Improving Diagnosis by Fast Field-Cycling MRI

Deliverables

Upgraded FFC-NMR relaxometers

Completion of upgrades of relaxometers at sites P1, P3a, P5 and P7

Image analysis and display toolbox for FFC-MRI

Demonstration of a software toolbox for image analysis and display in FFC-MRI

Numerical tool for non-exponential relaxation analysis

Robust numerical tool for decomposition and parameterization of non-exponential relaxation

Low‐field correction coils

Design and construction of low‐field correction coils

Software package for biomarkers

Software package for detecting, extracting and quantitatively describing biomarkers

Amplifier stability measurement techniques

Method and tools to measure the power supply amplifier’s actual stability, in isolation from the magnet which it is driving

Numerical tool for dispersion analysis

Robust numerical tool for decomposition and parameterization of relaxation dispersion

Theory of relaxation processes

Comprehensive theory of relaxation processes in tissue-mimicking systems and tissues

Array RF coils and receivers for FFC-MRI

Demonstration of multi-coil RF receiver arrays and associated electronics for FFC-MRI

Surface RF coil for relaxometer

Surface RF coil for use with FFC-NMR relaxometer, to enable T1-dispersion studies of perfused organs within the relaxometer

Speed-up of FFC-MRI

Speed-up of FFC-MRI data collection by factor of 16 or more

Midterm recruitment report

Report scheduled for the time point when 50% of the study population is expected to be recruited. Report will include an overview of recruited subjects, potential recruiting problems and a description of implemented and planned measures to compensate delays (if any) in the study subject recruitment.

Report on status of posting results in the study registry

Report on the status of the result posting, including timelines when the final posting of results is scheduled after the end of the funding period.

Analytical models of environmental magnetic fields

Analytical models of magnetic fields as a function of space and time B(x,y,z,t)

Currently-approved contrast agents for FFC-MRI

Assessment of the potential of currently approved MRI contrast agents for FFC-MRI applications

Identification of prominent biomarkers

Identification of most prominent biomarkers for in-vivo FFC-NMR and FFC-MRI studies at selected NMR frequencies

FFC-MRI biomarkers

Details of biomarkers available in FFC-MRI and their interpretation in the target diseases

Magnetic field mapping and correction with existing coils

Maps of DC and AC magnetic fields; recommendations to reach the lowest DC perturbation fields using the existing coil systems

T1 dispersion curve database

Database of T1 dispersion curves accurately acquired for the target diseases, showing typical response patterns

First study subject approvals package

For each clinical study: Final version of study protocol as submitted to ethics committee Registration number of clinical study Approval of ethics committee (North of Scotland Research Ethics Committee, NOSREC) Note that only P1 (UNIABDN) will carry out clinical studies, and ethical approval will be sought for all the clinical studies at the same time.

FFC-NMR and FFC-MRI protocols

Details of robust and streamlined FFC-NMR and FFC-MRI protocols

Magnetic field sensor survey

Survey of the availability and state of the art of the existing magnetic sensors and of possible applicability of known methods and physical principles for sensing magnetic fields

Publications

1H spin-lattice NMR relaxation in the presence of residual dipolar interactions – Dipolar relaxation enhancement

Author(s): Danuta Kruk, Pawel Rochowski, Malgorzata Florek – Wojciechowska, Pedro José Sebastião, David J. Lurie, Lionel M. Broche
Published in: Journal of Magnetic Resonance, Issue 318, 2020, Page(s) 106783, ISSN 1090-7807
Publisher: Academic Press
DOI: 10.1016/j.jmr.2020.106783

Towards applying NMR relaxometry as a diagnostic tool for bone and soft tissue sarcomas: a pilot study

Author(s): Elzbieta Masiewicz, George P. Ashcroft, David Boddie, Sinclair R. Dundas, Danuta Kruk, Lionel M. Broche
Published in: Scientific Reports, Issue 10/1, 2020, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-71067-x

Cancer cell death induced by ferritins and the peculiar role of their labile iron pool

Author(s): Juan Carlos Cutrin, Diego Alberti, Caterina Bernacchioni, Silvia Ciambellotti, Paola Turano, Claudio Luchinat, Simonetta Geninatti Crich, Silvio Aime
Published in: Oncotarget, Issue 9/46, 2018, Page(s) 27974-27984, ISSN 1949-2553
Publisher: Impact Journals
DOI: 10.18632/oncotarget.25416

Generation of multiparametric MRI maps by using Gd-labelled- RBCs reveals phenotypes and stages of murine prostate cancer

Author(s): Giuseppe Ferrauto, Enza Di Gregorio, Stefania Lanzardo, Laura Ciolli, Manuela Iezzi, Silvio Aime
Published in: Scientific Reports, Issue 8/1, 2018, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-018-28926-5

Multicomponent analysis of T 1 relaxation in bovine articular cartilage at low magnetic fields

Author(s): Oleg V. Petrov, Siegfried Stapf
Published in: Magnetic Resonance in Medicine, Issue 81, 2018, Page(s) 2858-2868, ISSN 0740-3194
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/mrm.27624

Evidence for the Role of Intracellular Water Lifetime as a Tumour Biomarker Obtained by In Vivo Field-Cycling Relaxometry

Author(s): Maria Rosaria Ruggiero, Simona Baroni, Stefania Pezzana, Gianni Ferrante, Simonetta Geninatti Crich, Silvio Aime
Published in: Angewandte Chemie International Edition, Issue 57/25, 2018, Page(s) 7468-7472, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201713318

Relaxometric investigations addressing the determination of intracellular water lifetime: a novel tumour biomarker of general applicability

Author(s): Maria Rosaria Ruggiero, Simona Baroni, Silvio Aime, Simonetta Geninatti Crich
Published in: Molecular Physics, Issue 117, 2018, Page(s) 1-7, ISSN 0026-8976
Publisher: Taylor & Francis
DOI: 10.1080/00268976.2018.1527045

Comparison of fast field-cycling magnetic resonance imaging methods and future perspectives

Author(s): Markus Bödenler, Ludovic de Rochefort, P. James Ross, Nicolas Chanet, Geneviève Guillot, Gareth R. Davies, Christian Gösweiner, Hermann Scharfetter, David J. Lurie, Lionel M. Broche
Published in: Molecular Physics, Issue 117, 2019, Page(s) 1-17, ISSN 0026-8976
Publisher: Taylor & Francis
DOI: 10.1080/00268976.2018.1557349

Theory of fast field-cycling NMR relaxometry of liquid systems undergoing chemical exchange

Author(s): Pascal H. Fries, Elie Belorizky
Published in: Molecular Physics, Issue 117, 2018, Page(s) 1-12, ISSN 0026-8976
Publisher: Taylor & Francis
DOI: 10.1080/00268976.2018.1538539

Towards a Model-Based Field-Frequency Lock for NMR

Author(s): G. Galuppini, C. Toffanin, D.M. Raimondo, A. Provera, Y. Xia, R. Rolfi, G. Ferrante, L. Magni
Published in: IFAC-PapersOnLine, Issue 50/1, 2017, Page(s) 13020-13025, ISSN 2405-8963
Publisher: Elsevier
DOI: 10.1016/j.ifacol.2017.08.1999

A whole-body Fast Field-Cycling scanner for clinical molecular imaging studies

Author(s): Lionel M. Broche, P. James Ross, Gareth R. Davies, Mary-Joan MacLeod, David J. Lurie
Published in: Scientific Reports, Issue 9/1, 2019, Page(s) 10402, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-019-46648-0

Load-dependent NMR low-field profiling and relaxation dispersion study of osteoarthritic articular cartilage

Author(s): Erik Rößler, Carlos Mattea, Siegfried Stapf, Sakari Karhula, Simo Saarakkala, Miika T. Nieminen
Published in: Microporous and Mesoporous Materials, Issue 269, 2017, Page(s) 160-165, ISSN 1387-1811
Publisher: Elsevier BV
DOI: 10.1016/j.micromeso.2017.02.069

Exploring the tumour extracellular matrix by in vivo Fast Field Cycling relaxometry after the administration of a Gadolinium-based MRI contrast agent

Author(s): Simona Baroni, Maria Rosaria Ruggiero, Silvio Aime, Simonetta Geninatti Crich
Published in: Magnetic Resonance in Chemistry, Issue 57/10, 2019, Page(s) 845-851, ISSN 0749-1581
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/mrc.4837

Use of FCC-NMRD relaxometry for early detection and characterization of ex-vivo murine breast cancer

Author(s): Enza Di Gregorio, Giuseppe Ferrauto, Stefania Lanzardo, Eliana Gianolio, Silvio Aime
Published in: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-019-41154-9

Dynamics of Solid Proteins by Means of Nuclear Magnetic Resonance Relaxometry

Author(s): Danuta Kruk, Elzbieta Masiewicz, Anna M. Borkowska, Pawel Rochowski, Pascal H. Fries, Lionel M. Broche, David J. Lurie
Published in: Biomolecules, Issue 9/11, 2019, Page(s) 652, ISSN 2218-273X
Publisher: MDPI
DOI: 10.3390/biom9110652

Mechanism of Water Dynamics in Hyaluronic Dermal Fillers Revealed by Nuclear Magnetic Resonance Relaxometry

Author(s): Danuta Kruk, Pawel Rochowski, Elzbieta Masiewicz, Slawomir Wilczynski, Milosz Wojciechowski, Lionel M. Broche, David J. Lurie
Published in: ChemPhysChem, Issue 20/21, 2019, Page(s) 2816-2822, ISSN 1439-4235
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/cphc.201900761

Ferritin: A Platform for MRI Contrast Agents Delivery

Author(s): Maria Ruggiero, Diego Alberti, Valeria Bitonto, Simonetta Geninatti Crich
Published in: Inorganics, Issue 7/3, 2019, Page(s) 33, ISSN 2304-6740
Publisher: MDPI
DOI: 10.3390/inorganics7030033

In vivo assessment of tumour associated macrophages in murine melanoma obtained by low-field relaxometry in the presence of iron oxide particles

Author(s): Simona Baroni, Maria Rosaria Ruggiero, Valeria Bitonto, Lionel M. Broche, David J. Lurie, Silvio Aime, Simonetta Geninatti Crich
Published in: Biomaterials, Issue 236, 2020, Page(s) 119805, ISSN 0142-9612
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2020.119805

Slow dynamics of solid proteins - Nuclear Magnetic Resonance relaxometry versus Dielectric Spectroscopy

Author(s): Danuta Kruk, Elzbieta Masiewicz, Milosz Wojciechowski, Malgorzata Florek-Wojciechowska, Lionel M. Broche, David J. Lurie
Published in: Journal of Magnetic Resonance, 2020, Page(s) 106721, ISSN 1090-7807
Publisher: Academic Press
DOI: 10.1016/j.jmr.2020.106721

Fast field-cycling magnetic resonance detection of intracellular ultra-small iron oxide particles in vitro: Proof-of-concept

Author(s): Hassan Abbas, Lionel M. Broche, Aiarpi Ezdoglian, Dmitriy Li, Raif Yuecel, P. James Ross, Lesley Cheyne, Heather M. Wilson, David J. Lurie, Dana K. Dawson
Published in: Journal of Magnetic Resonance, Issue 313, 2020, Page(s) 106722, ISSN 1090-7807
Publisher: Academic Press
DOI: 10.1016/j.jmr.2020.106722

Correction of environmental magnetic fields for the acquisition of Nuclear magnetic relaxation dispersion profiles below Earth’s field

Author(s): Vasileios Zampetoulas, David J. Lurie, Lionel M. Broche
Published in: Journal of Magnetic Resonance, Issue 282, 2017, Page(s) 38-46, ISSN 1090-7807
Publisher: Academic Press
DOI: 10.1016/j.jmr.2017.07.008

Simple algorithm for the correction of MRI image artefacts due to random phase fluctuations

Author(s): Lionel M. Broche, P. James Ross, Gareth R. Davies, David J. Lurie
Published in: Magnetic Resonance Imaging, Issue 44, 2017, Page(s) 55-59, ISSN 0730-725X
Publisher: Elsevier BV
DOI: 10.1016/j.mri.2017.07.023

Correlations of low-field NMR and variable-field NMR parameters with osteoarthritis in human articular cartilage under load

Author(s): Erik Rössler, Carlos Mattea, Simo Saarakkala, Petri Lehenkari, Mikko Finnilä, Lassi Rieppo, Sakari Karhula, Miika T. Nieminen, Siegfried Stapf
Published in: NMR in Biomedicine, Issue 30/8, 2017, Page(s) e3738, ISSN 0952-3480
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/nbm.3738

Parameterization of NMR relaxation curves in terms of logarithmic moments of the relaxation time distribution

Author(s): Oleg V. Petrov, Siegfried Stapf
Published in: Journal of Magnetic Resonance, Issue 279, 2017, Page(s) 29-38, ISSN 1090-7807
Publisher: Academic Press
DOI: 10.1016/j.jmr.2017.04.009

Deliverables

Publications

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