Common mechanisms and pathways in Stroke and Alzheimer's disease.

Risultati finali

Web application to compute and present results in a simple way for a broad audience

Online application to compute and present results of a risk assessment of AD in stroke patients in a simple way for a broad audience of clinicians and the general public

WP3 Midterm recruitment report

Overview of recruited subjects, potential recruiting problems and, if applicable, a detailed description of implemented and planned measures to compensate delays in the study subject recruitment

WP4 Report on status of posting results in the study registry(s)

Report on the status of the result posting including timelines when final posting of results is scheduled

WP3 Report on status of posting results in the study registry(s)

Report on the status of the result posting including timelines when final posting of results is scheduled

WP4 Midterm recruitment report

Overview of recruited subjects, potential recruiting problems and, if applicable, a detailed description of implemented and planned measures to compensate delays in the study subject recruitment

Report on knowledge and innovation management

Detailed report on knowledge and innovation management for CoSTREAM results and achievements

Pubblicazioni

Circulating Metabolites Differentiate Acute Ischemic Stroke from Stroke Mimics

Autori: Steffen Tiedt, Stefan Brandmaier, Hanna Kollmeier, Marco Duering, Anna Artati, Jerzy Adamski, Matthias Klein, Thomas Liebig, Lesca M. Holdt, Daniel Teupser, Rui Wang‐Sattler, Edzard Schwedhelm, Christian Gieger, Martin Dichgans
Pubblicato in: Annals of Neurology, Numero 88/4, 2020, Pagina/e 736-746, ISSN 0364-5134
Editore: John Wiley & Sons Inc.
DOI: 10.1002/ana.25859

Midlife vascular risk factors and risk of incident dementia: Longitudinal cohort and Mendelian randomization analyses in the UK Biobank

Autori: Rainer Malik, Marios K. Georgakis, Julia Neitzel, Kristiina Rannikmäe, Michael Ewers, Sudha Seshadri, Cathie L.M. Sudlow, Martin Dichgans
Pubblicato in: Alzheimer's & Dementia, 2021, ISSN 1552-5260
Editore: Elsevier BV
DOI: 10.1002/alz.12320

Can active life mitigate the impact of diabetes on dementia and brain aging?

Autori: Anna Marseglia, Alexander Darin‐Mattsson, Grégoria Kalpouzos, Giulia Grande, Laura Fratiglioni, Serhiy Dekhtyar, Weili Xu
Pubblicato in: Alzheimer's & Dementia, Numero 16/11, 2020, Pagina/e 1534-1543, ISSN 1552-5260
Editore: Elsevier BV
DOI: 10.1002/alz.12142

Shared risk and protective factors between Alzheimer's disease and ischemic stroke: A population‐based longitudinal study

Autori: Rui Wang, Chengxuan Qiu, Christina S. Dintica, Ying Shang, Amaia Calderón Larrañaga, Hui‐Xin Wang, Weili Xu
Pubblicato in: Alzheimer's & Dementia, Numero 17/2, 2021, Pagina/e 191-204, ISSN 1552-5260
Editore: Elsevier BV
DOI: 10.1002/alz.12203

Relationship between gut microbiota and circulating metabolites in population-based cohorts

Autori: Dina Vojinovic, Djawad Radjabzadeh, Alexander Kurilshikov, Najaf Amin, Cisca Wijmenga, Lude Franke, M. Arfan Ikram, Andre G. Uitterlinden, Alexandra Zhernakova, Jingyuan Fu, Robert Kraaij, Cornelia M. van Duijn
Pubblicato in: Nature Communications, Numero 10/1, 2019, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-019-13721-1

Herpes simplex virus 1 and the risk of dementia: a population-based study

Autori: Meghan J. Murphy, Lana Fani, M. Kamran Ikram, Mohsen Ghanbari, M. Arfan Ikram
Pubblicato in: Scientific Reports, Numero 11/1, 2021, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-021-87963-9

Impaired olfaction is associated with cognitive decline and neurodegeneration in the brain

Autori: Christina S. Dintica, Anna Marseglia, Debora Rizzuto, Rui Wang, Janina Seubert, Konstantinos Arfanakis, David A. Bennett, Weili Xu
Pubblicato in: Neurology, Numero 92/7, 2019, Pagina/e e700-e709, ISSN 0028-3878
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/wnl.0000000000006919

Genetically determined blood pressure, antihypertensive drug classes, and risk of stroke subtypes

Autori: Marios K. Georgakis, Dipender Gill, Alastair J.S. Webb, Evangelos Evangelou, Paul Elliott, Cathie L.M. Sudlow, Abbas Dehghan, Rainer Malik, Ioanna Tzoulaki, Martin Dichgans
Pubblicato in: Neurology, Numero 95/4, 2020, Pagina/e e353-e361, ISSN 0028-3878
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/wnl.0000000000009814

Relationship Between Blood Pressure and Incident Cardiovascular Disease: Linear and Nonlinear Mendelian Randomization Analyses

Autori: Rainer Malik, Marios K. Georgakis, Marijana Vujkovic, Scott M. Damrauer, Paul Elliott, Ville Karhunen, Alice Giontella, Cristiano Fava, Jacklyn N. Hellwege, Megan M. Shuey, Todd L. Edwards, Tormod Rogne, Bjørn O. Åsvold, Ben M. Brumpton, Stephen Burgess, Martin Dichgans, Dipender Gill
Pubblicato in: Hypertension, Numero 77/6, 2021, Pagina/e 2004-2013, ISSN 0194-911X
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/hypertensionaha.120.16534

RNA-Seq Identifies Circulating miR-125a-5p, miR-125b-5p, and miR-143-3p as Potential Biomarkers for Acute Ischemic Stroke

Autori: Steffen Tiedt, Matthias Prestel, Rainer Malik, Nicola Schieferdecker, Marco Duering, Veronika Kautzky, Ivelina Stoycheva, Julia Böck, Bernd H. Northoff, Matthias Klein, Franziska Dorn, Knut Krohn, Daniel Teupser, Arthur Liesz, Nikolaus Plesnila, Lesca Miriam Holdt, Martin Dichgans
Pubblicato in: Circulation Research, Numero 121/8, 2017, Pagina/e 970-980, ISSN 0009-7330
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.117.311572

Plasma amyloid β levels are driven by genetic variants near APOE, BACE1, APP, PSEN2 : A genome‐wide association study in over 12,000 non‐demented participants

Autori: Vincent Damotte, Sven J. Lee, Vincent Chouraki, Benjamin Grenier‐Boley, Jeannette Simino, Hieab Adams, Giuseppe Tosto, Charles White, Natalie Terzikhan, Carlos Cruchaga, Maria J. Knol, Shuo Li, Susanna Schraen, Megan L. Grove, Claudia Satizabal, Najaf Amin, Claudine Berr, Steven Younkin, Rebecca F. Gottesman, Luc Buée, Alexa Beiser, David S. Knopman, Andre Uitterlinden, Charles DeCarli, Jan Bre
Pubblicato in: Alzheimer's & Dementia, 2021, ISSN 1552-5260
Editore: Elsevier BV
DOI: 10.1002/alz.12333

Modifiable Lifestyle Factors and Risk of Stroke

Autori: Eric L. Harshfield, Marios K. Georgakis, Rainer Malik, Martin Dichgans, Hugh S. Markus
Pubblicato in: Stroke, Numero 52/3, 2021, Pagina/e 931-936, ISSN 0039-2499
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/strokeaha.120.031710

Association of life‐course depression with the risk of dementia in late life: A nationwide twin study

Autori: Wenzhe Yang, Xuerui Li, Kuan‐Yu Pan, Rongrong Yang, Ruixue Song, Xiuying Qi, Nancy L. Pedersen, Weili Xu
Pubblicato in: Alzheimer's & Dementia, 2021, ISSN 1552-5260
Editore: Elsevier BV
DOI: 10.1002/alz.12303

The genetic architecture of the human cerebral cortex

Autori: KATRINA L. GRASBY, NEDA JAHANSHAD, JODIE N. PAINTER, LUCÍA COLODRO-CONDE, JANITA BRALTEN, DERREK P. HIBAR, PENELOPE A. LIND, FABRIZIO PIZZAGALLI, CHRISTOPHER R. K. CHING, MARY AGNES B. MCMAHON, NATALIA SHATOKHINA, LEO C. P. ZSEMBIK, SOPHIA I. THOMOPOULOS, ALYSSA H. ZHU, LACHLAN T. STRIKE, INGRID AGARTZ, SAUD ALHUSAINI, MARCIO A. A. ALMEIDA, DAG ALNÆS, INGE K. AMLIEN, MICAEL ANDERSSON, TYLER ARD,
Pubblicato in: Science, 2020, ISSN 0036-8075
Editore: American Association for the Advancement of Science
DOI: 10.1126/science.aay6690

Integration of demographics, genetics, imaging and metabolomics data to identify Alzheimer’s disease patients

Autori: Vincent Damotte, Guillemette Marot, Aline Meirhaeghe, Philippe Amouyel, Céline Bellenguez, Vincent Chouraki
Pubblicato in: Alzheimer's & Dementia, Numero 16/S4, 2020, ISSN 1552-5260
Editore: Elsevier BV
DOI: 10.1002/alz.042659

Patterns of Mitochondrial TSPO Binding in Cerebral Small Vessel Disease: An in vivo PET Study With Neuropathological Comparison

Autori: Paul Wright, Mattia Veronese, Ndabezinhle Mazibuko, Federico E. Turkheimer, Eugenii A. Rabiner, Clive G. Ballard, Steven C. R. Williams, Avinash Kumar Hari Narayanan, Bahiya Osrah, Ricky Williams, Tiago R. Marques, Oliver D. Howes, Federico Roncaroli, Michael J. O'Sullivan
Pubblicato in: Frontiers in Neurology, Numero 11, 2020, ISSN 1664-2295
Editore: Frontiers Research Foundation
DOI: 10.3389/fneur.2020.541377

Common Genetic Variation Indicates Separate Causes for Periventricular and Deep White Matter Hyperintensities

Autori: Nicola J. Armstrong, Karen A. Mather, Muralidharan Sargurupremraj, Maria J. Knol, Rainer Malik, Claudia L. Satizabal, Lisa R. Yanek, Wei Wen, Vilmundur G. Gudnason, Nicole D. Dueker, Lloyd T. Elliott, Edith Hofer, Joshua Bis, Neda Jahanshad, Shuo Li, Mark A. Logue, Michelle Luciano, Markus Scholz, Albert V. Smith, Stella Trompet, Dina Vojinovic, Rui Xia, Fidel Alfaro-Almagro, David Ames, Najaf Ami
Pubblicato in: Stroke, Numero 51/7, 2020, Pagina/e 2111-2121, ISSN 0039-2499
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/strokeaha.119.027544

Multiomics integrative analysis identifies APOE allele-specific blood biomarkers associated to Alzheimer’s disease etiopathogenesis

Autori: Laura Madrid, Sonia Moreno-Grau, Shahzad Ahmad, Antonio González-Pérez, Itziar de Rojas, Rui Xia, Pamela V. Martino Adami, Pablo García-González, Luca Kleineidam, Qiong Yang, Vincent Damotte, Joshua C. Bis, Fuensanta Noguera-Perea, Céline Bellenguez, Xueqiu Jian, Juan Marín-Muñoz, Benjamin Grenier-Boley, Adela Orellana, M. Arfan Ikram, Philippe Amouyel, Claudia L. Satizabal, Luis Miguel Rea
Pubblicato in: Aging, Numero 13/7, 2021, Pagina/e 9277-9329, ISSN 1945-4589
Editore: Medline
DOI: 10.18632/aging.202950

A Key Role for Subiculum-Fornix Connectivity in Recollection in Older Age

Autori: Naomi Hartopp, Paul Wright, Nicola J. Ray, Tavia E. Evans, Claudia Metzler-Baddeley, John P. Aggleton, Michael J. O’Sullivan
Pubblicato in: Frontiers in Systems Neuroscience, Numero 12, 2019, ISSN 1662-5137
Editore: Frontiers Research Foundation
DOI: 10.3389/fnsys.2018.00070

Genetic determinants of blood lipids and cerebral small vessel disease: role of high-density lipoprotein cholesterol

Autori: Marios K Georgakis, Rainer Malik, Christopher D Anderson, Klaus G Parhofer, Jemma C Hopewell, Martin Dichgans
Pubblicato in: Brain, Numero 143/2, 2020, Pagina/e 597-610, ISSN 0006-8950
Editore: Oxford University Press
DOI: 10.1093/brain/awz413

Atrial Fibrillation Genetic Risk and Ischemic Stroke Mechanisms

Autori: Steven A. Lubitz, Owen E. Parsons, Christopher D. Anderson, Emelia J. Benjamin, Rainer Malik, Lu-Chen Weng, Martin Dichgans, Cathie L. Sudlow, Peter M. Rothwell, Jonathan Rosand, Patrick T. Ellinor, Hugh S. Markus, Matthew Traylor
Pubblicato in: Stroke, Numero 48/6, 2017, Pagina/e 1451-1456, ISSN 0039-2499
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/strokeaha.116.016198

Association of Circulating Monocyte Chemoattractant Protein–1 Levels With Cardiovascular Mortality

Autori: Marios K. Georgakis, James A. de Lemos, Colby Ayers, Biqi Wang, Harry Björkbacka, Tiberiu A. Pana, Barbara Thorand, Caroline Sun, Lana Fani, Rainer Malik, Josée Dupuis, Gunnar Engström, Marju Orho-Melander, Olle Melander, S. Matthijs Boekholdt, Astrid Zierer, Mohamed A. Elhadad, Wolfgang Koenig, Christian Herder, Ron C. Hoogeveen, Maryam Kavousi, Christie M. Ballantyne, Annette Peters, Phyo K.
Pubblicato in: JAMA Cardiology, Numero 6/5, 2021, Pagina/e 587, ISSN 2380-6583
Editore: JAMA
DOI: 10.1001/jamacardio.2020.5392

Deep learning‐guided joint attenuation and scatter correction in multitracer neuroimaging studies

Autori: Hossein Arabi, Karin Bortolin, Nathalie Ginovart, Valentina Garibotto, Habib Zaidi
Pubblicato in: Human Brain Mapping, Numero 41/13, 2020, Pagina/e 3667-3679, ISSN 1065-9471
Editore: John Wiley & Sons Inc.
DOI: 10.1002/hbm.25039

Association of Circulating Metabolites in Plasma or Serum and Risk of Stroke

Autori: Dina Vojinovic, Marita Kalaoja, Stella Trompet, Krista Fischer, Martin J. Shipley, Shuo Li, Aki S. Havulinna, Markus Perola, Veikko Salomaa, Qiong Yang, Naveed Sattar, Pekka Jousilahti, Najaf Amin, Claudia L. Satizabal, Nele Taba, Behnam Sabayan, Ramachandran S. Vasan, M. Arfan Ikram, David J. Stott, Mika Ala-Korpela, J. Wouter Jukema, Sudha Seshadri, Johannes Kettunen, Mika Kivimaki, Tonu Esko, C
Pubblicato in: Neurology, Numero 96/8, 2021, Pagina/e e1110-e1123, ISSN 0028-3878
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/wnl.0000000000011236

Dose–response relationship between genetically proxied average blood glucose levels and incident coronary heart disease in individuals without diabetes mellitus

Autori: Stephen Burgess, Rainer Malik, Bowen Liu, Amy M. Mason, Marios K. Georgakis, Martin Dichgans, Dipender Gill
Pubblicato in: Diabetologia, Numero 64/4, 2021, Pagina/e 845-849, ISSN 0012-186X
Editore: Springer Verlag
DOI: 10.1007/s00125-020-05377-0

Genetic variants influencing elevated myeloperoxidase levels increase risk of stroke

Autori: Chia-Ling Phuah, Tushar Dave, Rainer Malik, Miriam R Raffeld, Alison M Ayres, Joshua N Goldstein, Anand Viswanathan, Steven M Greenberg, Jeremiasz M Jagiella, Björn M Hansen, Bo Norrving, Jordi Jimenez-Conde, Jaume Roquer, Alexander Pichler, Christian Enzinger, Joan Montaner, Israel Fernandez-Cadenas, Arne Lindgren, Agnieszka Slowik, Reinhold Schmidt, Alessandro Biffi, Natalia Rost, Carl D Langef
Pubblicato in: Brain, Numero 140/10, 2017, Pagina/e 2663-2672, ISSN 0006-8950
Editore: Oxford University Press
DOI: 10.1093/brain/awx220

Genetically Predicted Blood Pressure Across the Lifespan

Autori: Marios K. Georgakis, Dipender Gill, Rainer Malik, Athanase D. Protogerou, Alastair J.S. Webb, Martin Dichgans
Pubblicato in: Hypertension, Numero 76/3, 2020, Pagina/e 953-961, ISSN 0194-911X
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/hypertensionaha.120.15136

A high-throughput, ultrafast, and online three-phase electro-extraction method for analysis of trace level pharmaceuticals

Autori: Yupeng He, Paul Miggiels, Bert Wouters, Nicolas Drouin, Faisa Guled, Thomas Hankemeier, Petrus W. Lindenburg
Pubblicato in: Analytica Chimica Acta, Numero 1149, 2021, Pagina/e 338204, ISSN 0003-2670
Editore: Elsevier BV
DOI: 10.1016/j.aca.2021.338204

Association of lifespan cognitive reserve indicator with the risk of mild cognitive impairment and its progression to dementia

Autori: Hui Xu, Rongrong Yang, Christina Dintica, Xiuying Qi, Ruixue Song, David A Bennett, Weili Xu
Pubblicato in: Alzheimer's & Dementia, Numero 16/6, 2020, Pagina/e 873-882, ISSN 1552-5260
Editore: Elsevier BV
DOI: 10.1002/alz.12085

Prevalence, Severity, and Clinical Management of Brain Incidental Findings in Healthy Young Adults: MRi-Share Cross-Sectional Study

Autori: Aïcha Soumaré, Naka Beguedou, Alexandre Laurent, Bruno Brochet, Constance Bordes, Sandy Mournet, Emmanuel Mellet, Edwige Pereira, Clothilde Pollet, Morgane Lachaize, Marie Mougin, Ami Tsuchida, Hugues Loiseau, Thomas Tourdias, Christophe Tzourio, Bernard Mazoyer, Stéphanie Debette
Pubblicato in: Frontiers in Neurology, Numero 12, 2021, ISSN 1664-2295
Editore: Frontiers Research Foundation
DOI: 10.3389/fneur.2021.675244

Plasma Brain-Derived Neurotropic Factor Levels Are Associated with Aging and Smoking But Not with Future Dementia in the Rotterdam Study

Autori: Sara Galle, Silvan Licher, Maarten Milders, Jan Berend Deijen, Erik Scherder, Madeleine Drent, Arfan Ikram, Cornelia M. van Duijn
Pubblicato in: Journal of Alzheimer's Disease, Numero 80/3, 2021, Pagina/e 1139-1149, ISSN 1387-2877
Editore: IOS Press
DOI: 10.3233/jad-200371

Cardiometabolic traits mediating the effect of education on osteoarthritis risk: a Mendelian randomization study

Autori: D. Gill, V. Karhunen, R. Malik, M. Dichgans, N. Sofat
Pubblicato in: Osteoarthritis and Cartilage, Numero 29/3, 2021, Pagina/e 365-371, ISSN 1063-4584
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.joca.2020.12.015

Circulating metabolites are associated with brain atrophy and white matter hyperintensities

Autori: Francisca A. Leeuw, Hata Karamujić‐Čomić, Betty M. Tijms, Carel F.W. Peeters, Maartje I. Kester, Philip Scheltens, Shahzad Ahmad, Dina Vojinovic, Hieab H.H. Adams, Thomas Hankemeier, Daniel Bos, Aad Lugt, Meike W. Vernooij, M. Arfan Ikram, Najaf Amin, Frederik Barkhof, Charlotte E. Teunissen, Cornelia M. Duijn, Wiesje M. Flier
Pubblicato in: Alzheimer's & Dementia, Numero 17/2, 2021, Pagina/e 205-214, ISSN 1552-5260
Editore: Elsevier BV
DOI: 10.1002/alz.12180

The role of Apolipoprotein E epsilon4 in the association between psychosocial working conditions and dementia

Autori: Kuan-Yu Pan, Weili Xu, Francesca Mangialasche, Giulia Grande, Laura Fratiglioni, Hui-Xin Wang
Pubblicato in: Aging, Numero 12/4, 2020, Pagina/e 3730-3746, ISSN 1945-4589
Editore: Impact Journals
DOI: 10.18632/aging.102843

Twenty-seven-year time trends in dementia incidence in Europe and the United States

Autori: Frank J. Wolters, Lori B. Chibnik, Reem Waziry, Roy Anderson, Claudine Berr, Alexa Beiser, Joshua C. Bis, Deborah Blacker, Daniel Bos, Carol Brayne, Jean-François Dartigues, Sirwan K.L. Darweesh, Kendra L. Davis-Plourde, Frank de Wolf, Stephanie Debette, Carole Dufouil, Myriam Fornage, Jaap Goudsmit, Leslie Grasset, Vilmundur Gudnason, Christoforos Hadjichrysanthou, Catherine Helmer, M. Arfan Ikr
Pubblicato in: Neurology, Numero 95/5, 2020, Pagina/e e519-e531, ISSN 0028-3878
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/wnl.0000000000010022

Cerebral Perfusion and the Risk of Dementia

Autori: Frank J. Wolters, Hazel I. Zonneveld, Albert Hofman, Aad van der Lugt, Peter J. Koudstaal, Meike W. Vernooij, M. Arfan Ikram
Pubblicato in: Circulation, Numero 136/8, 2017, Pagina/e 719-728, ISSN 0009-7322
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circulationaha.117.027448

Circulating biomarkers of immunity and inflammation, risk of Alzheimer’s disease, and hippocampal volume: a Mendelian randomization study

Autori: Lana Fani, Marios K. Georgakis, M. Arfan Ikram, M. Kamran Ikram, Rainer Malik, Martin Dichgans
Pubblicato in: Translational Psychiatry, Numero 11/1, 2021, ISSN 2158-3188
Editore: Nature Publishing Group
DOI: 10.1038/s41398-021-01400-z

Mendelian randomization for studying the effects of perturbing drug targets

Autori: Dipender Gill, Marios K. Georgakis, Venexia M. Walker, A. Floriaan Schmidt, Apostolos Gkatzionis, Daniel F. Freitag, Chris Finan, Aroon D. Hingorani, Joanna M.M. Howson, Stephen Burgess, Daniel I. Swerdlow, George Davey Smith, Michael V. Holmes, Martin Dichgans, Robert A Scott, Jie Zheng, Bruce M. Psaty, Neil M. Davies
Pubblicato in: Wellcome Open Research, Numero 6, 2021, Pagina/e 16, ISSN 2398-502X
Editore: F1000 Research
DOI: 10.12688/wellcomeopenres.16544.2

Genetic variation in PLEKHG1 is associated with white matter hyperintensities (n = 11,226)

Autori: Matthew Traylor, Daniel J. Tozer, Iain D. Croall, Danuta M. Lisiecka Ford, Abiodun Olubunmi Olorunda, Giorgio Boncoraglio, Martin Dichgans, Robin Lemmens, Jonathan Rosand, Natalia S. Rost, Peter M. Rothwell, Cathie L.M. Sudlow, Vincent Thijs, Loes Rutten-Jacobs, Hugh S. Markus
Pubblicato in: Neurology, Numero 92/8, 2019, Pagina/e e749-e757, ISSN 0028-3878
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/WNL.0000000000006952

Associations Between Cardiovascular Risk, Structural Brain Changes, and Cognitive Decline

Autori: Ruixue Song, Hui Xu, Christina S. Dintica, Kuan-Yu Pan, Xiuying Qi, Aron S. Buchman, David A. Bennett, Weili Xu
Pubblicato in: Journal of the American College of Cardiology, Numero 75/20, 2020, Pagina/e 2525-2534, ISSN 0735-1097
Editore: Elsevier BV
DOI: 10.1016/j.jacc.2020.03.053

Cerebrovascular Disease Knowledge Portal

Autori: Katherine M. Crawford, Cristina Gallego-Fabrega, Christina Kourkoulis, Laura Miyares, Sandro Marini, Jason Flannick, Noel P. Burtt, Marcin von Grotthuss, Benjamin Alexander, Maria C. Costanzo, Neil H. Vaishnav, Rainer Malik, Jennifer L. Hall, Michael Chong, Jonathan Rosand, Guido J. Falcone
Pubblicato in: Stroke, Numero 49/2, 2018, Pagina/e 470-475, ISSN 0039-2499
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/strokeaha.117.018922

Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

Autori: Rainer Malik, Ganesh Chauhan, Matthew Traylor, Muralidharan Sargurupremraj, Yukinori Okada, Aniket Mishra, Loes Rutten-Jacobs, Anne-Katrin Giese, Sander W. van der Laan, Solveig Gretarsdottir, Christopher D. Anderson, Michael Chong, Hieab H. H. Adams, Tetsuro Ago, Peter Almgren, Philippe Amouyel, Hakan Ay, Traci M. Bartz, Oscar R. Benavente, Steve Bevan, Giorgio B. Boncoraglio, Robert D. Brown, Ad
Pubblicato in: Nature Genetics, Numero 50/4, 2018, Pagina/e 524-537, ISSN 1061-4036
Editore: Nature Publishing Group
DOI: 10.1038/s41588-018-0058-3

Genetic Study of White Matter Integrity in UK Biobank (N=8448) and the Overlap With Stroke, Depression, and Dementia

Autori: Loes C.A. Rutten-Jacobs, Daniel J. Tozer, Marco Duering, Rainer Malik, Martin Dichgans, Hugh S. Markus, Matthew Traylor
Pubblicato in: Stroke, Numero 49/6, 2018, Pagina/e 1340-1347, ISSN 0039-2499
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/STROKEAHA.118.020811

Subregional volumes of the hippocampus in relation to cognitive function and risk of dementia

Autori: Tavia E. Evans, Hieab H.H. Adams, Silvan Licher, Frank J. Wolters, Aad van der Lugt, M. Kamran Ikram, Michael J. O'Sullivan, Meike W. Vernooij, M. Arfan Ikram
Pubblicato in: NeuroImage, Numero 178, 2018, Pagina/e 129-135, ISSN 1053-8119
Editore: Academic Press
DOI: 10.1016/j.neuroimage.2018.05.041

THE IMPACT OF NUTRIENT PATTERNS ON COGNITIVE DECLINE AMONG SWEDISH OLDER ADULTS: A POPULATION-BASED LONGITUDINAL STUDY

Autori: Federica Prinelli, Debora Rizzuto, Behnaz Shakersain, Ingegerd Johansson, Fulvio Daniele Adorni, Massimo Musicco, Laura Fratiglioni, Weili Xu
Pubblicato in: Alzheimer's & Dementia, Numero 14/7, 2018, Pagina/e P973-P975, ISSN 1552-5260
Editore: Elsevier BV
DOI: 10.1016/j.jalz.2018.06.1308

The Nordic Prudent Diet Reduces Risk of Cognitive Decline in the Swedish Older Adults: A Population-Based Cohort Study

Autori: Behnaz Shakersain, Debora Rizzuto, Susanna Larsson, Gerd Faxén-Irving, Laura Fratiglioni, Wei-Li Xu
Pubblicato in: Nutrients, Numero 10/2, 2018, Pagina/e 229, ISSN 2072-6643
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu10020229

Challenges and opportunities in stroke genetics

Autori: Rainer Malik, Martin Dichgans
Pubblicato in: Cardiovascular Research, 2018, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1093/cvr/cvy068

COL4A2 is associated with lacunar ischemic stroke and deep ICH: meta-analyses among 21,500 cases and 40,600 controls

Autori: Rannikmäe, K.; Sivakumaran, V.; Millar, H.; Malik, R.; Anderson, C.D.; Chong, M.; Dave, T.; Falcone, G.J.; Fernandez-Cadenas, I.; Jimenez-Conde, J.; Lindgren, A.; Montaner, J.; O'Donnell, M.; Paré, G.; Radmanesh, F.; Rost, N.S.; Slowik, A.; Söderholm, M.; Traylor, M.; Pulit, S.L.; Seshadri, S.; Worrall, B.B.; Woo, D.; Markus, H.S.; Mitchell, B.D.; Dichgans, M.; Rosand, J.; Sudlow, CLM; Stroke G
Pubblicato in: Neurology, Numero 1, 2017, ISSN 0028-3878
Editore: Lippincott Williams & Wilkins Ltd.
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Trends in the incidence of dementia: design and methods in the Alzheimer Cohorts Consortium

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Does Treating Vascular Risk Factors Prevent Dementia and Alzheimer’s Disease? A Systematic Review and Meta-Analysis

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Cognitive Trajectories of Older Adults With Prediabetes and Diabetes: A Population-Based Cohort Study

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Analysis of Whole-Exome Sequencing Data for Alzheimer Disease Stratified by APOE Genotype

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Interleukin-6 Signaling Effects on Ischemic Stroke and Other Cardiovascular Outcomes

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The Atherosclerosis Risk Variant rs2107595 Mediates Allele-Specific Transcriptional Regulation of HDAC9 via E2F3 and Rb1

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Type 2 diabetes in midlife and risk of cerebrovascular disease in late life: a prospective nested case−control study in a nationwide Swedish twin cohort

Autori: Rongrong Yang, Nancy L. Pedersen, Cuiping Bao, Weige Xu, Hui Xu, Ruixue Song, Xiuying Qi, Weili Xu
Pubblicato in: Diabetologia, Numero 62/8, 2019, Pagina/e 1403-1411, ISSN 0012-186X
Editore: Springer Verlag
DOI: 10.1007/s00125-019-4892-3

Balance between innate versus adaptive immune system and the risk of dementia: a population-based cohort study

Autori: Kimberly D. van der Willik, Lana Fani, Dimitris Rizopoulos, Silvan Licher, Jesse Fest, Sanne B. Schagen, M. Kamran Ikram, M. Arfan Ikram
Pubblicato in: Journal of Neuroinflammation, Numero 16/1, 2019, ISSN 1742-2094
Editore: BioMed Central
DOI: 10.1186/s12974-019-1454-z

Genetic risk of dementia mitigated by cognitive reserve: A cohort study

Autori: Serhiy Dekhtyar, Anna Marseglia, Weili Xu, Alexander Darin‐Mattsson, Hui‐Xin Wang, Laura Fratiglioni
Pubblicato in: Annals of Neurology, 2019, ISSN 0364-5134
Editore: John Wiley & Sons Inc.
DOI: 10.1002/ana.25501

Homocysteine and small vessel stroke: A mendelian randomization analysis

Autori: Susanna C. Larsson, Matthew Traylor, Hugh S. Markus
Pubblicato in: Annals of Neurology, Numero 85/4, 2019, Pagina/e 495-501, ISSN 0364-5134
Editore: John Wiley & Sons Inc.
DOI: 10.1002/ana.25440

Vitamin D Status and Risk of Stroke

Autori: Brian P. Berghout, Lana Fani, Alis Heshmatollah, Peter J. Koudstaal, M. Arfan Ikram, M. Carola Zillikens, M. Kamran Ikram
Pubblicato in: Stroke, Numero 50/9, 2019, Pagina/e 2293-2298, ISSN 0039-2499
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/strokeaha.119.025449

Association of variants in HTRA1 and NOTCH3 with MRI-defined extremes of cerebral small vessel disease in older subjects

Autori: Aniket Mishra, Ganesh Chauhan, Marie-Helene Violleau, Dina Vojinovic, Xueqiu Jian, Joshua C Bis, Shuo Li, Yasaman Saba, Benjamin Grenier-Boley, Qiong Yang, Traci M Bartz, Edith Hofer, Aïcha Soumaré, Fen Peng, Marie-Gabrielle Duperron, Mario Foglio, Thomas H Mosley, Reinhold Schmidt, Bruce M Psaty, Lenore J Launer, Eric Boerwinkle, Yicheng Zhu, Bernard Mazoyer, Mark Lathrop, Celine Bellenguez, Co
Pubblicato in: Brain, Numero 142/4, 2019, Pagina/e 1009-1023, ISSN 0006-8950
Editore: Oxford University Press
DOI: 10.1093/brain/awz024

Participating in Mental, Social, and Physical Leisure Activities and Having a Rich Social Network Reduce the Incidence of Diabetes-Related Dementia in a Cohort of Swedish Older Adults

Autori: Anna Marseglia, Hui-Xin Wang, Debora Rizzuto, Laura Fratiglioni, Weili Xu
Pubblicato in: Diabetes Care, Numero 42/2, 2019, Pagina/e 232-239, ISSN 0149-5992
Editore: American Diabetes Association
DOI: 10.2337/dc18-1428

Influence of Genetic Variation in PDE3A on Endothelial Function and Stroke

Autori: Matthew Traylor, Ali Amin Al Olama, Leo-Pekka Lyytikäinen, Sandro Marini, Jaeyoon Chung, Rainer Malik, Martin Dichgans, Mika Kähönen, Terho Lehtimäki, Christopher D. Anderson, Olli T. Raitakari, Hugh S. Markus
Pubblicato in: Hypertension, Numero 75/2, 2020, Pagina/e 365-371, ISSN 0194-911X
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/hypertensionaha.119.13513

Large-scale plasma metabolome analysis reveals alterations in HDL metabolism in migraine

Autori: Gerrit L.J. Onderwater, Lannie Ligthart, Mariska Bot, Ayse Demirkan, Jingyuan Fu, Carla J.H. van der Kallen, Lisanne S. Vijfhuizen, René Pool, Jun Liu, Floris H.M. Vanmolkot, Marian Beekman, Ke-xin Wen, Najaf Amin, Carisha S. Thesing, Judith A. Pijpers, Dennis A. Kies, Ronald Zielman, Irene de Boer, Marleen M.J. van Greevenbroek, Ilja C.W. Arts, Yuri Milaneschi, Miranda T. Schram, Pieter C. Dagne
Pubblicato in: Neurology, Numero 92/16, 2019, Pagina/e e1899-e1911, ISSN 0028-3878
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/wnl.0000000000007313

A healthy lifestyle mitigates the risk of heart disease related to type 2 diabetes: a prospective nested case–control study in a nationwide Swedish twin cohort

Autori: Rongrong Yang, Hui Xu, Nancy L. Pedersen, Xuerui Li, Jing Yu, Cuiping Bao, Xiuying Qi, Weili Xu
Pubblicato in: Diabetologia, Numero 64/3, 2021, Pagina/e 530-539, ISSN 0012-186X
Editore: Springer Verlag
DOI: 10.1007/s00125-020-05324-z

Individual changes in anthropometric measures after age 60 years: a 15-year longitudinal population-based study

Autori: Jie Guo, Ying Shang, Laura Fratiglioni, Kristina Johnell, Anna-Karin Welmer, Anna Marseglia, Weili Xu
Pubblicato in: Age and Ageing, 2021, ISSN 0002-0729
Editore: Oxford University Press
DOI: 10.1093/ageing/afab045

Association of Cardiovascular Risk Burden With Risk and Progression of Disability: Mediating Role of Cardiovascular Disease and Cognitive Decline

Autori: Kaiwang Cui, Ruixue Song, Hui Xu, Ying Shang, Xiuying Qi, Aron S. Buchman, David A. Bennett, Weili Xu
Pubblicato in: Journal of the American Heart Association, Numero 9/18, 2020, ISSN 2047-9980
Editore: Wiley-Blackwell
DOI: 10.1161/jaha.120.017346

The association of innate and adaptive immunity, subclinical atherosclerosis, and cardiovascular disease in the Rotterdam Study: A prospective cohort study

Autori: Lana Fani, Kimberly D. van der Willik, Daniel Bos, Maarten J. G. Leening, Peter J. Koudstaal, Dimitris Rizopoulos, Rikje Ruiter, Bruno H. C. Stricker, Maryam Kavousi, M. Arfan Ikram, M. Kamran Ikram
Pubblicato in: PLOS Medicine, Numero 17/5, 2020, Pagina/e e1003115, ISSN 1549-1676
Editore: PLOS
DOI: 10.1371/journal.pmed.1003115

Association of diabetes with stroke and post‐stroke dementia: A population‐based cohort study

Autori: Ying Shang, Laura Fratiglioni, Anna Marseglia, Anna Plym, Anna‐Karin Welmer, Hui‐Xin Wang, Rui Wang, Weili Xu
Pubblicato in: Alzheimer's & Dementia, Numero 16/7, 2020, Pagina/e 1003-1012, ISSN 1552-5260
Editore: Elsevier BV
DOI: 10.1002/alz.12101

Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors

Autori: Mark K. Bakker, Rick A. A. van der Spek, Wouter van Rheenen, Sandrine Morel, Romain Bourcier, Isabel C. Hostettler, Varinder S. Alg, Kristel R. van Eijk, Masaru Koido, Masato Akiyama, Chikashi Terao, Koichi Matsuda, Robin G. Walters, Kuang Lin, Liming Li, Iona Y. Millwood, Zhengming Chen, Guy A. Rouleau, Sirui Zhou, Kristiina Rannikmäe, Cathie L. M. Sudlow, Henry Houlden, Leonard H. van den Berg,
Pubblicato in: Nature Genetics, Numero 52/12, 2020, Pagina/e 1303-1313, ISSN 1061-4036
Editore: Nature Publishing Group
DOI: 10.1038/s41588-020-00725-7

Association of common genetic variants with brain microbleeds

Autori: Maria J. Knol, Dongwei Lu, Matthew Traylor, Hieab H.H. Adams, José Rafael J. Romero, Albert V. Smith, Myriam Fornage, Edith Hofer, Junfeng Liu, Isabel C. Hostettler, Michelle Luciano, Stella Trompet, Anne-Katrin Giese, Saima Hilal, Erik B. van den Akker, Dina Vojinovic, Shuo Li, Sigurdur Sigurdsson, Sven J. van der Lee, Clifford R. Jack, Duncan Wilson, Pinar Yilmaz, Claudia L. Satizabal, David C.
Pubblicato in: Neurology, Numero 95/24, 2020, Pagina/e e3331-e3343, ISSN 0028-3878
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/wnl.0000000000010852

Neurofilament light chain predicts future dementia risk in cerebral small vessel disease

Autori: Marco Egle, Laurence Loubiere, Aleksandra Maceski, Jens Kuhle, Nils Peters, Hugh S Markus
Pubblicato in: Journal of Neurology, Neurosurgery & Psychiatry, Numero 92/6, 2021, Pagina/e 582-589, ISSN 0022-3050
Editore: BMJ Publishing Group
DOI: 10.1136/jnnp-2020-325681

Association of low birth weight with cardiometabolic diseases in Swedish twins: a population-based cohort study

Autori: Xuerui Li, Rongrong Yang, Wenzhe Yang, Hui Xu, Ruixue Song, Xiuying Qi, Weili Xu
Pubblicato in: BMJ Open, Numero 11/6, 2021, Pagina/e e048030, ISSN 2044-6055
Editore: BMJ Publishing Group
DOI: 10.1136/bmjopen-2020-048030

In‐vivo imaging of locus coeruleus integrity at ultra‐high field: A feasibility study

Autori: Michela Pievani, Ileana O Jelescu, Joao Jorge, Olivier Reynaud, Paulina Andryszak, Valentina Garibotto, Jorge Jovicich, Giovanni B Frisoni
Pubblicato in: Alzheimer's & Dementia, Numero 16/S4, 2020, ISSN 1552-5260
Editore: Elsevier BV
DOI: 10.1002/alz.040835

Microstructural changes in the reward system are associated with post-stroke depression

Autori: Lena K.L. Oestreich, Paul Wright, Michael J. O'Sullivan
Pubblicato in: NeuroImage: Clinical, Numero 28, 2020, Pagina/e 102360, ISSN 2213-1582
Editore: Elsevier BV
DOI: 10.1016/j.nicl.2020.102360

Genetically Predicted Midlife Blood Pressure and Coronary Artery Disease Risk: Mendelian Randomization Analysis

Autori: Dipender Gill, Marios K. Georgakis, Verena Zuber, Ville Karhunen, Stephen Burgess, Rainer Malik, Martin Dichgans
Pubblicato in: Journal of the American Heart Association, Numero 9/14, 2020, ISSN 2047-9980
Editore: Wiley-Blackwell
DOI: 10.1161/jaha.120.016773

Use of Genetic Variants Related to Antihypertensive Drugs to Inform on Efficacy and Side Effects

Autori: Dipender Gill, Marios K. Georgakis, Fotios Koskeridis, Lan Jiang, Qiping Feng, Wei-Qi Wei, Evropi Theodoratou, Paul Elliott, Joshua C. Denny, Rainer Malik, Evangelos Evangelou, Abbas Dehghan, Martin Dichgans, Ioanna Tzoulaki
Pubblicato in: Circulation, Numero 140/4, 2019, Pagina/e 270-279, ISSN 0009-7322
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circulationaha.118.038814

Sleep, 24-h activity rhythms, and plasma markers of neurodegenerative disease

Autori: Thom S. Lysen, M. Arfan Ikram, Mohsen Ghanbari, Annemarie I. Luik
Pubblicato in: Scientific Reports, Numero 10/1, 2020, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-020-77830-4

Immunity and amyloid beta, total tau and neurofilament light chain: Findings from a community‐based cohort study

Autori: Lana Fani, Shahzad Ahmad, M. Kamran Ikram, Mohsen Ghanbari, M. Arfan Ikram
Pubblicato in: Alzheimer's & Dementia, Numero 17/3, 2021, Pagina/e 446-456, ISSN 1552-5260
Editore: Elsevier BV
DOI: 10.1002/alz.12212

ESO Guideline on covert cerebral small vessel disease

Autori: Joanna M Wardlaw, Stephanie Debette, Hanna Jokinen, Frank-Erik De Leeuw, Leonardo Pantoni, Hugues Chabriat, Julie Staals, Fergus Doubal, Salvatore Rudilosso, Sebastian Eppinger, Sabrina Schilling, Raffaele Ornello, Christian Enzinger, Charlotte Cordonnier, Martin Taylor-Rowan, Arne G Lindgren
Pubblicato in: European Stroke Journal, Numero 6/2, 2021, Pagina/e CXI-CLXII, ISSN 2396-9873
Editore: SAGE Publishing
DOI: 10.1177/23969873211012132

The relation of poor mastication with cognition and dementia risk: a population-based longitudinal study

Autori: Christina S. Dintica, Anna Marseglia, Inger Wårdh, Per Stjernfeldt Elgestad, Debora Rizzuto, Ying Shang, Weili Xu, Nancy L. Pedersen
Pubblicato in: Aging, Numero 12/9, 2020, Pagina/e 8536-8548, ISSN 1945-4589
Editore: Medline
DOI: 10.18632/aging.103156

Diabetes Mellitus, Glycemic Traits, and Cerebrovascular Disease

Autori: Marios K. Georgakis, Eric L. Harshfield, Rainer Malik, Nora Franceschini, Claudia Langenberg, Nicholas J. Wareham, Hugh S. Markus, Martin Dichgans
Pubblicato in: Neurology, Numero 96/13, 2021, Pagina/e e1732-e1742, ISSN 0028-3878
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/wnl.0000000000011555

Microfluidic models of the neurovascular unit

Autori: Nienke R Wevers
Pubblicato in: 2021, ISBN 978-94-6419-210-0
Editore: Vrije Universiteit Amsterdam

Genome-Wide Meta-Analysis of Late-Onset Alzheimer’s Disease Using Rare Variant Imputation in 65,602 Subjects Identifies Novel Rare Variant Locus NCK2: The International Genomics of Alzheimer’s Project (IGAP)

Autori: Adam C. Naj, Ganna Leonenko, Xueqiu Jian, Benjamin Grenier-Boley, Maria Carolina Dalmasso, Celine Bellenguez, Jin Sha, Yi Zhao, Sven J. van der Lee, Rebecca Sims, Vincent Chouraki, Joshua C. Bis, Brian W. Kunkle, Peter Holmans, Yuk Yee Leung, John J. Farrell, Alessandra Chesi, Hung-Hsin Chen, Badri Vardarajan, Penelope Benchek, Sandral Barral, Chien-Yueh Lee, Pavel Kuksa, Jacob Haut, Edward B. Lee
Pubblicato in: medRxiv, 2021
Editore: medRxiv
DOI: 10.1101/2021.03.14.21253553

Whole-exome sequencing in 16,511 individuals reveals a role of the HTRA1 protease and its substrate EGFL8 in brain white matter hyperintensities

Autori: Rainer Malik, Nathalie Beaufort, Simon Frerich, Benno Gesierich, Marios K Georgakis, Kristiina Rannikmäe, Amy C Ferguson, Christof Haffner, Matthew Traylor, Michael Ehrmann, Cathie LM Sudlow, Martin Dichgans
Pubblicato in: medRxiv, 2021
Editore: medRxiv
DOI: 10.1101/2021.03.26.21253954

Genetic study of circulating cytokines offers insight into the determinants, cascades and effects of systemic inflammation

Autori: Ville Karhunen, Dipender Gill, Rainer Malik, Mark J. Ponsford, Ari Ahola-Olli, Areti Papadopoulou, Saranya Palaniswamy, Shivaprakash Jagalur Mutt, Sylvain Sebert, Minna Männikkö, Juha Auvinen, Juha Veijola, Karl-Heinz Herzig, Markku Timonen, Sirkka Keinänen-Kiukaanniemi, Martin Dichgans, Marko Salmi, Sirpa Jalkanen, Terho Lehtimäki, Veikko Salomaa, Olli Raitakari, Simon A Jones, Konstantinos K
Pubblicato in: medRxiv, 2020
Editore: medRxiv
DOI: 10.1101/2020.10.26.20219477

Monocyte-chemoattractant protein-1 Levels in Human Atherosclerosis Associate with Plaque Vulnerability

Autori: Marios K. Georgakis, Sander W. van der Laan, Yaw Asare, Joost M. Mekke, Saskia Haitjema, Arjan H. Schoneveld, Dominique P.V. de Kleijn, Gert J. de Borst, Gerard Pasterkamp, Martin Dichgans
Pubblicato in: medRxiv, 2020
Editore: medRxiv
DOI: 10.1101/2020.09.04.20187955

Ischemic Heart Disease and Cognitive Prognosis in the First Year after Stroke

Autori: Michael J O’Sullivan, Paul Wright
Pubblicato in: medRxiv, 2020
Editore: medRxiv
DOI: 10.1101/2020.05.18.20106088

Vascular Territory, White Matter Connections and the Neuroanatomical Basis of Memory Impairment after Stroke

Autori: Paul Wright, Michael J. O’Sullivan
Pubblicato in: medRxiv, 2013
Editore: medRxiv
DOI: 10.1101/19012385

Genetic Determinants of Cortical Structure (Thickness, Surface Area and Volumes) among Disease Free Adults in the CHARGE Consortium

Autori: Edith Hofer, Gennady V Roshchupkin, Hieab Adams, Maria Knol, Honghuang Lin, Shuo Li, Habil Zare, Shahzad Ahmad, Nicola Armstrong, Claudia Satizabal, Manon Bernard, Joshua Bis, Nathan Gillespie, Michelle Luciano, Aniket Mishra, Markus Scholz, View ORCID ProfileAlexander Teumer, Rui Xia, Xueqiu Jian, Thomas Mosley, Yasaman Saba, Lukas Pirpamer, Stephan Seiler, James Becker, Owen Carmichael, Jerome
Pubblicato in: bioRxiv, 2018
Editore: bioRxiv
DOI: 10.1101/409649

Planar cell polarity pathway and development of the human visual cortex

Autori: Jean Shin, Shaojie Ma, Edith Hofer, Yash Patel, Gennady Roshchupkin, Andre M Sousa, Xueqiu Jian, Rebecca Gottesmann, Thomas H Mosley, Myriam Fornage, Yasaman Saba, Lukas Pirpamer, Reinhold Schmidt, Helena Schmidt, Bernard Mazoyer, Amaia Carrion-Castillo, Joshua Bis, Shuo Li, Qiong Yang, Michelle Luciano, Sherif Karama, Lindsay Lewis, Mark Bastin, Matthew A Harris, Ian Deary, Joanna M Wardlaw, Mark
Pubblicato in: bioRxiv, 2018
Editore: bioRxiv
DOI: 10.1101/404558

Meta-analysis of genetic association with diagnosed Alzheimer's disease identifies novel risk loci and implicates Abeta, Tau, immunity and lipid processing

Autori: Brian W. Kunkle, Benjamin Grenier-Boley, Rebecca Sims, Joshua C. Bis, Adam C. Naj, Anne Boland, Maria Vronskaya, Sven J van der Lee, Alex Amlie-Wolf, Celine Bellenguez, Aura Frizatti, Vincent Chouraki, Alzheimer's Disease Genetics Consortium (ADGC), European Alzheimer's Disease Initiative (EADI), Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE), Genetic and Environm
Pubblicato in: bioRxiv, 2018
Editore: bioRxiv
DOI: 10.1101/294629

Identification of hippocampal volume as a mediator of the association between APOE4 and dementia

Autori: Sixtine Brenek, Stéphanie Debette, Sophie Auriacombe, Philippe Amouyel, Vincent Chouraki, Aline Meirhaeghe, Vincent Damotte
Pubblicato in: medRxiv, 2020
Editore: medRxiv
DOI: 10.1101/2020.12.04.20242461

KL-VS heterozygosity is associated with reduced tau accumulation and lower memory impairment in Alzheimer’s disease

Autori: Julia Neitzel, Nicolai Franzmeier, Anna Rubinski, Martin Dichgans, Matthias Brendel, Rainer Malik, Michael Ewers, for the Alzheimer’s Disease Neuroimaging Initiative (ADNI)
Pubblicato in: medRxiv, 2020
Editore: medRxiv
DOI: 10.1101/2020.07.29.20164434

Metabolomic profiling in small vessel disease identifies multiple associations with disease severity

Autori: Eric L. Harshfield, Caroline J. Sands, Anil M. Tuladhar, Frank-Erik de Leeuw, Matthew R. Lewis, Hugh S. Markus
Pubblicato in: medRxiv, 2021
Editore: medRxiv
DOI: 10.1101/2021.05.13.21257190

New insights on the genetic etiology of Alzheimer’s and related dementia

Autori: Céline Bellenguez, Fahri Küçükali, Iris Jansen, Victor Andrade, Sonia Moreno-Grau, Najaf Amin, Adam C. Naj, Benjamin Grenier-Boley, Rafael Campos-Martin, Peter A. Holmans, Anne Boland, Luca Kleineidam, Vincent Damotte, Sven J. van der Lee, Teemu Kuulasmaa, Qiong Yang, Itziar de Rojas, Joshua C. Bis, Amber Yaqub, Ivana Prokic, Marcos R Costa, Julien Chapuis, Shahzad Ahmad, Vilmantas Giedraitis,
Pubblicato in: medRxiv, 2020
Editore: medRxiv
DOI: 10.1101/2020.10.01.20200659

In vivo human molecular neuroimaging of dopaminergic vulnerability along the Alzheimer’s disease phases

Autori: Daniela Perani, Arianna Sala, Silvia Paola Caminiti, Luca Presotto, Andrea Pilotto, Claudio Liguori, Agostino Chiaravalloti, Valentina Garibotto, Giovanni Battista Frisoni, Marcello D’Amelio, Barbara Paghera, Orazio Schillaci, Nicola Mercuri, Alessandro Padovani
Pubblicato in: Alzheimer's Research and Therapy, 2021, ISSN 1758-9193
Editore: BioMed Central
DOI: 10.21203/rs.3.rs-212818/v1

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