PROTEASES VISUALIZATION DURING TUMOR PROGRESSION

Project Information

PROVIST

Grant agreement ID: 661187

DOI 10.3030/661187

Project closed

EC signature date 24 April 2015

Start date 1 January 2016

End date 31 December 2018

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost € 227 361,60

EU contribution € 227 361,60

Coordinated by

POLITECHNIKA WROCLAWSKA
Poland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (11)

Counter Selection Substrate Library Strategy for Developing Specific Protease Substrates and Probes

Author(s): Marcin Poreba, Rigmor Solberg, Wioletta Rut, Ngoc Nguyen Lunde, Paulina Kasperkiewicz, Scott J. Snipas, Marko Mihelic, Dusan Turk, Boris Turk, Guy S. Salvesen, Marcin Drag
Published in: Cell Chemical Biology, Issue 23/8, 2016, Page(s) 1023-1035, ISSN 2451-9456
Publisher: Cell Press
DOI: 10.1016/j.chembiol.2016.05.020

Synthesis of a HyCoSuL peptide substrate library to dissect protease substrate specificity

Author(s): Marcin Poreba, Guy S Salvesen, Marcin Drag
Published in: Nature Protocols, Issue 12/10, 2017, Page(s) 2189-2214, ISSN 1754-2189
Publisher: Nature Publishing Group
DOI: 10.1038/nprot.2017.091

Highly sensitive and adaptable fluorescence-quenched pair discloses the substrate specificity profiles in diverse protease families

Author(s): Marcin Poreba, Aleksandra Szalek, Wioletta Rut, Paulina Kasperkiewicz, Izabela Rutkowska-Wlodarczyk, Scott J. Snipas, Yoshifumi Itoh, Dusan Turk, Boris Turk, Christopher M. Overall, Leszek Kaczmarek, Guy S. Salvesen, Marcin Drag
Published in: Scientific Reports, Issue 7, 2017, Page(s) 43135, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/srep43135

Selective imaging of cathepsin L in breast cancer by fluorescent activity-based probes

Author(s): Marcin Poreba, Wioletta Rut, Matej Vizovisek, Katarzyna Groborz, Paulina Kasperkiewicz, Darren Finlay, Kristiina Vuori, Dusan Turk, Boris Turk, Guy S. Salvesen, Marcin Drag
Published in: Chemical Science, Issue 9, 2018, Page(s) 2113-2129, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/C7SC04303A

Extensive peptide and natural protein substrate screens reveal that mouse caspase-11 has much narrower substrate specificity than caspase-1

Author(s): Monica L Gonzalez Ramirez, Marcin Poreba, Scott J Snipas, Katarzyna Groborz, Marcin Drag, Guy S Salvesen
Published in: Journal of Biological Chemistry, Issue 293(18):7058-7067, 2018, Page(s) jbc.RA117.001329, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.RA117.001329

Emerging challenges in the design of selective substrates, inhibitors and activity-based probes for indistinguishable proteases

Author(s): Paulina Kasperkiewicz, Marcin Poreba, Katarzyna Groborz, Marcin Drag
Published in: The FEBS Journal, Issue 284/10, 2017, Page(s) 1518-1539, ISSN 1742-464X
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/febs.14001

Caspase selective reagents for diagnosing apoptotic mechanisms

Author(s): Marcin Poreba, Katarzyna Groborz, Mario Navarro, Scott J. Snipas, Marcin Drag, Guy S. Salvesen
Published in: Cell Death & Differentiation, Issue 26/2, 2019, Page(s) 229-244, ISSN 1350-9047
Publisher: Nature Publishing Group
DOI: 10.1038/s41418-018-0110-y

Exploring the prime site in caspases as a novel chemical strategy for understanding the mechanisms of cell death: a proof of concept study on necroptosis in cancer cells

Author(s): Katarzyna Groborz, Monica L. Gonzalez Ramirez, Scott J. Snipas, Guy S. Salvesen, Marcin Drąg, Marcin Poręba
Published in: Cell Death & Differentiation, Issue Epub ahead of print, 2019, ISSN 1350-9047
Publisher: Nature Publishing Group
DOI: 10.1038/s41418-019-0364-z

Potent and selective caspase-2 inhibitor prevents MDM-2 cleavage in reversine-treated colon cancer cells

Author(s): Marcin Poreba, Wioletta Rut, Katarzyna Groborz, Scott J. Snipas, Guy S. Salvesen, Marcin Drag
Published in: Cell Death & Differentiation, Issue Epub ahead of print, 2019, ISSN 1350-9047
Publisher: Nature Publishing Group
DOI: 10.1038/s41418-019-0329-2

Fluorescent probes towards selective cathepsin B detection and visualization in cancer cells and patient samples

Author(s): Marcin Poreba, Katarzyna Groborz, Matej Vizovisek, Marco Maruggi, Dusan Turk, Boris Turk, Garth Powis, Marcin Drag, Guy S. Salvesen
Published in: Chemical Science, Issue Just accepted, 2019, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9sc00997c

Selective Substrates and Activity-Based Probes for Imaging of the Human Constitutive 20S Proteasome in Cells and Blood Samples

Author(s): Wioletta Rut, Marcin Poręba, Paulina Kasperkiewicz, Scott J. Snipas, Marcin Drąg
Published in: Journal of Medicinal Chemistry, Issue 61/12, 2017, Page(s) 5222-5234, ISSN 0022-2623
Publisher: American Chemical Society
DOI: 10.1021/acs.jmedchem.8b00026

Non-peer reviewed articles (1)

The Activome: multiplexed probing of activity of proteolytic enzymes using mass cytometry-compatible activity-based probes (TOF-probes)

Author(s): Marcin Poreba, Katarzyna Groborz, Wioletta Rut, Milind Pore, Scott J. Snipas, Matej Vizovisek, Boris Turk, Peter Kuhn, Marcin Drag, Guy S. Salvesen
Published in: bioRxiv, 2019, ISSN 1350-9047
Publisher: Nature Publishing Group
DOI: 10.1101/775627