Engineering of a minimal bacterial therapeutic chassis

Project Information

MYCOCHASSIS

Grant agreement ID: 670216

DOI 10.3030/670216

Project closed

EC signature date 14 October 2015

Start date 1 November 2015

End date 31 October 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 454 522,00

EU contribution € 2 454 522,00

Coordinated by

FUNDACIO CENTRE DE REGULACIO GENOMICA
Spain

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (14)

Engineering a genome-reduced bacterium to eliminate Staphylococcus aureus biofilms in vivo

Author(s): Garrido, V; Pinero-Lambea, C; Rodriguez-Arce, I; Paetzold, B; Ferrar, T; Weber, M; Garcia-Ramallo, E; Gallo, C; Collantes, M; Penuelas, I; Serrano, L; Grillo, MJ; Lluch-Senar, M
Published in: Molecular Systems Biology, 2021, ISSN 1744-4292
Publisher: Nature Publishing Group
DOI: 10.15252/msb.202010145

A reporter system coupled with high-throughput sequencing unveils key bacterial transcription and translation determinants

Author(s): Eva Yus, Jae-Seong Yang, Adrià Sogues, Luis Serrano
Published in: Nature Communications, Issue 8/1, 2017, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-017-00239-7

Alternative transcriptional regulation in genome-reduced bacteria

Author(s): Samuel Miravet-Verde, Verónica Lloréns-Rico, Luis Serrano
Published in: Current Opinion in Microbiology, Issue 39, 2017, Page(s) 89-95, ISSN 1369-5274
Publisher: Elsevier BV
DOI: 10.1016/j.mib.2017.10.022

Defined chromosome structure in the genome-reduced bacterium Mycoplasma pneumoniae

Author(s): Marie Trussart, Eva Yus, Sira Martinez, Davide Baù, Yuhei O. Tahara, Thomas Pengo, Michael Widjaja, Simon Kretschmer, Jim Swoger, Steven Djordjevic, Lynne Turnbull, Cynthia Whitchurch, Makoto Miyata, Marc A. Marti-Renom, Maria Lluch-Senar, Luís Serrano
Published in: Nature Communications, Issue 8, 2017, Page(s) 14665, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/ncomms14665

Assessing the limits of restraint-based 3D modeling of genomes and genomic domains

Author(s): M. Trussart, F. Serra, D. Bau, I. Junier, L. Serrano, M. A. Marti-Renom
Published in: Nucleic Acids Research, Issue 43/7, 2015, Page(s) 3465-3477, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkv221

Bacterial antisense RNAs are mainly the product of transcriptional noise

Author(s): V. Llorens-Rico, J. Cano, T. Kamminga, R. Gil, A. Latorre, W.-H. Chen, P. Bork, J. I. Glass, L. Serrano, M. Lluch-Senar
Published in: Science Advances, Issue 2/3, 2016, Page(s) e1501363-e1501363, ISSN 2375-2548
Publisher: Science Advances
DOI: 10.1126/sciadv.1501363

Defining a minimal cell: essentiality of small ORFs and ncRNAs in a genome-reduced bacterium

Author(s): M. Lluch-Senar, J. Delgado, W.-H. Chen, V. Llorens-Rico, F. J. O'Reilly, J. A. Wodke, E. B. Unal, E. Yus, S. Martinez, R. J. Nichols, T. Ferrar, A. Vivancos, A. Schmeisky, J. Stulke, V. van Noort, A.-C. Gavin, P. Bork, L. Serrano
Published in: Molecular Systems Biology, Issue 11/1, 2015, Page(s) 780-780, ISSN 1744-4292
Publisher: Nature Publishing Group
DOI: 10.15252/msb.20145558

Rescuing discarded spectra: Full comprehensive analysis of a minimal proteome

Author(s): Maria Lluch-Senar, Francesco M. Mancuso, H?ctor Climente-Gonz?lez, Marcia I. Pe?a-Paz, Eduard Sabido, Luis Serrano
Published in: PROTEOMICS, Issue 16/4, 2016, Page(s) 554-563, ISSN 1615-9853
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/pmic.201500187

Integration of multi-omics data of a genome-reduced bacterium: Prevalence of post-transcriptional regulation and its correlation with protein abundances

Author(s): Wei-Hua Chen, Vera van?Noort, Maria Lluch-Senar, Marco L. Hennrich, Judith A. H.?Wodke, Eva Yus, Andreu Alib?s, Guglielmo Roma, Daniel R. Mende, Christina Pesavento, Athanasios Typas, Anne-Claude Gavin, Luis Serrano, Peer Bork
Published in: Nucleic Acids Research, Issue 44/3, 2016, Page(s) 1192-1202, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkw004

Distinguishing between productive and abortive promoters using a random forest classifier in Mycoplasma pneumoniae

Author(s): V. Llorens-Rico, M. Lluch-Senar, L. Serrano
Published in: Nucleic Acids Research, Issue 43/7, 2015, Page(s) 3442-3453, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkv170

Insights into the Mechanisms of Basal Coordination of Transcription Using a Genome-Reduced Bacterium

Author(s): Ivan Junier, E.?Besray Unal, Eva Yus, Ver?nica Llor?ns-Rico, Luis Serrano
Published in: Cell Systems, Issue 2/6, 2016, Page(s) 391-401, ISSN 2405-4712
Publisher: Cell Systems
DOI: 10.1016/j.cels.2016.04.015

Comparative ?-omics? in Mycoplasma pneumoniae Clinical Isolates Reveals Key Virulence Factors

Author(s): Maria Lluch-Senar, Luca Cozzuto, Jaime Cano, Javier Delgado, Ver?nica Ll?rens-Rico, Sabine Pereyre, C?cile Bebear, Luis Serrano
Published in: PLOS ONE, Issue 10/9, 2015, Page(s) e0137354, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0137354

Impact of C‐terminal amino acid composition on protein expression in bacteria

Author(s): Marc Weber, Raul Burgos, Eva Yus, Jae‐Seong Yang, Maria Lluch‐Senar, Luis Serrano
Published in: Molecular Systems Biology, Issue 16/5, 2020, ISSN 1744-4292
Publisher: Nature Publishing Group
DOI: 10.15252/msb.20199208

Widespread ribosome stalling in a genome-reduced bacterium and the need for translational quality control

Author(s): Burgos, R; Weber, M; Gallo, C; Lluch-Senar, M; Serrano, L
Published in: Iscience, 2021, ISSN 2589-0042
Publisher: Elsevier
DOI: 10.1016/j.isci.2021.102985