Endoplasmic Reticulum Stress in Health and Disease

Risultati finali

ESR recruitment

Report on recruitment of ESRs

Training materials & educational animation

Selected raining materials from schools and workshops & educational animation available for public dissemination

TRAIN-ERS Facebook and Twitter accounts

Creation of Facebook and Twitter account

Website and data sharing platform

Development of Website and data sharing platform

Pubblicazioni

Dual IRE1 RNase functions dictate glioblastoma development

Autori: Stéphanie Lhomond, Tony Avril, Nicolas Dejeans, Konstantinos Voutetakis, Dimitrios Doultsinos, Mari McMahon, Raphaël Pineau, Joanna Obacz, Olga Papadodima, Florence Jouan, Heloise Bourien, Marianthi Logotheti, Gwénaële Jégou, Néstor Pallares‐Lupon, Kathleen Schmit, Pierre‐Jean Le Reste, Amandine Etcheverry, Jean Mosser, Kim Barroso, Elodie Vauléon, Marion Maurel, Afshin Samali, John B P
Pubblicato in: EMBO Molecular Medicine, Numero 10/3, 2018, Pagina/e e7929, ISSN 1757-4676
Editore: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.201707929

Amyotrophic lateral sclerosis (ALS) and Alzheimer’s disease (AD) are characterised by differential activation of ER stress pathways: focus on UPR target genes

Autori: L. Montibeller, J. de Belleroche
Pubblicato in: Cell Stress and Chaperones, 2018, ISSN 1355-8145
Editore: Cell Stress Society International
DOI: 10.1007/s12192-018-0897-y

Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy

Autori: Susan E. Logue, Eoghan P. McGrath, Patricia Cleary, Stephanie Greene, Katarzyna Mnich, Aitor Almanza, Eric Chevet, Róisín M. Dwyer, Anup Oommen, Patrick Legembre, Florence Godey, Emma C. Madden, Brian Leuzzi, Joanna Obacz, Qingping Zeng, John B. Patterson, Richard Jäger, Adrienne M. Gorman, Afshin Samali
Pubblicato in: Nature Communications, Numero 9/1, 2018, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-018-05763-8

RIP2 enhances cell survival by activation of NF-ĸB in triple negative breast cancer cells

Autori: Rola Jaafar, Katarzyna Mnich, Sarah Dolan, Jennifer Hillis, Aitor Almanza, Susan E. Logue, Afshin Samali, Adrienne M. Gorman
Pubblicato in: Biochemical and Biophysical Research Communications, Numero 497/1, 2018, Pagina/e 115-121, ISSN 0006-291X
Editore: Academic Press
DOI: 10.1016/j.bbrc.2018.02.034

Endoplasmic reticulum stress signalling - from basic mechanisms to clinical applications

Autori: Aitor Almanza, Antonio Carlesso, Chetan Chintha, Stuart Creedican, Dimitrios Doultsinos, Brian Leuzzi, Andreia Luís, Nicole McCarthy, Luigi Montibeller, Sanket More, Alexandra Papaioannou, Franziska Püschel, Maria Livia Sassano, Josip Skoko, Patrizia Agostinis, Jackie de Belleroche, Leif A. Eriksson, Simone Fulda, Adrienne M. Gorman, Sandra Healy, Andrey Kozlov, Cristina Muñoz-Pinedo, Markus Re
Pubblicato in: The FEBS Journal, 2018, ISSN 1742-464X
Editore: Blackwell Publishing Inc.
DOI: 10.1111/febs.14608

The Unfolded Protein Response and Membrane Contact Sites: Tethering as a Matter of Life and Death?

Autori: Alexander R. van Vliet, Maria Livia Sassano, Patrizia Agostinis
Pubblicato in: Contact, Numero 1, 2018, Pagina/e 251525641877051, ISSN 2515-2564
Editore: SAGE PUBLISHING
DOI: 10.1177/2515256418770512

Bax retrotranslocation potentiates Bcl-xL’s antiapoptotic activity and is essential for switch-like transitions between MOMP competency and resistance

Autori: Annika Hantusch, Kushal K. Das, Ana J. García-Sáez, Thomas Brunner, Markus Rehm
Pubblicato in: Cell Death & Disease, Numero 9/4, 2018, ISSN 2041-4889
Editore: Nature Publishing Group
DOI: 10.1038/s41419-018-0464-6

Control of anterior GRadient 2 (AGR2) dimerization links endoplasmic reticulum proteostasis to inflammation

Autori: Marion Maurel, Joanna Obacz, Tony Avril, Yong‐Ping Ding, Olga Papadodima, Xavier Treton, Fanny Daniel, Eleftherios Pilalis, Johanna Hörberg, Wenyang Hou, Marie‐Claude Beauchamp, Julien Tourneur‐Marsille, Dominique Cazals‐Hatem, Lucia Sommerova, Afshin Samali, Jan Tavernier, Roman Hrstka, Aurélien Dupont, Delphine Fessart, Frédéric Delom, Martin E Fernandez‐Zapico, Gregor Jansen, Leif
Pubblicato in: EMBO Molecular Medicine, Numero 11/6, 2019, Pagina/e e10120, ISSN 1757-4676
Editore: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.201810120

Alterations of EDEM 1 functions enhance ATF 6 pro‐survival signaling

Autori: Alexandra Papaioannou, Arisa Higa, Gwénaële Jégou, Florence Jouan, Raphael Pineau, Laure Saas, Tony Avril, Olivier Pluquet, Eric Chevet
Pubblicato in: The FEBS Journal, Numero 285/22, 2018, Pagina/e 4146-4164, ISSN 1742-464X
Editore: Blackwell Publishing Inc.
DOI: 10.1111/febs.14669

Endoplasmic reticulum stress signalling and the pathogenesis of non-alcoholic fatty liver disease

Autori: Cynthia Lebeaupin, Deborah Vallée, Younis Hazari, Claudio Hetz, Eric Chevet, Béatrice Bailly-Maitre
Pubblicato in: Journal of Hepatology, Numero 69/4, 2018, Pagina/e 927-947, ISSN 0168-8278
Editore: Elsevier BV
DOI: 10.1016/j.jhep.2018.06.008

Merits and pitfalls of conventional and covalent docking in identifying new hydroxyl aryl aldehyde like compounds as human IRE1 inhibitors

Autori: Antonio Carlesso, Chetan Chintha, Adrienne M. Gorman, Afshin Samali, Leif A. Eriksson
Pubblicato in: Scientific Reports, Numero 9/1, 2019, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-019-39939-z

The unfolded protein response modulators GSK2606414 and KIRA6 are potent KIT inhibitors

Autori: Mohamed Mahameed, Thomas Wilhelm, Odai Darawshi, Akram Obiedat, Weiss-Sadan Tommy, Chetan Chintha, Thomas Schubert, Afshin Samali, Eric Chevet, Leif A. Eriksson, Michael Huber, Boaz Tirosh
Pubblicato in: Cell Death & Disease, Numero 10/4, 2019, ISSN 2041-4889
Editore: Nature Publishing Group
DOI: 10.1038/s41419-019-1523-3

Selective Inhibition of IRE1 Signalling mediated by MKC9989: New Insights from Molecular Docking and Molecular Dynamics Simulations

Autori: Antonio Carlesso, Leif A. Eriksson
Pubblicato in: ChemistrySelect, Numero 4/11, 2019, Pagina/e 3199-3203, ISSN 2365-6549
Editore: Wiley-VCH
DOI: 10.1002/slct.201900810

Binding Analysis of the Inositol-Requiring Enzyme 1 Kinase Domain

Autori: Antonio Carlesso, Chetan Chintha, Adrienne M. Gorman, Afshin Samali, Leif A. Eriksson
Pubblicato in: ACS Omega, Numero 3/10, 2018, Pagina/e 13313-13322, ISSN 2470-1343
Editore: American Chemical Society
DOI: 10.1021/acsomega.8b01404

Smac mimetic suppresses tunicamycin-induced apoptosis via resolution of ER stress

Autori: Behnaz Ahangarian Abhari, Nicole McCarthy, Marie Le Berre, Michelle Kilcoyne, Lokesh Joshi, Patrizia Agostinis, Simone Fulda
Pubblicato in: Cell Death & Disease, Numero 10/3, 2019, ISSN 2041-4889
Editore: Nature Publishing Group
DOI: 10.1038/s41419-019-1381-z

Endoplasmic reticulum stress signaling and chemotherapy resistance in solid cancers

Autori: T Avril, E Vauléon, E Chevet
Pubblicato in: Oncogenesis, Numero 6/8, 2017, Pagina/e e373-e373, ISSN 2157-9024
Editore: Nature Publishing Group
DOI: 10.1038/oncsis.2017.72

Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics

Autori: Amado Carreras-Sureda, Fabián Jaña, Hery Urra, Sylvere Durand, David E. Mortenson, Alfredo Sagredo, Galdo Bustos, Younis Hazari, Eva Ramos-Fernández, Maria L. Sassano, Philippe Pihán, Alexander R. van Vliet, Matías González-Quiroz, Angie K. Torres, Cheril Tapia-Rojas, Martijn Kerkhofs, Rubén Vicente, Randal J. Kaufman, Nibaldo C. Inestrosa, Christian Gonzalez-Billault, R. Luke Wiseman, Patr
Pubblicato in: Nature Cell Biology, Numero 21/6, 2019, Pagina/e 755-767, ISSN 1465-7392
Editore: Nature Publishing Group
DOI: 10.1038/s41556-019-0329-y

CD90 Expression Controls Migration and Predicts Dasatinib Response in Glioblastoma

Autori: Tony Avril, Amandine Etcheverry, Raphaël Pineau, Joanna Obacz, Gwénaële Jegou, Florence Jouan, Pierre-Jean Le Reste, Masumeh Hatami, Rivka R. Colen, Brett L. Carlson, Paul A. Decker, Jann N. Sarkaria, Elodie Vauléon, Dan Cristian Chiforeanu, Anne Clavreul, Jean Mosser, Eric Chevet, Véronique Quillien
Pubblicato in: Clinical Cancer Research, Numero 23/23, 2017, Pagina/e 7360-7374, ISSN 1078-0432
Editore: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-17-1549

Post-treatment de-phosphorylation of p53 correlates with dasatinib responsiveness in malignant melanoma

Autori: Josip Skoko, Jan Rožanc, Emilie M. Charles, Leonidas G. Alexopoulos, Markus Rehm
Pubblicato in: BMC Cell Biology, Numero 19/1, 2018, ISSN 1471-2121
Editore: BioMed Central
DOI: 10.1186/s12860-018-0180-1

NF-κB contributes to Smac mimetic-conferred protection from tunicamycin-induced apoptosis

Autori: Behnaz Ahangarian Abhari, Nicole McCarthy, Patrizia Agostinis, Simone Fulda
Pubblicato in: Apoptosis, Numero 24/3-4, 2019, Pagina/e 269-277, ISSN 1360-8185
Editore: Kluwer Academic Publishers
DOI: 10.1007/s10495-018-1507-2

Regulation of tumor-stroma interactions by the unfolded protein response

Autori: Joanna Obacz, Tony Avril, Camila Rubio-Patiño, Jozef P. Bossowski, Aeid Igbaria, Jean-Ehrland Ricci, Eric Chevet
Pubblicato in: The FEBS Journal, Numero 286/2, 2019, Pagina/e 279-296, ISSN 1742-464X
Editore: Blackwell Publishing Inc.
DOI: 10.1111/febs.14359

Hepatic growth hormone - JAK2 - STAT5 signalling: Metabolic function, non-alcoholic fatty liver disease and hepatocellular carcinoma progression

Autori: Doris Kaltenecker, Madeleine Themanns, Kristina M. Mueller, Katrin Spirk, Tobias Suske, Olaf Merkel, Lukas Kenner, Andreia Luís, Andrey Kozlov, Johannes Haybaeck, Mathias Müller, Xiaonan Han, Richard Moriggl
Pubblicato in: Cytokine, 2018, ISSN 1043-4666
Editore: Academic Press
DOI: 10.1016/j.cyto.2018.10.010

Crosstalk between inflammatory mediators and endoplasmic reticulum stress in liver diseases

Autori: J. Catharina Duvigneau, Andreia Luís, Adrienne M. Gorman, Afshin Samali, Doris Kaltenecker, Richard Moriggl, Andrey V. Kozlov
Pubblicato in: Cytokine, 2018, ISSN 1043-4666
Editore: Academic Press
DOI: 10.1016/j.cyto.2018.10.018

Reshaping the Immune Tumor Microenvironment Through IRE1 Signaling

Autori: Camila Rubio-Patiño, Jozef P. Bossowski, Eric Chevet, Jean-Ehrland Ricci
Pubblicato in: Trends in Molecular Medicine, Numero 24/7, 2018, Pagina/e 607-614, ISSN 1471-4914
Editore: Elsevier BV
DOI: 10.1016/j.molmed.2018.05.005

Control of the Unfolded Protein Response in Health and Disease

Autori: Dimitrios Doultsinos, Tony Avril, Stéphanie Lhomond, Nicolas Dejeans, Philippe Guédat, Eric Chevet
Pubblicato in: SLAS DISCOVERY: Advancing Life Sciences R&D, Numero 22/7, 2017, Pagina/e 787-800, ISSN 2472-5552
Editore: SAGE publishing
DOI: 10.1177/2472555217701685

Mitochondria-Associated Membranes As Networking Platforms and Regulators of Cancer Cell Fate

Autori: Maria Livia Sassano, Alexander R. van Vliet, Patrizia Agostinis
Pubblicato in: Frontiers in Oncology, Numero 7, 2017, ISSN 2234-943X
Editore: Frontiers Media S. A.
DOI: 10.3389/fonc.2017.00174

In the Hunger Games, the Winner Takes Everything

Autori: Franziska Püschel, Cristina Muñoz-Pinedo
Pubblicato in: Trends in Biochemical Sciences, 2017, ISSN 0968-0004
Editore: Elsevier BV
DOI: 10.1016/j.tibs.2017.08.004

Glucose Deprivation Induces ATF4-Mediated Apoptosis through TRAIL Death Receptors

Autori: Raffaella Iurlaro, Franziska Püschel, Clara Lucía León-Annicchiarico, Hazel O'Connor, Seamus J. Martin, Daniel Palou-Gramón, Estefanía Lucendo, Cristina Muñoz-Pinedo
Pubblicato in: Molecular and Cellular Biology, Numero 37/10, 2017, Pagina/e e00479-16, ISSN 0270-7306
Editore: American Society for Microbiology
DOI: 10.1128/MCB.00479-16

Trial Watch: Immunogenic cell death induction by anticancer chemotherapeutics

Autori: Abhishek D. Garg, Sanket More, Nicole Rufo, Odeta Mece, Maria Livia Sassano, Patrizia Agostinis, Laurence Zitvogel, Guido Kroemer, Lorenzo Galluzzi
Pubblicato in: OncoImmunology, Numero 12 issues per year, 2017, Pagina/e 00-00, ISSN 2162-402X
Editore: Taylor & Francis
DOI: 10.1080/2162402X.2017.1386829

Constitutive IRE1α signaling maintains glioblastoma cell differentiation

Autori: Doultsinos D, McMahon M, Voutetaki K, Obacz J, Pineau R, Jouan F, Le Reste P-J, Obiedat A, Samal J, Patterson JB, Zheng Q, Samali A, Pandit A, Tirosh B, Chatziioannou A, Chevet E, Avril T.
Pubblicato in: BioRXiv, 2019
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/59463

Control of glioblastoma differentiated-to-stem cell reprogramming by IRElα/XBPls signaling

Autori: Dimitrios Doultsinos, Mari McMahon, Konstantinos Voutetakis, Joanna Obacz, Raphael Pineau, Florence Jouan, Pierre-Jean Le Reste, Akram Obiedat, Juhi Samal, John B. Patterson, Qingping Zheng, Afshin Samali, Abhay Pandit, Boaz Tirosh, Aristotelis Chatziioannou, View ORCID ProfileEric Chevet, Tony Avril
Pubblicato in: BioRXiv, 2019
Editore: Cold Spring Harbor
DOI: 10.1101/594630

Driving Cancer Tumorigenesis and Metastasis Through UPR Signaling

Autori: Alexandra Papaioannou, Eric Chevet
Pubblicato in: Current Topics in Microbiology and Immunology, 2017
Editore: Springer Berlin Heidelberg
DOI: 10.1007/82_2017_36

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