue 24;, 2022, Page(s) Pages: 15511, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms232415511

Definition of viroIogical endpoints improving the design of HIV cure strategies using analytical antiretroviral treatment interruption

Author(s): Marie Alexandre, Mélanie Prague, Edouard Lhomme, Jean-Daniel Lelievre, Linda Wittkop, Laura Richert, Yves Lévy, Rodolphe Thiébaut
Published in: medRxiv, 2024
Publisher: medRxiv
DOI: 10.1101/2024.01.26.24301813

Induction of MPER responses by immunization with Virus-Like Particles (VLPs) carrying a Broadly Neutralizing Antibody-selected HIV-1 Envelope

Author(s): Carolina Beltrán Pavez , Amanda Fabra García , Alberto Merino , Christian Brander, Josep M. Gatell, Felipe García Eloísa Yuste and Víctor Sánchez-Merino
Published in: 2016
Publisher: n/a

Identification of novel HIV-1 vaccine candidates using mammalian cell-surface display and FACS panning

Author(s): Benjamin Zimmer, Veronika Grassmann, Tim-Henrik Bruun, Thomas Schubert, Anna Gabele, Alexander Kliche and Ralf Wagner
Published in: 2016
Publisher: n/a

Generation of HIV-1 new envelope immunogens with optimized antigenicity profiles

Author(s): Glögl M., Schmid V., Kliche A., Peterhoff D. and Wagner R
Published in: 2016
Publisher: n/a

Structure guided molecular engineering of stable C-clade Env trimer scaffolds for vaccine design

Author(s): David Peterhoff, Alexandra Hauser, Iris Ganser, Ralf Wagner
Published in: 2017
Publisher: n/a

Identification and characterization of trimer stabilized HIV envelope protein

Author(s): Kliche A., Koop J., Ziegler C., Peterhoff D., Asbach B., Schütz A., Schmid V. and Wagner R
Published in: 2016
Publisher: n/a

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