Targeting epigenetic REPROGRamming of innate immune cells in Atherosclerosis Management and other chronic inflammatory diseases

Livrables

Final report on knowledge exploitation results, including filed patents, spin-off initiatives, etc. during REPROGRAM and thereafter

Quality Assurance File

Report defining the working conditions based on the intaconsortium agreement and procedures defined in Annex 1: standard operation procedures, details on document, knowledge and data management, publication procedures, conflict resolution procedures, meetings arrangements and decision making structure, among other issues

Gender-specific analysis addressing distinct patterns in inflammatory activity

Report on the gender-specific analysis addressing distinct patterns in inflammatory activity, epigenetic control in men vs. women

Ex vivo analysis of monocyte phenotype/function/epigenome in patients with active vs. remissive RA

Report on ex vivo analysis of monocyte phenotype / function / epigenome in patients with active vs. remissive RA

50 BMT experiments in various mouse models

Report on 50 BMT experiments in various mouse models

Data on phenotype, function and epigenome of myeloid cells

Report on study data on phenotype, function and epigenome of myeloid cells harvested from patients with atherogenic risk factors

Roadmap for exploitation

Report incorporating extensive market research, innovation strategies, technology transfer policy, business opportunities among others ensuring swift knowledge exploitation for the expected outcomes of the project: 1. New therapeutic targets; 2. New cellular biomarkers; 3. New therapeutic strategies based on newly discovered disease pathways common to several chronic inflammatory diseases; 4. New opportunities in nanotechnology for targeted drug delivery in chronic inflammatory diseases; 5. New multimodal imaging techniques for systemic activation of innate immune cells.

Relation between gene-score and cardiovascular risk

Evaluation report of the relation between gene-score and cardiovascular risk in the general population

Young researcher training program

Report on the proposed young talent program actions during the REPROGRAM project, including complementary trainings, invited lectures, short laboratory/clinic visits.

Nanoparticle vs. unpackaged epigenetic modulator in vitro and experimental model

Report on the comparison of nanoparticle vs. unpackaged epigenetic modulators in in vitro studies and experimental models

PET/CT studies in patients with active and remissive RA

Report on in vivo PET/CT studies in patients with active and remissive RA

Local delivery strategy development for a epigenetic modulator

Feasibility report of local delivery strategy development for a epigenetic modulator

24 ldlr-/- experiments using either placebo or epigenetic modulator

Report on the 24 ldlr-/- experiments using either placebo or epigenetic modulator for 4 weeks

Validated gene score for modified epigenetic modulation

Report on the delivery of a validated gene score for modified epigenetic modulation in humans

Data management plan

Report containing: (1) detailed information on the procedures that will be implemented for data collection, use, consent, storage, protection, retention, destruction, and how the participants will be consented (2) a document from the responsible data management structure/individual stating that all planned measures comply with national and EU legislation, (3) If applicable copies of the i. notifications ii. approvals iii. opinions iv. authorisations from the relevant national data protection authorities for the proposed data collection and processing as well as reuse must be provided to the EU prior to any use.

Dissemination final report

Final report on dissemination results, including all scientific publications, newsletters, etc. during REPROGRAM and thereafter

In vitro tests of atherogenic factors on phenotype/function/epigenetics of human myeloid cells

Report on in vitro tests of atherogenic factors on phenotype/function/epigenetics of human myeloid cells

CID-associated DAMPs on human monocyte phenotype/function/epigenome

Report on in vitro tests of CID-associated DAMPs on human monocyte phenotype / function / epigenome

Epigenetic modulators on in vitro cell systems

Report on in vitro testing of the library of epigenetic modulators on in vitro cell systems

Publications

CCR2 expression on circulating monocytes is associated with arterial wall inflammation assessed by 18F-FDG PET/CT in patients at risk for cardiovascular disease

Auteurs: Simone L Verweij, Raphaël Duivenvoorden, Lotte C A Stiekema, Nick S Nurmohamed, Fleur M van der Valk, Miranda Versloot, Hein J Verberne, Erik S G Stroes, Matthias Nahrendorf, Siroon Bekkering, Sophie J Bernelot Moens
Publié dans: Cardiovascular Research, Numéro 114/3, 2017, Page(s) 468-475, ISSN 0008-6363
Éditeur: Elsevier BV
DOI: 10.1093/cvr/cvx224

Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis

Auteurs: Tom T.P. Seijkens, Claudia M. van Tiel, Pascal J.H. Kusters, Dorothee Atzler, Oliver Soehnlein, Barbara Zarzycka, Suzanne A.B.M. Aarts, Marnix Lameijer, Marion J. Gijbels, Linda Beckers, Myrthe den Toom, Bram Slütter, Johan Kuiper, Johan Duchene, Maria Aslani, Remco T.A. Megens, Cornelis van ‘t Veer, Gijs Kooij, Roy Schrijver, Marten A. Hoeksema, Louis Boon, Francois Fay, Jun Tang, Samantha Bax
Publié dans: Journal of the American College of Cardiology, Numéro 71/5, 2018, Page(s) 527-542, ISSN 0735-1097
Éditeur: Elsevier BV
DOI: 10.1016/j.jacc.2017.11.055

Exploring immune checkpoints as potential therapeutic targets in atherosclerosis

Auteurs: Pascal J H Kusters, Esther Lutgens, Tom T P Seijkens
Publié dans: Cardiovascular Research, Numéro 114/3, 2017, Page(s) 368-377, ISSN 0008-6363
Éditeur: Elsevier BV
DOI: 10.1093/cvr/cvx248

Trained Innate Immunity as a Novel Mechanism Linking Infection and the Development of Atherosclerosis

Auteurs: Jenneke Leentjens, Siroon Bekkering, Leo A Joosten, Mihai G Netea, David P Burgner, Niels P Riksen
Publié dans: Circulation Research, Numéro 2018 Jan 24, 2018, Page(s) CIRCRESAHA.117.312465, ISSN 0009-7330
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/CIRCRESAHA.117.312465

The maturation of a ‘neural–hematopoietic’ inflammatory axis in cardiovascular disease

Auteurs: Lotte C.A. Stiekema, Johan G. Schnitzler, Matthias Nahrendorf, Erik S.G. Stroes
Publié dans: Current Opinion in Lipidology, Numéro 28/6, 2017, Page(s) 507-512, ISSN 0957-9672
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/MOL.0000000000000457

Monocyte and haematopoietic progenitor reprogramming as common mechanism underlying chronic inflammatory and cardiovascular diseases

Auteurs: Renate M Hoogeveen, Matthias Nahrendorf, Niels P Riksen, Mihai G Netea, Menno P J de Winther, Esther Lutgens, Børge G Nordestgaard, Michel Neidhart, Erik S G Stroes, Alberico L Catapano, Siroon Bekkering
Publié dans: European Heart Journal, 2017, ISSN 0195-668X
Éditeur: Oxford University Press
DOI: 10.1093/eurheartj/ehx581

Metabolic Induction of Trained Immunity through the Mevalonate Pathway

Auteurs: Siroon Bekkering, Rob J.W. Arts, Boris Novakovic, Ioannis Kourtzelis, Charlotte D.C.C. van der Heijden, Yang Li, Calin D. Popa, Rob ter Horst, Julia van Tuijl, Romana T. Netea-Maier, Frank L. van de Veerdonk, Triantafyllos Chavakis, Leo A.B. Joosten, Jos W.M. van der Meer, Henk Stunnenberg, Niels P. Riksen, Mihai G. Netea
Publié dans: Cell, Numéro 172/1-2, 2018, Page(s) 135-146.e9, ISSN 0092-8674
Éditeur: Cell Press
DOI: 10.1016/j.cell.2017.11.025

Epigenetics and Trained Immunity

Auteurs: Charlotte D.C.C. van der Heijden, Marlies P. Noz, Leo A.B. Joosten, Mihai G. Netea, Niels P. Riksen, Samuel T. Keating
Publié dans: Antioxidants & Redox Signaling, 2017, ISSN 1523-0864
Éditeur: Mary Ann Liebert Inc.
DOI: 10.1089/ars.2017.7310

PCSK9 monoclonal antibodies reverse the pro-inflammatory profile of monocytes in familial hypercholesterolaemia

Auteurs: Sophie J. Bernelot Moens, Annette E. Neele, Jeffrey Kroon, Fleur M. van der Valk, Jan Van den Bossche, Marten A. Hoeksema, Renate M. Hoogeveen, Johan G. Schnitzler, Marie T. Baccara-Dinet, Garen Manvelian, Menno P.J. de Winther, Erik S.G. Stroes
Publié dans: European Heart Journal, Numéro 38/20, 2017, Page(s) 1584-1593, ISSN 0195-668X
Éditeur: Oxford University Press
DOI: 10.1093/eurheartj/ehx002

Remnant Cholesterol Elicits Arterial Wall Inflammation and a Multilevel Cellular Immune Response in HumansHighlights

Auteurs: Sophie J. Bernelot Moens, Simone L. Verweij, Johan G. Schnitzler, Lotte C.A. Stiekema, Merijn Bos, Anne Langsted, Carlijn Kuijk, Siroon Bekkering, Carlijn Voermans, Hein J. Verberne, Børge G. Nordestgaard, Erik S.G. Stroes, Jeffrey Kroon
Publié dans: Arteriosclerosis, Thrombosis, and Vascular Biology, Numéro 37/5, 2017, Page(s) 969-975, ISSN 1079-5642
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/ATVBAHA.116.308834

Nile Red Quantifier: a novel and quantitative tool to study lipid accumulation in patient-derived circulating monocytes using confocal microscopy

Auteurs: Johan G. Schnitzler, Sophie J. Bernelot Moens, Feiko Tiessens, Guido J. Bakker, Geesje M. Dallinga-Thie, Albert K. Groen, Max Nieuwdorp, Erik S. G. Stroes, Jeffrey Kroon
Publié dans: Journal of Lipid Research, Numéro 58/11, 2017, Page(s) 2210-2219, ISSN 0022-2275
Éditeur: Lipid Research, Inc.
DOI: 10.1194/jlr.D073197

Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming

Auteurs: Anette Christ, Patrick Günther, Mario A.R. Lauterbach, Peter Duewell, Debjani Biswas, Karin Pelka, Claus J. Scholz, Marije Oosting, Kristian Haendler, Kevin Baßler, Kathrin Klee, Jonas Schulte-Schrepping, Thomas Ulas, Simone J.C.F.M. Moorlag, Vinod Kumar, Min Hi Park, Leo A.B. Joosten, Laszlo A. Groh, Niels P. Riksen, Terje Espevik, Andreas Schlitzer, Yang Li, Michael L. Fitzgerald, Mihai G. Net
Publié dans: Cell, Numéro 172/1-2, 2018, Page(s) 162-175.e14, ISSN 0092-8674
Éditeur: Cell Press
DOI: 10.1016/j.cell.2017.12.013

Monocyte and macrophage immunometabolism in atherosclerosis

Auteurs: Laszlo Groh, Samuel T. Keating, Leo A. B. Joosten, Mihai G. Netea, Niels P. Riksen
Publié dans: Seminars in Immunopathology, Numéro 40/2, 2018, Page(s) 203-214, ISSN 1863-2297
Éditeur: Springer Verlag
DOI: 10.1007/s00281-017-0656-7

Epigenetics in diabetic nephropathy, immunity and metabolism

Auteurs: Samuel T. Keating, Janna A. van Diepen, Niels P. Riksen, Assam El-Osta
Publié dans: Diabetologia, Numéro 61/1, 2018, Page(s) 6-20, ISSN 0012-186X
Éditeur: Springer Verlag
DOI: 10.1007/s00125-017-4490-1

Diabetes propels the risk for cardiovascular disease: sweet monocytes becoming aggressive?

Auteurs: Janna A. van Diepen, Kathrin Thiem, Rinke Stienstra, Niels P. Riksen, Cees J. Tack, Mihai G. Netea
Publié dans: Cellular and Molecular Life Sciences, 2016, ISSN 1420-682X
Éditeur: Birkhauser Verlag
DOI: 10.1007/s00018-016-2316-9

Oxidized Phospholipids on Lipoprotein(a) Elicit Arterial Wall Inflammation and an Inflammatory Monocyte Response in HumansClinical Perspective

Auteurs: Fleur M. van der Valk, Siroon Bekkering, Jeffrey Kroon, Calvin Yeang, Jan Van den Bossche, Jaap D. van Buul, Amir Ravandi, Aart J. Nederveen, Hein J. Verberne, Corey Scipione, Max Nieuwdorp, Leo A.B. Joosten, Mihai G. Netea, Marlys L. Koschinsky, Joseph L. Witztum, Sotirios Tsimikas, Niels P. Riksen, Erik S.G. Stroes
Publié dans: Circulation, Numéro 134/8, 2016, Page(s) 611-624, ISSN 0009-7322
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/CIRCULATIONAHA.116.020838

Unexpected arterial wall and cellular inflammation in patients with rheumatoid arthritis in remission using biological therapy: a cross-sectional study

Auteurs: Sophie J. Bernelot Moens, Fleur M. van der Valk, Aart C. Strang, Jeffrey Kroon, Loek P. Smits, Eva L. Kneepkens, Hein J. Verberne, Jaap D. van Buul, Michael T. Nurmohamed, Erik S. G. Stroes
Publié dans: Arthritis Research & Therapy, Numéro 18/1, 2016, ISSN 1478-6362
Éditeur: BioMed Central
DOI: 10.1186/s13075-016-1008-z

Erratum to: Unexpected arterial wall and cellular inflammation in patients with rheumatoid arthritis in remission using biological therapy: a cross-sectional study

Myeloid apolipoprotein E controls dendritic cell antigen presentation and T cell activation

Auteurs: Fabrizia Bonacina, David Coe, Guosu Wang, Maria P. Longhi, Andrea Baragetti, Annalisa Moregola, Katia Garlaschelli, Patrizia Uboldi, Fabio Pellegatta, Liliana Grigore, Lorenzo Da Dalt, Andrea Annoni, Silvia Gregori, Qingzhong Xiao, Donatella Caruso, Nico Mitro, Alberico L. Catapano, Federica M. Marelli-Berg, Giuseppe D. Norata
Publié dans: Nature Communications, Numéro 9/1, 2018, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-018-05322-1

Anti-PCSK9 antibodies for the treatment of heterozygous familial hypercholesterolemia: patient selection and perspectives

Auteurs: Alberico Catapano, Angela Pirillo, Giuseppe Danilo Norata
Publié dans: Vascular Health and Risk Management, Numéro Volume 13, 2017, Page(s) 343-351, ISSN 1178-2048
Éditeur: Dovepress
DOI: 10.2147/VHRM.S130338

Macrophages and Cardiovascular Health

Auteurs: Vanessa Frodermann, Matthias Nahrendorf
Publié dans: Physiological Reviews, Numéro 98/4, 2018, Page(s) 2523-2569, ISSN 0031-9333
Éditeur: American Physiological Society
DOI: 10.1152/physrev.00068.2017

Myeloid cell contributions to cardiovascular health and disease

Auteurs: Matthias Nahrendorf
Publié dans: Nature Medicine, Numéro 24/6, 2018, Page(s) 711-720, ISSN 1078-8956
Éditeur: Nature Publishing Group
DOI: 10.1038/s41591-018-0064-0

Imaging the Vascular Bone Marrow Niche During Inflammatory Stress

Auteurs: Katrien Vandoorne, David Rohde, Hye-Yeong Kim, Gabriel Courties, Gregory Wojtkiewicz, Lisa Honold, Friedrich Felix Hoyer, Vanessa Frodermann, Ribhu Nayar, Fanny Herisson, Yookyung Jung, Pauline A. Désogère, Claudio Vinegoni, Peter Caravan, Ralph Weissleder, David E. Sosnovik, Charles P. Lin, Filip K. Swirski, Matthias Nahrendorf
Publié dans: Circulation Research, Numéro 123/4, 2018, Page(s) 415-427, ISSN 0009-7330
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.118.313302

Myeloid Kdm6b deficiency results in advanced atherosclerosis

Auteurs: Annette E. Neele, Marion J.J. Gijbels, Saskia van der Velden, Marten A. Hoeksema, Marieke C.S. Boshuizen, Koen H.M. Prange, Hung-Jen Chen, Jan Van den Bossche, Cindy P.P.A. van Roomen, Annelie Shami, Johannes H.M. Levels, Jeffrey Kroon, Tina Lucas, Stefanie Dimmeler, Esther Lutgens, Menno P.J. de Winther
Publié dans: Atherosclerosis, Numéro 275, 2018, Page(s) 156-165, ISSN 0021-9150
Éditeur: Elsevier BV
DOI: 10.1016/j.atherosclerosis.2018.05.052

CD40L Deficiency Protects Against Aneurysm Formation

Auteurs: Pascal J.H. Kusters, Tom T.P. Seijkens, Linda Beckers, Dirk Lievens, Holger Winkels, Vivian de Waard, Adriaan Duijvestijn, Moritz Lindquist Liljeqvist, Joy Roy, Alan Daugherty, Andrew Newby, Norbert Gerdes, Esther Lutgens
Publié dans: Arteriosclerosis, Thrombosis, and Vascular Biology, Numéro 38/5, 2018, Page(s) 1076-1085, ISSN 1079-5642
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/atvbaha.117.310640

2016 Jeffrey M. Hoeg Award Lecture

Auteurs: Ellen Rouwet, Esther Lutgens
Publié dans: Arteriosclerosis, Thrombosis, and Vascular Biology, Numéro 38/8, 2018, Page(s) 1678-1688, ISSN 1079-5642
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/atvbaha.118.307742

Future directions for therapeutic strategies in post-ischaemic vascularization: a position paper from European Society of Cardiology Working Group on Atherosclerosis and Vascular Biology

Auteurs: Andrea Caporali, Magnus Bäck, Mat J Daemen, Imo E Hoefer, Elizabeth A Jones, Esther Lutgens, Christian M Matter, Marie-Luce Bochaton-Piallat, Arndt F Siekmann, Judith C Sluimer, Sabine Steffens, José Tuñón, Cecile Vindis, Jolanda J Wentzel, Seppo Ylä-Herttuala, Paul C Evans
Publié dans: Cardiovascular Research, Numéro 114/11, 2018, Page(s) 1411-1421, ISSN 0008-6363
Éditeur: Elsevier BV
DOI: 10.1093/cvr/cvy184

Macrophage CD40 plays a minor role in obesity-induced metabolic dysfunction

Auteurs: Suzanne A. B. M. Aarts, Myrthe E. Reiche, Myrthe den Toom, Linda Beckers, Marion J. J. Gijbels, Norbert Gerdes, Menno P. J. de Winther, Esther Lutgens
Publié dans: PLOS ONE, Numéro 13/8, 2018, Page(s) e0202150, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0202150

Innate immune cell activation and epigenetic remodeling in symptomatic and asymptomatic atherosclerosis in humans in vivo

Auteurs: Siroon Bekkering, Inge van den Munckhof, Tim Nielen, Evert Lamfers, Charles Dinarello, Joost Rutten, Jacqueline de Graaf, Leo A.B. Joosten, Mihai G. Netea, Marc E.R. Gomes, Niels P. Riksen
Publié dans: Atherosclerosis, Numéro 254, 2016, Page(s) 228-236, ISSN 0021-9150
Éditeur: Elsevier BV
DOI: 10.1016/j.atherosclerosis.2016.10.019

Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity

Auteurs: Rob J.W. Arts, Boris Novakovic, Rob ter Horst, Agostinho Carvalho, Siroon Bekkering, Ekta Lachmandas, Fernando Rodrigues, Ricardo Silvestre, Shih-Chin Cheng, Shuang-Yin Wang, Ehsan Habibi, Luís G. Gonçalves, Inês Mesquita, Cristina Cunha, Arjan van Laarhoven, Frank L. van de Veerdonk, David L. Williams, Jos W.M. van der Meer, Colin Logie, Luke A. O'Neill, Charles A. Dinarello, Niels P. Riksen,
Publié dans: Cell Metabolism, Numéro 24/6, 2016, Page(s) 807-819, ISSN 1550-4131
Éditeur: Cell Press
DOI: 10.1016/j.cmet.2016.10.008

In Vitro Experimental Model of Trained Innate Immunity in Human Primary Monocytes

Auteurs: Siroon Bekkering, Bastiaan A. Blok, Leo A. B. Joosten, Niels P. Riksen, Reinout van Crevel, Mihai G. Netea
Publié dans: Clinical and Vaccine Immunology, Numéro 23/12, 2016, Page(s) 926-933, ISSN 1556-6811
Éditeur: American Society for Microbiology
DOI: 10.1128/CVI.00349-16

Long-term activation of the innate immune system in atherosclerosis

Auteurs: Anette Christ, Siroon Bekkering, Eicke Latz, Niels P. Riksen
Publié dans: Seminars in Immunology, Numéro 28/4, 2016, Page(s) 384-393, ISSN 1044-5323
Éditeur: Academic Press
DOI: 10.1016/j.smim.2016.04.004

Biology of proprotein convertase subtilisin kexin 9: beyond low-density lipoprotein cholesterol lowering

Auteurs: Giuseppe Danilo Norata, Hagai Tavori, Angela Pirillo, Sergio Fazio, Alberico L. Catapano
Publié dans: Cardiovascular Research, Numéro 112/1, 2016, Page(s) 429-442, ISSN 0008-6363
Éditeur: Elsevier BV
DOI: 10.1093/cvr/cvw194

TET1 is an important transcriptional activator of TNFα expression in macrophages

Auteurs: Fangfang Sun, Irene Abreu-Rodriguez, Shuang Ye, Steffen Gay, Oliver Distler, Michel Neidhart, Emmanuel Karouzakis
Publié dans: PLOS ONE, Numéro 14/6, 2019, Page(s) e0218551, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0218551

Oligomeric S100A4 Is Associated With Monocyte Innate Immune Memory and Bypass of Tolerance to Subsequent Stimulation With Lipopolysaccharides

Auteurs: Michel Neidhart, Agnieszka Pajak, Katerina Laskari, Niels P. Riksen, Leo A. B. Joosten, Mihai G. Netea, Esther Lutgens, Eric S. G. Stroes, Adrian Ciurea, Oliver Distler, Mariam Grigorian, Emmanuel Karouzakis
Publié dans: Frontiers in Immunology, Numéro 10, 2019, ISSN 1664-3224
Éditeur: Frontiers
DOI: 10.3389/fimmu.2019.00791

Role of gut microbiota in chronic low-grade inflammation as potential driver for atherosclerotic cardiovascular disease: a systematic review of human studies

Auteurs: I. C. L. van den Munckhof, A. Kurilshikov, R. ter Horst, N. P. Riksen, L. A. B. Joosten, A. Zhernakova, J. Fu, S. T. Keating, M. G. Netea, J. de Graaf, J. H. W. Rutten
Publié dans: Obesity Reviews, Numéro 19/12, 2018, Page(s) 1719-1734, ISSN 1467-7881
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/obr.12750

Immunometabolism orchestrates training of innate immunity in atherosclerosis

Auteurs: Julia van Tuijl, Leo A B Joosten, Mihai G Netea, Siroon Bekkering, Niels P Riksen
Publié dans: Cardiovascular Research, Numéro 115/9, 2019, Page(s) 1416-1424, ISSN 0008-6363
Éditeur: Elsevier BV
DOI: 10.1093/cvr/cvz107

Plant-based sterols and stanols in health & disease: “Consequences of human development in a plant-based environment?”

Auteurs: J. Plat, S. Baumgartner, T. Vanmierlo, D. Lütjohann, K.L. Calkins, D.G. Burrin, G. Guthrie, C. Thijs, A.A. Te Velde, A.C.E. Vreugdenhil, R. Sverdlov, J. Garssen, K. Wouters, E.A. Trautwein, T.G. Wolfs, C. van Gorp, M.T. Mulder, N.P. Riksen, A.K. Groen, R.P. Mensink
Publié dans: Progress in Lipid Research, Numéro 74, 2019, Page(s) 87-102, ISSN 0163-7827
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.plipres.2019.02.003

Getting to the marrow of trained immunity

Auteurs: Laszlo Groh, Mihai G Netea, Niels P Riksen, Samuel T Keating
Publié dans: Epigenomics, Numéro 10/9, 2018, Page(s) 1151-1154, ISSN 1750-1911
Éditeur: Future Medicine Ltd.
DOI: 10.2217/epi-2018-0098

Be aware, innate immune cells remember

Auteurs: Niels P. Riksen, Mihai G. Netea
Publié dans: Aging, Numéro 10/9, 2018, Page(s) 2218-2219, ISSN 1945-4589
Éditeur: Aging
DOI: 10.18632/aging.101552

Metabolism of innate immune cells

Auteurs: Niels P. Riksen, Rinke Stienstra
Publié dans: Current Opinion in Lipidology, Numéro 29/5, 2018, Page(s) 359-367, ISSN 0957-9672
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/mol.0000000000000539

Aldosterone induces trained immunity: the role of fatty acid synthesis

Auteurs: Charlotte D C C van der Heijden, Samuel T Keating, Laszlo Groh, Leo A B Joosten, Mihai G Netea, Niels P Riksen
Publié dans: Cardiovascular Research, 2019, ISSN 0008-6363
Éditeur: Elsevier BV
DOI: 10.1093/cvr/cvz137

The mineralocorticoid receptor as a modulator of innate immunity and atherosclerosis

Auteurs: Charlotte D C C van der Heijden, Jaap Deinum, Leo A B Joosten, Mihai G Netea, Niels P Riksen
Publié dans: Cardiovascular Research, Numéro 114/7, 2018, Page(s) 944-953, ISSN 0008-6363
Éditeur: Elsevier BV
DOI: 10.1093/cvr/cvy092

Treatment with Statins Does Not Revert Trained Immunity in Patients with Familial Hypercholesterolemia

Auteurs: Siroon Bekkering, Lotte C.A. Stiekema, Sophie Bernelot Moens, Simone L. Verweij, Boris Novakovic, Koen Prange, Miranda Versloot, Jeanine E. Roeters van Lennep, Henk Stunnenberg, Menno de Winther, Erik S.G. Stroes, Leo A.B. Joosten, Mihai G. Netea, Niels P. Riksen
Publié dans: Cell Metabolism, Numéro 30/1, 2019, Page(s) 1-2, ISSN 1550-4131
Éditeur: Cell Press
DOI: 10.1016/j.cmet.2019.05.014

Trained immunity and atherosclerotic cardiovascular disease

Auteurs: Niels P. Riksen
Publié dans: Current Opinion in Lipidology, Numéro 30/5, 2019, Page(s) 395-400, ISSN 0957-9672
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/mol.0000000000000628

Deficiency of the T cell regulator Casitas B-cell lymphoma-B aggravates atherosclerosis by inducing CD8+ T cell-mediated macrophage death

Auteurs: Tom T P Seijkens, Kikkie Poels, Svenja Meiler, Claudia M van Tiel, Pascal J H Kusters, Myrthe Reiche, Dorothee Atzler, Holger Winkels, Marc Tjwa, Hessel Poelman, Bram Slütter, Johan Kuiper, Marion Gijbels, Jan Albert Kuivenhoven, Ljubica Perisic Matic, Gabrielle Paulsson-Berne, Ulf Hedin, Göran K Hansson, Gerry A F Nicolaes, Mat J A P Daemen, Christian Weber, Norbert Gerdes, Menno P J de Winther
Publié dans: European Heart Journal, Numéro 40/4, 2018, Page(s) 372-382, ISSN 0195-668X
Éditeur: Oxford University Press
DOI: 10.1093/eurheartj/ehy714

Identifying the anti-inflammatory response to lipid lowering therapy: a position paper from the working group on atherosclerosis and vascular biology of the European Society of Cardiology

Auteurs: José Tuñón, Lina Badimón, Marie-Luce Bochaton-Piallat, Bertrand Cariou, Mat J Daemen, Jesus Egido, Paul C Evans, Imo E Hoefer, Daniel F J Ketelhuth, Esther Lutgens, Christian M Matter, Claudia Monaco, Sabine Steffens, Erik Stroes, Cécile Vindis, Christian Weber, Magnus Bäck
Publié dans: Cardiovascular Research, Numéro 115/1, 2018, Page(s) 10-19, ISSN 0008-6363
Éditeur: Elsevier BV
DOI: 10.1093/cvr/cvy293

The Interplay of Lipids, Lipoproteins, and Immunity in Atherosclerosis

Auteurs: Angela Pirillo, Fabrizia Bonacina, Giuseppe Danilo Norata, Alberico Luigi Catapano
Publié dans: Current Atherosclerosis Reports, Numéro 20/3, 2018, ISSN 1523-3804
Éditeur: Current Science Inc.
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DOI: 10.1016/j.atherosclerosis.2018.06.859

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DOI: 10.1016/j.atherosclerosis.2018.08.013

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DOI: 10.1007/s00259-018-4038-8

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Éditeur: Elsevier BV
DOI: 10.1016/j.ijcard.2018.12.076

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DOI: 10.1056/nejmcibr1901397

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DOI: 10.1093/eurheartj/ehz283

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DOI: 10.1038/s41598-019-50976-6

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DOI: 10.1161/atvbaha.119.313345

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DOI: 10.1136/bmjdrc-2019-000751

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Éditeur: Cell Press
DOI: 10.1016/j.immuni.2019.10.010

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Auteurs: Vanessa Frodermann, David Rohde, Gabriel Courties, Nicolas Severe, Maximilian J. Schloss, Hajera Amatullah, Cameron S. McAlpine, Sebastian Cremer, Friedrich F. Hoyer, Fei Ji, Ian D. van Koeverden, Fanny Herisson, Lisa Honold, Gustavo Santos Masson, Shuang Zhang, Jana Grune, Yoshiko Iwamoto, Stephen P. Schmidt, Gregory R. Wojtkiewicz, I-Hsiu Lee, Karin Gustafsson, Gerard Pasterkamp, Saskia C. A. de
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Éditeur: Nature Publishing Group
DOI: 10.1038/s41591-019-0633-x

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Publié dans: European Heart Journal, Numéro 40/33, 2018, Page(s) 2775-2781, ISSN 0195-668X
Éditeur: Oxford University Press
DOI: 10.1093/eurheartj/ehy862

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DOI: 10.1016/j.cmet.2017.06.001

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Éditeur: Elsevier BV
DOI: 10.1016/j.ebiom.2017.05.007

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Publié dans: Epigenomics, Numéro 9/4, 2017, Page(s) 383-391, ISSN 1750-1911
Éditeur: Future Medicine Ltd.
DOI: 10.2217/epi-2016-0152

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Publié dans: JACC: Cardiovascular Imaging, Numéro 12/12, 2019, Page(s) 2571-2573, ISSN 1936-878X
Éditeur: Elsevier BV
DOI: 10.1016/j.jcmg.2019.06.022

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Inhibitors of CD40-TRAF6 Interaction

Numéro de demande/publication: US 20160228408 A1
Date: 2016-02-09

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